Rostock, Germany
Rostock, Germany

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Agency: European Commission | Branch: H2020 | Program: RIA | Phase: ISIB-06-2015 | Award Amount: 6.21M | Year: 2016

CELBICON aims at the development, from TRL3 to TRL5, of new CO2-to-chemicals technologies, conjugating at once small-scale for an effective decentralized market penetration, high efficiency/yield, low cost, robustness, moderate operating temperatures and low maintenance costs. In line with the reference Topic text, these technologies will bridge cost-effective CO2 capture and purification from the atmosphere through sorbents (with efficient heat integration of the CO2 desorption step with the subsequent process stages), with electrochemical conversion of CO2 (via PEM electrolysis concepts, promoting CO2 reduction at their cathode in combination with a fruitful oxidation carried out simultaneously at the anode), followed by bioreactors carrying out the fermentation of the CO2-reduction intermediates (syngas, C1 water-soluble molecules) to form valuable products (bioplastics like Poly-Hydroxy-Alkanoates - PHA -, isoprene, lactic acid, methane, etc.) as well as effective routes for their recovery from the process outlet streams. A distinctive feature of the CELBICON approach is the innovative interplay and advances of key technologies brought in by partners (high-tech SMEs & companies, research centres) to achieve unprecedented yield and efficiency results along the following two processing lines: i) High pressure process line tailored to the production of a PHA bioplastic and pressurized methane via intermediate electrochemical generation of pressurized syngas followed by specific fermentation steps; ii) Low pressure processing line focused on the production of value-added chemicals by fermentation of CO2-reduction water-soluble C1 intermediates. Over a 42 months project duration, the two process lines described will undergo a thorough component development R&D programme so as to be able to assemble three optimised TRL5 integrated test-rigs (one per TP) to prove the achievement of all the quantified techno-economical targets.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SPIRE-05-2015 | Award Amount: 4.42M | Year: 2015

TERRA project aims to develop, from TRL 3 to 5, a tandem electrocatalytic reactor (TER) coupling an oxidation reaction to a reduction reaction, with thus the great potential advantage of i) saving resources and energy (needed to produce the oxidant and reductants for the two separate reactions), and ii) intensify the process (reduce the nr. of steps, coupling two synthesis processes and especially eliminating those to prepare the oxidation and reduction agents). The proposal address one of SPIRE Roadmap Key Actions New ways of targeting energy input via electrochemical. The TER unit may be used in a large field of applications, but will be developed for a specific relevant case: the synthesis of PEF (PolyEthylene Furanoate), a next generation plastic. TERRA project aims to make a step forward in this process by coupling the FDCA and MEG synthesis in a single novel TER reactor, with relevant process intensification. Between the elements of innovation of the approach are: i) operation at higher T,P than conventional electrochemical devices for chemical manufacturing, ii) use of noble-metal-free electrocatalysts, iii) use of novel 3D-type electrodes to increase productivity, iv) use of electrode with modulation of activity, v) possibility to utilize external bias (from unused electrical renewable energy) to enhance flexibility of operations. In addition to scale-up reactor and test under environmental relevant conditions (TRL 5), the approach in TERRA project is to address the critical elements to pass from lab-scale experimentation to industrial prototype with intensified productivity. These developments are critical for a wider use of electrochemical manufacturing in chemical and process industries.

Jacobsen M.,University of Rostock | Flechsig G.-U.,University of Rostock | Flechsig G.-U.,Gensoric GmbH
Electroanalysis | Year: 2013

We report about hybridization detection of different nucleic acids on capture probe-modified heated gold wire electrodes. We have compared three kinds of nucleic acid targets: DNA, uracil-conjugated DNA, and RNA. All three sorts of nucleic acids targets could be labeled with osmium tetroxide bipyridine, hybridized with immobilized DNA capture probes and then detected by square-wave voltammetry. Heating the gold electrode instead of the entire bulk hybridization solution leads to improved hybridization efficiency in most cases. The reason could be found in a thermal micro-stirring effect around the heated wire electrode. Also selectivity was improved. Mismatches could be discriminated for DNA and uracil-conjugated DNA targets. Mismatches in RNA strands, however, are more difficult to detect due to relatively stable secondary structures. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Walter A.,University of Rostock | Surkus A.-E.,University of Rostock | Flechsig G.-U.,University of Rostock | Flechsig G.-U.,Gensoric GmbH
Analytical and Bioanalytical Chemistry | Year: 2013

In this report we describe an electrochemical DNA hybridization sensor approach, in which signal amplification is achieved using heated electrodes together with an enzyme as DNA-label. On the surface of the heatable low temperature co-fired ceramic (LTCC) gold electrode, an immobilized thiolated capture probe was hybridized with a biotinylated target using alkaline phosphatase (SA-ALP) as reporter molecule. The enzyme label converted the redox-inactive substrate 1-naphthyl phosphate (NAP) into the redox-active 1-naphthol voltammetrically determined at the modified gold LTCC electrode. During the measurement only the electrode was heated leaving the bulk solution at ambient temperature. Elevated temperature during detection led to increased enzyme activity and enhanced analytical signals for DNA hybridization detection. The limit of detection at 53 C electrode temperature was 1.2 nmol/L. © 2013 Springer-Verlag Berlin Heidelberg.

Flechsig G.-U.,University of Rostock | Flechsig G.-U.,Gensoric GmbH | Walter A.,University of Rostock
Electroanalysis | Year: 2012

This article comprehensively reviews a selected subfield of thermoelectrochemistry, which bases upon joule-heated working electrodes. Both directly and indirectly heated electrodes are considered. In all cases, an electric current (AC or DC) is used to elevate the electrode temperature during the electrochemical processes. The development of joule-heated electrodes started as early as 1966 and was greatly accelerated by Gründler etal. since 1993. However, during the last 5 years the development became even faster, when other groups started to contribute novel approaches and designs on how to implement electrically heated electrodes in capillary electrophoreses and spectroelectrochemistry. To date there are more than 90 publications on heated electrodes. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Mix M.,University of Rostock | Ruger J.,University of Rostock | Kruger S.,University of Rostock | Broer I.,University of Rostock | And 2 more authors.
Electrochemistry Communications | Year: 2012

We demonstrate an approach for the electrochemical detection of genetically modified maize in real maize flour samples by means of square-wave voltammetry (SWV). After labeling the asymmetric PCR-amplified targets with osmium tetroxide bipyridine [OsO 4(bipy)], they were hybridized with immobilized oligonucleotide probes on gold electrodes. We could detect the maize genes ivrp and SSIIb in near isogenic maize. The transgene cryIa/b and the MON810 specific fragment were detected in all transgenic maize samples, down to a content of 0.6% of MON810 in mixed samples. While it was possible to detect all sequences in the samples containing 100% near isogenic or respectively transgenic maize after a hybridization time of less than 10 min, a hybridization time of 30 min was necessary for the detection of the genetic modifications in samples containing only 0.9 to 0.6% of transgenic maize. No significant detection of the transgene cryIa/b or MON810 was possible when only 0.5% of transgenic maize was present in the sample, most likely due to insufficient amplification of the template DNA. © 2012 Elsevier B.V.

Gensoric GmbH | Date: 2012-08-01

This invention relates to an electrochemical sensor (1), comprising a base element (3), which is made of electrically insulating material and has a planar surface (9), and a pair of conductors (5), which are attached to said planar surface (9) of the base element (3), wherein the two conductors (5) of the pair are connected by at least one wire-shaped electrochemical working electrode (7). The invention further related to a sensor array (21), which has several previously described sensors (1), and to a method for coating a working electrode (7) of the previously described sensor (1).

Gensoric Gmbh | Date: 2016-02-24

The present invention relates to the field of DNA diagnosis, in particular, to detection of single nucleotide polymorphisms (SNPs). Single nucleotide polymorphisms play an important role in many diseases having a genetic component, e.g., in multiple sclerosis. The invention provides an electrochemical method of detection of SNP, which exploits the different temperature optima of detection of DNA of varying sequences labeled with a redox marker such as osmium tetroxide bipyridine, wherein the detection is preferably carried out at a directly heated electrode. The invention also relates to kits for carrying out said method, and a method of diagnosing a disease associated with a SNP.

Agency: European Commission | Branch: H2020 | Program: SME-1 | Phase: SIE-01-2014-1 | Award Amount: 71.43K | Year: 2015

BERTHA-G stands for Better enzymes than gas. Our first-of-its-class system enables independence from centralized supply of fossil fuel (i.e. natural gas, oil) for residential heating purposes (15000 kWh therm. p.a). Applied at a national level, our approach can help disrupt the conventional energy supply and shift the demand from limited oil / natural gas from external suppliers to synthetic fuels which are cost-efficient and non-volatile (price), not limited by nature and CO2 neutral.This will be achieved by a cutting-edge proprietary technology: using the platform technology of Gensoric GmbH, an electro-biocatalytical process converts plain water, CO2 from ambient air and electricity into preferably Methanol. In contrast to alternative CO2-to-fuel-technologies, this process runs under mild conditions: no high pressure, no high temperatures. Owing to the selectivity of the enzymatic process, CO2 can be taken from ambient air, there is no need for a refined or concentrated volume streams. All steps can be carried out at ambient conditions which makes it suitable for residential applications. All educts needed are available, even the electrolytic production of hydrogen can be waived, as the enzymes take the needed hydrogen directly from plain water. The electrical energy can be taken from installed renewable energies, an effect which can make installed system more economically viable, especially for storing purposes, which will dramatically increase the efficiency. To facilitate the usage, our system is compatible to already existing infrastructure. Through our solution, we empower the customer to become a prosumer or producer and consumer of energy to mitigate the volatility of energy prices, to become energy independent, and contribute to a CO2 neutral economy. In contrast to conventional device sellers, we can enhance the attractiveness of the underlying business model by introducing revolving sales through consumables.

Agency: European Commission | Branch: H2020 | Program: SME-2 | Phase: SMEInst-09-2016-2017 | Award Amount: 2.44M | Year: 2016

Our vision: we want Europe to be independent of fossil fuels. To turn this ambitious dream into reality, Gensoric targets in a first step a sector which accounts for more than 73% of the fossil fuel usage and 57% of all CO2 emissions in the EU: heating! To overcome this situation, Gensoric aspires to empower private uses to change things actively by themselves. As a means for that, the company introduces ist willpower system: the worldwide first residential CO2 utilization system. It empowers its users to their produce fuel at home from the surrounding atmospheric CO2. The core technology is a patent protected and widely validated electro-biocatalytical process and process technology that runs under ambient conditions. As it uses primarily energy from renewable sources such as installed solar panels or micro wind turbine, the system can also be used as an effective way to store energy from the renewables, but it has a greater capacity than power packs and batteries. During the previous SME-1project its potential to disrupt the conventional energy supply chains was confirmed. Moreover, the market potential of more than 7 bln Euro in alone in Western Europe and the underlying business model (ink cartridge) attracted strategic partners such as one of Germanys leading energy and utility company, with access to 30 million customers across Europe, who will take over the market introduction once the pilot project has been completed successfully. Outcome of the here proposed SME-2 project is a market ready system with an overall efficiency of 45% and an average capacity to reduce 11kg of CO2 emission per day and user.

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