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Providence, RI, United States

Kim M.Y.,Chungbuk National University | Lee S.H.,Chungbuk National University | Jang G.Y.,Chungbuk National University | Park H.J.,Chungbuk National University | And 6 more authors.
Food Chemistry | Year: 2015

This study was performed to evaluate the enhancement of functional components of germinated rough rice. Rough rice was germinated at 37 °C for 6 days, and subjected to a high hydrostatic pressure treatment (HPT) at 30 MPa for 24 h (HP24) and 48 h (HP48). Germinated rough rice without HPT (HP0), HP24, and HP48 were analysed for their functional components. The highest γ-aminobutyric acid, total arabinoxylan, and tricin 4′-O-(threo- β-guaiacylglyceryl) ether contents were 121.21 mg/100 g, 10.6%, and 85.82 μg/g, respectively, after HP48 for 2 days. γ-Oryzanol contents increased from 23.19-36.20 mg/100 g (at HP0) to 31.80-40.32 mg/100 g (at HP48). The highest vitamin B (60.99 mg/100 g) and E (4.07 mg/100 g) contents were observed after HP24 for 5 and 2 days, respectively. These results suggest that a combination of HPT and germination efficiently enhances the functional characteristics of rough rice. © 2014 Elsevier Ltd. All rights reserved. Source


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Grant
Agency: Department of Energy | Branch: | Program: SBIR | Phase: Phase I | Award Amount: 0.00 | Year: 2000

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Grant
Agency: Department of Energy | Branch: | Program: SBIR | Phase: Phase II | Award Amount: 600.00K | Year: 2000

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Grant
Agency: Department of Health and Human Services | Branch: | Program: SBIR | Phase: Phase II | Award Amount: 447.68K | Year: 2000

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Grant
Agency: Department of Health and Human Services | Branch: | Program: SBIR | Phase: Phase I | Award Amount: 971.14K | Year: 2003

DESCRIPTION (provided by investigator): Burkholderia pseudomallei is a bioterrorist threat. With the best current therapies, lethality is typically as high as 40%. The overall goal of this application is the development of new drugs against this organism. In Phase I, we will exploit the high sequence similarity between B. pseudomallei and its less virulent relative Pseudomonas aeruginosa to build innovative screens for rapid, safe discovery of effective therapeutic agents. The two species are similar in genome size and composition, with nucleotide and amino acid sequence identities for many genes in the 50-70% range, and in their mechanisms of drug resistance. We will identify genes for new drug targets in B. pseudomallei with orthologs in P. aeruginosa, validate them as essential for survival or growth of both species, and move them into P. aeruginosa as replacements for the native orthologs. Then, we will measure the whole-genome expression profile of P. aeruginosa strains engineered to under express each B. pseudomallei target gene, and use the results to construct a validated set of sensitive whole-cell reporter screens. In Phase II, we will apply these screens to a library of over 100,000 compounds and advance the most promising candidates into lead optimization and efficacy testing in animal models.

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