Burc Genetic Diagnosis Center

İstanbul, Turkey

Burc Genetic Diagnosis Center

İstanbul, Turkey
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Serce Pehlevan O.,Zeynep Kamil Maternity and Childrens Training and Research Hospital | Karatekin G.,Zeynep Kamil Maternity and Childrens Training and Research Hospital | Koksal V.,Burc Genetic Diagnosis Center | Benzer D.,Zeynep Kamil Maternity and Childrens Training and Research Hospital | And 3 more authors.
Journal of Perinatology | Year: 2015

Objective:The pathophysiologies of bronchopulmonary dysplasia (BPD) are inflammation, infection, tissue damage, angiogenesis defects and genetic susceptibility. Because of the role of the vitamin D binding protein (Gc globulin) on these factors, we investigated the relationship between Gc globulin polymorphisms and BPD.Study design:This case-control study was performed with 160 neonates (≤32 gestational ages, ≤1500 g). PCR DNA sequence analyses were used for GC gene rs4588 and rs7041 single-nucleotide polymorphisms.Result:In the univariate analyses, it was observed that Gc2 was the only variant that was protective against BPD (Odd ratio (OR)=0.47, 95% coinfidence interval (CI)=0.24 to 0.89, P=0.020). In the multivariate analyses, Gc2 decreased the risk of disease (OR=0.15, 95% CI=0.029 to 0.79, P=0.026) independent of gestational age, birth weight, 5-min Appearance, Pulse, Grimace, Activity, and Respiration scores, respiratory distress syndrome and sepsis.Conclusion:The Gc2 variant was, after adjusting for confounders, associated with a decrease in the frequency of BPD. Our study adds Gc globulin to the list of candidate genes that potentially contribute to the etiology of the disease. © 2015 Nature America, Inc.


PubMed | Zeynep Kamil Maternity and Childrens Training and Research Hospital and Burc Genetic Diagnosis Center
Type: Journal Article | Journal: Journal of perinatology : official journal of the California Perinatal Association | Year: 2015

The pathophysiologies of bronchopulmonary dysplasia (BPD) are inflammation, infection, tissue damage, angiogenesis defects and genetic susceptibility. Because of the role of the vitamin D binding protein (Gc globulin) on these factors, we investigated the relationship between Gc globulin polymorphisms and BPD.This case-control study was performed with 160 neonates (32 gestational ages, 1500g). PCR DNA sequence analyses were used for GC gene rs4588 and rs7041 single-nucleotide polymorphisms.In the univariate analyses, it was observed that Gc2 was the only variant that was protective against BPD (Odd ratio (OR)=0.47, 95% coinfidence interval (CI)=0.24 to 0.89, P=0.020). In the multivariate analyses, Gc2 decreased the risk of disease (OR=0.15, 95% CI=0.029 to 0.79, P=0.026) independent of gestational age, birth weight, 5-min Appearance, Pulse, Grimace, Activity, and Respiration scores, respiratory distress syndrome and sepsis.The Gc2 variant was, after adjusting for confounders, associated with a decrease in the frequency of BPD. Our study adds Gc globulin to the list of candidate genes that potentially contribute to the etiology of the disease.

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