GeneReach Biotechnology Corporation

Taichung, Taiwan

GeneReach Biotechnology Corporation

Taichung, Taiwan

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Patent
GeneReach Biotechnology Corporation | Date: 2014-05-07

The present invention provides a thermal convection polymerase chain reaction device (10). The thermal convection polymerase chain reaction device (10) of the present invention is used for bearing a test tube (12) in which the polymerase chain reaction is carried out; the polymerase chain reaction device comprises an adiabatic seat (20) and a heating seat (30), wherein the adiabatic seat (20) has a body (22), a chamber (24) located inside of the body (22) for housing the bottom (121) of the test tube (12), a side channel (261) connecting the chamber (24) with outside, and an upper channel (262) connecting the chamber (24) with outside for the test tube (12) to pass through; the heating seat (30) is passed through and located in the side channel (261) of the adiabatic seat (20) for leaning against the bottom (121) of the test tube (12). The device of the present invention can reduce the extent to which the high temperature produced by the heat source interferes with the thermal dissipation of the PCR mixed solution from the middle section (122) to the upper section (123) in the test tube (12), and is suitable for the synchronous polymerase chain reaction method.


Patent
GeneReach Biotechnology Corporation | Date: 2013-08-30

A method for detecting Bacillus Anthracis comprises steps: obtaining DNA of a sample; respectively mixing the DNA with Primer Sets pXO1, pXO2 and PL3 to form a first reactant mixture, a second reactant mixture and a third reactant mixture, wherein the Primer Sets pXO1, pXO2 and PL3 are respectively sequences specially designed for pXO1, pXO2 and PL3; respectively undertaking PCRs of the first reactant mixture, the second reactant mixture and the third reactant mixture; and detecting whether the sample contains sequences of pXO1, pXO2 and PL3 simultaneously to determine whether the sample contains Bacillus Anthracis. The present invention detects whether the sample contains pXO1, pXO2 and PL3 simultaneously to determine whether the sample contains Bacillus Anthracis and further uses specified primer sets to undertake PCRs and increase the sensitivity and specificity of detection. Thereby is increased the speed and accuracy of detection.


Patent
GeneReach Biotechnology Corporation | Date: 2013-05-31

A method for fluorescence detection is provided and includes mixing a fluorescence detecting reagent into a sample, placing the sample into a sample tray, where the sample tray includes at least a row of blank slots and at least a row of sampling slots. Then, exposing the sample tray to a background light, and obtaining a grayscale background image of the sample tray.


Patent
GeneReach Biotechnology Corporation | Date: 2014-10-01

Provided in the present invention is a device (10) for thermal convection polymerase chain reaction (PCR). The device (10) is used for bearing a heat radiating base (20) which has a body (22) and a passage (24) provided through the body (22) to be used for the insertion of the test tube (12), wherein the passage (24) has a large diameter section (241) and a small diameter section (242) positioned below the large diameter section (241). Therefore, it can be ensured that during the PCR process the surface temperature of the mixed liquid is lower than the temperature required in a primer annealing reaction.


Patent
GENEREACH BIOTECHNOLOGY Corporation | Date: 2013-03-18

A reaction tube for performing isothermal polymerase chain reaction therein is provided and includes an upper section, a lower capillary section, a linkage connecting the upper section and the lower capillary section, and a thermal conductor. The lower capillary section has an annealing portion, an annular heating groove, and a close end. The annealing portion is connected with the linkage, and the annular heating groove is connected with the annealing portion. The close end is connected with the annular heating groove. The thermal conductor tightly embraces the annular heating groove of the lower capillary section for conducting heat. Accordingly, a heat generated from the heating source will conduct to the annular heating groove of the lower capillary section of the reaction tube, a temperature gradient along the reaction tube is then provided in order to perform a thermal convection, thereby performing the isothermal polymerase chain reaction in the reaction tube.


Patent
GeneReach Biotechnology Corporation | Date: 2014-05-21

The present invention provides a container for a nucleic acid amplification reaction, comprising a capillary (100) and a heat conduction sleeve (200). The heat conduction sleeve (200) is tightly fitted on the outer side of the capillary (100) for heating the capillary (100) evenly when heat is transferred to the heat conduction sleeve (200), so that the capillary (100) is heated evenly. In this way, the speed of the nucleic acid amplification reaction is increased.


Patent
GENEREACH BIOTECHNOLOGY Corporation | Date: 2014-12-19

A biochemical reactor includes a temperature control device containing a substrate, a first conductive layer, a second conductive layer, a receiving hole, and a heating element. The substrate has a through hole for accommodating the vessel; the receiving hole is adjacent to the through hole for receiving the heating element; the first conductive layer has a connecting region formed on the wall of the through hole; and two terminals of the heating element are respectively connected electrically to the first and the second conductive layers. As such, the heat generated from the heating element can be transferred to the through hole via the first conductive layer to heat the vessel.


The present disclosure is related to a device for controlling thermal convection velocity of a biochemical reaction. The thermal convection velocity controlling device includes a base body for disposing a tube which is movable, wherein the tube is filled with a buffer of the biochemical reaction; a heating source located at a bottom of the tube or at a side of the tube to heat the buffer; and a flow rate adjusting apparatus for controlling a thermal convection flow direction of the buffer in the tube, whereby the flow rate adjusting apparatus changes a flow velocity and a flow time of the buffer. The present disclosure is also related to a method for controlling thermal convection velocity of a biochemical reaction using the device.


A method for steadying a thermal convection flow field in a PCR reaction solution during a thermal convective polymerase chain reaction (PCR) includes steps as follows. A PCR tube is provided. A PCR reaction solution is filled in the PCR tube. A bottom of the PCR tube is heated so that a thermal convection is induced. And the PCR to be is tilted at a tilt angle relative to a vertical line over a ground for causing a single-loop flow in the thermal convection flow field in the PCR reaction solution, whereby a denaturation an annealing reaction and an extension reaction occur sequentially and repeatedly in different temperature regions of the PCR reaction solution.


Patent
GENEREACH BIOTECHNOLOGY Corporation | Date: 2015-06-05

The present disclosure relates to a heating device and a biochemical reactor having the heating device. The heating device includes an upper plate, a lower plate, a middle plate, and an electric heating element. The upper plate has an upper heating hole, an upper receiving hole, and an upper conductive layer. The lower plate has a lower heating hole, a lower receiving hole, and a first lower conductive layer. The middle plate is disposed between the upper and lower plates and has a middle heating hole and a middle receiving hole. The upper, middle and lower receiving holes are connected together to form a receiving through hole. The electric heating element is disposed in the receiving through hole and has two terminals connected to the upper conductive layer and the lower conductive layer, respectively.

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