Liu J.,General Unit of Chinese Peoples Armed Police Force Hospital |
Cao B.,Tianjin University |
Cao B.,Tianjin Key Laboratory for Biomarkers of Occupational and Environmental Hazard |
Gao Y.,Tianjin University |
And 7 more authors.
Journal of Asian Natural Products Research | Year: 2013
In order to find novel synthetic compounds with superior antitumor activity and overcome multidrug resistance, a series of novel 4β-N-substituted podophyllotoxin derivatives were synthesized under mild conditions with satisfactory yield. Nine novel podophyllotoxin derivatives were synthesized by linking 4β-amino-podophyllotoxin with aldehydes via the formation of a Schiff's base, and imines were reducted to secondary amines. These novel derivatives have been evaluated for cytotoxicity against human cancer cell lines Hela, K562, and K562/AO2. The results indicated that these compounds possess superior bioactivity (IC50 values were found at the range of 10 -6-10-8 mol/l) and weak multidrug resistance. © 2013 Taylor and Francis.