Institute of General Surgery

Parma, Italy

Institute of General Surgery

Parma, Italy
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Arunagiri V.,Institute of General Surgery | Parimala M.,Institute of General Surgery | Ragumani P.,Institute of General Surgery | Anbalagan K.,Chennai Corporation
Indian Journal of Surgery | Year: 2017

Ever since the advent of Smartphones, Smartphone applications (SAs) are revolutionizing the contemporary medicine. Smartphone application which was created in view of swift communications among the general public has now intruded the medical fraternity. But the ethics for using these applications to transfer patients’ medical records through SA is bewildering among the medical professionals (MPs). © 2017 Association of Surgeons of India


Sridharan S.,Institute of Neurosurgery | Jagan Narayana G.S.,Institute of Neurosurgery | Chidambaram K.,Institute of General Surgery | Jayachandiran A.P.,Institute of General Surgery
Journal of Neurosciences in Rural Practice | Year: 2017

The zoonotic infection hydatidosis is caused by the tapeworm cestode, Echinococcus granulosus. Though considered endemic in India where association of humans with sheep and dogs form part of the livelihood, primary skeletal muscle involvement of the disease is an extremely rare event. We report a case of primary paraspinal hydatidosis with extradural extension causing acute paraplegia. Excision of the cyst and decompression of the cord was done along with albendazole therapy. Paraspinal hydatid disease is a rare entity, and in regions where hydatid disease is endemic, it can be involved in the differential diagnosis of acute compressive myelopathy. Although antihelminthic chemotherapy forms the mainstay of the treatment, surgical intervention forms a major part of the management. © 2017 Journal of Neurosciences in Rural Practice.


Azzoni C.,University of Parma | Bottarelli L.,University of Parma | Cecchini S.,Institute of General Surgery | Lagrasta C.,University of Parma | And 5 more authors.
Virchows Archiv | Year: 2011

HER-2/neu overexpression and/or gene amplification occurs in several human malignancies, frequently correlates with tumor aggressiveness, and provides the basis for treatment with trastuzumab. Among neuroendocrine neoplasms (NEN) of the gastroenteropancreatic (GEP) tract, ileal neuroendocrine tumors show peculiar features of malignancy with frequent metastases at the diagnosis. We investigated the overexpression and/or amplification of HER-2/neu and the involvement of the metastasis-related proteins c-Met, MTA-1, and VEGF in 24 primary ileal NEN by immunohistochemistry and fluorescence in situ hybridization (FISH). Data were compared with those of 43 GEP endocrine tumors of other sites. All primary ileal NEN showed an intense membranous and cytoplasmic immunostaining for HER-2/neu. According to the breast cancer scoring system, 17% of ileal carcinoids showed a score of 3+ and 71% with a score of 2+ with a significant difference respect the non-ileal GEP endocrine tumors (p<0.0000). FISH analysis revealed chromosome 17 polysomy in 33% of 2+/3+ ileal tumors but not HER-2/neu gene amplification. The c-Met and MTA-1 but not VEGF were overexpressed in almost all ileal NEN, whereas VEGF presented more frequently a normal staining. The comparisons with the other GEP NEN demonstrated significant differences for all the three proteins (p<0.0000, p<0.0002, and p<0.001, respectively). These findings suggest that in ileal NEN, HER-2/neu overexpression plays a role in the carcinogenetic process and by triggering the altered expression of c-Met and MTA-1, may activate the molecular pathway(s) promoting tumor progression and metastasis development. Ileal HER-2/neu overexpressing neuroendrocrine tumors may constitute potential candidates for target therapy with specific humanized monoclonal antibodies. © 2011 Springer-Verlag.

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