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Song Z.F.,General Hospital of Xuzhou Mining Business Group Co Ltd.
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases | Year: 2011

Analyzed associations among the incidence of coal workers' pneumoconiosis from 2003 to 2008, jobs, exposure years and cumulative total dust exposure levels (CTE) and found the current characteristics of the mine incidence of pneumoconiosis disease. collected the health care information of the new diagnosed pneumoconiosis of underground mine workers from 2003 to 2008 and the dust monitoring data of underground mine from 1949 and estimated the personnel cumulative total dust exposure levels (CTE); analyzed the incidence features of the new diagnosed pneumoconiosis. The rates of health surveillance of workers were gradually improved from 2003 to 2008 and 296 new coal workers pneumoconiosis were diagnosed. The total incidence was 0.57%, and the average annual rate was 0.32%. Among the new diagnosed cases, phase I accounted for 90.5% and the 87.2% from coal mine drillers. The shortest exposure period was 3 years and the longest was 38 years, and the cumulative total dose of dust was varied between 86.1 and 4926 mg/m(3) per year. The total dust accumulated limited dose was calculated by the percentile method to prevent 99% of miners from pneumoconiosis, which was 120.6 mg/m(3) per year, so we suggested that the exposure years should be shorter than 13 years under the current working conditions. Preventive coal workers' pneumoconiosis should be focused on mine drillers and their limited exposure years should be within 13 years.


Jin K.,Nanjing Medical University | Ji X.,Nanjing Medical University | Wang S.,Nanjing Medical University | Song Z.,Nanjing Medical University | And 5 more authors.
International Journal of Interferon, Cytokine and Mediator Research | Year: 2012

Objective: To investigate the possible relationship between macrophage migration inhibitory factor (MIF) -173 polymorphism (rs755622) and susceptibility to coal workers' pneumoconiosis (CWP) in a Chinese population. Methods: A total of 699 patients with CWP and 677 controls were genotyped for the polymorphism by TaqMan method. Results: Our results showed that the MIF -173CC genotype was associated with a significantly decreased risk of CWP (adjusted odds ratio = 0.44, 95% confidence interval = 0.22-0.85), compared with the GG/GC genotype, particularly among smokers. Conclusion: Our results indicate that the functional MIF -173G/C polymorphism is involved in the etiology of CWP and susceptibility to this disease. Further studies are warranted to validate our findings. © 2012 Jin et al, publisher and licensee Dove Medical Press Ltd.


Qian H.,Nanjing Medical University | Song Z.,General Hospital of Xuzhou Mining Business Group Co Ltd. | Wang M.,Nanjing Medical University | Jia X.,General Hospital of Xuzhou Mining Business Group Co Ltd. | And 6 more authors.
Journal of Biomedical Research | Year: 2010

Objective: The aim of this case-control study was to explore whether five tagging single nucleotide polymorphisms (tSNPs) within the transforming growth factor-β1 (TGF-β1) gene were involved in manifestation of inflammatory and fibrotic processes associated with coal workers' pneumoconiosis (CWP). Methods: The study included 508 CWP patients and 526 controls who were underground coal miners from Xuzhou Mining Business Group. Five tSNPs were selected from the HapMap and detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: The single SNP analysis showed that the genotype frequencies of SNP2 (rs1800470, +869T/C, extron 1) and SNP5 (rs11466345, intron 5) in CWP cases were significantly different from those in controls. Multivariate logistic regression analysis revealed that SNP2 (rs1800470) CC genotype was associated with decreased risk of CWP (OR = 0.50, 95% CI = 0.32-0.78), which was evident among subgroups of those never smoke (OR = 0.40, 95%CI = 0.24-0.66), cases with stage II (OR = 0.41, 95%CI = 0.22-0.76) and exposure period (< 28 y: OR = 0.54, 95%CI = 0.31-0.95; ≥ 28 y: OR = 0.52, 95%CI = 0.32-0.96). However, the SNP5 (rs11466345) GG genotype was associated with an increased risk of CWP (OR = 2.5, 95%CI = 1.36-4.57), and further stratification analysis showed that the risk of CWP was increased in both smoking and nonsmoking groups, shorter and longer exposure groups, while the risk of CWP was only increased in patients with stage I and II Conclusion: This study suggests that TGF-β1 polymorphisms may contribute to susceptibility of CWP. © 2010 The Editorial Board of Journal of Biomedical Research.


Wang M.,Nanjing Medical University | Wang S.,Nanjing Medical University | Song Z.,General Hospital of Xuzhou Mining Business Group Co Ltd. | Ji X.,General Hospital of Xuzhou Mining Business Group Co Ltd. | And 3 more authors.
PLoS ONE | Year: 2011

Background: The IL-4, IL-4 receptor (IL4R), and IL-13 genes are crucial immune factors and may influence the course of various diseases. In the present study, we investigated the association between the potential functional polymorphisms in IL-4, IL-4R, and IL-13 and coal workers' pneumoconiosis (CWP) risk in a Chinese population. Methods: Six polymorphisms (C-590T in IL-4, Ile50Val, Ser478Pro, and Gln551Arg in IL-4R, C-1055T and Arg130Gln in IL-13) were genotyped and analyzed in a case-control study of 556 CWP and 541 control subjects. Results: Our results revealed that the IL-4 CT/CC genotypes were associated with a significantly decreased risk of CWP (odds ratio (OR) = 0.74, 95% confidence interval (CI) = 0.58-0.95), compared with the TT genotype, particularly among subgroups of age <65 years (OR = 0.68, 95%CI = 0.46-0.99) and dust exposure years ≥26 years (OR = 0.69, 95%CI = 0.50-0.94). Moreover, the polymorphism was significantly associated with risk of CWP patients with stage I. In addition, a combined effect was observed in a dose-dependent manner with increasing numbers of risk variant alleles (P trend = 0.023), and individuals with 11-12 risk alleles had a 47% higher risk of CWP than those with 0-8 risk alleles (OR = 1.47, 95% CI = 1.05-2.05). Conclusions: Our results suggest that the IL-4 C-590T polymorphism is involved in the etiology of CWP and susceptibility to this disease. Larger studies are warranted to validate our findings. © 2011 Wang et al.


Wang M.,Nanjing Medical University | Ye Y.,Nanjing Medical University | Qian H.,Nanjing Medical University | Song Z.,General Hospital of Xuzhou Mining Business Group Co Ltd. | And 4 more authors.
Journal of Human Genetics | Year: 2010

microRNAs (miRNAs) are an abundant class of small noncoding RNA molecules thought to be involved in biological functions, including embryonic development, chromosome architecture, cell proliferation and apoptosis. We hypothesized that common variants in the miRNAs are associated with risk of coal workers' pneumoconiosis (CWP). In a case-control study of 496 CWP patients and 513 control subjects frequency matched by exposure years and work types, we genotyped four single-nucleotide polymorphisms (SNPs) (rs2910164, rs2292832, rs11614913 and rs3746444) in pre-miRNAs (miR-146a, miR-149, miR-196a2 and miR-499) and assessed the associations with risk of CWP. A significantly increased risk of CWP was found for the miR-149 rs2292832 TT genotype (odds ratio (OR), 1.31; 95% confidence interval (CI), 1.01-1.69), compared with the CT/CC genotypes, and this increased risk was evident among subgroups of those aged ≥68 years (OR=1.52, 95% CI=1.03-2.25), dust exposure ≥26 years (OR=1.42, 95% CI=1.04-1.93) and ever smokers (OR=1.48, 95% CI=1.00-2.20). Furthermore, a significant association was observed between the genotypes and patients with stages II and III (OR=1.50, 95% CI=1.05-2.14 for stage II, and OR=3.33, 95% CI=1.67-6.65 for stage III). These results suggest that miR-149 rs2292832 polymorphism is involved in susceptibility to developing CWP. © 2010 The Japan Society of Human Genetics. All rights reserved.

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