Wuhan Brain Hospital General Hospital of the Yangtze River Shipping

Wuhan, China

Wuhan Brain Hospital General Hospital of the Yangtze River Shipping

Wuhan, China
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Sun L.,Wuhan Brain Hospital General Hospital of the Yangtze River Shipping | Sun L.,Huazhong University of Science and Technology | Li Q.,Shanghai JiaoTong University | Wang W.-T.,Huazhong University of Science and Technology | And 2 more authors.
Neural Regeneration Research | Year: 2015

1-(2,6-Dimethylphenoxy)-2-(3,4-dimethoxyphenylethylamino)-propane hydrochloride (DDPH) is a novel antihypertensive agent based on structural characteristics of mexiletine and verapamine. We investigated the effect of DDPH on vasodilatation and neuroprotection in a rat model of cerebral ischemia in vivo, and a rabbit model of isolated basilar arteries in vitro. Our results show that DDPH (10 mg/kg) significantly increased hippocampal blood flow in vivo in cerebral ischemic rats, and exerted dose-dependent relaxation of isolated basilar arteries Accepted: 2015-03-16 contracted by histamine or KCl in the in vitro rabbit model. DDPH (3 x 10-5 M) also inhibited histamine-stimulated extracellular calcium influx and intracellular calcium release. Our findings suggest that DDPH has a vasodilative effect both in vivo and in vitro, which mediates a neuroprotective effect on ischemic nerve tissue. © 2015, Editorial Board of Neural Regeneration Research. All rights reserved.

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