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Zhang X.,Peking University | Zhou L.,Peking University | Liu Y.,First Hospital | Li W.,First Hospital | And 5 more authors.
Experimental and Therapeutic Medicine | Year: 2016

Vasoactive intestinal peptideoma (VIPoma) is a rare pancreatic endocrine tumor associated with a well-defined clinical syndrome characterized by watery diarrhea, hypokalemia and metabolic acidosis. In adults, VIPoma is most commonly found in the pancreas, with 80% of the tumors occurring in the body and tail and 20% occurring in the pancreatic head. VIPomas can represent a significant diagnostic challenge due to their nonspecific clinical presentation, which can result in the misdiagnosis of a VIPoma as another condition, such as laxative overdose or a carcinoid secreting tumor. Surgical clearance of the tumor is the first-line treatment, even in cases with metastasis. The present study describes the case of a patient who presented with chronic watery diarrhea and hypokalemia due to a tumor in the pancreatic head, which was confirmed to contain immunoreactive vasoactive intestinal polypeptide via immunohistochemistry. A hepatic metastasis lesion was diagnosed following computed tomography. Stable control of symptoms was achieved after surgery and drug treatment. The study additionally reviews the clinical, histological, radiological and diagnostic features of the condition, as well as the therapeutic modalities that can be used to treat VIPoma in the pancreatic head with hepatic metastasis. © 2016, Spandidos Publications. All Rights reserved. Source


Fang T.,Capital Medical University | Zhu H.,Capital Medical University | Yan R.,Sanbo Neurosurgical Hospital | Yang J.,Sanbo Neurosurgical Hospital | And 2 more authors.
Journal of Clinical Neuroscience | Year: 2013

During a 10-year period, 41 patients underwent surgery for resection of large or giant petroclival meningiomas. Gross total resection (GTR) was accomplished in 25 patients (61.0%), subtotal resection (STR) in 15 patients (36.6%), and partial resection in one patient (2.4%). Postoperative complications were observed in 27 patients (65.9%). Postoperative radiosurgery was administered in six patients who had residual tumors. Survival and postoperative quality of life are the goals of successful surgery on large or giant petroclival meningiomas, and the strategic surgical approach is based on the tumor location, the direction of growth, the invasion of adjacent structures, patient age and neurosurgeon expertise. Selectively pursuing STR with radiotherapy rather than GTR is a reasonable strategy. © 2012 Elsevier Ltd. All rights reserved. Source


Zhao F.,Xuzhou Medical College | Wang H.,Poten Biomedical Institute for Cancer Immunotherapy | Kunda P.,Poten Biomedical Institute for Cancer Immunotherapy | Chen X.,Poten Biomedical Institute for Cancer Immunotherapy | And 3 more authors.
Oncology Reports | Year: 2013

Retinoblastoma (RB) is an intraocular cancer that affects young children. There is an ongoing effort to find new agents for RB management that are effective, specific and with few side-effects. In the present study, we tested artesunate (ART), a synthetic derivative from the herbal drug artemisinin, used in the clinic for the treatment of malaria. We analyzed ART cytotoxicity in an RB cell line (RB-Y79) and in a retinal epithelial cell line (hTERT-RPE1) by flow cytometric analysis (FCM). We related the effect of ART to the expression of transferrin receptor 1 (TfR-1, also known as CD71) by knocking down CD71 with RNAi and analyzing cell cycle variables by FCM. We found that the cytotoxic action of ART is specific for RB cells in a dose-dependent manner, with low toxicity in normal retina cells. ART is more effective in RB than carboplatin with a markedly strong cytotoxic effect on carboplatin-resistant RB cells. RB had higher CD71 levels at the membrane compared to normal retinal cells. We showed that ART internalization in RB cells is dependent upon the expression of the CD71. In addition, ART blocked the cell cycle progression at the G1 phase, even at low doses, and decreased the proportion of RB cells in the S phase. In conclusion, we showed that ART is a promising drug exhibiting high selective cytotoxicity even against multidrug-resistant RB cells. Thus, we suggest that ART could be used in the treatment of RB. Source


Liu H.,Beijing Aerospace Control Device Institute | Wang W.,Beijing Aerospace Control Device Institute | Wang X.,Beijing Aerospace Control Device Institute | Yu W.,Beijing Aerospace Control Device Institute | Lv M.,General Hospital of the Chinese Peoples Armed Police Forces
Proceedings - 2014 7th International Symposium on Computational Intelligence and Design, ISCID 2014 | Year: 2015

A multiple rotor UAVs (Unmanned Aerial Vehicle) based photograph and image analysis system for earthquake damage evaluation is proposed. In contrast to other system, our multiple UAVs can fly with typical rectangle, triangle, or pentagonal formation shape in vertical or horizontal hovering mode, splice images to construct a big scene picture, and make a texture analysis of the ground earthquake images. The image mosaic method of projective transformation, the photograph visual field model of signal UAV, and an integrated texture analysis method are all proposed to analyze and evaluate the damage level of the typical target on ground. The Gray Level Co-occurrence Matrix (GLCM) features, the Tamura texture feature, the Gabor wavelet feature, and the basic line and circle elements, are all considered in our system. An application of earthquake damage evaluation is shown in this paper. Many experiment results have proved the correctness and the validity of our proposed system and method. © 2014 IEEE. Source


Wang Y.-F.,Xinxiang Medical University | Kunda P.E.,Poten Biomedical Institute for Cancer Immunotherapy | Lin J.-W.,Poten Biomedical Institute for Cancer Immunotherapy | Wang H.,Poten Biomedical Institute for Cancer Immunotherapy | And 3 more authors.
Oncology Reports | Year: 2013

Retinoblastoma (RB) is a challenging disease that affects mostly young children. Chemical therapy has been shown to have limitations during clinical practice, principally because of the ability of RB to become resistant to the treatment. Nevertheless, chemotherapy is still the main treatment for RB, and immunotherapy has become a promising treatment for most solid tumors with fewer side effects than traditional therapies. In this study, we explored the antitumor effects of cytokine-induced killer (CIK) cells co-cultured with dendritic cells (DCs) pulsed with complete tumor antigens (DC-Ag). Cytotoxicity and specificity were evaluated on an RB cell line (RB-Y79), on a human normal retina cell line (hTERT-RPE1) and a carboplatin-resistant RB cell line. Our results showed that CIK differentiation and cytotoxicity were enhanced by co-culturing CIKs with DC-Ag. Moreover, the co-culture improved the CIK proliferation rate by increasing IL-6 and decreasing IL-10 levels in the culture medium. Furthermore, the use of DC-Ag-CIK cells had little effect on normal retinal cells but high cytotoxicity on RB cells even on carboplatin-resistant retinoblastoma cells. This is the first study showing that DC cells pulsed with the complete tumor antigen improve proliferation, differentiation and cytotoxic activity of CIKs specific not only for RB but also for the chemotherapy- resistant form of the malady. Thus highly efficient immunotherapy based on DC-Ag-CIK cells may be a potential effective and safe mean of treating RB especially to patients where traditional chemical therapy has failed. Source

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