General Hospital Of Nikaia Ag Panteleimon

Athens, Greece

General Hospital Of Nikaia Ag Panteleimon

Athens, Greece
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Papazafiropoulou A.,Hellenic Association of Research and Continuing Education in Primary Care | Papazafiropoulou A.,General Hospital Of Nikaia Ag Panteleimon | Skliros E.,Hellenic Association of Research and Continuing Education in Primary Care | Skliros E.,Nemea Health Center | And 10 more authors.
BMC Family Practice | Year: 2011

Background: Except for the established risk factors, presence of target organ damage has an important role in the treatment of hypertensive subjects. The aim of the present study was to estimate the prevalence of target organ damage in primary care subjects. Methods. This multi-centre, cross-sectional survey of 115 primary care physicians recruited 1095 consecutive subjects with hypertension: 611 men (55.8%); and 484 women (44.2%). A detailed history for the presence of cardiovascular disease and a thorough clinical examination was performed to each subject. Results: Of the total study population, 44.5% (n = 487) had target organ damage (33.0% had left ventricular hypertrophy, 21.8% increased carotid intima media thickness, 11.0% elevated plasma creatinine levels and 14.6% microalbuminuria). Target organ damage was more prevalent in males than in females (P = 0.05). In addition, males had more often increased carotid intima media thickness than females (P = 0.009). On the contrary, females had more often microalbuminuria (P = 0.06) than males. No differences were observed between the two genders regarding left ventricular hypertrophy (P = 0.35) and elevated plasma creatinine levels (P = 0.21). Logistic regression analysis showed associations between target organ damage and dyslipidemia (P < 0.001), presence of metabolic syndrome (P = 0.005), diabetes (P < 0.001) and coronary artery disease (P < 0.001). Conclusion: A significant proportion of hypertensive subjects in primary care had documented associated target organ damage, with left ventricular hypertrophy being the most prevalent target organ damage. © 2011 Papazafiropoulou et al; licensee BioMed Central Ltd.


Papazafiropoulou A.,General Hospital Of Nikaia Ag Panteleimon | Sotiropoulos A.,General Hospital Of Nikaia Ag Panteleimon | Bousboulas S.,General Hospital Of Nikaia Ag Panteleimon | Stamataki P.,General Hospital Of Nikaia Ag Panteleimon | Pappas S.,General Hospital Of Nikaia Ag Panteleimon
Hellenic Journal of Cardiology | Year: 2010

Introduction: Type 2 diabetes mellitus (T2DM) is a major risk factor for peripheral arterial disease (PAD). A simple, noninvasive method for the estimation of PAD is ankle brachial index (ABI). The aim of the present study was to determine whether there is an association between ABI and cardiovascular risk factors in T2DM subjects without apparent macrovascular disease. Methods: A total of 125 T2DM subjects (84 males, 41 females, mean age ± standard deviation 62.2 ± 9.1 years) who had no apparent macrovascular disease and who attended the Health Center of Erymantheia between January 2008 and June 2009 were recruited to the study. Results: Of the study subjects 20% (n=25) had ABI <0.90. Univariate linear regression analysis showed that ABI was significantly associated with history of hypertension (p=0.02), fasting serum glucose levels (p=0.02), serum urea levels (p=0.005), serum uric acid levels (p=0.007) and white blood cell (WBC) count (p=0.04). Multivariate linear regression analysis demonstrated significant independent associations between ABI and fasting serum glucose levels (p=0.03) as well as WBC count (p=0.03). Conclusions: Elevated plasma glucose and WBC count increase the risk of PAD in asymptomatic diabetics.


Lyrakos G.N.,National and Kapodistrian University of Athens | Lyrakos G.N.,General Hospital Of Nikaia Ag Panteleimon | Vini D.,General Hospital Of Nikaia Ag Panteleimon | Aslani H.,General Hospital Of Nikaia Ag Panteleimon | Drosou-Servou M.,General Hospital Of Nikaia Ag Panteleimon
Patient Preference and Adherence | Year: 2012

Background: No specific questionnaire has been developed to assess the health-related quality of life of thalassemia patients. Thus, the main objective of this study was to develop, according to psychometric standards, a self-administered Specific Thalassemia Quality of Life Instrument (STQOLI) for adult patients. Methods: First, a qualitative phase was conducted to generate items and identify domains using the critical analysis incident technique and a literature review. A list of easily comprehensible, non-redundant items was defined using the Delphi technique and a pilot study on ten thalassemia patients. This phase involved both patients and experts. The second step was a quantitative validation phase comprising a study of 128 thalassemia patients in a single hospital. It was designed to select items, identify dimensions, and measure reliability and internal and concurrent validity. The psychometric and scaling properties of the proposed 41-item Specific Thalassemia Quality of Life Instrument were then assessed among patients recruited from the Thalassemia Unit at the General Hospital of Nikaia, Greece. Results: The final questionnaire had 41 items comprising four main domains and one global item about general health. The factorial structure was satisfactory (loading > 0.40 on each factor of the four domains for all items). Interscale correlations ranged from 0.06 to 0.78, Cronbach's α-coefficients were 0.78 for the psychosocial domain, 0.77 for the chelation domain, 0.72 for the transfusion domain, 0.81 for the disease and symptoms domain, and 0.840 for the total score of the questionnaire. Conclusion: The 41-item Specific Thalassemia Quality of Life Instrument seems to be a valid tool for assessing health-related quality of life for patients with thalassemia. More research is needed to explore the universal properties of the questionnaire. © 2012 Lyrakos et al, publisher and licensee Dove Medical Press Ltd.


Protopsaltis I.,Tzanio General Hospital of Piraeus | Ploumidis A.,Asklipieio General Hospital | Sergentanis T.N.,National and Kapodistrian University of Athens | Constantoulakis P.,Locus Medicus Laboratory | And 5 more authors.
PLoS ONE | Year: 2013

Benign prostatic hyperplasia (BPH) represents a pattern of non-malignant growth of prostatic fibromuscular stroma. Metabolic disturbances such us pre-diabetes and metabolic syndrome may have a role in BPH pathophysiology. A potential explanation for the above relationship involves the insulin-like growth factor (IGF) axis as well as IGF binding proteins, (IGFBPs) of which the most abundant form is IGFBP-3. Therefore, the aim of the present study was to investigate the association between intra-prostatic levels of IGF-1, IGF-2 as well as to evaluate the role of locally expressed IGFBP-3 in BPH development in pre-diabetes. A total of 49 patients admitted to the Urology department of a tertiary urban Greek hospital, for transurethral prostate resection, or prostatectomy and with pre-diabetes [impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) or both] were finally included. The majority of the sample consisted of subjects with IGT (51.0%), followed by IFG and IGT (32.7%) and isolated IFG (16.3%). For all participants a clinical examination was performed and blood samples were collected. In addition, total prostate (TP) volume or transitional zone (TZ) volume were estimated by transrectal ultrasonography. The results of the multivariate analysis regarding TP volume showed that higher PSA (p<0.001), larger waist circumference (p=0.007) and higher IGFBP-3 expression levels (p<0.001) independently predicted higher TP volume. The results regarding the volume of the TZ showed that higher PSA (p<0.001), larger waist circumference (p<0.001) and higher IGFBP-3 expression levels (p=0.024) were independently associated with higher TZ volume. Our findings show that intraprostatic levels of IGFBP-3, PSA and waist circumference, but not overall obesity, are positively associated with prostate volume. IGFBP-3 seems to be a multifunctional protein, which can potentiate or inhibit IGF activity. © 2013 Protopsaltis et al.


Sotiropoulos A.,General Hospital Of Nikaia Ag Panteleimon | Papadodima S.A.,General Hospital Of Nikaia Ag Panteleimon | Papazafiropoulou A.K.,General Hospital Of Nikaia Ag Panteleimon | Ioannidis A.,National and Kapodistrian University of Athens | And 4 more authors.
BMC Research Notes | Year: 2011

Background: The aim of the present study was to investigate whether selenium levels differ between type 2 diabetic subjects with and without coronary artery disease (CAD). Methods. A total of 200 subjects with type 2 diabetes (100 with CAD and 100 without CAD), consecutively selected from the diabetes outpatient clinic of our hospital were enrolled into the study. A detailed medical history and a physical examination were obtained by all the participants. Results: Serum selenium levels did not differ between diabetic subjects with and without CAD (102.40 31.10 vs. 108.86 33.88 microg/L, p = 0.16). In diabetic subjects with CAD multivariate linear regression analysis demonstrated significant independent associations between selenium and sex (beta = 0.21, p = 0.03) and glucose levels (beta = 0.25, p = 0.008). In diabetic subjects without CAD multivariate linear regression analysis demonstrated significant independent associations between selenium and peripheral artery disease (beta = 0.16, p = 0.05) and glucose levels (beta = -0.09, p = 0.05). Conclusion: Serum selenium levels did not differ between diabetic subjects with and without CAD. In diabetic subjects with CAD, the only determinants of serum selenium levels were sex and glucose levels. In diabetic subjects without CAD the only determinants of serum selenium levels were peripheral artery disease and glucose levels. © 2011 Papazafiropoulou et al; licensee BioMed Central Ltd.


PubMed | Locus Medicus Laboratory, Tzanio General Hospital of Piraeus, Asklipieio General Hospital, National and Kapodistrian University of Athens and General Hospital Of Nikaia Ag Panteleimon
Type: Journal Article | Journal: PloS one | Year: 2013

Benign prostatic hyperplasia (BPH) represents a pattern of non-malignant growth of prostatic fibromuscular stroma. Metabolic disturbances such us pre-diabetes and metabolic syndrome may have a role in BPH pathophysiology. A potential explanation for the above relationship involves the insulin-like growth factor (IGF) axis as well as IGF binding proteins, (IGFBPs) of which the most abundant form is IGFBP-3. Therefore, the aim of the present study was to investigate the association between intra-prostatic levels of IGF-1, IGF-2 as well as to evaluate the role of locally expressed IGFBP-3 in BPH development in pre-diabetes. A total of 49 patients admitted to the Urology department of a tertiary urban Greek hospital, for transurethral prostate resection, or prostatectomy and with pre-diabetes [impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) or both] were finally included. The majority of the sample consisted of subjects with IGT (51.0%), followed by IFG and IGT (32.7%) and isolated IFG (16.3%). For all participants a clinical examination was performed and blood samples were collected. In addition, total prostate (TP) volume or transitional zone (TZ) volume were estimated by transrectal ultrasonography. The results of the multivariate analysis regarding TP volume showed that higher PSA (p<0.001), larger waist circumference (p=0.007) and higher IGFBP-3 expression levels (p<0.001) independently predicted higher TP volume. The results regarding the volume of the TZ showed that higher PSA (p<0.001), larger waist circumference (p<0.001) and higher IGFBP-3 expression levels (p=0.024) were independently associated with higher TZ volume. Our findings show that intra-prostatic levels of IGFBP-3, PSA and waist circumference, but not overall obesity, are positively associated with prostate volume. IGFBP-3 seems to be a multifunctional protein, which can potentiate or inhibit IGF activity.


Papazafiropoulou A.K.,General Hospital Of Nikaia Ag Panteleimon | Kardara M.S.,General Hospital Of Nikaia Ag Panteleimon | Pappas S.I.,General Hospital Of Nikaia Ag Panteleimon
Recent Patents on Endocrine, Metabolic and Immune Drug Discovery | Year: 2012

Omega-3 fatty acids except for their effect on triglycerides levels have cardioprotective properties as well as antiarrhythmic properties.The pleiotropic effects of omega-3 fatty acids, also, include lowering of blood pressure and the favorable effect on endothelial function and high-density cholesterol levels. Furthermore, studies have showed their favorable action in subjects with dementia, Alzheimer's disease and learning disorders. In this paper, a review of the recent patents on omega-3 fatty acids will be presented. © 2012 Bentham Science Publishers.


Papazafiropoulou A.,General Hospital Of Nikaia Ag Panteleimon | Daniil I.,General Hospital Of Nikaia Ag Panteleimon | Sotiropoulos A.,General Hospital Of Nikaia Ag Panteleimon | Balampani E.,General Hospital Of Nikaia Ag Panteleimon | And 6 more authors.
BMC Research Notes | Year: 2010

Background. Diabetic subjects, especially women, show high prevalence of asymptomatic bacteriuria (ASB). The aim of the present study was to evaluate the prevalence of ASB in subjects with type 2 diabetes mellitus (T2D) with and without microalbuminuria (MA). Findings. A hundred diabetic subjects with MA (53 males/47 females, mean age standard deviation: 65.5 11.1 years) and 100 diabetic subjects without MA (52 males/48 females, mean age standard deviation: 65.4 11.3 years), consecutively attending the outpatient diabetes clinic of our hospital were recruited in the study. Subjects with overt diabetic nephropathy or nephropathy from other causes were excluded. In addition, subjects with symptoms of urinary track infection or use of antimicrobial drugs in the last 14 days were excluded by the study. Diabetic subjects with MA showed increased prevalence of ASB compared to diabetic subjects without MA (21% versus 8%, P < 0.001, respectively). Escherichia coli was the most prevalent pathogen isolated in diabetic subjects with and without MA (12% versus 3.0%, P = 0.01, respectively) followed by Proteus mirabilis (6% versus 5%, P = 0.75, respectively) and Klebsiella spp (5% versus 1%, P = 0.09, respectively). Univariate logistic analysis showed that ASB was associated with the presence of coronary artery disease [odds ratio (OR): 0.29, 95% Confidence Intervals (95% CI): 0.09-0.95, P = 0.04] and gender (OR: 0.09, 95% CI: 0.02-0.35, P < 0.001) in the diabetic study group with MA. Conclusions. ASB is more prevalent among T2D subjects with MA. Screening for ASB is warranted in diabetic patients especially if pyuria is detected in urine analysis since ASB has been found to be a risk factor for developing symptomatic urinary tract infection. © 2010 Papazafiropoulou et al; licensee BioMed Central Ltd.


PubMed | General Hospital Of Nikaia Ag Panteleimon
Type: Journal Article | Journal: Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese | Year: 2010

Type 2 diabetes mellitus (T2DM) is a major risk factor for peripheral arterial disease (PAD). A simple, noninvasive method for the estimation of PAD is ankle brachial index (ABI). The aim of the present study was to determine whether there is an association between ABI and cardiovascular risk factors in T2DM subjects without apparent macrovascular disease.A total of 125 T2DM subjects (84 males, 41 females, mean age standard deviation 62.2 9.1 years) who had no apparent macrovascular disease and who attended the Health Center of Erymantheia between January 2008 and June 2009 were recruited to the study.Of the study subjects 20% (n=25) had ABI <0.90. Univariate linear regression analysis showed that ABI was significantly associated with history of hypertension (p=0.02), fasting serum glucose levels (p=0.02), serum urea levels (p=0.005), serum uric acid levels (p=0.007) and white blood cell (WBC) count (p=0.04). Multivariate linear regression analysis demonstrated significant independent associations between ABI and fasting serum glucose levels (p=0.03) as well as WBC count (p=0.03).Elevated plasma glucose and WBC count increase the risk of PAD in asymptomatic diabetics.


PubMed | General Hospital Of Nikaia Ag Panteleimon
Type: Journal Article | Journal: Journal of clinical medicine research | Year: 2011

The aim of the present study was to determine the prevalence of thyroid dysfunction in patients with type 2 diabetes (T2D) attending an outpatient clinic.We examined thyroid dysfunction in a total of 1,092 patients with T2D.Prevalence rate of thyroid dysfunction was 12.3%. In the group with thyroid dysfunction there was an excess of females in comparison with the group without thyroid dysfunction (P < 0.001). In addition, patients with thyroid dysfunction had higher values of body mass index (P = 0.03) and HDL-cholesterol levels (P = 0.01), and lower values of LDL-cholesterol levels (P = 0.001) in comparison with patients without thyroid dysfunction. Multivariate analysis demonstrated that presence of thyroid dysfunction was related with gender (OR: 0.220, 95% CI: 0.141 - 0.352) and LDL-cholesterol levels (OR: 0.990, 95% CI: 0.985 - 0.995).The prevalence of thyroid dysfunction among Greek diabetic patients is 12.3%. Diabetic women were more frequently affected than men. Presence of thyroid dysfunction was associated with lower levels of LDL-cholesterol concentrations.Type 2 diabetes mellitus; Thyroid dysfunction; Hypothyroidism; Gender; LDL-cholesterol; Greece.

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