General Hospital of Jinan Military Commanding Region

Jinan, China

General Hospital of Jinan Military Commanding Region

Jinan, China

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Chen Y.,General Hospital of Jinan Military Commanding Region | Xu S.-F.,General Hospital of Jinan Military Commanding Region | Xu M.,General Hospital of Jinan Military Commanding Region | Yu X.-C.,General Hospital of Jinan Military Commanding Region
Oncology Letters | Year: 2017

A wide resection of the tumor with or without chemotherapy is the treatment of choice for periosteal osteosarcoma (PO) of the extremities, however, post‑operative limb function and quality of life could be compromised. The present study reports two cases of 14‑year‑old boys who presented with progressively enlarging masses in their right knee regions. Computed tomography and magnetic resonance imaging scans indicated a fusiform space‑occupying mass encircling the bone cortex, with stippled calcification. A diagnosis of PO was suspected. The histological findings confirmed the diagnosis of intermediate PO. Pre‑operative chemotherapies were started, and good responses were detected by clinical evaluation and histological findings. Surgeries preserving the functional structures, including neurovascular bundles, tendons, muscles and epiphyses, were performed, followed by routine chemotherapy. The two patients experienced disease‑free survival with follow‑up times of 37 and 108 months, respectively. The patients were satisfied with the results of the treatment and they returned to normal life activities. These two cases indicated that a marginal resection of the tumor in conjunction with effective neoadjuvant chemotherapy may be an ideal alternative treatment for intermediate PO, since survival along with well‑preserved limb function could be guaranteed. By contrast, a wide excision could result in the loss of limb function. © 2017, Spandidos Publications. All rights reserved.


Chang Z.,General Hospital of Jinan Military Commanding Region | Song R.,General Hospital of Jinan Military Commanding Region | Xu S.,General Hospital of Jinan Military Commanding Region | Xu M.,General Hospital of Jinan Military Commanding Region | Yu X.,General Hospital of Jinan Military Commanding Region
Tumor Biology | Year: 2014

Osteosarcoma has become a health threat for adolescents and young adults. To identify the genetic risk factor for the malignancy is in urgent need. Several studies have investigated the role of CD 152 polymorphisms in osteosarcoma in a sample of Chinese population. However, the association is poorly defined due to lack of a sufficiently large sample. In this study, we performed a meta-analysis of all CD 152 polymorphisms that had been implicated in osteosarcoma to examine the association. We searched the electronic MEDLINE database until December 31, 2013, to identify the studies regarding the association between CD 152 polymorphisms and osteosarcoma. Inclusion criteria were followed in the selection of eligible study. The genotypic and allelic data were collected from all studies included to evaluate the risk of osteosarcoma (odds ratio, OR). We found statistically significant evidence of the studied CD 152 polymorphisms and increased risk of osteosarcoma in homozygous (OR=1.79, 95 % CI=1.40-2.29, P=0.958), recessive (OR=1.77, 95 % CI=1.40-2.25, P=0.899), and allele model (OR=1.21, 95 % CI=1.09-1.34, P=1.000). This increased risk was also revealed in single nucleotide polymorphism (SNP) +49G>A and SNP 326G>A. Our meta-analysis indicates that there may be an association between CD 152 polymorphisms and risk of osteosarcoma in Chinese population. Further validation of the observation is necessary. © 2014 International Society of Oncology and BioMarkers (ISOBM).


Yu X.C.,General Hospital of Jinan Military Commanding Region
Orthopaedic surgery | Year: 2012

To study the long-term outcomes of inactivated bone reimplantation with preservation of the epiphysis in children with distal femoral osteosarcomas. Over 10 years, five children (mean age 9.2 years, one boy and four girls) with distal femoral osteosarcomas underwent inactivated bone reimplantation with preservation of the epiphysis following chemotherapy in our hospital. Three patients were type I on MRI classification (one with pathological fracture), and two type II. The therapeutic regime was two cycles of preoperative chemotherapy, surgery and six cycles of postoperative chemotherapy. Five patients were followed up for 60-126 months (mean 82 months). No local tumor recurrences or metastases occurred. Three patients with fractures of inactivated bone were treated by open reduction, bone grafting and internal fixation; their fractures had united by 6 months after reoperation. The mean functional score of the affected limbs was 25.6 points (13-30 points). Inactivated bone reimplantation with preservation of the epiphysis for distal femoral osteosarcomas in children optimizes recovery of limb function and preservation of limb length. The main measures for improving clinical outcomes include preoperative analysis of the lesion's boundaries and extent of tumor invasion, bone grafting between inactivated and host bone, and timely treatment of complications. © 2012 Tianjin Hospital and Blackwell Publishing Asia Pty Ltd.


Yu X.-C.,General Hospital of Jinan Military Commanding Region | Xu S.-F.,General Hospital of Jinan Military Commanding Region | Xu M.,General Hospital of Jinan Military Commanding Region | Liu X.-P.,General Hospital of Jinan Military Commanding Region | And 2 more authors.
Oncology Research and Treatment | Year: 2014

Aim: To evaluate clinical outcomes in patients who underwent alcohol-inactivated autograft replantation with joint preservation for the treatment of osteosarcoma of the distal femur.Patients and Methods: 10 patients (7 men, 3 women; mean age: 20.1 years) were treated. 9 patients had Enneking stage IIb tumors and 1 patient had stage III. The mean follow-up time was 34 months. All patients obtained first-stage healing.Results: 1 patient died of local recurrence and multiple metastases 13 months after surgery; 3 patients died of multiple metastases 9, 12, and 24 months after surgery, respectively. 3 patients required second surgery because of fracture of the inactivated autograft, 1 patient died 6 months later, 1 patient experienced bony healing 4 months later with no further complications, and 1 patient required subsequent open reduction and bone implantation with internal fixation (bony healing was evident 6 months later; however, joint instability and limited knee flexion were apparent). At final follow-up, the mean International Society of Limb Salvage (ISOLS) graft score was 31 (87%), whereas the mean Musculoskeletal Tumour Society (MSTS) function score was 23 (77%).Conclusions: These preliminary findings indicate that alcohol-inactivated autograft replantation with joint preservation may be effective in treating osteosarcoma of the distal femur in some patients. Larger-scale studies are needed to fully evaluate the efficacy/safety of this approach. © 2014 S. Karger GmbH, Freiburg.


Yu X.,General Hospital of Jinan Military Commanding Region | Xu M.,General Hospital of Jinan Military Commanding Region | Xu S.,General Hospital of Jinan Military Commanding Region | Su Q.,General Hospital of Jinan Military Commanding Region
Oncology Letters | Year: 2013

Giant cell tumor (GCT) of the bone is a relatively common primary bone tumor. Treatment with simple curettage often results in a high local recurrence rate. Tumor resection and reconstruction with prosthesis or an allograft has a low rate of local recurrence; however, the patient's native joint function becomes significantly impaired. With the development and usage of aggressive curettage, it is a priority to treat GCT with a method that reduces the local recurrence rate and preserves the native joint. To evaluate the feasibility of treating GCT with aggressive curettage and cement filling using internal fixation and oral bisphosphonates, 16 patients with GCT of the bone located in the distal femur and treated in our department from January 2008 to June 2011, were followed up. The patients had received aggressive curettage, bone cement filling, internal fixation and oral administration of bisphosphonates.There were seven males and nine females in total, with a mean age of 38 years. All patients were carefully assessed prior to surgery in order to determine the integrity of the tumor cavity. Subsequently, patients were treated with aggressive curettage by high-speed burring and cementation with internal fifixation, and were administered postoperative oral alendronate sodium tablets (10 mg/day) for two years. The median follow-up time was 25 months. None of the patients were lost to follow-up. No local recurrence or metastasis was observed in the last follow-up. The Enneking limb function score range of the affected limb was 24-29 (average, 26.7). At the last follow-up, all patients exhibited solid fixation without fracture of the subchondral bone in plain radiographs. Based on these data, we suggest that patients with distal femoral GCT may be treated with aggressive curettage and cement filling, with internal fixation and oral bisphosphonates. The advantages of this method are its safety and efficacy. However, the long-term outcomes require further investigation.


Chang Z.,General Hospital of Jinan Military Commanding Region | Yu X.,General Hospital of Jinan Military Commanding Region
Tumor Biology | Year: 2014

Many published data on the association between p53 codon 72 polymorphism and sarcoma risk showed inconclusive results. The present study was designed to derive a more precise estimation of this connection among Caucasians. We conducted a literature search in PubMed, EMBASE,Web of Science, and CNKI databases for case-control studies examining the association between p53 codon 72 polymorphism and sarcoma risk. The meta-analysis was performed using STATA 12.0 software. Crude odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were used to measure the strength of any association. The results of this meta-analysis did not provide statistical evidence for significant sarcoma risk associated with p53 codon 72 polymorphism (OR Arg/Arg vs. Pro/Pro = 1.00, 95% CI = 0.80-1.26, P heterogeneity = 0.980; ORArg/Arg + Arg/Pro vs. Pro/Pro = 0.99, 95% CI = 0.83-1.19, Pheterogeneity = 0.990; OR Arg/Arg vs. Arg/Pro + Pro/Pro = 1.09, 95% CI = 0.89-1.35, P heterogeneity = 0.532; ORallele Arg vs. allele Pro = 1.03, 95% CI = 0.90-1.18, Pheterogeneity = 0.883; OR Arg/Pro vs. Pro/Pro = 0.95, 95% CI = 0.71-1.27, P heterogeneity = 0.919). We also did not find significant links in further subgroup analyses by ethnicity, control source, and sarcoma type. The present meta-analysis of currently available data suggests that the p53 codon 72 polymorphism may not play a role in sarcoma development in Caucasians. © International Society of Oncology and BioMarkers (ISOBM) 2014.


Xu M.,General Hospital of Jinan Military Commanding Region | Xu S.,General Hospital of Jinan Military Commanding Region | Yu X.,General Hospital of Jinan Military Commanding Region
World Journal of Surgical Oncology | Year: 2014

Background: We report the long-term outcomes of patients with osteosarcoma who underwent effective preoperative chemotherapy and subsequently underwent marginal resection. Methods: We reviewed the records of 50 patients with osteosarcoma who underwent marginal resection following effective preoperative chemotherapy; 18 were treated with the MMIA (high-dose methotrexate (HD-MTX), adriamycin (ADR), ifosfamide (IFO)) and cisplatin (DDP), and 32 patients were treated with the DIA (DDP, ADR and IFO). protocol. The functions of the affected limb were evaluated using the revised MSTS93 system. The Kaplan-Meier method was used for survival analysis. Results: After a median follow-up of 5.5 years, the rates were: overall 5-year cumulative survival 61.7%, event-free survival 57.7%, recurrence 8.5%, pulmonary metastases 42.6%, and excellent to good function of the affected limb 57.7%. Conclusions: Our results showed that marginal resection can be performed in patients with osteosarcoma who obtain clinically favorable responses to chemotherapy. Patients had a good clinical course and there was no negative effect on rates of survival or local recurrence.


Chang Z.,General Hospital of Jinan Military Commanding Region | Xing J.,General Hospital of Jinan Military Commanding Region | Yu X.,General Hospital of Jinan Military Commanding Region
Tumor Biology | Year: 2014

The antitumor effects of curcumin have attracted widespread attention worldwide. One of its major functions is to induce the apoptosis of tumor cells, but the antitumor mechanism is currently unclear. In the present study, we found that cell mortality and curcumin concentration were dose dependent. Curcumin of low concentrations (10 μ?) could reduce the level of reactive oxygen species (ROS) in tumor cells, while curcumin of high concentrations (80 μ?) was able to significantly increase the content of ROS. In addition, Western blotting detection suggested that curcumin of high concentrations can induce the release of Cyto-C and the activation of Caspase-3, and that ROS scavenger NAC apparently inhibits apoptosis protein release and activation, consequently slowing the curcumin-induced apoptosis. Taken together, curcumin further activates the mitochondrial apoptotic pathway by inducing cells to generate ROS and ultimately promotes the apoptosis of tumor cells.


PubMed | General Hospital of Jinan Military Commanding Region
Type: Journal Article | Journal: Spine | Year: 2016

A bibliometric review of the literature.Back pain is a global burden that leads people to seek medical service and results in work disability. Numerous studies are published annually to give new insights into back pain. However, characteristics of the high-impact articles on back pain have not been explored. The current study aimed to identify the 100 most cited articles on back pain and determine their characteristics.Back pain is a globally leading cause of work disability. Numerous studies have been published annually to give new insight to back pain. However, comprehensive analysis to identify the most influential articles is not available until now.The Web of Science core database was searched using the subject terms back NEAR pain, dorsalgia, backache, lumbar NEAR pain, lumbago, back NEAR disorder*, discitis. The searching results were listed by citation times and the top 100 cited articles on back pain were identified. Important information such as author, journal, publishing year, country, institution, and study type were elicited.A total of 44,460 articles on back pain were displayed. Citation times of the enrolled 100 articles ranged from 249 to 1638 with a mean value of 418. The most productive periods were 1991 to 1995 and 1996 to 2000. The journal Spine holds the largest number of 45 articles, followed by Pain with seven articles. A total of 11 countries contribute to the 100 articles and the United States topped the list. None of the high-impact articles were produced in Asian and African.The current citation analysis demonstrated the essential advances in the history of back pain research and determined the influential authors, institutions, countries, and journals that had outstanding contributions to the studies of back pain.3.


PubMed | General Hospital of Jinan Military Commanding Region
Type: | Journal: BMC musculoskeletal disorders | Year: 2016

Polyetheretherketone (PEEK) rod system is a novel pedicle-based dynamic stabilization system. This study evaluated clinical and radiographic outcomes of non-fusion surgery by PEEK rod systems for treatment of degenerative lumbar diseases with a 2-year follow-up.From February 2012 to October 2012, 38 patients who underwent non-fusion surgery using PEEK rod systems were included in the study. Data on Oswestry Disability Index (ODI) score and Japanese Orthopaedics Association (JOA) score were collected and radiographs were obtained to evaluate disc height index (DHI) and range of motion (ROM) at each interval.Both JOA and ODI scores significantly improved postoperatively. DHI showed a slight increase immediately after the surgery but gradually dropped below preoperative levels. Mean ROM values changed from 8.8 preoperatively to 1.8 at the 2-year follow-up point. Screw loosening occurred in one case at the 2-year follow-up.The preliminary results indicated a significant improvement in clinical outcomes and advantageous implant safety. The non-fusion procedure using PEEK rod systems might be a viable alternative for treatment of lumbar degenerative diseases. The distraction technique needs to be improved for better postoperative DHI.

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