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Yu X.C.,General Hospital of Jinan Military Commanding Region
Orthopaedic surgery | Year: 2012

To study the long-term outcomes of inactivated bone reimplantation with preservation of the epiphysis in children with distal femoral osteosarcomas. Over 10 years, five children (mean age 9.2 years, one boy and four girls) with distal femoral osteosarcomas underwent inactivated bone reimplantation with preservation of the epiphysis following chemotherapy in our hospital. Three patients were type I on MRI classification (one with pathological fracture), and two type II. The therapeutic regime was two cycles of preoperative chemotherapy, surgery and six cycles of postoperative chemotherapy. Five patients were followed up for 60-126 months (mean 82 months). No local tumor recurrences or metastases occurred. Three patients with fractures of inactivated bone were treated by open reduction, bone grafting and internal fixation; their fractures had united by 6 months after reoperation. The mean functional score of the affected limbs was 25.6 points (13-30 points). Inactivated bone reimplantation with preservation of the epiphysis for distal femoral osteosarcomas in children optimizes recovery of limb function and preservation of limb length. The main measures for improving clinical outcomes include preoperative analysis of the lesion's boundaries and extent of tumor invasion, bone grafting between inactivated and host bone, and timely treatment of complications. © 2012 Tianjin Hospital and Blackwell Publishing Asia Pty Ltd.


Chang Z.,General Hospital of Jinan Military Commanding Region | Yu X.,General Hospital of Jinan Military Commanding Region
Tumor Biology | Year: 2014

Many published data on the association between p53 codon 72 polymorphism and sarcoma risk showed inconclusive results. The present study was designed to derive a more precise estimation of this connection among Caucasians. We conducted a literature search in PubMed, EMBASE,Web of Science, and CNKI databases for case-control studies examining the association between p53 codon 72 polymorphism and sarcoma risk. The meta-analysis was performed using STATA 12.0 software. Crude odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were used to measure the strength of any association. The results of this meta-analysis did not provide statistical evidence for significant sarcoma risk associated with p53 codon 72 polymorphism (OR Arg/Arg vs. Pro/Pro = 1.00, 95% CI = 0.80-1.26, P heterogeneity = 0.980; ORArg/Arg + Arg/Pro vs. Pro/Pro = 0.99, 95% CI = 0.83-1.19, Pheterogeneity = 0.990; OR Arg/Arg vs. Arg/Pro + Pro/Pro = 1.09, 95% CI = 0.89-1.35, P heterogeneity = 0.532; ORallele Arg vs. allele Pro = 1.03, 95% CI = 0.90-1.18, Pheterogeneity = 0.883; OR Arg/Pro vs. Pro/Pro = 0.95, 95% CI = 0.71-1.27, P heterogeneity = 0.919). We also did not find significant links in further subgroup analyses by ethnicity, control source, and sarcoma type. The present meta-analysis of currently available data suggests that the p53 codon 72 polymorphism may not play a role in sarcoma development in Caucasians. © International Society of Oncology and BioMarkers (ISOBM) 2014.


Zhang J.,General Hospital of Jinan Military Commanding Region | Wang D.,Affiliated Hospital | Chen Z.,Shanghai University | Gao J.,South China Normal University | And 3 more authors.
Spine | Year: 2011

STUDY DESIGN.: Comparative study. OBJECTIVE.: To analyze the effect of conservative treatment on self-concept in patients with mild to moderate scoliosis. SUMMARY OF BACKGROUND DATA.: The choice of surgery or conservative treatment in adolescent idiopathic scoliosis is usually done on the basis of the magnitude of the initial Cobb angle in these patients. However, mental effect of the therapy choice should be considered. METHODS.: Between August 2006 and December 2008, 65 patients with adolescent idiopathic scoliosis were selected for this study. Twenty-two patients with Cobb angles between 20° and 40° received conservative treatment, 18 patients with Cobb angles between 40° and 50° received conservative treatment, and 25 patients with Cobb angles between 40° and 50° received surgical treatment. All subjects were required to fill the Children's Self-Concept Scale at the beginning of the study and at the follow-up visit 1 year later. Scores on this scale were compared among the three different groups, and between the initial visit and the follow-up visit in each group. RESULTS.: At the initial test, the total self-concept score was significantly higher in the group of patients with Cobb angles between 20° and 40° than in the two groups with Cobb angles between 40° and 50°. At the follow-up visit, the total self-concept score had increased significantly in the surgically treated group (Cobb angle between 40° and 50°), however, it had decreased in the two conservatively treated groups. No significant difference was seen between the two conservatively treated groups in the amount by which the self-concept score had decreased at follow-up. CONCLUSION.: In terms of mental health, conservative treatment is not ideal for patients with mild to moderate scoliosis, and in particular, it is not conducive to mental health in patients with Cobb angles between 40° and 50°. Copyright © 2011 Lippincott Williams & Wilkins.


Xu M.,General Hospital of Jinan Military Commanding Region | Xu S.,General Hospital of Jinan Military Commanding Region | Yu X.,General Hospital of Jinan Military Commanding Region
World Journal of Surgical Oncology | Year: 2014

Background: We report the long-term outcomes of patients with osteosarcoma who underwent effective preoperative chemotherapy and subsequently underwent marginal resection. Methods: We reviewed the records of 50 patients with osteosarcoma who underwent marginal resection following effective preoperative chemotherapy; 18 were treated with the MMIA (high-dose methotrexate (HD-MTX), adriamycin (ADR), ifosfamide (IFO)) and cisplatin (DDP), and 32 patients were treated with the DIA (DDP, ADR and IFO). protocol. The functions of the affected limb were evaluated using the revised MSTS93 system. The Kaplan-Meier method was used for survival analysis. Results: After a median follow-up of 5.5 years, the rates were: overall 5-year cumulative survival 61.7%, event-free survival 57.7%, recurrence 8.5%, pulmonary metastases 42.6%, and excellent to good function of the affected limb 57.7%. Conclusions: Our results showed that marginal resection can be performed in patients with osteosarcoma who obtain clinically favorable responses to chemotherapy. Patients had a good clinical course and there was no negative effect on rates of survival or local recurrence.


Chang Z.,General Hospital of Jinan Military Commanding Region | Xing J.,General Hospital of Jinan Military Commanding Region | Yu X.,General Hospital of Jinan Military Commanding Region
Tumor Biology | Year: 2014

The antitumor effects of curcumin have attracted widespread attention worldwide. One of its major functions is to induce the apoptosis of tumor cells, but the antitumor mechanism is currently unclear. In the present study, we found that cell mortality and curcumin concentration were dose dependent. Curcumin of low concentrations (10 μ?) could reduce the level of reactive oxygen species (ROS) in tumor cells, while curcumin of high concentrations (80 μ?) was able to significantly increase the content of ROS. In addition, Western blotting detection suggested that curcumin of high concentrations can induce the release of Cyto-C and the activation of Caspase-3, and that ROS scavenger NAC apparently inhibits apoptosis protein release and activation, consequently slowing the curcumin-induced apoptosis. Taken together, curcumin further activates the mitochondrial apoptotic pathway by inducing cells to generate ROS and ultimately promotes the apoptosis of tumor cells.

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