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Jing Y.,General Hospital of Jinan Military Command of The PLA | Zhao H.,General Hospital of Jinan Military Command of The PLA | Ge Y.,General Hospital of Jinan Military Command of The PLA | Jia F.,General Hospital of Jinan Military Command of The PLA | And 3 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2015

Background: Secondary hyperparathyroidism (sHPT) is a common acquired disorder in patients with chronic renal failure. Despite the development of new therapeutic agents, a majority of patients will require parathyroidectomy. The aim of this study was to evaluate total parathyroidectomy with auto-transplantation of trace amounts of parathyroid tissue as a surgical option in uremia sHPT treatment. Methods: Clinical data of 50 sHPT patients who underwent total parathyroidectomy with auto-transplantation between January 2011 and December 2013 were reviewed retrospectively. Symptoms such as bone pain and fractures, concentrations of intact parathyroid hormone (iPTH), levels of ionized calcium and serum phosphorus, and activity of alkaline phosphatase were recorded before and after parathyroidectomy. Results: After operation, signs of pruritus, bone pain and muscle weakness was disappeared, iPTH level and serum phosphate concentration were declined markedly. No serious postoperative complications were observed. Follow-up observation was around 28 months. One female patient (2%) died 3 months after surgery due to heart failure, and another patient (2%) had persistent disease. All other patients recovered during the follow-up period. Conclusions: Total parathyroidectomy with auto-transplantation of trace amounts of parathyroid tissue was considered to be a feasible, safe and effective surgical option for the treatment of sHPT. © 2015 E-Century Publishing Corporation. All rights reserved. Source


Li D.,General Hospital of Jinan Military Command of The PLA | Meng J.,General Hospital of Jinan Military Command of The PLA | Yu N.,General Hospital of Jinan Military Command of The PLA | Jia F.,General Hospital of Jinan Military Command of The PLA | And 5 more authors.
Journal of Artificial Organs | Year: 2011

To study the correlation between the levels of IFN-c and IL-4 and the expression of Fas and Bcl-2 in peripheral blood lymphocytes (PBL) in hemodialysis patients, the indirect immune fluorescein labeling method of flow cytometry and solid sandwich enzyme-linked immunosorbent assay were performed for detecting the expression of Fas and Bcl-2 in PBL and the levels of IFN-c and IL-4 in the serum of 30 hemodialysis patients, respectively. It was found that the expression of Fas in PBL and the level of IL-4 in the serum of hemodialysis patients were significantly higher (P\0.01), whereas Bcl-2 in PBL and IFN-c in the serum were significantly lower (P\0.01) than those of the normal controls. According to statistical analysis, the expression of Fas in PBL had a negative correlation with the level of IFN-c, but a positive correlation with IL-4 in the serum of hemodialysis patients. Contrarily, the expression of Bcl-2 had a positive correlation with IFN-c, but a negative correlation with IL-4 in the serum of hemodialysis patients. These results suggest that hemodialysis patients have a suppressed secretion of Th1-associated cytokine IFN-c, but an increased secretion of Th2-associated cytokines IL-4, and these two aspects may play an important role in the abnormal apoptosis of PBL and its accompanying immune deficiency. © The Japanese Society for Artificial Organs 2011. Source

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