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Wang Z.,Hebei Medical University | Shen L.,Hebei Medical University | Li X.,Hebei Medical University | Shu X.,General Hospital of Chinese Armed Police Force | And 3 more authors.
Molecular Medicine Reports | Year: 2013

Acute radiation-induced esophagitis (ARIE) is a common complication of radiotherapy. The aim of this study was to clarify the molecular mechanism of pain relief by the compound of white peony root oral liquid (cWPROL) in ARIE. An animal model of ARIE was established and either cWPROL or a mixture of lidocaine, dexamethasone and gentamycin (mLDG) was administered. We indirectly observed rat symptoms of pain by recording the weight of food and the volume of water consumed by the rats, along with changes in body weight. Additionally, the expression levels of substance P (SP) in the esophageal tissues were detected by immunohistochemistry. It was demonstrated that cWPROL was able to release the pain of ARIE by decreasing the expression of SP; this may be one of the molecular mechanisms via which cWPROL induces pain relief. Copyright © 2013 Spandidos Publications Ltd. All rights reserved.

Zhai L.,Affiliated Hospital | Sun N.,Affiliated Hospital | Zhang B.-Q.,Health Team | Wang J.-G.,Affiliated Hospital | Xing G.-Y.,General Hospital of Chinese Armed Police Force
Journal of Clinical Rehabilitative Tissue Engineering Research | Year: 2010

BACKGROUND: No method is ideal for treating traumatic avascular necrosis of talus up to now. Extracorporeal shock wave therapy (ESWT) is a micro-traumatic, simple, and effective method to treat musculoskeletal diseases; however, the therapeutic effect on necrosis of talus needs to be further studied. OBJECTIVE: To evaluate the therapeutic effect of liquid-electric extracorporeal shock wave on traumatic avascular necrosis of talus, and to explore new treatments of traumatic avascular necrosis of talus. METHODS: A total of 34 patients with traumatic avascular necrosis of talus were selected from the Affiliated Hospital of Medical College of Chinese Armed Police Force from September 2004 to June 2009. The patients were randomly divided into ESWT and control groups, with 17 patients per group. All patients were treated with pain point positioning combined with surface X-ray localization, the working voltage of 8-10 kV, energy flow density of 0.12-0.16 mJ/mm2, impact frequency of 40-50 times/min, and impact of 800-1 000 times, once a week, for 3-5 cycles. Pain was evaluated with VAS before and after treatment, function of ankle was evaluated with AOFAS standards, and MRI of ankle was re-checked at 18 months after treatment to compare necrotic area before and after treatment. RESULTS AND CONCLUSION: VAS pain, function of ankle, and necrotic area of ankle in the ESWT group were significantly improved compared to those in the control group at 18 months after treatment (P < 0.01). Activity of one case in the control group was limited by severe pain due to traumatic arthritis in the first 15 weeks after ankle arthrodesis surgery. This suggested that liquid-electric extracorporeal shock wave was a non-invasive method which was simple minimally invasive treatment and had significant effect and fewer complications, for treating traumatic avascular necrosis of talus.

Zhu X.-D.,General Hospital of Chinese Armed Police Force | Shen Z.-Y.,General Hospital of Chinese Armed Police Force | Chen X.-G.,General Hospital of Chinese Armed Police Force | Zang Y.-J.,General Hospital of Chinese Armed Police Force
Experimental and Clinical Transplantation | Year: 2013

Objectives: To summarize the pathotyping and clinical manifestations of biliary cast syndrome in patients after an orthotopic liver transplant. Materials and Methods: The clinical manifestations, auxiliary examination, therapeutic regimen, and clinical efficacy of 103 biliary cast syndrome patients who underwent an orthotopic liver transplant were retrospectively analyzed. Patients were divided into 6 groups from type 1 to type 6, according to the injury level of the biliary duct epithelium. Results: Many biliary cast syndrome patients showed symptoms including jaundice, dark urine, argillaceous stool, itchy skin, and fever. Serum levels of alanine aminotransferase, γ-glutamyl transpeptidase, alkaline phosphatase, and total bilirubin were increased. In addition, total white cell counts in peripheral blood also were increased. T-tube cholangiography showed filling defects of various amounts. Optical fiber choledochoscope examination revealed that the biliary tract was filled with solid substances, and necrosis of the biliary tract epithelium was observed in some biliary cast syndrome patients. From type 1 to type 6 biliary cast syndrome patients, the probability of clinical symptoms and biliary tract stricture gradually increased, the time needed for supporting gradually prolonged after removal of the biliary cast, and T-tube cholangiography showed that the filling defects gradually expanded. Conclusions: Clinical manifestations and cholangiography presentations mainly depend on pathotyping. © Başkent University 2013.

Liu C.-Y.,General Hospital of Chinese Armed Police Force | Jin L.,General Hospital of Chinese Armed Police Force | Peng B.-G.,General Hospital of Chinese Armed Police Force
Chinese Journal of Tissue Engineering Research | Year: 2014

BACKGROUND: Methylene blue can hinder abnormal pain conduction via the sensory nerve, and its mechanism is to block bradykinin-induced hyperalgesia and eliminate pain caused by local tissue inflammation. OBJECTIVE: To observe the influence of methylene blue solution on the lumbar spinal cord and spinal ganglia function of rats, and to investigate whether methylene blue is safe for treating discogenic low back pain. METHODS: Totally 120 Wistar rats were randomly divided into five groups: three experimental groups, a saline control group and a blank control group, n=24 in each group. Lumbar segmental dura was exposed in rats. In the three experimental groups, 0.2, 1, and 2 mL methylene blue were injected epidurally, respectively. The saline control group was subjected to the epidural injection of 1 mL saline. In the blank control group, there was no treatment. Six rats from each group were selected randomly and perfused at 30 minutes, 2 hours, 24 hours, 72 hours after injection, respectively. Then, the corresponding segments of the spinal cord and ganglions were removed. Hematoxylin eosin staining was used for comparing histological and structural changes under light microscope. RESULTS AND CONCLUSION: Hematoxylin-eosin staining showed that at 30 minutes, 2 hours, 24 hours and 72 hours after injection of methylene blue, the spinal dorsal side exhibited the structural integrity, clear boundaries between the white matter and gray matter, dense nerve fibers in the white matter, and round or oval nuclei of glial cells among fibers; dense nerve fibers in the posterior horn of gray matter; light-colored neuronal nuclei with prominent nucleoli; a bundle of nerve fibers among cell populations. There was no significant change in tissue structure of lumbar spinal cord and spinal ganglia between the experimental groups and the saline control group or between the experimental groups and the blank control group. Thus, the epidural injection of 1% methylene blue has no significant effect on the spinal cord and spinal nerve structures. © 2014, Journal of Clinical Rehabilitative Tissue Engineering Research. All Rights Reserved.

Han C.,General Hospital of Chinese Armed Police Force | Xu Q.,General Hospital of Chinese Armed Police Force | Liu N.,General Hospital of Chinese Armed Police Force | Feng H.-P.,General Hospital of Chinese Armed Police Force | And 2 more authors.
Ophthalmology in China | Year: 2013

Objective: To evaluate the feasibility and value of screening for fundus diseases with digital nonmydriatic fundus camera in 50-year-old or elder community citizens. Design: cross-sectional survey. Participants: 3742 residents aged 50-year-old or elder by telephone notices and posters recruitment from Wanshoulu blocks and Tiancun blocks, Haidian district, Beijing. Methods: Fundus photos were taken with digital nonmydriatic fundus camera and slit-lamp microscopic examination of the anterior segment of all subjects was performed after visual acuity examination. Cases screened as macular diseases with photos were undergone optical coherence tomography (OCT) examination. Main Outcome Measures: Composition ratios of fundus diseases. Results: Among all the screened 3742 subjects, 2914 subjects acquired qualified fundus photos, 13 fundus diseases were screened, including retinal arteriosclerosis (37.1%), suspect glaucoma (9.27%), aged-related macular degeneration (6.11%), diabetic retinopathy (2.23%), asteroid hyalosis (0.89%), myelinated nerve fibers (0.58%), retinal vasculitis (0.51%), epiretinal membrane of macula (1.30%), suspect macular hole (1.20%), retinal vein occlusion (0.14%), optic atrophy (0.17%), optic disc macroaneurysm (0.03%), other fundus abnormality (0.32%). Images of macular degeneration, epi-macular membrane and macular hole were compared with OCT scanning, the result consistent rate of the two methods is 86.90%. 828 subjects (22.13%) are excluded because their fundus images were unclear and couldn't be analyzed. The rate un-evaluation of fundus images was increasing with aging. Conclusion: It is an objective and feasible screening method for fundus disease with digital nonmydriatic fundus camera in most 50-year-old or elder subjects. (Ophthalmol CHN, 2013, 22: 230-233). Copyright © 2013 by the Editorial Board of OPHTHALMOLOGY IN CHINA.

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