General Hospital of Chengdu Command

Chengdu, China

General Hospital of Chengdu Command

Chengdu, China
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Yang J.,Chongqing Medical University | Yang J.,General Hospital of Chengdu Command | Zhang Y.-L.,General Hospital of Chengdu Command | Dai F.-D.,General Hospital of Chengdu Command | And 4 more authors.
Medical Journal of Chinese People's Liberation Army | Year: 2016

Objective To quickly establish the To quickly establish the atherosclerosis (AS) model in apoprotein E gene knockout (ApoE-/-) rats by short-term high-fat diet combined with balloon injury. Methods Eight-week-old male SD and ApoE-/- rats (10 each) were used in the experiments. After fed with high-fat diet for 2 weeks, the blood routine, hepatorenal function, blood lipid profile and C-reactive protein (CRP) were measured, and then all the left common carotid arteries were processed by balloon injury. After 2 weeks, rats euthanasia were carried out by excessive chloral hydrate, and then the operation side common carotid arteries were stained with HE, Masson trichrome and oil red O. While the common carotid arteries accepted CD68, α-SMA immunofluorescent staining. Results The blood lipid level was significantly higher in ApoE-/- rats than in SD rats [total cholestrol (TC): 18.56±2.82mmol/L vs 5.69±1.98mmol/L, P<0.01; low density lipoprotein (LDL): 6.86±1.47mmol/L vs 1.92±0.76mmol/L, P<0.01]. In the condition of serious blood lipid disorders, the ApoE-/- rats had been in a state of inflammation [CRP: 4.66±0.57mg/L vs 0.39±0.21mg/L, P<0.05; white blood cell: (21.79±5.10)×109/L vs (14.82±2.41)×109/L, P<0.01; neutrophil: (9.28±3.35)×109/L vs (2.10±0.96)×109/L, P<0.01]. HE and Masson staining showed that obvious hyperplasia formed and collagen fibers deposited slightly in the two groups. Oil red O staining revealed the obvious hyperplastic plaques in ApoE-/- rats, but a negative result in SD rats. Immunofluorescence staining showed the significant positive CD68 and weak positive α-SMA in the plaque of ApoE-/- rats, while in SD rats the positive -SMA was pointed out with no CD68 coloration. Conclusion The atherosclerosis model of ApoE-/- rat may be quickly established by short-term high-fat diet combined with balloon injury. © 2016, People’s Military Medical Press. All rights reserved.


Zhou J.-J.,184th Hospital of PLA | Zhao M.,184th Hospital of PLA | Liu D.,General Hospital of Chengdu Command | Liu H.-Y.,Tianjin University of Technology | Du C.-F.,Tianjin University of Technology
Journal of Healthcare Engineering | Year: 2017

In this study, we developed and validated a refined three-dimensional finite element model of middle femoral comminuted fracture to compare the biomechanical stability after two kinds of plate fixation: a newly designed assembly locking compression plate (NALCP) and a locking compression plate (LCP). CT data of a male volunteer was converted to middle femoral comminuted fracture finite element analysis model. The fracture was fixated by NALCP and LCP. Stress distributions were observed. Under slow walking load and torsion load, the stress distribution tendency of the two plates was roughly uniform. The anterolateral femur was the tension stress area, and the bone block shifted toward the anterolateral femur. Maximum stress was found on the lateral border of the number 5 countersink of the plate. Under a slow walking load, the NALCP maximum stress was 2.160e+03 MPa and the LCP was 8.561e+02 MPa. Under torsion load, the NALCP maximum stress was 2.260e+03 MPa and the LCP was 6.813e+02 MPa. Based on those results of finite element analysis, the NALCP can provide adequate mechanical stability for comminuted fractures, which would help fixate the bone block and promote bone healing. © 2017 Jiang-Jun Zhou et al.


Yang X.-K.,General Hospital of Chengdu Command | Xu G.-S.,General Hospital of Chengdu Command
Medical Journal of Chinese People's Liberation Army | Year: 2013

Objective To evaluate the therapeutic effect of glucocorticoid in the treatment of HBV-related hepatic failure. Methods Literature was retrieved from Medline, PubMed, EMbase, OUP, Elesiver, BIOSIS, HMIC, CNKI, VIP, WANFANG Database and CBM Database from Jan. 1989 to Jan. 2012 to collect the papers concerning the clinical trials (published in English and Chinese) referring to glucocorticoid treatment and routine treatment for hepatic failure by meta-analysis method. Weighted mean (WM) was applied to evaluate the effect of glucocorticoid on prothrombin time (PT) and total bilirubin (TBil), and odds ratio (OR) was applied to evaluate the effect of glucocorticoid on survival rate, secondary infection and alimentary tract hemorrhage. Results Above-mentioned indexes included 24, 6, 9, 10, and 9 related articles. The effective indexes and 95% confidence interval (CI) were 3.12 (95%CI: 2.53-3.86), -0.48 (95%CI: -0.71--0.25), -1.01 (95%CI: -1.29--0.73), 0.80 (95%CI: -0.58-1.10) and 0.59 (95%CI: -0.41-0.85), respectively. Treatment with glucocorticoid decreased the mortality of patients with hepatic failure (Z=10.37, P=0.000), and improved PT and TBil levels (Z=4.10, P=0.000; Z=7.07, P=0.000), but no change was found in incidence of secondary infection and alimentary tract hemorrhage (Z=1.39, P=0.165; Z=1.69, P=0.095). Conclusion Glucocorticoid shows an obvious effect on the prognosis of patients with hepatic failure with no increase in complications.


Gao M.,Luzhou Medical College | Xiao Z.-L.,General Hospital of Chengdu Command | Li F.-X.,General Hospital of Chengdu Command
Medical Journal of Chinese People's Liberation Army | Year: 2013

Acute respiratory distress syndrome (ARDS) is closely correlated with infection. Severe infection, e.g., sepsis and septic shock, can result in ARDS. Ventilator associated pneumonia (VAP) is one of the common complications in ARDS related infection. As regards ARDS related infection, community acquired infection (CAI) is different from hospital acquired infection (HAI) in bacterial spectrum. The former is mainly caused by Streptococcus pneumonia, Hemophilus influenzae, Moraxelle catarrhalis, atypical pathogens and Klebsiella pneumoniae. However, HAI is mainly caused by Pseudomonas aeruginosa, Acinetobacter baumanii, methicillin- resistant Staphylococcus aureus (MRSA), and other drug-resistant bacteria. The drug-resistant bacterial infection not only makes treatment difficult, but also leads to an increase in mechanical ventilation time, length of ICU stay, mortality rate, and medical costs. The present paper has reviewed the relationship between ARDS and infection, therapeutic principles and measures of ARDS related infection, and introduced the optimal strategy of anti-infectious treatment of ARDS.


Li W.,General Hospital of Chengdu Command | Dan G.,General Hospital of Chengdu Command | Jiang J.,General Hospital of Chengdu Command | Zhao Y.,University of Sichuan | Deng D.,University of Sichuan
Journal of Surgical Research | Year: 2013

Background: Chylothorax is a pathologic condition defined by an accumulation of lymphatic fluid, the chyle, in the thorax. Postoperative chylothorax is a potentially lethal complication, with a reported mortality rate of 15.4%-25%. Patients and methods: Esophageal cancer patients hospitalized for elective radical esophagectomy by thoracotomy (n =10,574) were consecutively enrolled between January 1996 and December 2011. Patients (n =306) who experienced post-esophagectomy chylothorax were assigned to a 48-h (group A, n =186) or to a 2-wk (group B, n =120) conservative treatment regimen. For patients with a daily chylothorax output >1000 mL, thoracic duct ligation (TDL) was performed by thoracotomy. Measured outcomes included frequency of TDL, overall and treatment-specific morbidity and mortality rates, and the rate of chylothorax recurrence. Results: A total of 171 patients (171 of 306 [55.9%]) underwent TDL. A larger proportion of patients in group A required TDL compared with group B (72.6% versus 30.0%, P < 0.001). Group A had a significantly higher rate of overall morbidity compared with group B (31.7% versus 19.2%, P =0.02). Moreover, the overall mortality rate was significantly higher in group A (14.0% versus 4.2%, P =0.006). Chylothorax recurred in nine patients (9 of 306 [2.9%]), and there was no difference between the two groups (3.2% versus 2.5%, P =1.000). Conclusions: The 2-wk regimen reduced the requirement for TDL and the overall morbidity and mortality rates compared with the 48-h regimen. Importantly, this regimen does not increase the risk of chylothorax recurrence. © 2013 Elsevier Inc. All rights reserved.


Du F.-Z.,General Hospital of Chengdu Command | Gu M.,General Hospital of Chengdu Command | He C.,General Hospital of Chengdu Command | Jiang R.,General Hospital of Chengdu Command | Guan J.,General Hospital of Chengdu Command
Medical Journal of Chinese People's Liberation Army | Year: 2014

Objective The perfusion and vascular architecture features were investigated and evaluated by use of one-stop imaging technique with 320 rows CT for exploring the clinical value of one-stop imaging technique in the diagnosis of intracranial lesions. Methods The perfusion parameters and vascular architecture of intracranial high perfusion lesions of 52 patients were collected in General Hospital of Chengdu Command from Oct. 2010 to Apr. 2013, who were examined by one-stop imaging technique with 320 rows CT, were retrospectively analyzed. The perfusion values of normal contralateral cerebral tissue were used as control to analyze the perfusion and vascular architecture features of injured parts. Results Of the 52 patients, there were 16 cases of subacute cerebral infarction, 9 cases of arteriovenous malformation, 7 cases of hemangioma, 12 cases of meningioma, and 8 cases of glioma. All the patients showed elevated CBV and/or CBF and different changes in mean transit time (MTT), time to peak (TTP) and delay time (Delay). In the cases of subacute cerebral infarction, the parameters of MTT, TTP and Delay increased. In the cases of arteriovenous malformation, all the parameters decreased. In the cases of hemangioma, the MTT decreased, while TTP and Delay increased. In the cases of glioma, the TTP and Delay increased, while the change of MTT varied. Meanwhile, abnormality of vascular structures was found in all the cases by CT angiography. Conclusion With whole brain perfusion and one-stop vascular imaging with 320 rows CT, the perfusion characteristics of intracranial lesions can be revealed completely, including blood supply and microcirculation changes in the lesions, and it may be of benefit in guiding the clinical diagnosis and treatment.


Gong J.-Q.,Peoples Liberation Army General Hospital of Chengdu Command | Ren J.-D.,Peoples Liberation Army General Hospital of Chengdu Command | Tian F.-Z.,Peoples Liberation Army General Hospital of Chengdu Command | Jiang R.,General Hospital of Chengdu Command | And 2 more authors.
World Journal of Gastroenterology | Year: 2011

To propose a new classifcation system for sphincter of Oddi dysfunction (SOD) based on clinical data of patients. METHODS: The clinical data of 305 SOD patients documented over the past decade at our center were analyzed retrospect tively, and typical cases were reported. RESULTS: The new classifcation with two more types (double-duct, biliary-pancreatic reflux) were set up on the basis of the Milwaukee criteria. There were 229 cases of biliary-type SOD, including 192 (83.8%) cases cured endoscopically, and 29 (12.7%) cured by open abdominal surgery, and the remaining 8 (3.5%) cases observed with unstable outcomes. Eight (50%) patients with pancreatic-type SOD were cured by en-doscopic treatment, and the remaining 8 patients were cured after open abdominal surgery. There were 19 cases of double-duct-type SOD, which consisted of 7 (36.8%) patients who were cured endoscopically and 12 (63.2%) who were cured surgically. A total of 41 cases were diagnosed as biliary-pancreatic-reflux-type SOD. Twenty (48.8%) of them were treated endoscopically, 16 (39.0%) were treated by open abdominal surgery, and 5 (12.2%) were under observation. CONCLUSION: The newly proposed SOD classification system introduced in this study better explains the clinical symptoms of SOD from the anatomical perspective and can guide clinical treatment of this disease. © 2011 Baishideng. All rights reserved.


Gong J.,The Peoples Liberation Army General Hospital of Chengdu Command | Wang Y.,The Peoples Liberation Army General Hospital of Chengdu Command | Jiang R.,General Hospital of Chengdu Command | Zhang G.,The Peoples Liberation Army General Hospital of Chengdu Command | Tian F.,The Peoples Liberation Army General Hospital of Chengdu Command
Biochemical and Biophysical Research Communications | Year: 2013

Objective: The purpose of this study was to investigate the expression of collagen type I and the mRNA level of its regulatory factor, TGF-β1, in tissue samples of acute pancreatitis and to determine the significance of collagen type I in predisposition to pancreatic fibrosis during acute pancreatitis. Methods: Sprague-Dawley rats were divided into an experimental group (30 rats) and a control group (12 rats). The rats in the experimental group were intraperitoneally injected with cerulein to induce acute pancreatitis. The distribution and expression of collagen type I in the pancreatic tissues were examined by immunohistochemical staining. The mRNA level of TGF-β1 was determined by real-time polymerase chain reaction (PCR). Results: (1) Collagen type I was localized in the cytoplasm of pancreatic acinar cells. With pancreatitis progressed, strong positive staining for collagen type I covered whole pancreatic lobules, whereas, the islet tissue, interlobular area, and pancreatic necrotic area were negative for collagen type I. (2) The level of TGF-β1 mRNA in rats from the experimental group increased gradually the establishment of acute pancreatitis, and was significantly higher than that in the control group at every time point. Conclusions: (1) During acute pancreatitis, pancreatic acinar cells, not pancreatic stellate cells as traditionally believed, were the naïve effector cells of collagen type I. (2) TGF-β1 played a key role in regulating collagen I expression during acute pancreatitis. © 2013 Elsevier Inc.


Li W.,General Hospital of Chengdu Command | Dan G.,General Hospital of Chengdu Command | Jiang J.,General Hospital of Chengdu Command | Yang L.,General Hospital of Chengdu Command | Huang X.,Chongqing Medical University
Chinese Journal of Lung Cancer | Year: 2010

Background and objective: 125I seed implantation treatment of pulmonary metastases, often because of complicated structure of the chest, was considered as restricted areas. The aim of this study is to evaluate the effectiveness of CT guided radioactive 125I seed implantation in treating lung metastatic tumors. Methods: Totally 115 metastatic masses were found in 30 patients with CT guiding. 125I seeds were implanted into lung metastatic masses. The approach of implantation was determined according to the location of the lesions (hilar masses, peripheral masses and masses covered by skeletal thorax). The therapeutic effects were evaluated by CT. Results: Uniform distribution were achieved by single puncture in 84.3% of patients. The rest patients (15.7%) were received replanting. The follow-up period was 6-24 months (mean 14.6). Among 115 lesions in 30 cases, complete response (CR) was achieved in 80 nodes, partial response (PR) in 20 nodes, No change (NC) in 8 nodes and progressive disease (PD) in 7 nodes. The total response rate was 86.9%. The one-year local control rate were 93.9% (108/115). No severe perioperative complications occurred. Conclusion: CT guided radioactive seed 125I implantation is a safe and effective procedure in treating multiple lung metastatic tumor with minimal invasion.


PubMed | General Hospital of Chengdu Command
Type: Journal Article | Journal: Zhongguo fei ai za zhi = Chinese journal of lung cancer | Year: 2010

125I seed implantation treatment of pulmonary metastases, often because of complicated structure of the chest, was considered as restricted areas. The aim of this study is to evaluate the effectiveness of CT guided radioactive 125I seed implantation in treating lung metastatic tumors.Totally 115 metastatic masses were found in 30 patients with CT guiding. 125I seeds were implanted into lung metastatic masses. The approach of implantation was determined according to the location of the lesions (hilar masses, peripheral masses and masses covered by skeletal thorax). The therapeutic effects were evaluated by CT.Uniform distribution were achieved by single puncture in 84.3% of patients. The rest patients (15.7%) were received replanting. The follow-up period was 6-24 months (mean 14.6). Among 115 lesions in 30 cases, complete response (CR) was achieved in 80 nodes, partial response (PR) in 20 nodes, No change (NC) in 8 nodes and progressive disease (PD) in 7 nodes. The total response rate was 86.9%. The one-year local control rate were 93.9% (108/115). No severe perioperative complications occurred.CT guided radioactive seed 125I implantation is a safe and effective procedure in treating multiple lung metastatic tumor with minimal invasion.

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