Xu J.-F.,General Hospital of Beijing Millitary Command |
Wang Z.-Q.,General Hospital of Beijing Millitary Command |
Yan C.-X.,General Hospital of Beijing Millitary Command |
Xu Q.,General Hospital of Beijing Millitary Command |
And 3 more authors.
Medicinal Chemistry Research | Year: 2012
The aim of the study is to identify the effect of UDP- glucuronosyltransferase (UGT) genetic polymorphism on the interindividual variability in mitiglinide pharmacokinetics (PK) in Chinese. PK and genetic data were obtained from 42 healthy Chinese volunteers (Han ethnic group) treated with single-dose and multiple-dose oral mitiglinide using liquid chromatography/mass spectrometry and DNA sequencing technologies. And the result showed there were great interindividual variabilities in main PK parameters (AUC, Cmax and CL/F) for multiple oral mitiglinide. The enzyme activity of the carriers of UGT1A3 *2/*4 or UGT2B7-1 T/T was stronger than that of the carriers of other genotypes. These results demonstrate that UGT1A3 and UGT2B7-1 genetic polymorphism may have a significant impact on interindividual variability in the PK of mitiglinide in Chinese. © Springer Science+Business Media, LLC 2011.