Han Y.,General Hospital of Beijing Military District
Chinese Journal of New Drugs | Year: 2012
Although proton pump inhibitors (PPI) have achieved a remarkable success in the management of gastroesophageal reflux disease (GERD). However, the challenges such as insufficient action duration and poor compliance still exist as the reason for treatment failure. Recently, dexlansoprazole dual delayed release (DDR, Takeda Pharmaceuticals) under the trade name of Dexilant TM got approved by FDA, which provides longer duration of action and more effective acid suppression. It is currently approved for the treatment of erosive esophagitis (acute, maintenance) and symptom release of NERD.
Liu J.,General Hospital of Beijing Military District
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery | Year: 2012
To investigate the effect of anterior chest wall depression on the cardiac function and the effectiveness of minimally invasive surgery for pectus excavatum by comparing cardiac function and morphology between pre- and post-operation. Between August 2009 and December 2010, 102 adult patients with pectus excavatum were treated with minimally invasive surgery, including the primary operation in 95 cases and the reoperation in 7 cases. There were 84 males and 18 females, aged 18-57 years (mean, 23.4 years). The haller index (HI) was 4.59 +/- 1.51. Of 102 patients, 59 were classified as pectus excavatum type I and 43 as type II; 42 had clinical symptoms and 19 had the physical sign of heart. The preoperative chest CT examination showed cardiac compression in all patients and heart displacement in 74 patients. The left ventricular ejection fraction (LVEF) was 68.9% +/- 6.2%. The procedure was successful in all patients, and no death or serious complication occurred. The patients were followed up 12-28 months (mean, 21 months). The clinical symptoms and cardiac physical sign of the patients disappeared after operation. HI was 2.70 +/- 0.33 at 12 months after operation, showing significant difference when compared with preoperative HI (t = 5.83, P = 0.00). According to Nuss's evaluation method, the results were excellent in 99 patients and good in 3 patients. CT examination showed complete relief of cardiac compression in 101 patients and mild cardiac compression in 1 patient; the heart position was normal at 12 months after operation. Electrocardiogram returned to normal in 4 patients having abnormal electrocardiogram. LVEF was 70.5% + 4.8% after operation, showing no significant difference when compared with preoperative LVEF (t = 1.08, P = 0.30). CONCLUSION; The main effects of pectus excavatum in adults on heart are compression and displacement. Cardiac compression may be relieved efficiently and the patient's clinical symptoms can be abated by minimally invasive surgery.
Wei Z.,General Hospital of Beijing Military District |
Ouyang Q.,General Hospital of Beijing Military District |
Li H.,General Hospital of Beijing Military District
Chinese Journal of Rehabilitation Medicine | Year: 2015
Objective: To observe the clinical therapeutic effects of infrasound of low sound pressure level(8-12Hz, 0-80dB, infratonic 9 instrument, Infratonic Solutions CHI) on patients with posttraumatic elbow joint dysfunction. Method: Twenty- nine patients with posttraumatic elbow joint dysfunction were randomly divided into two groups: the infrasound treatment group (n=15) receiving joint mobilization combined with infrasound, and the control group (n=14) receiving joint mobilization only. All the patients in the two groups were also given conventional therapy. All the patients were assessed with Mayo elbow-performance score and range of motion (ROM) before and after the treatment. Result: After treatment for 6 weeks, the effect assessed with Mayo elbow scores and ROM were significantly different in two groups when compared with those before treatment (P<0.01), the effect of infrasound treatment group was significantly different from the control group after treatment (P<0.05), the clinical effect of infrasound treatment group was superior to that of the control group (χ2=4.212, P<0.05). After treatment, there was no obvious side effect in both two groups. Conclusion: Infrasound of low sound pressure level combined with joint mobilization can obviously improve motor function and relieve pain of elbow joint after trauma. The infrasound of low sound pressure possess good security, and is very effective for limb function recovery. It is worthy using in clinic. ©, 2015, China-Japan Friendship Hospital. All right reserved.
Zhang W.,General Hospital of Beijing Military District |
Liu L.,General Hospital of Beijing Military District |
Huo Y.,General Hospital of Beijing Military District |
Yang Y.,General Hospital of Beijing Military District |
Wang Y.,General Hospital of Beijing Military District
BioMed Research International | Year: 2014
Hypoxia preconditioning has been confirmed as an effective strategy to enhance the therapeutic potentials of mesenchymal stem cells (MSCs), such as for myocardial ischemia. However, whether hypoxia preconditioning would produce beneficial effects on MSC-based renal repair has not been demonstrated. In the study, we aimed to determine the feasibility and efficacy of hypoxia preconditioning to enhance MSC-based therapy of acute kidney injury (AKI). MSCs were isolated from human adipose tissues. The paracrine effects of MSCs under normoxia and hypoxia were determined in vitro. Rats of AKI were induced by kidney I/R surgery and randomly divided into three groups: I/R control receiving PBS injection; MSC group receiving normal MSC injection; hypoMSC group receiving hypoxia-preconditioned MSC injection. It was demonstrated in vitro that paracrine effects of MSCs were significantly enhanced, especially angiogenic factors. Dihydroethidium (DHE) staining showed that antioxidative activities of MSCs were significantly enhanced by hypoxia stimulation. Vascularization, apoptosis, and histological injury were all significantly improved in hypoMSC injected group compared with that in control and MSC injected groups. Finally, the renal function was also significantly improved in hypoMSC injected group compared with that in the other two groups as assessed by the serum creatinine and BUN levels. © 2014 Wenbo Zhang et al.