General Hospital of Armed Police

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General Hospital of Armed Police

China

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Yin Y.,General Hospital of Armed Police | Mu X.,General Hospital of Armed Police | Wang H.,General Hospital of Armed Police
Chinese Journal of Interventional Imaging and Therapy | Year: 2016

Objective: To explore the feasibility of Argus software on evaluation of neoadjuvant chemotherapy (NAC) in patients with breast cancer. Methods: Twenty-three patients with histopathologically proven invasive ductal carcinoma (twenty-four sides totally, one case with bilateral breast cancer), and underwent NAC were collected. All patients underwent 3.0T dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) before and after 4 cycles of chemotherapy, and the images in second phase were transported to Argus software. The volume of tumor before and after 4 cycles of chemotherapy were measured by two experience radiologists blindly, the final results were averaged. The tumor volumes measured before and after NAC were compared with paired samples t test. Results: Before and after 4 cycles of chemotherapy, the averaged volume of 24 sides breast tumor was (13.71±9.47)cm3 ([3.9-42.1]cm3) and (4.81±4.15)cm3 ([0.3-29.4]cm3), respectively, and the difference was statistically significant (t=6.36, P<0.01). Conclusion: It is convenient and accurate of breast tumors volume measured using Argus software. It can be used to assess the efficacy of NAC in patients with breast cancer effectively. Copyright © 2016 by the Press of Chinese Journal of Medical Imaging and Technology.


Jiang H.,Peking University | Bai W.,Capital Medical University | Wang W.,Peking University | Zhang J.,Peking University | And 5 more authors.
Experimental Gerontology | Year: 2017

Menopause is a cardiovascular risk factor in women, and cardiovascular changes during perimenopause can increase the risk. We observed the influence of plasma adrenalin and norepinephrine and their metabolites on the cardiovascular system and the rectification effect of estrogen in ovariectomized rats. Fifty-four adult female Sprague-Dawley rats were randomly divided into sham (Sham), ovariectomized (OVX), or ovariectomized + estrogen treatment groups (OVX + E), with 18 rats in each. The Sham and OVX groups were given normal saline and the OVX + E group was given estradiol valerate beginning 2 weeks after ovariectomy and continuing for 4 weeks. Radioimmunoassay, high-performance liquid chromatography, high-performance liquid chromatography-tandem mass spectrometry, and chromatography-spectrophotometry were used to detect estradiol, adrenalin, norepinephrine, metanephrine, and normetanephrine in plasma and vanillylmandelic acid in urine. Echocardiography, Doppler blood flow detection technologyand hamnatodynamometer were applied to assess cardiovascular function. After ovariectomy, levels of estrogen reduced, adrenalin and metanephrine increased, and norepinephrine and normetanephrine in the plasma and vanillylmandelic acid in urine decreased. Symptoms indicative of cardiac diastolic dysfunction, including decreased diastolic left ventricular cavity capacity, increased wall thickness and decreased cardiac rate were observed. Different degrees of vasomotor dysfunction appeared in different peripheral positions, and the tail vessels were in relatively systolic conditions. However, the claw pad vessels were diastolic. Besides, blood pressure also increased. After ovariectomy, estrogen levels reduced and the metabolic processes of adrenalin and norepinephrine changed, which impacted cardiovascular functions. Changes of adrenalin and norepinephrine and its metabolites were correlated with the cardiovascular function. Cardiovascular disease occurred during the perimenopausal period. Estrogen replacement therapy can mitigate, rectify, and improve menopause-related conditions such as hot flash. © 2017 Elsevier Inc.


Cui G.,Peking University | Leng H.,Peking University | Wang K.,Peking University | Wang J.,Peking University | And 6 more authors.
PLoS ONE | Year: 2013

This study aims to evaluate the effects of Remifemin (isopropanolic extract of Cimicifuga Racemosa) on postmenopausal osteoporosis. 120 female Sprague-Dawley rats were randomly assigned to four groups: sham surgery with vehicle, ovariectomy with vehicle, ovariectomy with estradiol valerate, or ovariectomy with Remifemin. Daily oral administrations of the vehicle, estradiol valerate, or Remifemin began 2 weeks after surgery and lasted to 4, 8, or 12 weeks. Ten rats in each group were sacrificed at each timestep with assessment of bone mineral density, trabecular bone structure, and biomechanical parameters of the femur and lumbar vertebra. Bone turnover markers were evaluated 12 weeks after surgery. Both drugs prevented bone density loss in the distal end of the femur and preserved the trabecular bone structure in both the lumbar vertebra and distal end of the femur following ovariectomy. Both drugs protected bone stiffness at the tested regions and reduced bone reabsorption in ovariectomized rats. The preventive effects of Remifemin against bone-loss can rival those of estradiol valerate if treatment duration is adequately extended. In conclusion, Remifemin may demonstrate equivalent effects to estradiol valerate in terms of preventing postmenopausal osteoporosis. Copyright: © 2013 Cui et al.


Yang L.,Peking University | Chen X.,Peking University | Liu H.,Hebei Yanda Hospital | Chen Y.,Zunyi Medical College Affiliated Hospital | And 3 more authors.
Transplant Immunology | Year: 2015

We investigated the clinical characteristics of acute lymphoblastic leukemia (ALL) patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) using haploidentical donors carrying HLA-B*:01/. TNFα - 308A (B*:01-TNF2) haplotype. A total of 136 B*:01-TNF2 haplotype in related donors was determined B*:01-TNF2 haplotype (21 cases), those using haploidentical donors without B*:01-TNF2 haplotype (100 cases), and those using HLA-identical siB*:01-TNF2 haplotype (44 cases). Compared with the other two groups, patients using haploidentical donors carrying B*:01-TNF2 haplotype had higher overall mortality (adjusted P= 0.039) and non-relapse mortality (adjusted P= 0.001) within 2. years, delayed platelet engraftment (adjusted P<. 0.0001), higher incidences of severe acute graft-versus-host disease (aGVHD) (P= 0.007), severe late-onset hemorrhagic cystitis (P= 0.002), B*:01-TNF2 haplotype may cause more serious complications and poorer outcomes to ALL recipients. © 2014 Elsevier B.V.


Yang L.,Beijing 301 Hospital | Yang L.,General Hospital of Armed Police | Liu H.,Beijing Daopei Hospital | Zhao J.,Peking University | And 5 more authors.
Leukemia Research | Year: 2011

To address whether mutations and single nucleotide polymorphisms (SNPs) in perforin gene (PRF1) are correlated with acute lymphoblastic leukemia (ALL) in Chinese, we screened mutations in codon region of PRF1 in 111 ALL patients, and correlated the results with patients' immunophenotype, karyotype and fusion genes. Four novel monoallelic missense and two novel monoallelic synonymous mutations (G198R, R225Q, D486G, R509K, S388S and Q540Q) were identified in 9 B-ALL, of whom 7 cases carried BCR-ABL gene, one carried MLL-AF4 fusion gene, and one lost two chromosomes. Our results suggest that mutations in PRF1 may play a role in the pathogenesis of B-ALL. © 2010 Elsevier Ltd.


Wang W.,Peking University | Bai W.,Peking University | Cui G.,Peking University | Cui G.,Civil Aviation General Hospital | And 5 more authors.
Neuroendocrinology | Year: 2015

Aims: We investigated the norepinephrine pathway changes from the locus coeruleus (LC) to the preoptic area of the hypothalamus (POAH) in the brain of ovariectomized rats under low estrogen levels and explored the therapeutic effects of estradiol valerate (E2) and Remifemin (ICR) on these changes. Methods: 40 female Sprague-Dawley rats were randomly divided into the following groups: surgery with vehicle (SHAM), ovariectomy surgery with vehicle (OVX), ovariectomy with E2 treatment (OVX + E2), and ovariectomy with Remifemin (OVX + ICR). After 4 weeks of treatment, we observed the changes by immunohistochemistry. Results: (1) The average optical density of DBH-ir fibers and the number of α1-adrenoreceptor-and estrogen receptor (ER)α-positive neurons in the main nuclei of POAH were all reduced in OVX rats compared with the SHAM group. The above changes were normalized in all nuclei of the POAH in the E2 group, while they were normalized in some nuclei in the ICR group. Coexpression of ERα and α1-adrenoreceptor was observed in the POAH. (2) The number of DBH-and ERα-positive neurons in the LC decreased in the OVX group compared with the SHAM group and increased after treatment with E2 and ICR. Coexpression of ERα and DBH was observed in the LC. Conclusion: Low estrogen (OVX) altered norepinephrine synthesis in the LC, the projection of norepinephrine fibers and α1-adrenoreceptor expression in the POAH. Both E2 and ICR normalized the norepinephrine pathway, but E2 achieved greater effects than ICR. ICR had different effects in different nuclei in the POAH and its therapeutic effect was better in the LC. © 2015 S. Karger AG, Basel.


PubMed | General Hospital of Armed Police and Peking University
Type: Journal Article | Journal: PloS one | Year: 2013

This study aims to evaluate the effects of Remifemin (isopropanolic extract of Cimicifuga Racemosa) on postmenopausal osteoporosis. 120 female Sprague-Dawley rats were randomly assigned to four groups: sham surgery with vehicle, ovariectomy with vehicle, ovariectomy with estradiol valerate, or ovariectomy with Remifemin. Daily oral administrations of the vehicle, estradiol valerate, or Remifemin began 2 weeks after surgery and lasted to 4, 8, or 12 weeks. Ten rats in each group were sacrificed at each timestep with assessment of bone mineral density, trabecular bone structure, and biomechanical parameters of the femur and lumbar vertebra. Bone turnover markers were evaluated 12 weeks after surgery. Both drugs prevented bone density loss in the distal end of the femur and preserved the trabecular bone structure in both the lumbar vertebra and distal end of the femur following ovariectomy. Both drugs protected bone stiffness at the tested regions and reduced bone reabsorption in ovariectomized rats. The preventive effects of Remifemin against bone-loss can rival those of estradiol valerate if treatment duration is adequately extended. In conclusion, Remifemin may demonstrate equivalent effects to estradiol valerate in terms of preventing postmenopausal osteoporosis.


PubMed | General Hospital of Armed Police and Peking University
Type: Journal Article | Journal: Acta histochemica | Year: 2014

The purpose of this study was to investigate the difference in neuronal activity in the preoptic area of the hypothalamus (POAH) under low estrogen condition induced by ovariectomy. One hundred and twenty sham-operated (SHAM) and ovariectomized (OVX) rats were placed in different temperatures for 2h. Twelve rats from each group were stimulated by 4C, 10C, 25C, 33C and 38C, respectively. c-Fos expression in the POAH was detected by immunohistochemistry. Following exposure to warm and cold stimuli, there were markedly lower c-Fos-positive cell densities in the OVX group compared with the SHAM group in the median preoptic nucleus (MnPO) at 4C, 10C, 33C and 38C, in the medial preoptic area (MPA) at 25C and 38C, in the ventromedial preoptic nucleus (VMPO) at 4C, 10C and 38C and in the ventrolateral preoptic nucleus (VLPO) at 4C and 38C. Both temperature and surgery had an impact on c-Fos expression by two-way ANOVA method except in the lateral preoptic area (LPO). c-Fos expression differed within different nuclei of the two groups in the same and different temperature stimuli. This indicated that the temperature-sensitive nuclei in the POAH exhibited lower and different activities during temperature stimuli following ovariectomy, which possibly resulted in abnormal thermoregulation and menopausal symptoms.


Tian Y.-M.,No 474 Hospital Of Chinese Pla | Xiao L.-H.,General Hospital of Armed Police | Gao X.-W.,No 474 Hospital Of Chinese Pla
International Journal of Ophthalmology | Year: 2011

AIM: To assess features of cavernous hem angioma (CH) in the orbit revealed by CT and MRI and summarize prediction of preoperative CT and MRI for the adhesion degree of CH in the orbit. METHODSA: total of 97 patients with pathologically confirmed CH in the orbit were exam ined with axial and coronal CT scan, and axial, coronal, sagittal, and enhanced fat suppression MRI scan. CT and MRI findings and intraoperative adhesion degrees were retrospectively analyzed. RESULTS: There were 47 patients with slight adhesion, for whom CT and MRI showed round masses with well defined margins in the extraocular muscles; 1 4 patients with mild adhesion, for whom CT and MRI revealed irregular masses with unclear boundary between CH and the opticnerve in coronal images, and emissaryveins in the posterior region of masses in contrast-enhanced images; 36 patients with severe adhesion, for whom CT and MRI exhibited an irregular or ovoid mass filling the orbital apex, or showed distorted and even spiky margins in the posterior region of masses in contrast enhanced images at the presence of a transparent triangle between the mass and the orbital apex. CONCLUSION: Preoperative CT and MRI aid in accurate diagnosis, selection of the surgical approach, and assessment of the adhesion degree and surgicalrisks for CH. © International Journal of Ophthalmology Press.


Mu X.,Chinese PLA General Hospital | Mu X.,General Hospital of Armed Police | Wang H.,General Hospital of Armed Police | Ma Q.,General Hospital of Armed Police | And 2 more authors.
Academic Radiology | Year: 2014

Rationale and Objectives: The objective of this study was to determine the diagnostic accuracy of contrast-enhanced magnetic resonance angiography (MRA) when used in the preoperative evaluation of hepatic vascular anatomy in living liver donors. Materials and Methods: A computer-assisted literature searching of EMBASE, PubMed (MEDLINE), and the Cochrane library databases was conducted to identify potentially relevant articles which primarily examined the utility of contrast-enhanced MRA in the preoperative evaluation of hepatic vascular anatomy in living liver donors. We used the Q statistic of chi-squared value test and inconsistency index (I-squared, I2) to estimate the heterogeneity of the data extracted from all selected studies. Meta-Disc software (version 1.4) (ftp://ftp.hrc.es/pub/programas/metadisc/Metadisc_update.htm) was used to perform our analysis. Results: Eight studies were included in the present meta-analysis. A total of 289 living liver donor candidates and 198 patients who underwent liver harvesting were included in the present study. The pooled sensitivities of hepatic artery (HA), portal vein (PV), and hepatic vein (HV) in this meta-analysis were 0.84, 0.97, and 0.94, respectively. The pooled specificities of HA, PV, and HV were 1.00, 1.00, and 1.00, respectively. The pooled diagnostic odds ratios of HA, PV, and HV were 127.28, 302.80, and 256.59, respectively. The area under the summary receiver-operating characteristic curves of HA, PV, and HV were 0.9917, 0.9960, and 0.9813, respectively. Conclusions: The high sensitivity and specificity demonstrated in this meta-analysis suggest that contrast-enhanced MRA was a promising test for the preoperative evaluation of hepatic vascular anatomy in living liver donors. © 2014 AUR.

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