General Hospital of Armed Police

China

General Hospital of Armed Police

China
SEARCH FILTERS
Time filter
Source Type

Yin Y.,General Hospital of Armed Police | Mu X.,General Hospital of Armed Police | Wang H.,General Hospital of Armed Police
Chinese Journal of Interventional Imaging and Therapy | Year: 2016

Objective: To explore the feasibility of Argus software on evaluation of neoadjuvant chemotherapy (NAC) in patients with breast cancer. Methods: Twenty-three patients with histopathologically proven invasive ductal carcinoma (twenty-four sides totally, one case with bilateral breast cancer), and underwent NAC were collected. All patients underwent 3.0T dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) before and after 4 cycles of chemotherapy, and the images in second phase were transported to Argus software. The volume of tumor before and after 4 cycles of chemotherapy were measured by two experience radiologists blindly, the final results were averaged. The tumor volumes measured before and after NAC were compared with paired samples t test. Results: Before and after 4 cycles of chemotherapy, the averaged volume of 24 sides breast tumor was (13.71±9.47)cm3 ([3.9-42.1]cm3) and (4.81±4.15)cm3 ([0.3-29.4]cm3), respectively, and the difference was statistically significant (t=6.36, P<0.01). Conclusion: It is convenient and accurate of breast tumors volume measured using Argus software. It can be used to assess the efficacy of NAC in patients with breast cancer effectively. Copyright © 2016 by the Press of Chinese Journal of Medical Imaging and Technology.


Jiang H.,Peking University | Bai W.,Capital Medical University | Wang W.,Peking University | Zhang J.,Peking University | And 5 more authors.
Experimental Gerontology | Year: 2017

Menopause is a cardiovascular risk factor in women, and cardiovascular changes during perimenopause can increase the risk. We observed the influence of plasma adrenalin and norepinephrine and their metabolites on the cardiovascular system and the rectification effect of estrogen in ovariectomized rats. Fifty-four adult female Sprague-Dawley rats were randomly divided into sham (Sham), ovariectomized (OVX), or ovariectomized + estrogen treatment groups (OVX + E), with 18 rats in each. The Sham and OVX groups were given normal saline and the OVX + E group was given estradiol valerate beginning 2 weeks after ovariectomy and continuing for 4 weeks. Radioimmunoassay, high-performance liquid chromatography, high-performance liquid chromatography-tandem mass spectrometry, and chromatography-spectrophotometry were used to detect estradiol, adrenalin, norepinephrine, metanephrine, and normetanephrine in plasma and vanillylmandelic acid in urine. Echocardiography, Doppler blood flow detection technologyand hamnatodynamometer were applied to assess cardiovascular function. After ovariectomy, levels of estrogen reduced, adrenalin and metanephrine increased, and norepinephrine and normetanephrine in the plasma and vanillylmandelic acid in urine decreased. Symptoms indicative of cardiac diastolic dysfunction, including decreased diastolic left ventricular cavity capacity, increased wall thickness and decreased cardiac rate were observed. Different degrees of vasomotor dysfunction appeared in different peripheral positions, and the tail vessels were in relatively systolic conditions. However, the claw pad vessels were diastolic. Besides, blood pressure also increased. After ovariectomy, estrogen levels reduced and the metabolic processes of adrenalin and norepinephrine changed, which impacted cardiovascular functions. Changes of adrenalin and norepinephrine and its metabolites were correlated with the cardiovascular function. Cardiovascular disease occurred during the perimenopausal period. Estrogen replacement therapy can mitigate, rectify, and improve menopause-related conditions such as hot flash. © 2017 Elsevier Inc.


Hui Z.,Beihang University | Xiaoyan M.,Beihang University | Mukun Y.,Beihang University | Ke W.,Health Science University | And 5 more authors.
Journal of Ethnopharmacology | Year: 2012

Ethnopharmacological relevance: Cimicifuga racemosa (L.) Nutt. (CR), known as black cohosh, has been used in Europe as a medicinal plant for more than a century and its roots have been widely used for the treatment of menopausal symptoms. Remifemin, the main ingredient in liquid or tablet medications prepared from isopropyl alcohol extracts of black cohosh rhizome, has also been evaluated in clinical studies. Objectives: To observe changes in the expression of the c-Fos protein in the hypothalamic nuclei of four groups of rats - sham-operated group (SHAM), ovariectomized (OVX) group, ovariectomized group treated with estrogen(OVXE), and ovariectomized group treated with the isopropanol extract of Cimicifuga racemosa (OVXICR) - and to investigate the mechanisms of black cohosh and estrogen that take place in the hypothalamic nuclei of ovariectomized rats. Methods: Fifty rats were assigned to each of the four groups and placed in incubators at 4 °C, 10 °C, 25 °C, 33 °C, or 38 °C for 2 h. They were then anesthetized, and their brains were removed after heart perfusion. c-Fos expression in the hypothalamic nuclei was evaluated using immunohistochemical methods. Results: In the median preoptic nucleus (MnPO), ventromedial preoptic nucleus (VMPO), and suprachiasmatic nucleus (SCh) of the SHAM group, in the anterior hypothalamic area (AH) and supraoptic nucleus (SO) of all four groups, and in the paraventricular nucleus (PVN) of the SHAM, OVX and OVXE groups, the c-Fos-positive cell densities all changed in a similar manner: the cell density decreased when the temperature was less than 25 °C and the density increased when the temperature was greater than 25 °C, demonstrating a V-type curve. The c-Fos density was lowest at 25 °C. The other nuclei demonstrated irregular changes. The positive cell densities in the MnPO, AH, and PVN of the SHAM, OVXE, and OVXICR groups were greater than the densities measured in the OVX group at all temperatures, except 25 °C. Positive cell densities in the SHAM, OVXE, and OVXICR groups were greater than the densities measured in the OVX groups in the MPA at 25 °C, in the VMPO at 4 °C, 33 °C, and 38 °C, in the SO at 4 °C, 10 °C, and 38 °C, and in the SCh at 33 °C. Conclusion: Regardless of the temperature, positive cell densities were lower in the MnPO, MPA, VMPO, AH, SCh, SO, and PVN of the OVX groups in comparison with the densities measured in the same sites in the SHAM group. Following the administration of black cohosh and estrogen, the positive cell densities in the OVX groups increased and became closer to, or exceeded, those measured in the SHAM group, suggesting that both drugs may act on the hypothalamic nuclei and have therapeutic effects on menopausal symptoms. © 2012 Elsevier Ireland Ltd.


Ma X.,Peking University | Zhang H.,Peking University | Wang K.,Peking University | Yang L.,Peking University | And 6 more authors.
Journal of Ethnopharmacology | Year: 2011

Ethnopharmacological relevance: Black cohosh (Cimicifuga racemosa) is widely used in menopause symptoms strategy. Aim of the study: The aim of this study was to examine the effect of isopropanolic black cohosh extract (iCR) on the central body temperature (CBT) of ovariectomized rats (OVX) and elaborate its possible effects in alleviating menopause related hot flushes. Materials and methods: 64 female Sprague-Dawley rats, weighing 230 ± 10 g and aged 6-8 weeks, were divided into four groups: ovariectomy (OVX), sham, ovariectomy plus estradiol valerate (OVX + E), and ovariectomy plus iCR (OVX + ICR). The sham group underwent a sham surgery without ovariectomies, while the other three groups underwent bilateral ovariectomies under sterile conditions and a temperature implant was embedded in the abdominal cavity of all four groups. After 2-week recovery period, the temperature of all animals was monitored for 6 weeks. Results: CBT of four groups maintained a normal circadian rhythm, with a low day CBT and a high night CBT. CBTs of the sham group were lower than that of the other three groups. The day CBTs of the (OVX + E) group and (OVX + ICR) group were lower than that of the OVX group from day 2 and day 22 respectively. For the difference between day and night CBT, the sham group was smallest, while (OVX + E) and (OVX + ICR) groups were higher than that of OVX group. The amplitude of day and night CBT, CBT fluctuation frequency at 5 min intervals, were higher for the OVX group than the sham group; the amplitude of day and night CBT of (OVX + E) group and the amplitude of night CBT of (OVX + ICR) group were higher than those of OVX group; while the amplitude of day CBT of (OVX + ICR) group was lower than that of OVX group; CBT fluctuation frequency at 5 min intervals was higher for the (OVX + E) and (OVX + ICR) groups than the OVX group. Conclusions: Ovariectomized rats had abnormal thermoregulation, demonstrating an increase in day and night CBT, greater difference between day and night CBT, higher amplitude of day and night CBT, and more CBT fluctuation frequency. For the herbal extract iCR, the onset of affecting abnormal thermoregulation took longer than that of estradiol valerate. ICR had a significant effect on day CBT but was only little effective on night CBT of ovariectomized rats. © 2011 Elsevier Ireland Ltd.


Zhang J.,Peking University | Bai W.,Beijing Shijitan Hospital | Wang W.,Peking University | Jiang H.,Peking University | And 6 more authors.
Neuroscience | Year: 2017

Hot flushes are common in menopause. Norepinephrine (NE), primarily synthesized in the locus coeruleus (LC), plays a major role in central thermoregulation. Furthermore, we previously observed decreased dopamine beta hydroxylase (DβH), a key enzyme in NE synthesis, in LC neurons following ovariectomy. In this study, we explore the mechanisms underlying decreased NE levels in the LC (LC-NE) in ovariectomized (OVX) rats, and the modulating effects of estradiol valerate (E2) and black cohosh (ICR). We used high-performance liquid chromatography to detect LC-NE in SHAM, OVX, OVX-E2, and OVX-ICR groups. Western blotting and immunohistochemistry were performed to investigate the expression of NE metabolic enzymes, the NE reuptake transporter (NET), and estrogen receptors (ERs) in the LC. We observed significant LC-NE decreases in the OVX group. E2 and ICR enhanced LC-NE but did not restore them to SHAM levels. Ovariectomy affected NE synthesis, degradation, and reuptake. Levels of NE catabolic enzymes monoamine oxidase A (MAOA) and catechol-O-methyltransferase (COMT) decreased, while NET expression increased. E2 restored MAOA and COMT to SHAM levels but had no effect on NET. ICR restored COMT and NET to SHAM levels but had no effect on MAOA. Moreover, the OVX group also exhibited decreased expression of ERα and ERβ. E2 enhanced the expression of ERα and ERβ, while ICR only enhanced ERβexpression. Taken together, reduced NE in OVX rats resulted from reduced synthesis and increased degradation and reuptake. E2 and ICR may regulate these processes in different ways through various ERs. © 2017 IBRO


Cui G.,Peking University | Leng H.,Peking University | Wang K.,Peking University | Wang J.,Peking University | And 6 more authors.
PLoS ONE | Year: 2013

This study aims to evaluate the effects of Remifemin (isopropanolic extract of Cimicifuga Racemosa) on postmenopausal osteoporosis. 120 female Sprague-Dawley rats were randomly assigned to four groups: sham surgery with vehicle, ovariectomy with vehicle, ovariectomy with estradiol valerate, or ovariectomy with Remifemin. Daily oral administrations of the vehicle, estradiol valerate, or Remifemin began 2 weeks after surgery and lasted to 4, 8, or 12 weeks. Ten rats in each group were sacrificed at each timestep with assessment of bone mineral density, trabecular bone structure, and biomechanical parameters of the femur and lumbar vertebra. Bone turnover markers were evaluated 12 weeks after surgery. Both drugs prevented bone density loss in the distal end of the femur and preserved the trabecular bone structure in both the lumbar vertebra and distal end of the femur following ovariectomy. Both drugs protected bone stiffness at the tested regions and reduced bone reabsorption in ovariectomized rats. The preventive effects of Remifemin against bone-loss can rival those of estradiol valerate if treatment duration is adequately extended. In conclusion, Remifemin may demonstrate equivalent effects to estradiol valerate in terms of preventing postmenopausal osteoporosis. Copyright: © 2013 Cui et al.


PubMed | General Hospital of Armed Police and Peking University
Type: Journal Article | Journal: PloS one | Year: 2013

This study aims to evaluate the effects of Remifemin (isopropanolic extract of Cimicifuga Racemosa) on postmenopausal osteoporosis. 120 female Sprague-Dawley rats were randomly assigned to four groups: sham surgery with vehicle, ovariectomy with vehicle, ovariectomy with estradiol valerate, or ovariectomy with Remifemin. Daily oral administrations of the vehicle, estradiol valerate, or Remifemin began 2 weeks after surgery and lasted to 4, 8, or 12 weeks. Ten rats in each group were sacrificed at each timestep with assessment of bone mineral density, trabecular bone structure, and biomechanical parameters of the femur and lumbar vertebra. Bone turnover markers were evaluated 12 weeks after surgery. Both drugs prevented bone density loss in the distal end of the femur and preserved the trabecular bone structure in both the lumbar vertebra and distal end of the femur following ovariectomy. Both drugs protected bone stiffness at the tested regions and reduced bone reabsorption in ovariectomized rats. The preventive effects of Remifemin against bone-loss can rival those of estradiol valerate if treatment duration is adequately extended. In conclusion, Remifemin may demonstrate equivalent effects to estradiol valerate in terms of preventing postmenopausal osteoporosis.


PubMed | General Hospital of Armed Police and Peking University
Type: Journal Article | Journal: Acta histochemica | Year: 2014

The purpose of this study was to investigate the difference in neuronal activity in the preoptic area of the hypothalamus (POAH) under low estrogen condition induced by ovariectomy. One hundred and twenty sham-operated (SHAM) and ovariectomized (OVX) rats were placed in different temperatures for 2h. Twelve rats from each group were stimulated by 4C, 10C, 25C, 33C and 38C, respectively. c-Fos expression in the POAH was detected by immunohistochemistry. Following exposure to warm and cold stimuli, there were markedly lower c-Fos-positive cell densities in the OVX group compared with the SHAM group in the median preoptic nucleus (MnPO) at 4C, 10C, 33C and 38C, in the medial preoptic area (MPA) at 25C and 38C, in the ventromedial preoptic nucleus (VMPO) at 4C, 10C and 38C and in the ventrolateral preoptic nucleus (VLPO) at 4C and 38C. Both temperature and surgery had an impact on c-Fos expression by two-way ANOVA method except in the lateral preoptic area (LPO). c-Fos expression differed within different nuclei of the two groups in the same and different temperature stimuli. This indicated that the temperature-sensitive nuclei in the POAH exhibited lower and different activities during temperature stimuli following ovariectomy, which possibly resulted in abnormal thermoregulation and menopausal symptoms.


Tian Y.-M.,No 474 Hospital Of Chinese Pla | Xiao L.-H.,General Hospital of Armed Police | Gao X.-W.,No 474 Hospital Of Chinese Pla
International Journal of Ophthalmology | Year: 2011

AIM: To assess features of cavernous hem angioma (CH) in the orbit revealed by CT and MRI and summarize prediction of preoperative CT and MRI for the adhesion degree of CH in the orbit. METHODSA: total of 97 patients with pathologically confirmed CH in the orbit were exam ined with axial and coronal CT scan, and axial, coronal, sagittal, and enhanced fat suppression MRI scan. CT and MRI findings and intraoperative adhesion degrees were retrospectively analyzed. RESULTS: There were 47 patients with slight adhesion, for whom CT and MRI showed round masses with well defined margins in the extraocular muscles; 1 4 patients with mild adhesion, for whom CT and MRI revealed irregular masses with unclear boundary between CH and the opticnerve in coronal images, and emissaryveins in the posterior region of masses in contrast-enhanced images; 36 patients with severe adhesion, for whom CT and MRI exhibited an irregular or ovoid mass filling the orbital apex, or showed distorted and even spiky margins in the posterior region of masses in contrast enhanced images at the presence of a transparent triangle between the mass and the orbital apex. CONCLUSION: Preoperative CT and MRI aid in accurate diagnosis, selection of the surgical approach, and assessment of the adhesion degree and surgicalrisks for CH. © International Journal of Ophthalmology Press.


Mu X.,Chinese PLA General Hospital | Mu X.,General Hospital of Armed Police | Wang H.,General Hospital of Armed Police | Ma Q.,General Hospital of Armed Police | And 2 more authors.
Academic Radiology | Year: 2014

Rationale and Objectives: The objective of this study was to determine the diagnostic accuracy of contrast-enhanced magnetic resonance angiography (MRA) when used in the preoperative evaluation of hepatic vascular anatomy in living liver donors. Materials and Methods: A computer-assisted literature searching of EMBASE, PubMed (MEDLINE), and the Cochrane library databases was conducted to identify potentially relevant articles which primarily examined the utility of contrast-enhanced MRA in the preoperative evaluation of hepatic vascular anatomy in living liver donors. We used the Q statistic of chi-squared value test and inconsistency index (I-squared, I2) to estimate the heterogeneity of the data extracted from all selected studies. Meta-Disc software (version 1.4) (ftp://ftp.hrc.es/pub/programas/metadisc/Metadisc_update.htm) was used to perform our analysis. Results: Eight studies were included in the present meta-analysis. A total of 289 living liver donor candidates and 198 patients who underwent liver harvesting were included in the present study. The pooled sensitivities of hepatic artery (HA), portal vein (PV), and hepatic vein (HV) in this meta-analysis were 0.84, 0.97, and 0.94, respectively. The pooled specificities of HA, PV, and HV were 1.00, 1.00, and 1.00, respectively. The pooled diagnostic odds ratios of HA, PV, and HV were 127.28, 302.80, and 256.59, respectively. The area under the summary receiver-operating characteristic curves of HA, PV, and HV were 0.9917, 0.9960, and 0.9813, respectively. Conclusions: The high sensitivity and specificity demonstrated in this meta-analysis suggest that contrast-enhanced MRA was a promising test for the preoperative evaluation of hepatic vascular anatomy in living liver donors. © 2014 AUR.

Loading General Hospital of Armed Police collaborators
Loading General Hospital of Armed Police collaborators