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Nova Gradiška, Croatia

Jukic Z.,General Hospital Nova Gradiska | Limani R.,University of Prishtina | Luci L.G.,University of Prishtina | Nikic V.,University of Zagreb | And 3 more authors.
Anticancer Research | Year: 2012

Large cell neuroendocrine carcinoma (LCNEC) is an aggressive neoplasm with a low frequency of occurrence in the digestive tract. We present a series of eight patients diagnosed with LCNEC of the colon and rectum. Grossly, tumors were presented as endophytic/ulcerative, annular and polypoid masses, with a gray-white color and necrosis in most cases. Histologically, they were high-grade tumors composed of large cells of organoid, nesting, trabecular, rosette-like and palisading patterns, with a high mitotic rate. Tumors were immunoreactive for neuroendocrine markers, including chromogranin A (2/8), synaptophysin (7/8), and neuron-specific enolase (8/8). Moreover, we analyzed the expression of growth hormone (hGH) and growth hormone receptor (GHR) in colorectal LCNECs and six tumors were immunoreactive for hGH, while five tumors were immunoreactive for GHR. To our knowledge hGH and GHR expression has not been previously analyzed in colorectal LCNEC. Their overexpression suggests a role of hGH and GHR in the development of colorectal LCNEC. Source


Jukic Z.,General Hospital Nova Gradiska | Ferencic Z.,Childrens Hospital Srebrnjak | Radulovic P.,Clinical Hospital Center Sestre milosrdnice | Mijic A.,Clinical Hospital Center Sestre milosrdnice | Fucic A.,Institute for Medical Research and Occupational Health
Anticancer Research | Year: 2014

Background/Aim: Vanek's tumor is an inflammatory fibroid polyp (IFP) of very low incidence, which originates in the submucosa of the stomach, duodenum, jejunum and ileum. The etiology of this tumor is still unknown. Histologically, IFP is characterized by submucosal spindle cell proliferation in fibromyxoid stroma with inflammatory infiltrate. The aim of the present study was to investigate the presence of estrogen and androgen receptors in IFP and compare it with its proliferative loci. Patients and Methods: The study analyzed a 79-year-old patient suffering from IFP. Analyses were performed by immunohistochemistry. Results: Androgen-positive spindle cells were detected at the periphery of onion skin-like formations. Estrogen receptorpositive cells were not detected and Ki67 showed low proliferative activity. Conclusion: This case report shows for the first time the presence of androgen receptor-positive cells whose location corresponds with the distribution of Ki67-positive cells in IFP. Source


Dzombeta T.,University of Zagreb | Francina M.,General Hospital Nova Gradiska | Matkovic K.,General Hospital Nova Gradiska | Markovic I.,General Hospital Nova Gradiska | And 3 more authors.
In Vivo | Year: 2012

Angiomyolipomatous hamartoma is a variant of angiomyomatous hamartoma (AMH), a rare nodal smooth muscle proliferation, first identified as a distinct entity by Chan et al. in 1992. To date, several cases have been described, mostly involving inguinal lymph nodes. We present two cases of angiomyolipomatous hamartoma, in a 52-year-old male and 67-year-old female patient. Both patients were surgically treated. Microscopically, in the affected nodes, the parenchyma was mostly replaced with bundles of smooth muscle cells, fibrous tissue and lobules of mature adipocytes. Only a few atrophic lymphatic follicles were maintained in the subcapsular area. The presence of smooth muscle cells and endothelial cells was confirmed immunohistochemically by staining for smooth muscle actin, desmin and CD31. The hilus contained numerous thick-walled vessels extending to the medulla. Pleomorphism, mitoses and necrosis were absent. Considering there are no reported recurrences of AMH, it probably has benign behaviour; thus extensive resection may not be needed. Nevertheless, we believe that recognition of AMH is important in the differential diagnosis of other pathological conditions that may affect lymph nodes. Source

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