Agios Dimitrios General Hospital

Ágios Dimítrios, Greece

Agios Dimitrios General Hospital

Ágios Dimítrios, Greece
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Fuchs M.,University of Basel | Briel M.,University of Basel | Briel M.,McMaster University | Daikeler T.,University of Basel | And 18 more authors.
European Journal of Nuclear Medicine and Molecular Imaging | Year: 2012

Purpose: We aimed to assess the impact of 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) on the management of patients with suspected large vessel vasculitis. Methods: An international expert panel determined diagnoses and clinical management in patients with suspected large vessel vasculitis, with and without the results of 18FFDG PET, respectively. The accuracy of the clinical diagnosis and the resulting clinical management with and without the 18F-FDG PET results were compared using logistic regression models. Results: The analysis included 30 patients referred to a tertiary care centre with large vessel vasculitis and 31 controls. 18F-FDG PET had an overall sensitivity of 73.3% [95% confidence interval (CI) 54.1-87.7%], a specificity of 83.9% (95% CI 66.3-94.5%), a positive predictive value of 81.5% (95% CI 61.9-93.7%) and a negative predictive value of 76.5% (95% CI 58.8-89.3%). The diagnostic accuracy of 18F-FDG PET was higher in patients not receiving immunosuppressive drugs (93.3 vs 64.5%, p=0.006). Taken in context with other available diagnostic modalities, the addition of 18F-FDG PET increased the clinical diagnostic accuracy from 54.1 to 70.5% (p=0.04). The addition of 18F-FDG PET increased the number of indicated biopsies from 22 of 61 patients (36.1%) to 25 of 61 patients (41.0%) and changed the treatment recommendation in 8 of 30 patients (26.7%) not receiving immunosuppressive medication and in 7 of 31 patients (22.6%) receiving immunosuppressive medication. Conclusion: 18F-FDG PET is a sensitive and specific imaging tool for large vessel vasculitis, especially when performed in patients not receiving immunosuppressive drugs. It increases the overall diagnostic accuracy and has an impact on the clinical management in a significant proportion of patients. © Springer-Verlag 2011.


Stellos K.,Goethe University Frankfurt | Katsiki N.,Agios Dimitrios General Hospital | Tatsidou P.,Goethe University Frankfurt | Bigalke B.,King's College London | And 2 more authors.
Current Vascular Pharmacology | Year: 2014

Cardiovascular risk factors are associated with coronary artery disease (CAD) and with cognitive dysfunction. However, the precise pathogenic mechanisms responsible for this association remain elusive. In the present study, CAD patients with cognitive impairment showed significantly higher platelet activation compared with CAD patients without cognitive impairment. In addition, we identified platelet activity to be a significant independent predictor for the severity of cognitive impairment in these patients. We discuss the link between platelet hyperactivity and dementia (including Alzheimer's disease) based on the literature and our findings. We also discuss the potential mechanisms involved. This link may become a therapeutic option. © 2014 Bentham Science Publishers.


Katsourakis A.,Agios Dimitrios General Hospital | Noussios G.,Aristotle University of Thessaloniki | Svoronos C.,Agios Dimitrios General Hospital | Alatsakis M.,Agios Dimitrios General Hospital | Chatzitheoklitos E.,Agios Dimitrios General Hospital
International Journal of Surgery Case Reports | Year: 2014

INTRODUCTION Inguinal hernia containing bladder carcinoma is a very rare occurrence. PRESENTATION OF CASE We report a case of a male patient who presented with a left groin hernia containing an irregular mass. The hernia was repaired without the use of mesh and a partial cystectomy was done. DISCUSSION Only 1-3% of all inguinal hernias involve the bladder, with very few reports containing a carcinoma. CONCLUSION Treatment consists of removing the tumor and repairing the hernia. © 2014 The Authors.


Katsourakis A.,Agios Dimitrios General Hospital | Svoronos C.,Agios Dimitrios General Hospital | Chatzitheoklitos E.,Agios Dimitrios General Hospital | Hadjis I.,Agios Dimitrios General Hospital | And 4 more authors.
Journal of the Pancreas | Year: 2015

Context Sarcomas represent a relatively rare malignancy. Primary sarcomas of the pancreas represent an extremely rare pathology. Case report We report a case of primary pancreatic carcinoma that presented with anaemia. The patient underwent a Kausch-Whipple operation, and, 16 months after the operation, the patient is disease free. Conclusion This unique case describes an extremely rare gastrointestinal tumour that was found during the patient's anaemia assessment. © 2015, E.S. Burioni Ricerche Bibliografiche. All rights reserved.


Katsiki N.,Agios Dimitrios General Hospital | Athyros V.G.,Aristotle University of Thessaloniki | Mikhailidis D.P.,University College London | Karagiannis A.,Aristotle University of Thessaloniki
Current Vascular Pharmacology | Year: 2012

In this issue of Curr Vasc Pharmacol, Pfeiffer et al. [1] and Glorioso et al. [2] report the efficacy and tolerability of aliskiren/amlodipine single-pill combinations (SPCs) in patients with inadequate blood pressure (BP) response to amlodipine or aliskiren monotherapy, respectively. © 2012 Bentham Science Publishers.


Stavrakis T.,Aristotle University of Thessaloniki | Kalogiannidis I.,Aristotle University of Thessaloniki | Petousis S.,Aristotle University of Thessaloniki | Tsompanidou C.,Agios Dimitrios General Hospital | And 3 more authors.
Oncology Letters | Year: 2016

Sertoli-Leydig cell tumors (SLCTs) are an uncommon subtype of sex-cord stromal tumors of the ovary, which most commonly arise in women of reproductive age, creating an issue with regard to the preservation of fertility. The clinical manifestation of SLCTs varies widely, ranging from an asymptomatic clinical profile to extreme virilization. Correct diagnosis of SLCT is crucial and is primarily based on histopathological results. The current study presents the case of a 20-year-old woman who underwent unilateral salpingo-oophorectomy and adjuvant chemotherapy due to the diagnosis of an SLCT of the left ovary. Almost 2 years after the initial surgery, during the follow-up period, the patient conceived normally. Pregnancy was uneventful and the patient vaginally delivered a healthy infant at 38 weeks of gestation. A total of 1 year after delivery (3 years after the initial diagnosis), follow-up of the patient did not reveal any disease recurrence. In conclusion, SLCTs may be adequately treated by fertility-sparing surgery and chemotherapy in young women who wish to preserve their fertility. Natural conception, an uncomplicated pregnancy and a vaginal delivery are possible. © 2016, Spandidos Publications. All rights reserved.


Papadopoulos C.E.,University Hospital | Zioutas D.G.,University Hospital | Giannakoulas G.A.,University Hospital | Matsiras S.,Agios Dimitrios General Hospital | And 4 more authors.
Cardiovascular Revascularization Medicine | Year: 2011

Background: Preinfarction angina (PA) is a clinical analogue of ischemic preconditioning that improves postinfarct prognosis. Data concerning the association of PA with post infarction left ventricular (LV) remodeling and LV diastolic function are limited. We aimed to evaluate this association in patients with acute myocardial infarction (AMI) in the modern clinical era of widespread use of revascularization and antiremodeling medical treatment. Methods: We studied 53 patients with anterior AMI who underwent complete reperfusion and received up to date antiremodeling medical treatment. LV remodeling, systolic and diastolic function were assessed using 2D echocardiography at baseline and 6 at months follow-up. Patients were divided into two groups regarding the presence or absence of PA. Results: LV remodeling at follow-up was less frequent in the PA group (25 vs. 55 %, P<.05). Patients with PA had lower end-systolic volume index at baseline and follow up (24.1±6 vs. 30.1±14 ml/m 2, P<.001 and 25.3±8 vs. 35.6±2 ml/m 2, P=.001 respectively). Additionally at 6 months, they had better LV ejection fraction (52.1±9 vs. 42.9±10 %, P=.002) and exhibited improved diastolic filling as reflected by mitral E/e′ (14.6±5 vs. 18.8±8, P=.05). Conclusions: Ischemic preconditioning in the form of PA promotes better LV systolic and diastolic function in the mid-term and is associated with less postinfarct LV remodeling in this specific study population. The results of the study underline the possible need for further risk stratification of AMI patients regarding the absence of PA. © 2011 Elsevier Inc.


Karras S.,Aristotle University of Thessaloniki | Karras S.,Panagia General Hospital | Goulis D.G.,Aristotle University of Thessaloniki | Mintziori G.,Aristotle University of Thessaloniki | And 2 more authors.
Current Vascular Pharmacology | Year: 2012

Energy homeostasis in mammalians is a teleological process regulated by the interplay between caloric intake and energy expenditure. Incretins are a significant component of the complex homeostatic network regulating the metabolic state in humans. This narrative review will focus on the basic concepts regarding incretins physiology and their regulatory feedback mechanisms affecting energy homeostasis. In this context, glucagon-like peptide 1 (GLP-1) promotes satiety and weight loss through centrally and peripherally mediated pathways. On the other hand, gastric inhibitory peptide (GIP) is implicated in energy storage by its actions on adipose tissue. Understanding this biological model requires a holistic approach, since it is dually manifested by promoting weight reduction, in the case of GLP-1, or favoring lipid accumulation, in the case of GIP. The complete spectrum of incretin actions related to energy homeostasis is yet to be fully elucidated. Currently, new drugs based on incretin physiology are available for treatment of type 2 diabetes mellitus, whereas the implication of similar drugs in the treatment of obesity is under investigation. These agents exert several beneficial effects that minimize cardiovascular risk. © 2012 Bentham Science Publishers.


Kolea A.,Agios Dimitrios General Hospital | Baltatzidis A.,Aristotle University of Thessaloniki | Margaritis V.,Agios Dimitrios General Hospital | Almoghrabi B.,Agios Dimitrios General Hospital | And 2 more authors.
Asian Journal of Ophthalmology | Year: 2011

A 38-year-old man presented with an acute right homonymous visual field defect due to occipital lobe infarct caused by hyperhomocysteinaemia. Visual field testing, magnetic resonance imaging, laboratory studies, and genetic analysis were carried out. On magnetic resonance imaging, a left occipital lesion with bright signal on the diffusion-weighted and fluid-attenuated inversion recovery images suggested a diagnosis of an acute infarct. Blood tests revealed raised homocysteine of 52.08 μmol/L (reference range, <15 μmol/L) and genetic analysis showed the patient to be homozygote to 5, 10-methylenetetrahydrofolate reductase deficiency. Hyperhomocysteinaemia is a rare causes of acute visual loss due to cerebral ischaemia and should always be suspected and investigated with the appropriate tests to diagnose the condition and limit further vision deterioration. © 2011 Singapore Scientific Publishing House Pte Ltd.


Birmpili E.,Aristotle University of Thessaloniki | Katsiki N.,Agios Dimitrios General Hospital | Malhotra A.,Harefield Hospital | Dimopoulou E.,Brunel University | And 2 more authors.
Open Cardiovascular Medicine Journal | Year: 2012

Despite the well-known health risks, smoking is still highly prevalent worldwide. Greece has the highest level of adult smoking rate (40%) across the European Union. We investigated gender and socio-economic differences in daily smoking and smoking cessation among Greek adults. We conducted a cross-sectional survey between October and November 2009 in 434 adults residing in a Greek rural area. Data were collected with the use of the World Health Organization Global Adult Tobacco Survey (WHO GATS) Core Questionnaire. Respondents were classified into smokers (if they had smoked at least 100 cigarettes in their lifetime and continued to smoke) or non-smokers. Overall, 58.1% (n=252) were smokers (58.5% male, n=127 and 57.8% female, n=125); 51.2% (n=222) were younger than 18 years-old when they started smoking. Men tended to start smoking at a younger age, to smoke more cigarettes/day and to have smoked a greater average of cigarettes during the last 5 days. Overall, 82.5% of smokers attempted to stop smoking a year prior to the study, with women having a greater difficulty in quitting smoking. The main source of information on smoking was the mass media (73.5%) and books (53.7%), whereas doctors and other health professionals were the least listed source of relative information (27.7 and 8.1%, respectively). Smoking rates among Greek adults were high, but a considerable number of individuals who smoked, wished to quit and had attempted to do so. Smoking cessation clinics are not perceived as a valuable support in quitting effort. © Birmpili et al.; Licensee Bentham Open.

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