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A system, device and method for receiving multiple aligned genetic sequences obtained from genetic samples of multiple organisms of one or more different species. A measure of evolutionary variation may be computed for one or more alleles at each of one or more aligned genetic loci. The aligned genetic loci in the multiple organisms may be derived from one or more common ancestral genetic loci or may be otherwise related. The measure of evolutionary variation may be a function of variation in alleles at corresponding aligned genetic loci in the multiple aligned genetic sequences. One or more likelihoods may be computed that an allele mutation at each of the one or more genetic loci in a simulated virtual progeny will be deleterious based on the measure of evolutionary variation of alleles at the corresponding aligned genetic loci for the multiple organisms.


Methods and systems for assessing the probabilities of the expression of one or more traits in progeny are described.


News Article | April 18, 2014
Site: gizmodo.com

Remember those slightly horrifying sites that mash up two faces to tell you what your hypothetical babies might look like? With genome sequencing and "virtual embryos," we might actually be able to do that—using science. Those days are not quite here yet, but New Scientist has an intriguing report about a company called GenePeeks. We already screen for common genetic disorders by testing the DNA of prospective parents. GenePeeks goes one step further: its software takes the genome sequences of both parents to produce "10,000 simulated pairings"—in other words, 10,000 virtual, hypothetical children. The company's current test only looks for disease risk, but, as New Scientist points out, its patent is much, much broader. Its technique could screen for any number of traits with a genetic basis, according to the patent, including skin color, breast size, hair texture, and even eyelash length. There are plenty of caveats to pick at, of course, like how siblings from the same family can look quite distinct or how the same kid raised in two different environments turns out differently. But a world in which we can approximate hypothetical children is closer than you might think. Faces reconstructed from the DNA evidence left at, say, crimes scenes are already surprisingly accurate. In the future, you might very well be able to take anyone off the street and imagine what your progeny would look like. Or flick through profiles in a dating app while evaluating potential children—our genetic futures played out in virtual reality. [New Scientist]


Pacific NW Fertility announced today that their center will be the first in the United States to introduce a new technology provided by GenePeeks, a genetic information company. GenePeeks’ new technology, featured last October and July 5, 2015 on CBS’ 60 Minutes, offers parents an innovative option for genetic testing to reduce the risk of hundreds of heritable conditions in their children. GenePeeks’ service at Pacific NW Fertility analyzes a patient’s DNA, in combination with the DNA of prospective egg donors, screening each client/donor combination for hundreds of inherited genetic disorders and diseases. The process uncovers disease risk hidden inside DNA before conception. A personalized catalogue of donors, specifically screened for the patient’s unique genetic profile, assists patients in egg donor selection. GenePeeks also provides patients seeking donor sperm a catalogue of risk-screened donor matches. “This option for parents is unprecedented and we are very excited to be one of the first clinics to offer this to our patients,” Dr. Lorna Marshall of PNWF, says. “All parents want to minimize the chance of their baby having a recessive genetic disorder and this technology maximizes the help we can provide them.” PNWF, home to one of the country’s most successful donor egg programs, is a national leader utilizing frozen donor eggs. Their patients have had over 200 live births using frozen eggs. Utilizing GenePeeks new tools, PNWF’s donors are all genetically screened before being matched with patients. “We’ve tested our egg donors for recessive genetic diseases for many years but GenePeeks takes testing to a whole new level,” Stephanie Frickleton, the donor egg program director at PNWF, says. “Now we can use GenePeeks' technology to help our patients make the best choice, the healthiest choice possible when they select an egg donor.”


News Article | July 1, 2014
Site: www.finsmes.com

GenePeeks, Inc., a Cambridge, MA and New York, NY-based genetic information company focused on reproductive risk prediction, received a $3m venture loan from Horizon Technology Finance Corporation (NASDAQ: HRZN). The company intends to use the proveeds to support its growth. Led by Anne Morriss, CEO, GenePeeks is a genetic information company focused on identifying inherited disease risk in future generations. It digitally combines the genetic information of two potential parents, using patented algorithms to simulate the genetic interactions that occur naturally in human reproduction. With this technology The solution digitally creates and analyzes thousands of hypothetical genomes to uncover disease risk that cannot be seen with existing pre-pregnancy screening tools. Its initial focus is the donor sperm industry, where it creates personalized catalogues of donors screened specifically for a client’s unique genetic profile, enabling families to make a safer donor choice.

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