Palo Alto, CA, United States
Palo Alto, CA, United States

Genencor is a biotechnology company based in Palo Alto, CA and a subsidiary of DuPont. Genencor is a leading producer of industrial enzymes and low-priced bulk protein. The name Genencor originates with Genencor, Inc., the original joint venture between Genentech and Corning Incorporated, which was founded in 1982. It is considered to have pioneered the field of industrial biotechnology, as distinct from traditional applications of biotechnology to health care and agriculture. Genencor ranks number 12 in revenues in the List of biotechnology companies. In 2008 Genencor entered a joint venture with DuPont, called DuPont Danisco Cellulosic Ethanol LLC, to develop and commercialize low cost technology for the production of cellulosic ethanol. In 2008, Genencor and Goodyear announced they are working to develop BioIsoprene. Wikipedia.


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Grant
Agency: European Commission | Branch: H2020 | Program: IA | Phase: BIOTEC-3-2014 | Award Amount: 11.39M | Year: 2015

Oxygen functionalities are key functional groups in many of todays chemicals and materials. The efficient introduction of oxygen-functionalities into raw materials are key chemical transformations in bulk and fine chemicals. Innovative bio-catalytic oxidation routes using molecular oxygen (from air) under benign and mild (pH) conditions such as ambient temperature and pressure can greatly improve the sustainability and economics of processes, but were so far mainly been applied in the pharma segments. In this segment, the enzyme-catalyzed step often represents the highest added value and the high price of the end-product (> 1000/kg) justifies less than optimal enzyme production and limitations in its catalytic efficiency. In order to achieve the widening of industrial application of enzymatic bio-oxidation processes to also larger volume but lower price chemical markets, ROBOX will demonstrate the techno-economic viability of bio-transformations of four types of robust oxidative enzymes: P450 monooxygenases (P450s), Baeyer-Villiger MonoOxygenase (BVMOs), Alcohol DeHydrogenase (ADH) and Alcohol OXidase (AOX) for which target reactions have already been validated on lab-scale in pharma, nutrition, fine & specialty chemicals and materials applications. ROBOX will demonstrate 11 target reactions on large scale for these markets in order to prepare them for scale up to commercial-scale plants. ROBOX is industry-driven with 2 major industrial players and 6 SMEs. It will assess the potential of technologies applied to become platform technologies technologies (multi-parameter screening systems, computational methodologies, plug bug expression systems) for broad replication throughout the chemical industry. The markets addressed within ROBOX represent a joint volume of over 6.000 ktons/year. The introduction of bio-oxidation processes is expected to bring substantial reductions in cost (up to -50%), energy use (-60%), chemicals (-16%) and GHG-emissions (-50%).


Grant
Agency: European Commission | Branch: H2020 | Program: BBI-IA-DEMO | Phase: BBI.VC2.D2-2015 | Award Amount: 11.17M | Year: 2016

The aim of PULPACKTION project is to develop cellulose-based tailored-to-purpose packaging solutions for specific food and electronic packaging applications which needs medium and high barrier requirements and that nowadays are packing in polymer fossil based solutions. This innovation will take advantage of the flexibility in the wet-moulding production of wood pulp based materials. Different types of wood pulp will be combined to prepare slurries for wet-moulding applications. These slurries will be additivated with biopolymers and other bio-based compounds in order to tailor the final properties of the resulting wet-moulded materials. By tailoring the composition of the wet mouldable slurry, a wide range of final properties in the resulting dry material will be achieved. This flexible packaging manufacturing system will be combined with 100% bio-based coatings and films on the cellulose-based substrate. To fulfil the properties required for PULPACKTIONs specific packaging applications using a fully bio-based approach, additional barriers will be implemented onto the wet moulded substrate. For this purpose, new bio-based polymer blends will be optimized. These new blends, containing biopolymers such as thermoplastic starch (TPS), poly (lactic acid) (PLA), other bio-additives, and reinforcements such as microfibrillated cellulose (MFC), will be processed into multilayer films, composites and coatings. In this manner, not only coatings for improved barrier properties, but also 100% bio-based films for packages top lids will be produced. Therefore, a final 100% bio-biobased integral packaging solution with similar properties to existing fossil-based packaging solutions will be achieved.


Grant
Agency: European Commission | Branch: H2020 | Program: BBI-IA-DEMO | Phase: BBI.D7-2015 | Award Amount: 6.61M | Year: 2016

Genencor International BV has recently developed a new enzyme product, C1-LC4, that in recent field trials has shown a promising 10% cost-reduction in the production of biogas from organic waste. Although the efficacy of the enzyme has clearly been shown, the current fermentation process does not provide sufficient yield in industrial production to be cost-effective for large-scale application. The objective of DEMETER is to increase the yield of this industrial fermentation process by at least 20%, improve the product recovery process by 40%, and reduce overall product cost by at least 15% while increasing the productivity of the process. In addition, DEMETER will demonstrate the efficacy of the enzyme in 8 field trials in biogas plants throughout Europe. The DEMETER consortium includes the entire value chain: enzyme producer Genencor International, enzyme retailer Miavit, the pilot plant BioBase Europe Pilot Plant, anaerobic digester expert OWS, independent biogas research centre DBFZ, Ciaotech for independent economic and environmental evaluation, and large farm, Biomoer, for field trials. DEMETER follows a multi-scale approach. First, the enzyme productivity will be improved on lab- and small pilot-scale, while obtaining insights for further scale-up. In parallel, the effect of enzymes on biogas yield will be quantified, using 5 commonly used biomass substrates. The improved fermentation and downstream process will be scaled up and demonstrated in a 15 000 L pilot plant. Finally, the improvement of the biogas production process due to the use of the C1-LC4 enzyme will be demonstrated in practice in 8 field trials. The results of these field trials will be fed back to further improve the production process and its yield. Ultimately, DEMETER will not only produce a fermentation process with increased yield, an improved product recovery process resulting in reduced production costs. The resulting product will lead to an increase in renewable biogas production in Europe.


Patent
Genencor and Danisco | Date: 2012-06-14

Described herein are variants of H. jecorina CBH I, a Cel7 enzyme. The present invention provides novel cellobiohydrolases that have improved thermostability and reversibility.


Patent
Genencor | Date: 2013-04-24

The invention relates to apparatuses, machines, systems and methods for the recovery and purification of proteins, peptides, nucleic acids, biologically produced polymers and other compounds from aqueous fluids. The aqueous fluids can comprise enzyme concentrates and or a fermentation broth with or without cells or other starting material. The fermentation broth can be produced by fermentations of fungal, yeast, bacterial, mammalian, insect or plant cells.


Patent
Genencor | Date: 2013-04-17

The invention is directed to peptides. Specifically, the invention is directed to peptides which bind skin and do not bind hair. Alternatively, the invention is drawn to peptides which bind hair and do not bind skin.


The present invention relates to variant phytase enzymes having altered properties.


Disclosed are variants of the -amylase derived from Bacillus sp. no. 707, compositions comprising said variants, compositions comprising the variants, and methods of using the variants. The methods of use include methods of cleaning surfaces, laundering textiles, desizing, hydrolyzing biofilms of various substrates, and treating starch (e.g., liquefaction and saccharification).


The present invention provides novel amylase variants that exhibit reduced immunogenic responses, as compared to the parental proteins. The present invention further provides DNA molecules that encode novel amylase variants, host cells comprising DNA encoding novel amylase variants, as well as methods for making amylases less allergenic. In addition, the present invention provides various compositions that comprise these amylase variants that are less immunogenic than the wild-type amylases.


Patent
Genencor | Date: 2012-07-02

Described are variants (mutants) of a parent alpha-amylase having alpha-amylase activity and exhibiting altered properties relative to the parent alpha-amylase, and methods of use, thereof.

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