Tsutsui T.,Laboratory of Gene Regulation |
Fukasawa R.,Laboratory of Gene Regulation |
Shinmyouzu K.,University of Toyama |
Nakagawa R.,University of Toyama |
And 3 more authors.
Journal of Biological Chemistry | Year: 2013
Background: Two CDK subunits of the Mediator complex play pivotal roles in transcription by a mechanism that has not yet been elucidated. Results: The histone arginine methyltransferase PRMT5 is a Mediator CDK-interacting protein. Conclusion: Mediator-associated PRMT5 symmetrically dimethylates histone H4 arginine 3, and this might cause transcriptional repression. Significance: This work enables further exploration of Mediator functions in transcriptional repression. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.