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Masotti A.,Gene Expression Microarrays Laboratory
Recent Patents on Nanotechnology | Year: 2010

In recent years, polymeric scaffolds have been used in several biomedical applications for the delivery of drugs or other biologically relevant molecules. Polymeric nanostructures possess different (and in some cases more powerful) properties respect to bulk materials. This, leaded academic researchers and industry to cooperate in developing pioneering nanostructured materials for industrial and biomedical applications. Moreover, the preparation and use of systems with multiple (multifunctional) properties (i.e., bioconjugation with superparamagnetic, fluorescent or targeting molecules) will represent in the future a viable and innovative tool for application in several clinical fields. This brief critical review collects and discusses some recent patents about the preparation and use of these multifunctional nanoparticles in biomedicine and in non-invasive bioimaging applications. © 2010 Bentham Science Publishers Ltd. Source


Masotti A.,Gene Expression Microarrays Laboratory
Methods in molecular biology (Clifton, N.J.) | Year: 2011

Polyamine polymers are among the commonest polymers used in biomedicine. Among polyamine -polymers, polyethylenimine (PEI) may be used as an efficient delivery vehicle for nucleic acids (DNA, RNA, etc.) or employed as a versatile imaging probe in vivo. In this chapter, the preparation of various PEI bioconjugates will be fully explained and discussed. Source


In recent years, polymeric scaffolds have been used in several biomedical applications for delivery of drugs or other biologically relevant molecules. Polymeric nanostructures display different (and in some cases more powerful) properties respect to bulk materials. This, lead academic researchers and industry to cooperate in developing pioneering nanostructured materials for industrial and biomedical applications. Moreover, the preparation and use of systems with multiple (multifunctional) properties (i.e., bioconjugation with superparamagnetic, fluorescent or targeting molecules) is positioned to become a viable and innovative tool for application in several clinical fields. Other nanostructured systems like nanocages and degradable nanoparticles, are emerging as potential innovative systems that could be exploited as multifunctional delivery vectors. This brief critical review is aimed at collecting and discussing some recent patents dealing with the preparation and use of multifunctional nanoparticles, nanocages and degradable nanoparticles in biomedicine and non-invasive bioimaging applications. Perspectives for a potential use of these multifunctional nanosystems in pediatries have been also discussed. © 2011 Bentham Science Publishers. Source


Masotti A.,Gene Expression Microarrays Laboratory | Caporali A.,Queens Medical Research Institute
International Journal of Molecular Sciences | Year: 2013

Carbon nanotubes (CNTs) have been widely studied for their potential applications in many fields from nanotechnology to biomedicine. The preparation of magnetic CNTs (Mag-CNTs) opens new avenues in nanobiotechnology and biomedical applications as a consequence of their multiple properties embedded within the same moiety. Several preparation techniques have been developed during the last few years to obtain magnetic CNTs: grafting or filling nanotubes with magnetic ferrofluids or attachment of magnetic nanoparticles to CNTs or their polymeric coating. These strategies allow the generation of novel versatile systems that can be employed in many biotechnological or biomedical fields. Here, we review and discuss the most recent papers dealing with the preparation of magnetic CNTs and their application in biomedical and biotechnological fields. © 2013 by the authors; licensee MDPI, Basel, Switzerland. Source


Da Sacco L.,Gene Expression Microarrays Laboratory | Masotti A.,Gene Expression Microarrays Laboratory
Marine Drugs | Year: 2010

Chitin and chitosan are natural polysaccharide polymers. These polymers have been used in several agricultural, food protection and nutraceutical applications. Moreover, chitin and chitosan have been also used in biomedical and biotechnological applications as drug delivery systems or in pharmaceutical formulations. So far, there are only few studies dealing with arsenic (As) removal from groundwater using chitin or chitosan and no evidence of the use of these natural polymers for arsenic trioxide (As2O3) delivery in tumor therapy. Here we suggest that chitin and/or chitosan might have the right properties to be employed as efficient polymers for such applications. Besides, nanotechnology offers suitable tools for the fabrication of novel nanostructured materials of natural origin. Since different nanostructured materials have already been employed successfully in various multidisciplinary fields, we expect that the integration of nanotechnology and natural polymer chemistry will further lead to innovative applications for environment and medicine. © 2010 by the authors; licensee MDPI. Source

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