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Agrawal M.,Oncquest Laboratories Ltd | Peters B.P.,JLN Medical College and Hospital | Kaushal V.,Geetanjali Medical College and Hospital
Indian Journal of Public Health Research and Development

Surgical site infections are the third most commonly reported nosocomial infection which has an adverse impact on the hospital as well as on the patient. A prospective study of 100 surgical wounds was conducted. All the wounds were examined for the presence of infection and those with infection were studied bacteriologically and their antibiotic sensitivity testing was done. The overall infection rate was 21%. The infection rate in clean surgeries was 4%, clean contaminated 12.5%, contaminated 3.3% and dirty 47.2%. Operation carried out in emergency carries high risk of development of SSI than in elective surgeries. Significant increase was seen in SSI rate with an increase in preoperative stay of patient, duration of operation and number of persons in operation theatre. Predominant organisms found were gram negative bacilli namely members of Enterobacteriaceae. High level of multidrug resistance was observed in gram negative bacterial isolates from wounds. Thus antibiotic sensitivity should be carried out for all bacterial surgical wounds before chemotherapy administered to detect drug resistant strains. © 2015, Indian Journal of Public Health Research and Development. All Rights Reserved. Source

Agarwal N.,Geetanjali Medical College and Hospital | Gupta L.K.,RNT Medical College | Khare A.K.,RNT Medical College | Kuldeep C.M.,SMS Medical College | Mittal A.,RNT Medical College
Dermatologic Surgery

Background: Acne scarring is a common sequela of acne for which no single treatment method is uniformly effective. The chemical reconstruction of skin scars (CROSS) therapy using high-concentration trichloroacetic acid (TCA) has shown promise as a cheap, safe, and effective modality of treatment in acne scars. Objective: To assess the therapeutic response of 70% TCA CROSS on atrophic acne scars and to evaluate the adverse effects of this therapy. Materials and methods: Fifty-three patients with postacne atrophic scars were treated with 70% of TCA focal application every 2 weeks by the CROSS technique and results evaluated on 3 parameters: physician assessment, patient assessment, and satisfaction level of patients, after a follow-up of 3 months. Results: Good or excellent improvement (>50%) was seen in 66% of patients on physician and patient assessments. The patients were either very satisfied or satisfied in 81.1% of cases. Patients with predominantly boxcar scars and higher pretreatment scar severity were associated with better treatment outcomes. Age, sex, duration of scars, or type of skin did not significantly influence the treatment outcome and adverse effects. Conclusion: The study showed that 70% of TCA is a safe and effective treatment option in all types of atrophic acne scars, especially in severe boxcar scars. © 2015 by the American Society for Dermatologic Surgery, Inc. Source

Soni N.,Jawaharlal Nehru Medical College and Hospital | Kaushik G.G.,Jawaharlal Nehru Medical College and Hospital | Sharma N.,Geetanjali Medical College and Hospital
National Journal of Physiology, Pharmacy and Pharmacology

Background: Fructosamine (FA) is the product of a reaction between glucose (sugar) and albumin (protein). It is used to monitor the short-term glycemic changes in patients with diabetes and may have a role in conjugation with glycated hemoglobin.Aims & Objective: Fructosamine test is used to evaluate the average amount of glucose in blood over a period of 2–3 weeks. FA is a useful indicator to measure the peripheral metabolic function in patients with thyroid disorders. As serum thyroid function tests, fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), serum FA ratios occupied our attention, their inconsistency in the subjects with subclinical hypothyroidism, overt hypothyroidism, and hyperthyroidism in relation to the euthyroid healthy control subjects was studied here.Materials and Methods: This study was conducted on 100 patients with overt hypothyroidism, subclinical hypothyroidism, and hyperthyroidism attending the medical OPD and radioimmunoassay laboratory of the Department of Biochemistry, Jawaharlal Nehru Medical College and Hospital, Ajmer, Rajasthan, India.Results: The mean glycated hemoglobin level was higher in study group than in controls, and it was not statistically significant. The mean serum FA level was higher in patients with overt hypothyroidism and subclinical hyperthyroidism and lower in those with hyperthyroidism than that in controls. It was found to be highly statistically significant.Conclusion: The FA values, which are largely higher than FPG and HbA1c values, indicate a higher propensity to glycation and a decrease turnover of the proteins in the patients with overt hypothyroidism and subclinical hypothyroidism; contrary results were observed in individuals with hyperthyroidism. © 2015 Mrs Deepika Charan. All rights reserved. Source

Gangrade Rehman P.,Geetanjali Medical College and Hospital | Mishra V.,C o Vardhman MRI
Journal of Forensic Medicine and Toxicology

This paper presents a 17 years old female with recurrent chest infections with idiopathic etiology presenting as polysplenia syndrome with cardiovascular manifestations. In addition to multiple spleens, the thoracic findings included a 'left' sided inferior vena cava with both azygous and hemiazygous continuation. The cardiovascular findings revealed an anomalous origin of right subclavian artery along with common origin for carotid arteries. Source

Nagpal S.,Geetanjali Medical College and Hospital | Walia L.,Geetanjali Medical College and Hospital | Walia L.,Dayanand Medical College and Hospital
Journal of the Indian Medical Association

Coronary artery disease is the leading cause of death and disability in women. The incidence of coronary artery disease increases sharply after menopause. Coronary artery disease results from imbalance between myocardial oxygen supply and oxygen demand of the heart. Myocardial oxygen consumption is a helpful indicator of the response of the coronary circulation to the myocardial oxygen demand. Myocardial oxygen consumption is calculated by indirect methods like Stroke's work, Fick's principle, tension time index and rate pressure product. Rate pressure product is a major determinant of cardiac oxygen consumption. It is the product of heart rate with systolic blood pressure. It indicates that adequate stress was achieved and is an important indicator of ventricular function. It increases progressively with exercise. Peak rate pressure product is the rate pressure product at peak of exercise. Peak rate pressure product gives an accurate reflection of the myocardial oxygen demand and myocardial workload. The higher the peak rate pressure product, more will be the myocardial oxygen consumption. The ability to reach higher peak rate pressure product is associated with more adequate coronary perfusion. Thus the low value of peak rate pressure product suggests significant compromise of coronary perfusion and decreased left ventricular function. In the present study effect of exercise on haemodynamic parameters of postmenopausal women without coronary artery disease and postmenopausal women with coronary artery disease were compared. The percentage increase in systolic blood pressure was significantly more in postmenopausal women without coronary artery disease. The peak rate pressure product was significantly more in postmenopausal women without coronary artery disease (28.04 ± 0.8293 mm of Hg beats/minute × 10-3) as compared to postmenopausal women with coronary artery disease (25.14± 0.8993 mm of Hg beats/minute x 10-3) indicating more compromised coronary perfusion in postmenopausal woman with coronary artery disease. Source

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