Geetanjali Institute of Pharmacy

Udaipur Rajasthan, India

Geetanjali Institute of Pharmacy

Udaipur Rajasthan, India
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Singhal M.,Jaipur National University | Singh H.P.,JKK Nataraja Dental College and Hospital | Dubey S.K.,Jaipur National University | Gaur K.,Geetanjali Institute of Pharmacy
Journal of Chemical and Pharmaceutical Research | Year: 2011

In present study, a series of chalconesemicarbazones was synthesized, characterized and evaluated for their reducing power assay. Most of the compounds were found to be potent antioxidant. Free radicals play an important role in various pathological and xenotoxic effects so antioxidant may have protective role in these pathological conditions. Based on the results of reducing power assay an anti-oxidant study, 1-[1-{4-aminophenyl-3-(4- chlorophenyl)}allylidene]-4-o-tolylsemicarbazide (Compound 26) was the most active compound. It was found that Chloride substitution in aldehydic and amino substitution in acetophenic moiety of chalconesemicarbazones exhibited potent reducing power and unsubstituted compound showed less reducing potential.

Sahu D.,Geetanjali Institute of Pharmacy | Rana A.C.,Rayat Institute of Pharmacy
International Journal of PharmTech Research | Year: 2010

The main objective of the present work was to develop sustained release matrix tablets of quetiapine fumarate using different polymers viz. Hydroxy propyl methyl cellulose (HPMC) and PVP K30. Varying ratios of drug and polymer like were selected for the study. After fixing the ratio of drug and polymer for control the release of drug up to desired time, the release rates were modulated by combination of two different rates controlling material and triple mixture of two different rate controlling material. After evaluation of physical properties of tablet, the in vitro release study was performed in 0.1 N HCl pH 1.2 for 2 hrs and in phosphate buffer pH 6.8 up to 12 hrs. The effect of polymer concentration and polymer blend concentration were studied. Dissolution data was analysed by Higuchi expression. It was observed that matrix tablets contained polymer blend of HPMC/PVP K30 were successfully sustained the release of drug up to 12 hrs. Among all the formulations, formulation QFSRT/08 which contains 60% HPMC K15M and 06% of PVP K30 release the drug which follow Higuchi kinetics via, swelling, diffusion and erosion and the release profile of formulation QFSRT/08 was comparable with the prepared batch products. Stability studies (40±2°C/75±5%RH) for 6 months indicated that quetiapine fumarate was stable in the matrix tablets. The DSC and FTIR study revealed that there was no chemical interaction between drug and excipients.

Kumar N.,Geetanjali Institute of Pharmacy | Sharma C.S.,JKK Nataraja Dental College and Hospital | Ranawat M.S.,JKK Nataraja Dental College and Hospital | Singh H.P.,JKK Nataraja Dental College and Hospital | And 2 more authors.
Journal of Pharmaceutical Investigation | Year: 2015

A series of novel mannich bases of 2-substituted benzimidazoles was synthesized by the reaction of 2-substituted benzimidazoles with corresponding aldehyde and acetophenones. The structures of all synthesized compounds were confirmed by elemental analysis, IR, 1H-NMR, 13C-NMR and LCMS. The compounds were evaluated for in vivo analgesic and in vivo anti-inflammatory activities by a tail flick method and carrageenan-induced rat paw edema test respectively. Among all the compounds synthesized, compound A1 and B3 exhibited significant analgesic and anti-inflammatory activities. Acute ulcerogenicity studies showed that compound A1 and B3 were devoid of gastrointestinal toxicities. © 2014, The Korean Society of Pharmaceutical Sciences and Technology.

Kushwaha S.K.,Geetanjali Institute of Pharmacy | Dashora A.,Geetanjali Institute of Pharmacy | Dashora N.,Geetanjali Institute of Pharmacy | Patel J.R.,Dr Hari Singh Gour University
Journal of Pharmacy Research | Year: 2013

Objectives: To determine the acute toxicity of standardized methanolic extract of Phyllanthus amarus invivo in female albino rats. Methods: Treated group of animals were administrated 300, 600, 2000 and 5000mg/kg body weight of extract orally and the control group received standard laboratory diet and water ad libitum following OECD guideline 423 with some modifications. All animals were sacrificed after 14 days of treatment. Results: The extract was standardized by HPLC to contain phyllanthin and hypophyllanthin. No mortality was noted and the study exhibited no significant changes in general behavior, body weight, gross appearance of internal organs, hematological and biochemical parameters and the histological profile of liver also indicated the nontoxic nature of this drug. Biochemical studies showed no significant change in the levels of ALT, AST, albumin, triglycerides, cholesterol and albumin. There were no evidence found about congestion of sinusoids, hemorrhage, hepatocytes, fatty changes, centrilobular necrosis and the changes in number of Kupffer cells in the liver. There was no increase of blood pressure and does not induce any nephrotoxicity and acute severe hepatotoxicity. Conclusion: The present study provides pivotal evidences for ascertaining the safety of the standardized MEPA (LD50>5000mg/kg) that could be used as tonic or food supplement in folklore medicine. © 2013 JPR Solutions. Published by Reed Elsevier India Pvt. Ltd.

Sharma C.S.,JKK Nataraja Dental College and Hospital | Shekhawat K.S.,JKK Nataraja Dental College and Hospital | Chauhan C.S.,JKK Nataraja Dental College and Hospital | Kumar N.,Geetanjali Institute of Pharmacy
Journal of Chemical and Pharmaceutical Research | Year: 2013

In this article, we have fused chalcone and semicarbazone nucleus and design a scheme for synthesizing a series of chalconesemicarbazones was evaluated for antimicrobial activity. Most of the compounds were found to be more or comparable potent than the reference standard drug. © 2013, Journal of Chemical and Pharmaceutical Research. All rights reserved.

Saxena A.,Geetanjali Institute of Pharmacy | Kitawat S.,Geetanjali Institute of Pharmacy | Gaur K.,Geetanjali Institute of Pharmacy | Singh V.,Geetanjali Institute of Pharmacy
International Journal of Drug Delivery Technology | Year: 2016

The main goal of any drug delivery system is to achieve desired concentration of the drug in blood or tissue, which is therapeutically effective and nontoxic for a prolonged period. Various attempts have been made to develop gastroretentive delivery systems such as high density system, swelling, floating system. The recent developments of FDDS including the physiological and formulation variables affecting gastric retention, approaches to design single-unit and multiple-unit floating systems, and their classification and formulation aspects are covered in detail. Gastric emptying is a complex process and makes in vivo performance of the drug delivery systems uncertain. In order to avoid this variability, efforts have been made to increase the retention time of the drug-delivery systems for more than 12 hours. The floating or hydrodynamically controlled drug delivery systems are useful in such application. Background of the research: Diltiazem HCL (DTZ), has short biological half life of 3-4 h, requires rather high frequency of administration. Due to repeated administration there may be chances of patient incompliance and toxicity problems. Objective: The objective of study was to develop sustained release alginate beads of DTZ for reduction in dosing frequency, high bioavailability & better patient compliance. Methodology: Five formulations prepared by using different drug to polymer ratios, were evaluated for relevant parameters and compared. Alginate beads were prepared by ionotropic external gelation technique using CaCl2 as cross linking agent. Prepared beads were evaluated for % yield, entrapment efficiency, swelling index in 0.1N HCL, drug release study and SEM analysis. In order to improve %EE and drug release, LMP and sunflower oil were used as co-polymers along with sodium alginate. © 2016, International Journal of Drug Delivery Technology. All rights reserved.

Santosh K.,Geetanjali Institute Of Pharmacy | Jyoti M.,Geetanjali Institute Of Pharmacy
International Journal of PharmTech Research | Year: 2013

Considering that most inflammatory diseases occur locally and near the body surface, transdermal drug delivery of non-steroidal anti-inflammatory drugs (NSAIDs) may be an interesting strategy for delivering these drugs directly to the diseased site. Ketoprofen (KP), a potent non-steroidal anti-inflammatory drug (NSAID) inhibits arachidonic acid metabolism by cyclo-oxigenase and lipoxygenase. The compound has been widely used in the treatment of rheumatoid arthritis, osteoarthritis, as well as a mild to moderate painkiller. In these study ketoprofen transdermal patches was prepared by solvent evaporation method using polymer PVP and Ethyl cellulose. Dibutyl phthalate used as a plasticizer. The prepared patches will evaluated for thickness, folding endurance, tensile strength, flatness, drug contain uniformity, in-vitro permeation study. In vitro release study was performed by using Franz-diffusion cell.

Gautam R.K.,RIICO Institutional Area | Bhambu A.K.,RIICO Institutional Area | Rai S.,RIICO Institutional Area | Sahu D.,Geetanjali Institute of Pharmacy
Research Journal of Pharmacy and Technology | Year: 2013

Information Technology (IT) can be used potentially in every sector of the economy. Information Technology has been a dynamic sector in many developed economies and India has stood out as a developing country where IT sector has grown indefinitely. Information Technology jobs in India are the first choice career for the bright brains who are innovative. Hence, IT jobs in India are also booming with increasing demand for information technology professionals. Use of Information & Technology in Pharmacy field is known as health informatics. Health informatics is a discipline at the intersection of information science, computer science, and health care. It deals with the resources, devices, and methods required optimizing the acquisition, storage, retrieval, and use of information in health and biomedicine. Health informatics tools include not only computers but also clinical guidelines, formal medical terminologies, and information and communication systems. It is applied to the areas of nursing, clinical care, dentistry, pharmacy, public health, occupational therapy, and (bio) medical research. The review mainly focus on Health informatics, Medical writing, Medical transcription, Medical coding, Knowledge process outsourcing (KPO). © RJPT.

Gaurang P.,Geetanjali Institute of Pharmacy | Deepak S.,Geetanjali Institute of Pharmacy | Ashok D.,Geetanjali Institute of Pharmacy | Rahul G.,Geetanjali Institute of Pharmacy | And 3 more authors.
International Journal of Pharmacy and Technology | Year: 2013

Controlled drug delivery occurs when a polymer, whether natural or synthetic, is judiciously combined with a drug or other active agent in such a way that the active agent is released from the material in a predesigned manner. The release of the active agent may be constant over a long period, it may be cyclic over a long period, or it may be triggered by the environment or other external events. In any case, the purpose behind controlling the drug delivery is to achieve more effective therapies while eliminating the potential for both under- and overdosing. Other advantages of using controlled-delivery systems can include the maintenance of drug levels within a desired range, the need for fewer administrations, optimal use of the drug in question, and increased patient compliance. Biodegradable materials are used in packaging, agriculture, medicine and other areas. In recent years there has been an increase in interest in biodegradable polymers. Two classes of biodegradable polymers can be distinguished: synthetic or natural polymers. There are polymers produced from feedstocks derived either from petroleum resources (non renewable resources) or from biological resources (renewable resources). In general natural polymers offer fewer advantages than synthetic polymers. The following review presents an overview of the different biodegradable polymers that are currently being used and their properties, as well as new developments in their applications.

Sharma C.S.,JKK Nataraja Dental College and Hospital | Verma T.,JKK Nataraja Dental College and Hospital | Singh H.P.,JKK Nataraja Dental College and Hospital | Kumar N.,Geetanjali Institute of Pharmacy
Medicinal Chemistry Research | Year: 2014

A series of novel flavone incorporated semicarbazides (Y2a-Y2j) was synthesized and characterized by elemental analyses, 1H NMR, 13C NMR, and mass spectral studies. The newly synthesized compounds were screened for their anticonvulsant activity against maximal electroshock seizure model in male wistar rats and compared with the standard drug phenytoin. Compound Y2g i.e., with dimethylamino substitution was found to be most active compound as comparable to standard drug phenytoin and free from in silico neurotoxicity. © Springer Science+Business Media 2014.

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