Kushwaha S.K.,Geetanjali Institute of Pharmacy |
Dashora A.,Geetanjali Institute of Pharmacy |
Dashora N.,Geetanjali Institute of Pharmacy |
Patel J.R.,Dr Hari Singh Gour University
Journal of Pharmacy Research | Year: 2013
Objectives: To determine the acute toxicity of standardized methanolic extract of Phyllanthus amarus invivo in female albino rats. Methods: Treated group of animals were administrated 300, 600, 2000 and 5000mg/kg body weight of extract orally and the control group received standard laboratory diet and water ad libitum following OECD guideline 423 with some modifications. All animals were sacrificed after 14 days of treatment. Results: The extract was standardized by HPLC to contain phyllanthin and hypophyllanthin. No mortality was noted and the study exhibited no significant changes in general behavior, body weight, gross appearance of internal organs, hematological and biochemical parameters and the histological profile of liver also indicated the nontoxic nature of this drug. Biochemical studies showed no significant change in the levels of ALT, AST, albumin, triglycerides, cholesterol and albumin. There were no evidence found about congestion of sinusoids, hemorrhage, hepatocytes, fatty changes, centrilobular necrosis and the changes in number of Kupffer cells in the liver. There was no increase of blood pressure and does not induce any nephrotoxicity and acute severe hepatotoxicity. Conclusion: The present study provides pivotal evidences for ascertaining the safety of the standardized MEPA (LD50>5000mg/kg) that could be used as tonic or food supplement in folklore medicine. © 2013 JPR Solutions. Published by Reed Elsevier India Pvt. Ltd.
Gautam R.K.,RIICO Institutional Area |
Bhambu A.K.,RIICO Institutional Area |
Rai S.,RIICO Institutional Area |
Sahu D.,Geetanjali Institute of Pharmacy
Research Journal of Pharmacy and Technology | Year: 2013
Information Technology (IT) can be used potentially in every sector of the economy. Information Technology has been a dynamic sector in many developed economies and India has stood out as a developing country where IT sector has grown indefinitely. Information Technology jobs in India are the first choice career for the bright brains who are innovative. Hence, IT jobs in India are also booming with increasing demand for information technology professionals. Use of Information & Technology in Pharmacy field is known as health informatics. Health informatics is a discipline at the intersection of information science, computer science, and health care. It deals with the resources, devices, and methods required optimizing the acquisition, storage, retrieval, and use of information in health and biomedicine. Health informatics tools include not only computers but also clinical guidelines, formal medical terminologies, and information and communication systems. It is applied to the areas of nursing, clinical care, dentistry, pharmacy, public health, occupational therapy, and (bio) medical research. The review mainly focus on Health informatics, Medical writing, Medical transcription, Medical coding, Knowledge process outsourcing (KPO). © RJPT.
Gaurang P.,Geetanjali Institute of Pharmacy |
Deepak S.,Geetanjali Institute of Pharmacy |
Ashok D.,Geetanjali Institute of Pharmacy |
Rahul G.,Geetanjali Institute of Pharmacy |
And 3 more authors.
International Journal of Pharmacy and Technology | Year: 2013
Controlled drug delivery occurs when a polymer, whether natural or synthetic, is judiciously combined with a drug or other active agent in such a way that the active agent is released from the material in a predesigned manner. The release of the active agent may be constant over a long period, it may be cyclic over a long period, or it may be triggered by the environment or other external events. In any case, the purpose behind controlling the drug delivery is to achieve more effective therapies while eliminating the potential for both under- and overdosing. Other advantages of using controlled-delivery systems can include the maintenance of drug levels within a desired range, the need for fewer administrations, optimal use of the drug in question, and increased patient compliance. Biodegradable materials are used in packaging, agriculture, medicine and other areas. In recent years there has been an increase in interest in biodegradable polymers. Two classes of biodegradable polymers can be distinguished: synthetic or natural polymers. There are polymers produced from feedstocks derived either from petroleum resources (non renewable resources) or from biological resources (renewable resources). In general natural polymers offer fewer advantages than synthetic polymers. The following review presents an overview of the different biodegradable polymers that are currently being used and their properties, as well as new developments in their applications.
Sharma C.S.,JKK Nataraja Dental College and Hospital |
Verma T.,JKK Nataraja Dental College and Hospital |
Singh H.P.,JKK Nataraja Dental College and Hospital |
Kumar N.,Geetanjali Institute of Pharmacy
Medicinal Chemistry Research | Year: 2014
A series of novel flavone incorporated semicarbazides (Y2a-Y2j) was synthesized and characterized by elemental analyses, 1H NMR, 13C NMR, and mass spectral studies. The newly synthesized compounds were screened for their anticonvulsant activity against maximal electroshock seizure model in male wistar rats and compared with the standard drug phenytoin. Compound Y2g i.e., with dimethylamino substitution was found to be most active compound as comparable to standard drug phenytoin and free from in silico neurotoxicity. © Springer Science+Business Media 2014.