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Bryans Road, MD, United States

De Soete W.,Ghent University | Dewulf J.,Ghent University | Cappuyns P.,Janssen Pharmaceutical | Van Der Vorst G.,Janssen Pharmaceutical | And 4 more authors.
Green Chemistry

Identifying better performing Active Pharmaceutical Ingredient (API) synthesis routes with reference to green chemistry and green engineering principles was of the highest importance in the pharmaceutical industry during the past decade. However, very little attention was paid to other life cycle stages such as the Drug Product (DP) production, packaging and distribution. In this case, the environmental sustainability of batch versus continuous granulation based tablet manufacturing is quantified from a resource point of view by conducting Exergy Analysis (EA) and Exergetic Life Cycle Analysis (ELCA) at three different levels in order to identify and locate resource losses throughout the pharmaceutical supply chain. Assessing the potential implementation of the continuous production line ConsiGma™ at the Janssen-Cilag SpA pharmaceutical manufacturing plant and thereby replacing the conventional batch manufacturing mode would result in a resource consumption reduction of 10.2% (65.6 to 58.9 kJex per tablet), 15.2% (111 to 94.0 kJex per tablet) and 2.2% (2.3 to 2.2 MJex per tablet) at the process (α), plant (β) and overall industrial level (γ) respectively. Focusing on DP production processes by excluding transiting exergy in API, excipients and packaging materials resulted in a reduction of 34.0%, 25.9% and 14.7% at the respective system boundaries. The API dose seemed to be the parameter with highest sensitivity towards environmental burden. From an emission point of view, a Carbon Footprint (CF) reduction of 2.0% (0.22 to 0.21 kg CO2-eq per tablet) was obtained at the γ level in shifting from batch to continuous manufacturing of Tramacet®. Focusing on DP production revealed a CF reduction of 16.2%. © 2013 The Royal Society of Chemistry. Source

GEA Process Engineering Inc. | Date: 2011-07-06

A nozzle for cleaning-in-place of a vessel has a nozzle body to be connected to a wall of the vessel and defining an opening, a nozzle insert is contained within the nozzle body and is able to assume at least two distinct positions relative to the nozzle body, a first position in which the nozzle insert is retracted into the nozzle body and a second position in which the nozzle insert is advanced in the axial direction relative to the nozzle body and protrudes into the vessel. Apertures are exposed in the second position to allow distribution of a cleaning fluid. The nozzle insert has two nozzle insert parts, in mutual abutment in the first position and spaced from each other in a direction transverse to the axial direction in the second position to form a gap between adjacent nozzle insert parts, the apertures being exposed in the gap.

GEA Process Engineering Inc. | Date: 2010-07-12

In the application a spray dryer absorption apparatus for treating a stream of flue gas containing acidic components is disclosed. The apparatus comprises a chamber having vertical cylindrical walls, said chamber comprises (i) an inlet for a flue gas stream containing an acidic component, (ii) an atomizer for spraying droplets of an absorbent slurry into said flue gas stream to effect a chemical reaction between the droplets and the acidic component of the flue gas, thereby forming a particulate reaction product, and (iii) an outlet for the treated flue gas and entrained particulate reaction product, wherein the bottom of the chamber having vertical cylindrical walls is substantially horizontal and impervious to gases. The apparatus of the invention has the advantage of a simplified geometry accounting for lower building and maintenance costs.

GEA Process Engineering Inc. | Date: 2010-06-23

The closure element (

GEA Process Engineering Inc. | Date: 2014-02-11

Crystallization (evaporation) installations.

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