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Prasad M.S.,GBN Institute of Pharmacy
Asian Journal of Chemistry | Year: 2012

The study is aimed to investigate the pharmacognostic, phytochemical, antimicrobial screening and antioxidant activity of different extracts of Amaranthus tricolor with a view of justifying the use of the plant. The test tube reactions and TLC examination revealed the presence of phenols, tannins and flavonoids in chloroform, ethanolic and aqueous extracts of A. tricolor. By present work, it is concluded that the plant A. tricolor is endowed with significant antimicrobial and antioxidant activity due to the presence active constituents like polyphenolic conents and others, thus justifying its use in the indigenous system of medicine. The results of organoleptic, microscopical and physical evaluation were satisfactory and can be correlated with earlier reports. Source


Goli V.,Venkateshwara Institute of Pharmaceutical science | Gowrishankar N.L.,Swami Viveka nanda institute of pharmaceutical science | Macharla S.P.,GBN Institute of Pharmacy | Bhaskar J.,Venkateshwara Institute of Pharmaceutical science | Bhaskar K.V.,Venkateshwara Institute of Pharmaceutical science
International Journal of Pharmacy and Technology | Year: 2011

The present study was carried out to investigate the anti-inflammatory property of petroleum ether, alcoholic and aqueous extracts of spindus mukorossi leaves using experimental animal models. The antiinflammatory activity of the various extracts was studied based on their effects on carrageenan-induced paw oedema and cotton pellet granuloma in rats,.The extracts in dose levels of 50,100 and 200 mg/kg orally were used for anti-inflammatory studies. The ethanol and aqueous extracts of leaves of spindus mukorossi significant (P<0.05) anti-inflammatory activities in a dose-dependent manner to that of standard drug indomethacin, while petroleum ether extract exhibit minimum inhibitory effect in carageenan induced hind paw oedema and cotton pellet granuloma in rats. all the doses used when compared to the control group. The results obtained indicate that the crude leaf extracts of spindus mukorossi possess potent anti-inflammatory by supporting the folkloric usage of the plant to treat various inflammatory conditions. Source


Goli V.,Venkateshwara Institute of Pharmaceutical science | Macharla S.P.,GBN Institute of Pharmacy | Vijaya Bhasker K.,Venkateshwara Institute of Pharmaceutical science | Gowrishankar N.L.,Swami Viveka nanda institute of pharmaceutical science | And 2 more authors.
Research Journal of Pharmacy and Technology | Year: 2011

The present work was evaluated anti-ulcer potential of the ethanol extract of leaf of Lawsonia inermis against in vivo indomethacin- induced gastric ulcer using pylorus ligation method. All the dose of the leaf extract (100, 200 and 400 mg/kg) significantly (P 0.01) reduced the ulcer index in this experiment. In conclusion, the present study provides preliminary data on the antiulcer potential of Trianthema portulacastrum leaf and support the traditional uses of the plant for the treatment of gastric ulcer. © RJPT All right reserved. Source


Sravan Prasad M.,GBN Institute of Pharmacy | Venkateshwarlu G.,Venkateshwara Institute of Pharmaceutical science | Alekhya K.,GBN Institute of Pharmacy | Pawan kumar B.,Guru nanak Institute of Pharmacy | Venkat Rajkumar J.,GBN Institute of Pharmacy
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2011

The entire wound healing process is a complex series of events that begins at the moment of injury and can continue for months to years. The objective of our study is to investigate wound healing activity of the methanolic leaf extract of Pongamia pinnata in albino rats using excision and incision wound models. 200 mg/kg/day of leaf extract of pongamia pinnata was evaluated for its wound healing activity and compared with povidone iodine (Standard). The present investigation may be concluded that the plant Pongamia pinnata is endowed with significant wound healing activity due to the presence active constituents, there by justifying its use in the indigenous system of medicine. Source


Ganapathiraman,Swami Ramananda Tirtha Institute of Science and Technology | Sravan Prasad M.,GBN Institute of Pharmacy | Suresh Kumar P.,GBN Institute of Pharmacy | Hematheerthani N.,GBN Institute of Pharmacy
Asian Journal of Chemistry | Year: 2012

Whole plant of Dipteracanthus prostratus (poir) nees were subjected to extraction and further fractionation to obtain isolated compounds. Different concentrations of methanolic extract were subjected to analgesic, antiinflammatory and wound healing assay by hotplate, paw oedema and excision wound model methods respectively. The methanolic extracts showed dose dependent analgesic, antiinflammatory and wound healing property as compared to standards. The extracts showed significant results in all three assays with increasing concen- tration. The phytochemical screenings confirm the presence of triterpenoids, flavonoids, alkaloids, phytosterols glycosides and carbohydrates, which are responsible for the analgesic, antiinflammatory and wound healing activity. Source

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