Inanir A.,Gaziosmapasa University |
Akif Sariyildiz M.,Dicle University
European Journal of General Medicine | Year: 2013
Ankylosing spondylitis (AS) is chronic, progressive, systemic inflammatory rheumatic diseases that lead to serious disability. The objective of this study was to determine the demographic, clinic characteristics and CYP2D6*4 gene mutation profiles of the AS patients in Tokat, Turkey. In this retrospective study, we evaluated 103 patients that were diagnosed and followed up as AS in Tokat, Turkey between 2008-2011. Demographical properties (age, sex, education level, age at diagnosis, disease duration), clinical characteristics (HLA27, peripheral/extraarticular involvoment, chest expansion, enthesopathy, modified schouber) and genetic analysis results (CYP2D6*4 gene mutation frequency) of AS patients were assessed. The mean age of AS patients was 36.80±9.25 years. The mean age of female and male 39.10±7.89, 35.40± 9.79 respectively. The female to male ratio was 1:1.6. Major histocompatibility complex, class I, B 27 (HLAB27) was investigated and the rate of positivity was 73.78 %. There was a statistically significant difference between CYP2D6 gene mutation and peripheral /extraarticular involvement (p<0.05). Determining the clinical characteristics and CYP2D6*4 gene mutations of rheumatologic diseases as AS will provide benefits for early diagnosis, treatment, and disease outcome.
Arisoy A.,Gaziosmapasa University |
Memic K.,Hitit University |
Diken O.E.,Corum State Chest Hospital |
Karavelioglu Y.,Hitit University |
And 6 more authors.
Acta Medica Mediterranea | Year: 2015
Aims: Chronic obstructive pulmonary disease (COPD) has been associated with a high frequency of cardiac arrhythmia. While many studies have examined the development of atrial fibrillation (AF) in COPD patients, there is insufficient data about atrial conduction time (ACT) and its relationship with the Neutrophil to Lymphocyte ratio (NLR) in these patients. The aim of the present study was to evaluate atrial conduction features and its relationship with NLR. Materials and methods: The study groups comprised 40 patients with COPD and 40 healthy subjects, who were subjected to pulmonary function tests, 12-lead surface electrocardiograms, echocardiographic examinations and blood sample tests. ACT was measured through tissue Doppler imaging, while NLR was measured by dividing the neutrophil count by the lymphocyte count. Results: Pulmonary function values were significantly lower in COPD patients than in the control group, as would be expected (p<0,001). According to the ACT measurements, tricuspid ACT was significantly longer in COPD patients than in the controls (26.4 ± 11.4 ms vs 17.7 ± 7.7 ms, p<0.001). Also, NLR was higher in COPD patients than in the control group (2.4 ±1.2 vs 1.94 ±0.8 p=0.009). A negative correlation was observed between tricuspid ACT and the percent of forced expiratory volume in one second (FEV1 %) (r = - 0.45; p <0.001), and a significant positive correlation was identified between tricuspid ACT and NLR (r=+0.38; p< 0.001). Conclusion: Our study revealed prolonged tricuspid ACT and increased NLR in COPD patients, and the existence of a relationship between these parameters was identified. Previous studies claim that hypoxia and chronic inflammation may be the underlying mechanisms explaining arrhythmia in patients with COPD, while many studies also show that a prolongation of ACT and increased NLR is associated with atrial arrhythmias. In the light of our findings and previous data, the assessment of ACT and NLR can be considered a clinically useful approach to detecting the risk of AF development in the population.
Yigit S.,Gaziosmapasa University |
Tural S.,Ondokuz Mayis University |
Rustemoglu A.,Gaziosmapasa University |
Inanir A.,Gaziosmapasa University |
And 5 more authors.
Molecular Biology Reports | Year: 2013
Behcet's disease (BD) is a chronic, multi-systemic and inflammatory disorder. The local renin-angiotensin system (RAS) in the vessel wall plays a role in the endothelial control and contributes to inflammatory processes. Angiotensin-converting enzyme (ACE) is the regulatory component of the RAS. This study was conducted in Turkish patients with BD to determine the frequency of I/D polymorphism genotypes of ACE gene. Genomic DNA obtained from 566 persons (266 patients with BD and 300 healthy controls). ACE gene I/D polymorphism genotypes were determined using polymerase chain reaction using I and D allele-specific primers. There was statistically significant difference between the groups with respect to genotype distribution (p<0.001). This study is the largest study in Turkish population that ACE gene I/D polymorphism investigated in BD. As a result of this study, ACE gene I/D polymorphism DD genotype could be a genetic marker in BD in Turkish study population. © 2012 Springer Science+Business Media Dordrecht.
Alparslan O.,Gaziosmapasa University |
Demirel Y.,Cumhuriyet University
Japan Journal of Nursing Science | Year: 2013
Aim: The research was conducted as a descriptive and cross-sectional study in order to identify the traditional neonatal care practices applied by women in the 15-49year age range. Methods: The research sample comprised 263 married mothers aged 15-49years living in the seven health center regions in Sivas city center and agreeing to participate in the study between 7March 2008 and 30April 2008. In data collection, a questionnaire form devised by the researchers on the basis of expert opinion was used. The data collected were assessed by computer by means of percentage analysis and χ2-tests. Results: The traditional neonatal care practices for treatment of jaundice, rash, thrush, earache, swelling in the baby's chest (milk accumulation), falling of the umbilical cord, umbilical infection, eye crust, nail cut, and temperature were examined. The most frequently conducted traditional practices were identified as rubbing swollen nipples, "making the forties" (bathing the mother and neonate in a special ritual on the 40th day postpartum), salting, using holluk (sand-filled nappy), and swaddling the baby. It was found that the mothers with low levels of education applied traditional practices like swaddling, salting, holluk, and making the forties more frequently (P<0.05). Conclusion: According to the study findings, mothers practiced traditional applications at least once during neonatal care. It was observed that the lower the mother's educational level, the more frequent the traditional practices were applied. For this reason, neonatal healthcare services should be delivered by midwives/nurses or other healthcare workers. © 2012 The Authors Japan Journal of Nursing Science © 2012 Japan Academy of Nursing Science.