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Ozkan Z.,Elazig Training and Research Hospital | Aksoy N.,Istanbul Gaziosmanpasa Taksim Training and Research Hospital | Yazar F.M.,Elazig Training and Research Hospital | Bozkurt M.,Elazig Training and Research Hospital | And 4 more authors.
Acta Medica Mediterranea | Year: 2015

Introduction: Helicobacter pylori (H. pylori) infection is the most common gastrointestinal bacterial infection found around the world. A chronic gastric condition associated with H. pylori infection has been reported to cause precancerous pathologies such as atrophic gastritis, intestinal metaplasia and dysplasia. H. pylori colonization of the gastric mucosa is affected by host, bacteria and environmental factors. Host defense mechanisms are affected by endogenous glucocorticoids. Cortisol is the major glucocorticoid in human circulation. Salivary cortisol is a good indication of serum cortisol and is easier to obtain. Materials and methods: The study was carried out on voluntary subjects who underwent upper gastrointestinal system (GIS) endoscopy at the endoscopy unit of Elazig Training and Research Hospital. Saliva samples of patients were collected between the hours of 8:30 and 9:30 am., centrifuged and kept frozen. The electrochemiluminescence method was used for the analysis of salivary cortisol levels. Upper GIS endoscopy was done. A biopsy for H.pylori was taken from the antrum. The biopsies were evaluated by a single pathologist according to the Sydney method. Endoscopic evaluation, H. pylori positivity and salivary cortisol levels of patients were reported. Statistical analysis was carried out using the Number Cruncher Statistical System (NCSS). Results: A total of 68 patients were included in the study. Pathologic analysis showed H. pylori positivity in 33 (48.5%) patients, while no H.pylori was identified in 35 (51.5%) patients. H.pylori positive and H. pylori negative groups were compared in terms of cortisol levels and no statistically significant difference was found (p=0.692). Both groups had similar distributions according to endoscopic images. There was no statistically significant relationship between age, gender and endoscopic image and H.pylori positivity (p>0.05). Conclusion: Cortisol levels in saliva had no effect on gastric mucosa and had no relationship to H. pylori colonization. Endogenous cortisol might not have made a positive or negative contribution to H. pylori colonization. Source

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