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Yurdakul O.V.,Gaziosmanpasa Taksim Education and Research Hospital | Mesc N.,Haydarpasa Numune Education and Research Hospital | Cetnkaya Y.,Haydarpasa Numune Education and Research Hospital | Kulcu D.G.,Haydarpasa Numune Education and Research Hospital
Journal of Clinical Neurology (Korea) | Year: 2016

Background and PurposezzWe determined the reliability of ultrasonography (US) measurements for diagnosing carpal tunnel syndrome (CTS) and their correlation with symptom duration and electrophysiology findings. We determined whether the ratio of the median-to-ulnar cross-sectional areas (CSAs) can support CTS diagnoses. MethodszzThe pisiform CSA (CSApisiform), swelling ratio (SR), palmar bowing, and CSApisiform/ ulnar CSA (CSAulnar) measurements made in two subgroups of CTS patients (having sensory affection alone or having both sensory and motor affection) were compared with controls. CSAulnar was measured in Guyon’s canal at the level of most-protuberant portion of the pisiform bone. ResultszzThe values of all of the measured US parameters were higher in patients with CTS (n=50) than in controls (n=62). CSApisiform could be used to diagnose CTS of mild severity. All of the parameters were positively correlated with the distal latency of the compound muscle action potential, and all of them except for SR were negatively correlated with the sensory nerve conduction velocity. A CSApisiform/CSAulnar ratio of ≥1.79 had a sensitivity of 70% and a specificity of 76% for diagnosing CTS. ConclusionszzOnly CSApisiform measurements were reliable for diagnosing early stages of CTS, and CSApisiform/CSAulnar had a lower diagnostic value for diagnosing CTS. © 2016 Korean Neurological Association. Source


Ozucer B.,Gaziosmanpasa Taksim Education and Research Hospital | Ozturan O.,Bezmialem Foundation University
Current Opinion in Otolaryngology and Head and Neck Surgery | Year: 2016

Purpose of review To review recent studies on nasal osseocartilaginous anatomy, osteotomy techniques and contemporary methods of nasal bone reshaping carried out under direct vision. Recent findings Current cadaver studies on osseocartilaginous vault anatomy, osteotomy techniques provide valuable information that can reduce outcome variability and increase reliability of osteotomies. Nevertheless, osteotomes have limitations and contemporary approaches - namely, piezoelectric instrumentations, osteoectomy, and osteotomy carried out under direct vision - can provide valuable solutions to certain shortcomings. Contrary to widespread understanding, extended wide periosteal dissection is the common thread in newly introduced methods which claim enhanced control, reduced soft tissue trauma, and reproducible results. Comparative and cadaver studies show promising results regarding protection of underlying mucosa, reduced comminuted fractures, reduced postoperative ecchymosis, and edema. Summary Improvements in nasal bone reshaping are promising for better esthetic and functional outcomes. Nevertheless, these approaches need to be validated by randomized controlled trials and test of time before being incorporated in routine surgical practice. © 2016 Wolters Kluwer Health, Inc. Source


Guvenc M.G.,Acibadem University | Dizdar D.,Gaziosmanpasa Taksim Education and Research Hospital | Dizdar S.K.,Hamidiye Sisli Etfal Education and Research Hospital | Okutur S.K.,Acibadem University | Demir G.,Acibadem University
Journal of Chemotherapy | Year: 2016

Oxaliplatin is used to treat advanced colorectal cancer. Platinum-containing chemotherapeutic agents are known to be ototoxic. However, ototoxicity is rare with newer generation platinum-derived agents, such as oxaliplatin. This case report presents a rare case of sudden unilateral sensorineural hearing loss following intravenous (IV) infusion of oxaliplatin in a 64-year-old woman with advanced colon cancer. The hearing loss was severe and did not respond to treatment. To the best of our knowledge, this is the fifth reported case of oxaliplatin ototoxicity. Although oxaliplatin ototoxicity is rare, physicians must be aware of this important adverse effect, and an audiometric evaluation must be performed when necessary. Patients treated with oxaliplatin should be followed closely for early signs and symptoms of hearing loss, and if hearing loss is detected, treatment should be stopped immediately. © 2016 Edizioni Scientifiche per l'Informazione su Farmaci e Terapia Source


Ozde C.,Gaziosmanpasa Taksim Education and Research Hospital | Dogru M.,Zeynep Kamil Woman and Child Diseases Education and Research Hospital | Erdogan F.,Istanbul University | Ipek I.O.,Istanbul University | And 2 more authors.
Asian Pacific Journal of Allergy and Immunology | Year: 2015

Background: There is an association between adiponectin (APN) and asthma. However, the mechanisms underlying this association is unclear. APN is a predominantly antiinflammatory protein with possible signalling activity in the lung that can be secreted by Epicardial Adipose Tissue (EAT). Our hypothesis is that serum APN levels may be directly and simply related to the amount of EAT accumulation, particularly when it is expressed as thickness in children with asthma. Objective: The aim of this study was to investigate whether serum adiponectin (APN) and epicardial adipose tissue thickness (EATT) have an effect in non-obese children with asthma and in healthy non-asthmatic children, and analyze their relationships with clinical outcomes. Methods: 68 childrens diagnosed with asthma (20 girls/48 boys) who had applied at the pediatric allergy and clinical immunology clinic of the hospital were included in this cross-sectional, observational study. The age-matched control group included 39 healthy children (18 girls/21 boys). EATT was measured by transthoracic echocardiography. The serum APN levels were also checked. Statistical analysis was performed by using independent sample t-test and Spearman correlation analyses. Results: The mean age of the asthma group was 10.2 ± 2.7 years, and the average EATT was found to be 5.7±1.1 mm. The mean age of the control group was 10.5 ± 2.8 years, and the average EATT was found to be 5.1 ± 0.7 mm. The EATT of the asthma group was found to be significantly higher (p < 0.001) in study group. In the asthma group the APN was 10.0 ± 5.3 mg/L, and in the control group the APN was 15.8 ± 10.5 mg/L (p < 0.001). We found that APN was significantly negatively correlated with EATT (r = -0.266, p = 0.006) in asthma and control groups. Conclusion: EATT is associated with non-obese asthmatic childrens. High EATT may be related with high release of pro-inflammatory cytokine and low release of APN. Low levels of APN may be related to low anti-inflammatory effects. Therefore, high EATT and low levels of APN may indicate pro-inflammantory profiles in nonobese asthmatic childrens. © 2009 is a Digital Portal of health science journals in Thailand. Source


Boyuk B.,Gaziosmanpasa Taksim Education and Research Hospital | Guzel E.C.,Namik Kemal University | Atalay H.,Gaziosmanpasa Taksim Education and Research Hospital | Guzel S.,Namik Kemal University | And 2 more authors.
Clinical Respiratory Journal | Year: 2015

Background and Aims: Chronic inflammation of the lung is a characteristic finding in chronic obstructive pulmonary disease (COPD). The protein chemerin has been identified in inflammatory fluid and in inflamed tissues. This study aimed to determine the association between serum chemerin levels and the severity of COPD. Methods: Forty-three COPD patients and 38 healthy subjects were enrolled in this study. Fasting plasma samples were obtained from the patient and the control group. Serum chemerin levels were measured using a commercial enzyme-linked immunosorbent assay. C-reactive protein levels, the erythrocyte sedimentation rate, and fibrinogen analysis were used to assess the inflammation status of the patients. Spirometric measurements with reversibility testing were performed in all the subjects. Results: Serum chemerin levels were significantly elevated in the COPD patients (6.44±0.52 vs 5.22±0.59; P<0.001). A Mann-Whitney U-test revealed that the serum chemerin levels of stage 2 COPD patients were higher than those of stage 1 and 3 COPD patients (P=0.651). Cigarette smoking and plasma chemerin relation was also understudied; however, there was no significant relationship between current smokers and ex-smokers (P>0.05). Pearson's correlation analysis indicated that serum chemerin levels were positively correlated only with total cholesterol (T. cholesterol) (P<0.05, r=0.382). In the linear regression analysis, chemerin levels were associated with age (β=0.321), triglycerides (β=0.299) and T. cholesterol (β=0.555). Conclusion: Our study points to a relation between plasma chemerin levels and COPD. Larger patient groups are needed to verify the role of chemerin in the severity of COPD. © 2015 John Wiley & Sons Ltd. Source

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