Cingi C.,Eskiehir Osmangazi University |
Muluk N.B.,Kirikkale University |
Hanci D.,Liv Hospital |
Ulusoy S.,Gaziosmanpasa Taksim Education and Research Hospital |
Sahin F.,Eskiehir Osmangazi University
International Forum of Allergy and Rhinology | Year: 2015
Background: Although the effectiveness of allergen monotherapy immunotherapy for allergic rhinitis (AR) has been well established by many prior studies, other aspects of immunotherapy are still incompletely documented by high-quality studies. The many published papers describe various results. The aim of the present study was to conduct a meta-analysis on the effectiveness of allergen immunotherapy. Methods: A total of 56 homogeneous studies were included in the analysis. The inclusion criteria used to select articles were as follows: (1) placebo-controlled clinical trials; (2) the use of immunotherapy; (3) participants and/or physicians were or were not blinded to immunotherapy or placebo assignment (single-blinding, double-blinding, or no-blinding studies); and (4) randomization or not of those in the immunotherapy and placebo groups. Results: Between 2003 and 2013, 114 placebo-controlled clinical trials were reported in Medline. Studies describing recovery rates in immunotherapy and placebo groups numbered 56. The distribution of such works was homogeneous (heterogeneity chi-square = 16.11; degrees of freedom [df] = 55; p = 1.000). The extent of recovery in immunotherapy groups was 53.671-fold greater than in placebo groups (Mantel-Haenszel [M-H] pooled risk ratio [RR] = 53.671; 95% confidence interval [CI], 36.981 to 77.893; z = 20.96; p < 0.001). Conclusion: Our meta-analysis suggests that immunotherapy is associated with a recovery rate 53.671-fold that of placebo. © 2014 ARS-AAOA, LLC.
PubMed | Gaziosmanpasa Taksim Education and Research Hospital, Zeynep Kamil Woman and Child Diseases Education and Research Hospital and Bakrkoy Dr Sadi Konuk Education And Research Hospital
Type: Journal Article | Journal: Pregnancy hypertension | Year: 2016
Preeclampsia (PE) is a multisystemic disorder characterized by hypertension and proteinuria that is specific to pregnancy and associated with maternal and fetal morbidity-mortality.To assess right heart structure and function in PE by echocardiography using conventional and tissue Doppler techniques.In total, 67 women with untreated PE and 46 matched healthy pregnant women were included. PE was defined according to the ACOG (2002) criteria. Right and left heart functions were evaluated using transthoracic two-dimensional (2D) echocardiography with color Doppler and tissue Doppler imaging techniques.Right ventricular basal and outflow tract diameters and free wall thickness, right atrial end-systolic maximum diameter, and area were significantly higher in the PE group than the control group (p<0.05). Tricuspid annular plane systolic excursion, isovolumic acceleration time, tissue Doppler-derived tricuspid lateral annular systolic velocity (S), right ventricle fractional area change, and myocardial performance index (Tei) were significantly lower in the PE group than the controls (p<0.05).PE does not only affect the left side of the heart but also the right side. This finding may open new scenarios, because right ventricular dysfunction may also be responsible for PE-related morbidity.
PubMed | Namik Kemal University and Gaziosmanpasa Taksim Education and Research Hospital
Type: Journal Article | Journal: The clinical respiratory journal | Year: 2016
Chronic inflammation of the lung is a characteristic finding in chronic obstructive pulmonary disease (COPD). The protein chemerin has been identified in inflammatory fluid and in inflamed tissues. This study aimed to determine the association between serum chemerin levels and the severity of COPD.Forty-three COPD patients and 38 healthy subjects were enrolled in this study. Fasting plasma samples were obtained from the patient and the control group. Serum chemerin levels were measured using a commercial enzyme-linked immunosorbent assay. C-reactive protein levels, the erythrocyte sedimentation rate, and fibrinogen analysis were used to assess the inflammation status of the patients. Spirometric measurements with reversibility testing were performed in all the subjects.Serum chemerin levels were significantly elevated in the COPD patients (6.440.52 vs 5.220.59; P<0.001). A Mann-Whitney U-test revealed that the serum chemerin levels of stage 2 COPD patients were higher than those of stage 1 and 3 COPD patients (P=0.651). Cigarette smoking and plasma chemerin relation was also understudied; however, there was no significant relationship between current smokers and ex-smokers (P>0.05). Pearsons correlation analysis indicated that serum chemerin levels were positively correlated only with total cholesterol (T. cholesterol) (P<0.05, r=0.382). In the linear regression analysis, chemerin levels were associated with age (=0.321), triglycerides (=0.299) and T. cholesterol (=0.555).Our study points to a relation between plasma chemerin levels and COPD. Larger patient groups are needed to verify the role of chemerin in the severity of COPD.
PubMed | Atatürk University, 100 Yil University, Gaziosmanpasa Taksim Education and Research Hospital, Erzurum Region Education and Research Hospital and 3 more.
Type: Journal Article | Journal: Indian journal of pharmacology | Year: 2016
In this study, we investigated the effect of metamizole on ischemia/reperfusion (I/R) injury an analysis of biochemistry, molecular gene expression, and histopathology in the rat ovary of female albino Wistar rats.Animals were divided into four groups; control group with induced ischemia-reperfusion (IRC), ischemia-reperfusion +100 mg/kg metamizole sodium (MS) (IRM-100), ischemia-reperfusion +200 mg/kg MS (IRM-200), and healthy group applied sham operation (SG).Myeloperoxidase (MPO) activity and gene expression increased significantly in IRC and IRM-100 group rat ovarian tissue compared with the SG group (P < 0.0001). However, MPO activity and gene expression in IRM-200 group ovarian tissue decreased significantly compared with the IRC and IRM-100 groups (P < 0.0001). Histopathologically, pronounced congestion, dilated vessels, hemorrhage, edema, degenerative cells, and neutrophil migration and adhesion to the endothelium were observed in the IRC and IRM-100 group ovarian tissues. A small number of congested dilated vessels, mild congestion, and edema were observed in the IRM-200 group, but no neutrophil migration and adhesion to the endothelium or degenerative cells.At 200 mg/kg dose metamizole prevented ovarian injury induced with I/R. This data show that metamizole can be used in the ovarian I/R injury treatment.
Ekin E.E.,Gaziosmanpasa Taksim Education and Research Hospital |
Yldz H.K.,Gaziosmanpasa Taksim Education and Research Hospital |
Mutlu H.,Gaziosmanpasa Taksim Education and Research Hospital
Diagnostic and Interventional Radiology | Year: 2016
PURPOSE We aimed to investigate the prevalence of lumbar multifidus muscle (LMM) atrophy in patients having mechanical low back pain with and without disc hernia. METHODS In total, 2028 lumbar magnetic resonance imaging scans of low back pain patients (age range, 18-88 years) were re-evaluated retrospectively. LMM atrophy was visually assessed in axial sections of L4-L5 and L5-S1 levels. RESULTS LMM atrophy prevalence at both levels was significantly higher in subjects ≥40 years compared with younger adults (P < 0.001). LMM atrophy was significantly more frequent in women than in men (P < 0.001). Among patients with low back pain without hernia, LMM atrophy was significantly more frequent than normal muscle (n=559 vs. n=392; P < 0.001). Frequency of LMM atrophy in low back pain patients without disc hernia was 13%. Hernia was more frequent in patients with LMM atrophy compared with patients without atrophy (P < 0.001). CONCLUSION LMM atrophy is more common in women; its prevalence and severity are observed to increase with advancing age, and disc hernia is found more frequently in individuals with LMM atrophy. © Turkish Society of Radiology 2016.
Ulusoy S.,Gaziosmanpasa Taksim Education and Research Hospital |
Dinc M.E.,Gaziosmanpasa Taksim Education and Research Hospital |
Dalgc A.,Gaziosmanpasa Taksim Education and Research Hospital |
Dizdar D.,Gaziosmanpasa Taksim Education and Research Hospital |
And 2 more authors.
Aesthetic Plastic Surgery | Year: 2016
Background: Following rhinoplasty, the cross-sectional parts of the nose may be significantly reduced, and nasal air movement and olfaction may be altered. Studies on olfactory function after surgical procedures are quite limited and have largely focused on sinus surgery or septoplasty. Objectives: The objective of this study is to assess the consequences of spreader grafts on olfactory function. Methods: This prospective study was conducted at the Gaziosmanpaşa Taksim Education and Research Hospital, Department of Otolaryngology, from January 2014 to June 2015. In total, 68 patients who had undergone an open-technique septorhinoplasty were included. In 35 patients, bilateral spreader grafts were included with the open septorhinoplasty (group 1), and 33 patients underwent open septorhinoplasties without spreader grafts (group 2). Results: The age and gender distributions of the patients in the two groups did not differ (p > 0.05). Preoperative threshold, discrimination, and identification values in both groups did not differ (p > 0.05). In groups 1 and 2, postoperative threshold values were significantly higher than preoperative values (p < 0.05). The change in threshold, discrimination, and identification level was significantly higher postoperatively versus preoperatively in group 1 (p < 0.05); however, the changes in discrimination and identification values did not significantly differ between in group 2 (p > 0.05). Conclusions: Our study demonstrates the superior widening effect of spreader grafts over the nasal valve and favorable results in olfactory function in primary septorhinoplasty patients. Level of Evidence IV: This journal requires that the authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266. © 2015, Springer Science+Business Media New York and International Society of Aesthetic Plastic Surgery.
Ozucer B.,Gaziosmanpasa Taksim Education and Research Hospital |
Ozturan O.,Bezmialem Foundation University
Current Opinion in Otolaryngology and Head and Neck Surgery | Year: 2016
Purpose of review To review recent studies on nasal osseocartilaginous anatomy, osteotomy techniques and contemporary methods of nasal bone reshaping carried out under direct vision. Recent findings Current cadaver studies on osseocartilaginous vault anatomy, osteotomy techniques provide valuable information that can reduce outcome variability and increase reliability of osteotomies. Nevertheless, osteotomes have limitations and contemporary approaches - namely, piezoelectric instrumentations, osteoectomy, and osteotomy carried out under direct vision - can provide valuable solutions to certain shortcomings. Contrary to widespread understanding, extended wide periosteal dissection is the common thread in newly introduced methods which claim enhanced control, reduced soft tissue trauma, and reproducible results. Comparative and cadaver studies show promising results regarding protection of underlying mucosa, reduced comminuted fractures, reduced postoperative ecchymosis, and edema. Summary Improvements in nasal bone reshaping are promising for better esthetic and functional outcomes. Nevertheless, these approaches need to be validated by randomized controlled trials and test of time before being incorporated in routine surgical practice. © 2016 Wolters Kluwer Health, Inc.
PubMed | Gaziosmanpasa Taksim Education and Research Hospital
Type: Journal Article | Journal: American journal of rhinology & allergy | Year: 2016
Reactive oxygen species has a crucial role in the pathogenesis of many diseases. Reactive oxygen species has been effectively documented in patients with asthma, but very little research has been reported in subjects with allergic rhinitis.To investigate thiol (SH)-disulfide (SS) homeostasis, a new oxidative stress marker present in patients with seasonal allergic rhinitis (SAR).A total of 64 subjects, including 32 patients with SAR and 32 healthy controls, were included in the study. We measured the SH levels as a marker of antioxidant protection and SS as a marker related to oxidant stress. Sera specimens were taken from patients with SAR during exacerbation and during asymptomatic time periods. In addition, sera samples from the control group were also obtained during the pollen season to compare with those from patients with SAR.In patients with SAR, during exacerbation periods, SH, SS, % SS/SH, % SS to total SH (TT), and % SH/TT were significantly different (p < 0.05) than in patients with SAR during asymptomatic periods. Although SS was significantly higher in patents with SAR during exacerbation periods, SH was significantly higher in patients with SAR during asymptomatic periods. Patients with SAR during asymptomatic periods and the control group did not significantly differ (p > 0.05) regarding SH, SS, TT, % SS/SH, % SS/TT, and % SH/TT.SAR is a disorder that elevates systemic oxidative stress and reduces antioxidant enzyme activities. Our results shed light on the etiopathogenesis of the disease and can help develop new therapeutic approaches.
PubMed | Gaziosmanpasa Taksim Education and Research Hospital
Type: Journal Article | Journal: Diagnostic and interventional radiology (Ankara, Turkey) | Year: 2016
We aimed to investigate the prevalence of lumbar multifidus muscle (LMM) atrophy in patients having mechanical low back pain with and without disc hernia.In total, 2028 lumbar magnetic resonance imaging scans of low back pain patients (age range, 18-88 years) were re-evaluated retrospectively. LMM atrophy was visually assessed in axial sections of L4-L5 and L5-S1 levels.LMM atrophy prevalence at both levels was significantly higher in subjects 40 years compared with younger adults (P < 0.001). LMM atrophy was significantly more frequent in women than in men (P < 0.001). Among patients with low back pain without hernia, LMM atrophy was significantly more frequent than normal muscle (n=559 vs. n=392; P < 0.001). Frequency of LMM atrophy in low back pain patients without disc hernia was 13%. Hernia was more frequent in patients with LMM atrophy compared with patients without atrophy (P < 0.001).LMM atrophy is more common in women; its prevalence and severity are observed to increase with advancing age, and disc hernia is found more frequently in individuals with LMM atrophy.
PubMed | Istanbul Kemerburgaz University and Gaziosmanpasa Taksim Education and Research Hospital
Type: | Journal: Brazilian journal of otorhinolaryngology | Year: 2016
The olfactory system is affected by the nutritional balance and chemical state of the body, serving as an internal sensor. All bodily functions are affected by energy loss, including olfaction; hunger can alter odour perception.In this study, we investigated the effect of fasting on olfactory perception in humans, and also assessed perceptual changes during satiation.The Sniffin Sticks olfactory test was applied after 16h of fasting, and again at least 1h after Ramadan supper during periods of satiation. All participants were informed about the study procedure and provided informed consent. The study protocol was approved by the local Ethics Committee of Gaziosmanpaa Taksim Education and Research Hospital (09/07/2014 no: 60). The study was conducted in accordance with the basic principles of the Declaration of Helsinki.This prospective study included 48 subjects (20 males, 28 females) with a mean age of 33.69.7 (range 20-72) years; their mean height was 169.17.6 (range 150.0-185.0)cm, mean weight was 71.217.6 (range 50.0-85.0)kg, and average BMI was 24.85.3 (range 19.5-55.9). Scores were higher on all items pertaining to olfactory identification, thresholds and discrimination during fasting vs. satiation (p<0.05). Identification (I) results: Identification scores were significantly higher during the fasting (median=14.0) vs. satiation period (median=13.0). Threshold (T) results: Threshold scores were significantly higher during the fasting (median=7.3) vs. satiation period (median=6.2). Discrimination (D) results: Discrimination scores were significantly higher during the fasting (median=14.0) vs. satiation period (median=13.0). The total TDI scores were 35.2 (fasting) vs. 32.6 (satiation). When we compared fasting threshold value of >9 and 9, the gap between the fasting and satiety thresholds was significantly greater in >9 (p<0.05).Olfactory function improved during fasting and declined during satiation. The olfactory system is more sensitive, and more reactive to odours, under starvation conditions, and is characterised by reduced activity during satiation. This situation was more pronounced in patients with a better sense of smell. Olfaction-related neurotransmitters should be the target of further study.