Yanar Y.,Gaziosmanpa a University |
Kadioglu I.,Gaziosmanpa a University |
Gokce A.,Gaziosmanpa a University |
Demirtas B.,University of Science and Arts of Iran |
And 3 more authors.
African Journal of Biotechnology | Year: 2011
Antifungal activities of 26 plant extracts were tested against Phytophthora infestans using radial growth technique. While all tested plant extracts produced some antifungal activities Xanthium strumarium, Lauris nobilis, Salvia officinalis and Styrax officinalis were the most active plants that showed potent antifungal activity. They totally inhibited the mycelial growth of P. infestans. The other tested plant extracts exhibited moderate activity and average daily radial growth of fungus varied from 0.8 to 5.0 mm/day which were significantly lower than the control. The lowest antifungal activity was observed on Cynodon dactylon extract. The minimum inhibitory concentration (MIC) of the extracts ranged between 2 and 8% (w/v). X. strumarium extract produced the lowest MIC value of 2% which was lower than the standard fungicide Ridomil Gold mz 68 WP. Further studies on isolation and characterization of the active (antifungal) compound is needed before the possible use of the tested extracts in control strategies of this fungus. © 2011 Academic Journals.
Tekin S.,University of Art |
Barut S.,Gaziosmanpa a University |
Bursali A.,University of Art |
Aydogan G.,University of Art |
And 3 more authors.
African Journal of Microbiology Research | Year: 2010
Crimean Congo Haemorrhagic Fever (CCHF) is a fatal viral haemorrhagic fever affecting humans. Serious CCHF outbreaks with high mortality have been reported from Asia, Africa and Europe. Endemic CCHF outbreaks have been seen in Turkey between 2002 and 2009, with about 5% mortality rate. People working with animals, people having tick bites, health workers and relatives of CCHF patients may be infected by CCHF virus and therefore they have been considered as CCHF risk groups. In the present study, CCHF prevalence of a control group, people working with animals (PA), people having tick bites (PT), health workers (HW) and relatives of CCHF patients (RP) from Tokat province in Turkey was investigated. A total of 715 people in control and risk groups were tested for the presence of the anti-CCHF IgG in their sera by using anti-CCHF IgG ELISA and compared. Results showed that people working with animals and relatives of CCHF patients had significantly higher CCHF prevalence (p <0.001) than other groups. The higher seroprevalence of CCHF in people working with animals and relatives of patients indicate that they might be infected with CCHFV in a way that clinical symptoms of disease did not occur or not apparent in a hyper endemic region. © 2010 Academic Journals.
PubMed | Gaziosmanpa a University
Type: Journal Article | Journal: Genetics and molecular research : GMR | Year: 2012
The multidrug resistance (MDR1) gene encodes a P-glycoprotein that plays a key role in drug bioavailability and response to drugs in different human populations. More than 50 SNPs have been described for the MDR1 gene. Familial Mediterranean fever (FMF) is considered an autosomal recessive hereditary disease, associated with a single gene named the Mediterranean fever gene (MEFV). However, about one-third of FMF patients have only one mutated allele, suggesting that this disease is expressed as an autosomal dominant trait with partial penetration or an additional gene might be responsible for the disease. We made genotype and haplotype analyses of the MDR1 gene in 142 FMF patients and 130 unrelated Turkish subjects; two MDR-1 genetic markers (C1236T and C3435T) were analyzed by PCR-RFLP analysis. FMF patients had a significantly higher frequency of the 3435 CT genotype compared with the control group (59.9% in FMF patients versus 44.6% in controls; odds ratio [OR] = 1.85; 95% confidence interval [CI] = 1.14-3.00). Based on haplotype analysis, the T-C shift was significantly more frequent in controls (14.4% versus 7.1% in FMF patients). This haplotype could be protective for FMF disease (OR = 0.45; 95%CI = 0.25-0.84). The frequency of CC-CT (1236-3435) binary genotype was significantly higher in FMF patients (14.79% versus 4.61% in controls; OR = 3.59; 95%CI = 1.40-9.20).