Gauhati Medical College Hospital

Assam, India

Gauhati Medical College Hospital

Assam, India
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Borgohain M.P.,National Institute of Pharmaceutical Education and Research | Lahkar M.,National Institute of Pharmaceutical Education and Research | Lahkar M.,Gauhati Medical College & Hospital | Ahmed S.,National Institute of Pharmaceutical Education and Research | And 4 more authors.
Basic and Clinical Pharmacology and Toxicology | Year: 2017

Diabetic nephropathy is one of the major microvascular complications of diabetes mellitus which ultimately gives rise to cardiovascular diseases. Prolonged hyperglycaemia and chronic renal inflammation are the two key players in the development and progression of diabetic nephropathy. Nuclear factor kB (NF-kB)-mediated inflammatory cascade is a strong contributor to the renovascular inflammation in diabetic nephropathy. Here, we studied the effects of piceatannol, a potent NF-kB inhibitor, on various oxidative stress markers and NF-kB dependent diabetic renoinflammatory cascades in rat induced by alloxan (ALX). Experimental diabetes was induced in male Wistar rats by a single intraperitoneal dose, 150 mg/kg body-weight (b.w.) of ALX. Diabetic rats were treated with Piceatannol (PCTNL) at a dose of 30 and 50 mg/kg b.w. After 14 days of oral treatment, PCTNL significantly restored blood sugar level, glomerular filtration rate, serum markers and plasma lipids. PCTNL administration also reversed the declined activity of cellular antioxidant machineries namely superoxide dismutase and glutathione and the elevated levels of malondialdehyde and nitric oxide. Moreover, piceatannol-treated groups showed marked inhibition of renal pro-inflammatory cytokines and NF-kB p65/p50 binding to DNA. Renal histopathological investigations also supported its ameliorative effects against diabetic kidney damage. Importantly, effects were more prominent at a dose of 50 mg/kg, and in terms of body-weight gain, PCTNL failed to effect significantly. However, overall findings clearly demonstrated that PCTNL provides remarkable renoprotection in diabetes by abrogating oxidative stress and NF-kB activation – and might be helpful in early stage of diabetic nephropathy. © 2016 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society)

Goswami A.,Gauhati Medical College Hospital | Baruah A.R.,Gauhati Medical College Hospital
Asian Cardiovascular and Thoracic Annals | Year: 2017

Thymolipoma is an unusual benign tumor of the mediastinum, comprising 2%-9% of thymic neoplasms. Most presentations are atypical. Here we present the case of a 68-year-old man with effort intolerance and fatigue for 4 months. Computed tomography of the chest revealed a lipomatous mass in the anterior mediastinum and bilateral hemithoraces. There were atelectatic changes in both lungs. The tumor was resected via a midline sternotomy. The patient had to be ventilated for 3 days postoperatively. The histopathological diagnosis was pleomorphic thymolipoma. © SAGE Publications.

Sonowal H.,Indian Institute of Technology Guwahati | Kumar A.,Indian Institute of Technology Guwahati | Bhattacharyya J.,Gauhati Medical College Hospital | Gogoi P.K.,Gauhati Medical College Hospital | Jaganathan B.G.,Indian Institute of Technology Guwahati
Journal of Biomedical Science | Year: 2013

Background: Mesenchymal Stem Cells (MSC) are important candidates for therapeutic applications due to their ex vivo proliferation and differentiation capacity. MSC differentiation is controlled by both intrinsic and extrinsic factors and actin cytoskeleton plays a major role in the event. In the current study, we tried to understand the initial molecular mechanisms and pathways that regulate the differentiation of MSC into osteocytes or adipocytes. Results: We observed that actin modification was important during differentiation and differentially regulated during adipogenesis and osteogenesis. Initial disruption of actin polymerization reduced further differentiation of MSC into osteocytes and osteogenic differentiation was accompanied by increase in ERK1/2 and p38 MAPK phosphorylation. However, only p38 MAPK phosphorylation was down regulated upon inhibition of actin polymerization which as accompanied by decreased CD49E expression. Conclusion: Taken together, our results show that actin modification is a pre-requisite for MSC differentiation into osteocytes and adipocytes and osteogenic differentiation is regulated through p38 MAPK phosphorylation. Thus by modifying their cytoskeleton the differentiation potential of MSC could be controlled which might have important implications for tissue repair and regeneration. © 2013 Sonowal et al.; licensee BioMed Central Ltd.

PubMed | Indian Institute of Technology Guwahati and Gauhati Medical College Hospital
Type: Review | Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine | Year: 2016

THY1 (CD90) is a 25-37-kDa heavily N-glycosylated, glycophosphatidylinositol (GPI) anchored cell surface protein. It is usually expressed on thymocytes, mesenchymal stem cells, hematopoietic stem cells, natural killer cells, neurons, endothelial cells, renal glomerular mesangial cells, follicular dendritic cells, fibroblasts, and myofibroblasts. It has been found to regulate cell adhesion, migration, apoptosis, axon growth, cell-cell and cell-matrix interactions, T-cell activation, and fibrosis. Several reports have shown that CD90 has an important role in cancer in regulating cancer cell proliferation, metastasis, and angiogenesis. There are also evidences that CD90 is an important prognostic marker in many cancers. Consequently, therapies that target CD90 have great promise in treating many cancers. However, several studies also indicate a contradictory role for CD90, where it acts as a tumor suppressor. In this review, we summarize the expression, function of CD90 in different cancers and its possible use as a biomarker or a therapeutic target in cancer. The challenges and future prospects for the use of CD90 for clinical applications are also discussed in this review.

Introduction and Objective: Benign prostatic hyperplasia is the most common neoplastic disorder affecting the aging male population worldwide. Various factors such as age, prostate volume, serum prostate-specific antigen, and testicular androgens determine the natural history and its progression. The objective of the study is to correlate the relationship between these factors in men with benign prostatic hyperplasia. Methods: A total of 121 men aged above 50 years with benign prostatic hyperplasia were enrolled in this study. Patients were evaluated by history, digital rectal examination, focused neurological evaluation, uroflowmetry, transrectal ultrasonography of the prostate, serum prostate-specific antigen, serum testosterone (free and total), and prostate biopsy done in patients with prostate-specific antigen > 4 ng/ml to exclude prostatic carcinoma. Patients were divided by age, and a Spearman rank correlation test was done to compare variables. Results: There was a positive correlation within age, prostate volume, and serum prostate-specific antigen level. Age negatively correlated with serum total and free testosterone level. A comparison among serum PSA, prostate volume, and serum testosterone level did not reveal any statistically significant relationship. Conclusion: We observed statistically significant correlations within age, prostate volume, and serum prostatespecific antigen level. These variables bear no significant relationship with serum testosterone levels. Considering the contradictory data on the inter-relationship of various variables, further evaluation in a large cohort of the aging population with benign enlargement of the prostate is needed to establish the influence of one over the other. © 2012 Digital Science Press, Inc.

Nath S.J.,Gauhati Medical College Hospital
UroToday International Journal | Year: 2012

Penile carcinoma with metastasis to umbilicus is a rare entity. We report a case of penile carcinoma with umbilical metastasis in a 46-year-old male. On initial presentation with penile growth over glans and shaft of the penis he was treated by total penectomy with perineal urethrostomy. Three months later, he developed a painful ulcerative mass over umbilicus. Biopsy from the ulcer confirmed metastasis from squamous cell carcinoma penis. Chemotherapy was given, but the patient succumbed to the disease after the first cycle. © 2012 Digital Science Press, Inc.

Bawri B.,Gauhati Medical College Hospital
UroToday International Journal | Year: 2012

Adrenocortical carcinoma (ACC) is a rare tumor that accounts for only 0.02% of all cancers. About 60% of patients present with symptoms of excessive hormone production. However, ACC is usually nonfunctional when it occurs in adults. Its presentation with only virilizing symptoms is extremely rare. We report a case of a huge functional, virilizing ACC of the right adrenal gland that measured 14 cm by 9 cm by 6 cm and weighed 600 gm, which was successfully extirpated. ©2012 Digital Science Press, Inc.

Nath M.P.,Gauhati Medical College Hospital | Chakrabarty A.,Gauhati Medical College Hospital | Choudhary D.,Gauhati Medical College Hospital | Garg R.,Gauhati Medical College Hospital | Talukdar T.,Gauhati Medical College Hospital
Saudi Journal of Anaesthesia | Year: 2012

Background: Intrathecal magnesium has been found to prolong the duration of analgesia in various surgical procedures like lower limb surgeries and as adjuncts to general anesthesia for pain management. The present study was designed to examine whether addition of intrathecal magnesium sulfate would enhance the analgesic efficacy of intrathecal bupivacaine and fentanyl in patients undergoing total abdominal hysterectomy. Methods: After taking informed consent, 60 patients were randomised into two groups with 30 patients. Group "S" received 2.5 mL (12.5 mg) of hyperbaric bupivacaine + 0.5 mL (25 mcg) of fentanyl + 0.5 mL of normal saline and Group "M" received 2.5 mL (12.5 mg) of hyperbaric bupivacaine + 0.5 mL (25 mcg) of fentanyl + 0.5 mL (100 mg) of magnesium sulfate. Onset of sensory, motor block and duration of analgesia was noted. Results: Demographic profile and duration of surgery were comparable (P>0.5). Time of onset of sensory and motor blockade was delayed in Group M compared with Group S, and this was statistically significant. A statistically significant longer duration of analgesia was observed in Group M compared with the control Group S. However, the recovery of motor blockade was found to be statistically insignificant in both the groups. The hemodynamic parameters were comparable in the perioperative period (P>0.05). The incidence of side-effects in both the groups were also comparable (P>0.05). Conclusion: The addition of 100 mg intrathecal magnesium led to prolonged duration of analgesia significantly without increasing the incidence of side-effects. Also, there was a significant delay in the onset of both sensory and motor blockade.

Goswami A.,Gauhati Medical College Hospital | Baruah A.R.,Gauhati Medical College Hospital
Indian Journal of Thoracic and Cardiovascular Surgery | Year: 2016

Internal thoracic artery aneurysms are extremely rare vascular anomalies with very few cases reported so far. Relevant sources of the literature show only a few reported cases. Here we present a case of incidentally diagnosed case of right internal thoracic/mammary artery (RIMA) aneurysm. © 2015, Indian Association of Cardiovascular-Thoracic Surgeons.

Basumatary L.J.,Gauhati Medical College Hospital | Raja D.,Gauhati Medical College and Hospital | Bhuyan D.,Gauhati Medical College and Hospital | Das M.,Gauhati Medical College Hospital | And 2 more authors.
Journal of the Neurological Sciences | Year: 2013

Introduction Japanese encephalitis (JE) is mosquito-borne flaviviral encephalitis that remains to be a major health problem in India - it still continues to cause havoc in many parts of the country. We undertook the study to analyze the clinical & radiological spectrum of JE in adults and children. Method This prospective study consists of 148 patients with JE. The diagnosis of JE was based on clinical, epidemiological, radiological features and demonstration of JE virus specific IgM in CSF and serum by JE virus immunoglobulin M capture enzyme-linked immunosorbent assay (MAC ELISA). All patients underwent a detailed neurological examination, CSF study & neuroimaging of brain (either CT or MRI or both). All patients were followed-up at regular interval. Result Seizures were present in adults (52.88%) and in children (43.18%). Dystonia was more common in children 19 (43.18%) compared to adults 19 (18.2%), and Parkinsonian features were observed in both groups 47 (45.19%) of the adults and 20 (45.45%) of the children. JE-specific IgM antibody was detected in both CSF and serum in 81.7%. In neuroimaging, apart from classical involvement of thalami, basal ganglia & midbrain, prominent involvement of hippocampus and other areas of the cortex was also found in 27 (45.6%) patients. Presence of thalamic lesion in CT/MRI showed significant relationship to the development of dystonia. However, no correlation was found between the neuroimaging features and poor clinical outcome. Twenty three patients (15.5%) died during acute phase of illness. On multivariate logistic regression analysis age, prolonged fever, Glasgow coma scale, recurrent seizures and reflex changes were found to be the predictors of outcome at the time of discharge. Conclusion A trend of severe and frequent involvement in younger patients with dystonia and other movement disorders was observed. It should be emphasized that presence of atypical cranial CT/MRI features in JE was not unknown and they need to be differentiated from herpes simplex encephalitis in appropriate clinical setting. © 2012 Elsevier B.V.

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