Borah M.,Gauhati Medical College and Hospital |
Das S.,Assam Medical College and Hospital
Indian Journal of Pharmacology | Year: 2017
Objectives: To evaluate the antidiabetic, antihyperlipidemic, and antioxidant activities of the ethanolic extracts of the flowers and inflorescence stalk of Musa balbisiana Colla. in streptozotocin (STZ)-induced Type 1 diabetic rats. Materials and Methods: Diabetes was induced in male Wistar albino rats (150-200 g) by single intraperitoneal injection of STZ (60 mg/kg b.w. i.p.). Albino rats (n = 25) were divided into five groups, of which five animals each. Group A (normal control) and Group B (diabetic control) received normal saline (10 ml/kg/day p.o.), whereas Group C and Group D received 250 mg/kg/day p.o. of flower and inflorescence stalk ethanolic extracts, respectively, for 2 weeks. Group E (diabetic standard) received 6 U/kg/day s.c of Neutral Protamine Hagedorn insulin. Fasting blood sugar, serum insulin, catalase (CAT), malondialdehyde (MDA), and serum lipid profile were estimated at specific intervals of time. Effect of the extracts on intestinal glucose absorption was also evaluated to know the probable mechanism of action. Results: Diabetic control exhibited significant increase in blood glucose, serum cholesterol, triglycerides, low-density lipoprotein, serum MDA levels and decreased serum CAT, and high-density lipoprotein levels which were significantly reverted by flower and inflorescence stalk ethanolic extracts after 2 weeks. Serum insulin levels were in increased (P < 0.05), and intestinal glucose absorption decreased significantly (P < 0.01) in extract-treated groups. Conclusion: Flower and inflorescence stalk of M. balbisiana Colla. possess significant antidiabetic, antihyperlipidemic, and antioxidant activities in STZ-induced Type 1 diabetic rats. © 2017 Indian Journal of Pharmacology Published by Wolters Kluwer - Medknow.
Thakur B.K.,Sikkim Manipal Institute of Medical science |
Verma S.,Sikkim Manipal Institute of Medical science |
Hazarika D.,Gauhati Medical College and Hospital
Indian Journal of Dermatology | Year: 2012
Background: Cutaneous tuberculosis forms a small subset of extra pulmonary tuberculosis and has a worldwide distribution. Aims: The present study is an attempt to find out the incidence, clinical spectrum, and histopathological features of cutaneous tuberculosis. Materials and Methods: A total of 42 cases of newly diagnosed patients of cutaneous tuberculosis attending dermatology out patient department over a period of 1 year were included in the study. A detailed clinical examination and investigations including histopathological examination were carried out. Results: Scrofuloderma was the most common form seen in 50% cases followed by lupus vulgaris in 42.86%, tuberculosis verrucosa cutis in 4.76%, and lichen scrofulosorum in 2.38% cases. The Mantoux test was positive in 83.33% cases. Characteristic tuberculoid granulomas were seen in 72.22% cases of lupus vulgaris, 42.86% cases of scrofuloderma and all cases of tuberculosis verrucosa cutis and lichen scrofulosorum. Conclusion: Cutaneous tuberculosis is still highly prevalent in upper Assam. Early diagnosis and treatment are essential to prevent its complications.
Mazumder A.,Gauhati Medical College and Hospital
Journal of Indian Academy of Forensic Medicine | Year: 2014
Pregnancy is the condition of having a developing embryo or foetus in the female, when an ovum is fertilized by spermatozoa. In twin pregnancy there are two developing foetus in the uterus. The present case is a 29 years old lady with 33 weeks twin pregnancy, who died suddenly and brought for medico-legal autopsy. On examination all the organs were found pale. Heart was found enlarged. Left lung was found to be adherent to the under surface of lungs and chest wall. Post-mortem hypostasis was faint and not fixed. Heart, lungs and liver has been send for Histo-pathological examination. Opinion regarding cause of death was kept pending till the receipt of histopathology report. This is a case of sudden death in advanced pregnancy coming to the mortuary of Forensic Medicine, Gauhati Medical College and Hospital. Such cases emerging as a major burden now days and needs thorough discussion. Hence this case was discussed in details.
Jyoti Nath S.,Gauhati Medical College and Hospital
UroToday International Journal | Year: 2013
Introduction: Urolithiasis typically affects adult men more commonly than women with a two- to threefold higher incidence. Stone disease has been found to have an inverse relationship as one ages. This gender and age differentiation invites the role of testosterone as a possible lithogenic factor. Our study aims at determining the role of testosterone as lithogenic factor and its relation to urinary and stone components. Methods: A total of 87 men older than 18 years were enrolled in our study. Early morning free and total testosterone, serum level of the parathyroid hormone, calcium acid, and uric acid were estimated between the 2 groups. Twenty-four hours of urinary oxalate, uric acid, and calcium were estimated in all patients and the control. Stone analysis was done to determine stone composition for stones in the former group. Results: Of the 87 patients, 48 patients had a history of urolithiasis and 39 patients had no history of urolithiasis. In comparison to non-stone formers, stone formers have higher serum-free and total testosterone, and 24-hour urinary oxalate. A positive and weak-positive correlation was found in relation to 24 hours of urinary oxalate for free and total testosterone, respectively. Calcium oxalate stones were found in 40 patients. Other differences between the 2 groups were not statistically significant. Conclusions: A higher serum-free and total testosterone, and 24 hours of urinary oxalate were found in male stone formers compared to non-stone formers. Serum testosterone had a positive correlation to urinary oxalate. These findings have a similarity with animal and human studies. A larger prospective study is necessary to establish testosterone as a lithogenic factor in male former-stone patients. © 2013 Digital Science Press, Inc.
Mazumder S.,Gauhati Medical College and Hospital
UroToday International Journal | Year: 2012
A 15-year-old girl presented with rapid weight gain over a couple of months, depression, and suicidal tendencies. On subsequent evaluation she was found to have Cushingoid features such as centripetal obesity, hirsutism, moon facies, irregular menstrual cycles, and mood disorders. Her blood biochemistry showed raised basal serum cortisol levels and was positive for low and high dexamethasone suppression tests. An ultrasound of the abdomen and later a 64-slice multi-detector computed tomography (MDCT) of the abdomen confirmed an enhanced right-sided adrenal tumor approximately 32 mm x 27 mm x 25 mm. The patient was subjected to open adrenalectomy, and subsequent histopathology revealed adrenal oncocytoma. Postoperative recovery was uneventful. Her serum cortisol done on the eighth postoperative day showed a normal value. Herein we report a rare case of adrenal oncocytic adenoma presenting with Cushing syndrome. © 2012 Digital Science Press, Inc.
Nath J.,Gauhati Medical College and Hospital |
Dubey A.,Bhimrao Ambedkar Multispecialty Hospital |
Pavan R.,Gauhati Medical College and Hospital
Indian Journal of Dermatology, Venereology and Leprology | Year: 2015
Background: Tuberous sclerosis complex (TSC) is a neuro-cutaneous disease characterized by hamartoma formation in various organs particularly the skin, brain, eye, kidney, heart and lungs. Patients usually have multisystem involvement and thus present to different medical specialties with varied complaints while the true nature of the disease and the hidden manifestations may remain unattended. Aim: To assess the frequency and characteristics of various cutaneous and systemic manifestations in TSC and the total impact on different system in a cohort of pediatric patients. Methods: The study included 20 patients fulfilling the diagnostic criteria for TSC from dermatology, pediatrics, and neurology department. Detailed history, examination, and investigations such as chest X-ray, electrocardiography (ECG), ultrasonography (USG) abdomen, echocardiography, fundoscopy, computed tomography (CT) scan of brain and abdomen were done. Results: Dermatological manifestations included ash leaf macules, angiofibromas, shagreen patch, and fibrous plaque. Systemic findings observed were subependymal calcified nodules, subependymal giant cell astrocytoma, cortical tubers, renal cysts, angiomyolipomas, lung cyst, retinal hamartomas, mental deficits and epilepsy. Limitation: Wechsler's Intelligence Scale for Children would have been more appropriate for assessing the intelligence. Dental check-up was not done in our group of patients. Conclusion: Our study highlights the wide variety of cutaneous and systemic manifestations of TSC. The study emphasizes the need for comprehensive multidisciplinary treatment and periodic follow-up which are necessary for appropriate management of this multisystem disorder. Counseling regarding education and rehabilitation of the patients and genetic counseling of parents are important.
Sangma L.N.,Gauhati Medical College and Hospital |
Nath J.,Gauhati Medical College and Hospital |
Bhagabati D.,Gauhati Medical College and Hospital
Indian Journal of Dermatology | Year: 2015
Background : Vitiligo is an acquired discoloration of skin and mucous membrane of great cosmetic importance affecting 1-4% of the world's population. It causes disfiguration in all races, more so in dark-skinned people because of strong contrast. Men, women, and children with vitiligo face severe psychological and social disadvantage. Aim: To assess the impact of the disease on the quality of life of patients suffering from vitiligo, also to ascertain any psychological morbidity like depression associated with the disease and to compare the results with that of healthy control group. Materials and Methods: Dermatology Life Quality Index (DLQI) and Hamilton Depression Rating Scale (HAMD) are administered to 100 vitiligo patients presenting to the Dermatology OPD and 50 age- and sex-matched healthy controls. Results were analyzed and compared with that of control group. Findings are also correlated in relation to demographic and clinical profile of the disease. Statistical analysis is made to see the significance. Results : Vitiligo-affected patients had significantly elevated total DLQI scores (P < 0.001) compared to healthy controls. There is increase in parameters like itch, embarrassment, social and leisure activities in the patient cohort than the control group. Patients of vitiligo are also found to be more depressed (P < 0.001) than the controls. Conclusion : Quality of life (QOL) in patients affected with vitiligo declined more severely, and also there is increase in incidence of depression than in the control group. These changes are critical for the psychosocial life of the affected people. © 2015, Medical Knowledge. All rights reserved.
Kumar R.,Gauhati Medical College and Hospital |
Phookun H.R.,Gauhati Medical College and Hospital |
Datta A.,Gauhati Medical College and Hospital
Asian Journal of Psychiatry | Year: 2014
Objective: Koro is a culture bound syndrome, endemic in South-East Asia. The present study attempts to correlate the socio-cultural and demographic variables of the patients with the occurrence of the Koro and the differences in presentation between the classical features of the Koro and the actual presentation of the disease that has been observed in the present study. Method: A cross-sectional observational study was performed and data collected during the period was compared, analyzed and studied. A total number of 70 patients who presented to the Department of Psychiatry with symptoms of Koro over the period of 5 days were taken into the study. Results: Most of the patients were, young, unmarried males belonging to a lower socioeconomic status. Most of these patients suffered the attacks in the evening mostly while at home. It was common in migrant and migrant lineage. Media had a major role to spread this epidemic. Conclusions: Koro epidemics are considered to be the result of panic that spread following the occurrence of symptoms in one or more individuals within the same geographical zone. While the issues concerning phenomenology, diagnosis and nosology of Koro are still being discussed, it is apparent that Koro which presents as an acute anxiety state is treatment responsive and has good prognosis. © 2014 Elsevier B.V.
Choudhury D.K.,Gauhati Medical College and Hospital |
Bezbaruah B.K.,Gauhati Medical College and Hospital
Indian Journal of Pharmacology | Year: 2016
Objectives: The aim of this study is to evaluate the prescribing pattern of analgesics and analyze the rational use of analgesic in orthopedic in-patient department of tertiary care teaching hospital, Guwahati, Assam. Subjects and Methods: An observational and cross-sectional study was carried out for 1 month from April to May 2014. Collected data included age, sex, diagnosis and line of management during the study. The generic name and the average cost of treatment per patient were evaluated using Indian Drug Review, 2014. The prescribed drugs were assessed with respective National Model List of Essential Medicines (NLEM), 2011 and the rationality of prescriptions was determined using the World Health Organization indicators of drug utilization. The patients' details were recorded in a predeigned data collection form and results were analyzed by descriptive statistics. Results: Out of 200 patients, 123 were male and 77 were female. The average number of analgesic per prescription was 1.46. In this study, 55.5% of patients had received single analgesic. Diclofenac was the most commonly prescribed analgesic (43.49%). During hospitalization, majority of the patients have received parenteral preparation. Gastroprotective agents and antimicrobials were frequently prescribed along with analgesics. Out of 292 analgesics prescribed, 183 (62.67%) were from the NLEM, India. Furthermore, 176 (57.19%) analgesics were prescribed by generic name. The average cost of treatment per patient was 2151.72 INR. Utilization of analgesic in terms of defined daily dose/100 bed-days was 104.01. Conclusion: The percentages of analgesics prescribing from NLEM and the use of analgesic by generic name were found satisfactory. Regular educational interventions to improve prescribing practices among physicians at different levels may further promote rational prescribing. © 2016 Indian Journal of Pharmacology Published by Wolters Kluwer - Medknow.
Mahanta P.,Gauhati Medical College and Hospital
International Journal of Medical Toxicology and Legal Medicine | Year: 2010
This presentation describes 100 deaths with abdomino-pelvic injuries. Most vulnerable age group was (21-30) years with male female ratio 9:1. Incidence of lower socioeconomic, under graduate, bachelor and businessmen group was more. Urban incidents were more with 43% that to in between 09.01pm to 12.00 am. A heavy truck was the most common offending vehicle with pedestrian as common category. Spleen was the most common (52%) organ injured. Peritoneal haemorrhages (54%) were the common accompanying finding. Injuries to two or more than two body region were present in 27% of cases. The present study also described four burn cases. Maximum (34%) cases died on spot. Person of age group 21-30 years and 31-40 years had long survival period as compared to the children up to 10 years of age and elderly people more than 60 years. Shock and haemorrhage was the main cause of death for 55% of cases. Seat belt and crash helmets were found important besides other like mass people education in preventing fatal injuries. Development of infrastructure of road agent and easy availability of multi disciplinary medical staff as and where required is also equally important.