Tekeli H.,GATA Haydarpasa Training Hospital |
Altundag A.,Istanbul Surgery Hospital |
Salihoglu M.,GATA Haydarpasa Training Hospital |
Cayonu M.,Amasya University |
Kendirli M.T.,GATA Haydarpasa Training Hospital
Medical Science Monitor | Year: 2013
Background: Olfactory assessment is often neglected in clinical practice, although olfactory loss can assist in diagnosis and may lead to significant morbidity. "Sniffin' Sticks" is a modern test of nasal chemosensory performance that was developed in Germany and validated in many countries. Our aim was to validate the applicability of "Sniffin' Sticks" in a Turkish population. Material/Methods: The study included 123 healthy volunteers with a reported normal sense of smell and 51 patients complaining of a reduction in their olfactory function presenting either at rhinology or neurology clinics. The mean age of the subjects tested was 30.2±12.5 years in 126 males and 48 females. The participants were divided into 2 groups according to subjective olfactory function - healthy or abnormal. Each subject's olfactory function was assessed using the "Sniffin' Sticks" test. Results: We found significant differences in "Sniffin' Sticks" test results between the abnormal and healthy groups. In healthy subjects, the 10th percentiles of odor threshold score, odor discrimination score, odor identification score, and TDI score were 7.25, 12, 11, and 32, respectively. Considering the 2 groups together, apple and turpentine were the least well-recognized odors from the 16 odors presented. Conclusions: Our study provides an update of normative values for routine clinical use of "Sniffin' Sticks" in a Turkish population. Also, the present study validates that "Sniffin' Sticks" olfactory test was applicable for clinical usage in a Turkish population. © Med Sci Monit, 2013.
Aydemir G.,GATA Haydarpasa Training Hospital |
Ozkurt F.E.,Turkish Naval High School Infirmary
Journal of International Medical Research | Year: 2011
The prevalence of otitis media with effusion (OME) and environmental risk factors were investigated in 423 children aged 7-12 years at three primary schools in Princes' Islands, Istanbul, Turkey. An ear, nose and throat examination, including tympanometry, was performed in April (end of the school year) and the families completed a questionnaire about potential risk factors. Type B or C2 tympanograms were taken as indicating OME. The overall prevalence of OME was 16%. OME was significantly associated with numbers of episodes of upper respiratory tract infections (URTI) and acute otitis media (AOM) during the previous year, class size and snoring, but not with allergic symptoms, kindergarten years, breastfeeding duration, parental smoking, domestic animals at home, numbers of siblings and family members, type of home heating, parents' educational level or monthly income. Four or more URTIs and two or more AOM episodes in a year, snoring and class size larger than 20 were risk factors for OME. © 2011 Field House Publishing LLP.
Oktenli C.,Anadolu Medical Center |
Celik S.,GATA Haydarpasa Training Hospital
International Journal of Hematology | Year: 2012
Familial Mediterranean fever is an autosomal recessive disease occurring in populations originating from the Mediterranean basin. This autoinflammatory syndrome is caused by mutations in the Mediterranean FeVer (MEFV) gene. MEFV encodes a 781 amino acid protein known as pyrin. Pyrin is an important modulator of apoptosis, inflammation, and cytokine processing. In more recent pilot studies, inherited variant analysis of the MEFV gene in patients with hematologic neoplasm showed an unexpectedly high frequency of these variants in the gene. Here, we summarize the current state of knowledge of the relationship between inherited variants in the MEFV gene and hematologic neoplasms. Although no single underlying defect could be targeted in all hematologic neoplasms, it will be important to fully exploit the mechanisms underlying the neoplasm promoting role of inherited variants in MEFV. However, it is unclear how inherited variants in the MEFV gene are associated with tumor susceptibility or promotion in hematologic neoplasms. Further investigations are needed to determine the actual role of the MEFV gene in pathogenesis of these neoplasms. © 2012 The Japanese Society of Hematology.
Extensively drug resistant and extremely drug resistant tuberculosis forms after multi-drug resistant tuberculosis: New faces of the old disease [Çok Ilaca Dirençli Tüberkülozdan Sonra Yaygin Ilaca Dirençli ve Tum ilaçlara Dirençli Tüberküloz Formlari: Eski Hastahgm Yeni Yüzleri]
Baylan O.,GATA Haydarpasa Training Hospital
Mikrobiyoloji Bulteni | Year: 2011
Drug resistance in tuberculosis is a growing global problem. The emergence of multi-drug resistant tuberculosis cases, particularly in the 1990s, has become an important health problem and threatens tuberculosis control worldwide. Resistance to isoniazid and rifampicin, two of the most potent anti-tuberculosis drugs currently available, in multi-drug resistant tuberculosis cases is clinically quite important. The treatment of multi-drug resistant tuberculosis requires prolonged use of costly second-line drugs with significant toxic potentials under supervision and long-term hospitalization of patients. The appropriate management of tuberculosis, clinical/radiological and bacteriological follow-up, and surgery when needed are essential factors in the successful treatment of multi-drug resistant tuberculosis patients. An extensively drug resistant tuberculosis outbreak seen in KwaZulu-Natal region of the Republic of South Africa in 2005 led to certain doubts worldwide; this outbreak, introduced the importance and emergence of the counter measures against multi-drug resistant tuberculosis cases. Extensively drug resistant tuberculosis is defined as resistance to at least isoniazid and rifampicin from the first-line anti-tuberculosis drugs (the definition of multi-drug resistant tuberculosis) in addition to resistance to any fluoroquinolone, and to at least one of the three injectable second-line anti-tuberculosis drugs (kanamycin, capreomycin and amikacin) used in tuberculosis treatment. Mistreatment of multi-drug resistant tuberculosis cases by physicians, the use of anti-tuberculosis drugs with low quality, poor experience in management, lack of laboratories to perform second-line anti-tuberculosis drug susceptibility testing and problems in adherence of patients to treatment are factors associated to the development of extensively drug resistant tuberculosis. With the emergence of extensively drug resistant tuberculosis, World Health Organization gives importance to the mycobacteriology laboratory improvement, better multi-drug resistant tuberculosis case management, adequate drug supply, prevention of tuberculosis transmission and development of new drugs and diagnostics. Recently, a new form of tuberculosis, resistant to all first-and second-line anti-tuberculosis drugs seen in just a few number of cases, has been defined as extremely drug resistant tuberculosis and this is the end point in resistance problem in tuberculosis. In the view of this situation the stages of tuberculosis in terms of developing resistance are as follows: drugsensitive tuberculosis, mono-drug resistant tuberculosis, poly-drug resistant tuberculosis, multi-drug resistant tuberculosis, extensively drug resistant tuberculosis, and extensively drug resistant tuberculosis. In this review, the recent information about drug resistant tuberculosis forms, particularly extremely drug resistant tuberculosis that has been popular since 2005, has been discussed.
Baloglu H.,GATA Haydarpasa Training Hospital |
Yigit N.,GATA Haydarpasa Training Hospital
Cancer Letters | Year: 2011
Epithelia and stroma are the main components of carcinomas that have impact on carcinogenesis. Many of the genetic changes harboring in the epithelia may possibly be seen in stromal cells during neoplastic transformation. We intended to investigate weather KRAS mutations are shared by the stromal cells in colorectal adenocarcinomas. Forty cases with KRAS mutation were studied. Glandular/epithelial and the stromal components of each primary tumor were collected and KRAS mutation analysis was performed. None of the cases revealed KRAS mutations in stromal integral. We concluded that stromal cells in colorectal carcinoma do not share KRAS mutations that the epithelial component harbors. © 2011 Elsevier Ireland Ltd.
Tanoglu A.,GATA Haydarpasa Training Hospital |
Karagoz E.,GATA Haydarpasa Training Hospital
Rheumatology International | Year: 2014
We read with interest the recent article 'The relationship of neutrophil-to-lymphocyte ratio with gastrointestinal bleeding in Henoch-Schonlein purpura' by Makay et al. (Rheumatol Int. doi: 10.1007/s00296-014-2986-2 , 2014). In their study, researchers aimed to evaluate the relationship between blood neutrophil to lymphocyte ratio (NLR) and gastrointestinal bleeding in children with Henoch-Schonlein purpura (HSP). In discussion part, the authors concluded that blood NLR may be considered as a useful marker for predicting gastrointestinal bleeding in HSP. We would like to thank Makay et al. for their valuable contribution. © 2014 Springer-Verlag.
Okutan O.,GATA Haydarpasa Training Hospital |
Ayten O.,GATA Haydarpasa Training Hospital
Tuberkuloz ve Toraks | Year: 2014
Venous thromboembolism (VTE) is one of the complications which have significant influence on mortality in patient with cancer. Early mortality rate is high in cancer patients who have VTE. This complication is related with cell type and stage of the cancer, surgery applied during cancer treatment, applying catheter and the chemotherapeutic agents. VTE prophylaxis and/or treatment in treatment and follow-up of cancer patients will provide a reduction in mortality and morbidity rates. VTE prophylaxis and treatment poses differences according to both treatment approaches which will be applied and the type of cancer. It has been aimed to describe pathogenesis, risk factors and treatment approaches taking into account international consensus reports in this review. © 2014 Ankara University. All rights reserved.
Hatipoglu M.,GATA Haydarpasa Training Hospital |
Turhan V.,GATA Haydarpasa Training Hospital
Mikrobiyoloji Bulteni | Year: 2014
We read the article entitled "Investigation of the presence of New Delhi metallo- beta-lactamase-1 (NDM-1) by PCR in carbapenem-resistant gram-negative isolates" by Yanik et al. [Mikrobiyol Bul 2013; 47(2):382], with a great interest. Today, gram-negative enteric bacteria expressing NDM-1 are spreading rapidly all over the world and this is of great concern when increasing carbapenem resistance is considered. Yanik et al. reported that there were no NDM-1 positive Isolates in their study involving a part of Turkey. It is well-known that the most sensitive Indicator related to carbapenem resistance is ertapenem resistance [Perçin et al. Mikrobiyol Bul 2012; 46(4);546], In their study Yanik et al. used imlpenem, meropenem or dorlpenem instead of ertapenem resistance for screening carbapenem resistance. Thus, carbapenem-resistant strains might be unnoticed In their study. They also used Modified Hodge Test MHT for the Investigation of carbapenem resistance In the second stage of their study. MHT is known to have a low sensitivity as a screening test for NDM-1 positive strains. To Increase its sensitivity, ZnS04 should be added to the culture medium [Girlich et al. J Clin Microbiol 2012; 50(2):477]. However, this issue was not specified in Yanik et al's study. Thus, this may be another possible cause of failure to detect NDM-1 expressing strains. Yanik et al. reported in their study that NDM-1-producing isolates were not detected in Turkey. However, very recently, four NDM-1 isolates which were not associated with importation from abroad, were reported in a study from Turkey [Alp et al. J Hosp Infect 2013; 84(2):178] and this was the first report of domestic NDM-1 secreting strains in Turkey. In conclusion, there is a need in our country to a carbapenem group antibiotic investigate the presence of NDM-1 positive strains. The use of ertapenem for screening carbapenem resistance and also adding ZnS04 to MHT for the detection of NDM-1 strains are of great importance.
Hachamdioglu B.,GATA Haydarpasa Training Hospital |
Hachamdioglu D.,GATA Haydarpasa Training Hospital |
Delil K.,Marmara University
Application of Clinical Genetics | Year: 2015
Chromosome 22q11 is characterized by the presence of chromosome-specific low-copy repeats or segmental duplications. This region of the chromosome is very unstable and susceptible to mutations. The misalignment of low-copy repeats during nonallelic homologous recombination leads to the deletion of the 22q11.2 region, which results in 22q11 deletion syndrome (22q11DS). The 22q11.2 deletion is associated with a wide variety of phenotypes. The term 22q11DS is an umbrella term that is used to encompass all 22q11.2 deletion-associated phenotypes. The haploinsufficiency of genes located at 22q11.2 affects the early morphogenesis of the pharyngeal arches, heart, skeleton, and brain. TBX1 is the most important gene for 22q11DS. This syndrome can ultimately affect many organs or systems; therefore, it has a very wide phenotypic spectrum. An increasing amount of information is available related to the pathogenesis, clinical phenotypes, and management of this syndrome in recent years. This review summarizes the current clinical and genetic status related to 22q11DS. © 2015 Hacıhamdioğlu et al.
Aykan U.,GATA Haydarpasa Training Hospital |
Erdurmus M.,GATA Haydarpasa Training Hospital |
Yilmaz B.,GATA Haydarpasa Training Hospital |
Bilge A.H.,GATA Haydarpasa Training Hospital
Graefe's Archive for Clinical and Experimental Ophthalmology | Year: 2010
Background: To evaluate the effect of the Valsalva maneuver (VM) on short-term variations of intraocular pressure (IOP) and ocular pulse amplitude (OPA) values in healthy, young, male subjects. Methods: IOP and OPA values were measured before and during VM by Pascal dynamic contour tonometer (DCT) in 55 eyes of 55 healthy male volunteers aged 20 through 27 years. Results: Mean IOP before VM was 17.2 ± 2.9 mmHg and during the VM was 19.8 ± 4 mmHg. The increase in mean IOP during the VM was found to be statistically significant (p = 0.001). The IOP increased in 46 (83.6%) of 55 eyes. However, in nine eyes (16.4%), IOP decreased during the VM. Mean OPA value before VM was 3.6 ± 1.4 mmHg and during the VM was 3.6 ± 1.3 mmHg. The change in mean OPA value was found to be statistically insignificant (p = 0.9). Conclusions: The IOP significantly increases during VM, whereas OPA remains stable. Strong autoregulatory mechanisms may provide consistent ocular perfusion in healthy subjects during VM. © 2010 Springer-Verlag.