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Oktenli C.,Anadolu Medical Center | Celik S.,GATA Haydarpasa Training Hospital
International Journal of Hematology | Year: 2012

Familial Mediterranean fever is an autosomal recessive disease occurring in populations originating from the Mediterranean basin. This autoinflammatory syndrome is caused by mutations in the Mediterranean FeVer (MEFV) gene. MEFV encodes a 781 amino acid protein known as pyrin. Pyrin is an important modulator of apoptosis, inflammation, and cytokine processing. In more recent pilot studies, inherited variant analysis of the MEFV gene in patients with hematologic neoplasm showed an unexpectedly high frequency of these variants in the gene. Here, we summarize the current state of knowledge of the relationship between inherited variants in the MEFV gene and hematologic neoplasms. Although no single underlying defect could be targeted in all hematologic neoplasms, it will be important to fully exploit the mechanisms underlying the neoplasm promoting role of inherited variants in MEFV. However, it is unclear how inherited variants in the MEFV gene are associated with tumor susceptibility or promotion in hematologic neoplasms. Further investigations are needed to determine the actual role of the MEFV gene in pathogenesis of these neoplasms. © 2012 The Japanese Society of Hematology.

Drug resistance in tuberculosis is a growing global problem. The emergence of multi-drug resistant tuberculosis cases, particularly in the 1990s, has become an important health problem and threatens tuberculosis control worldwide. Resistance to isoniazid and rifampicin, two of the most potent anti-tuberculosis drugs currently available, in multi-drug resistant tuberculosis cases is clinically quite important. The treatment of multi-drug resistant tuberculosis requires prolonged use of costly second-line drugs with significant toxic potentials under supervision and long-term hospitalization of patients. The appropriate management of tuberculosis, clinical/radiological and bacteriological follow-up, and surgery when needed are essential factors in the successful treatment of multi-drug resistant tuberculosis patients. An extensively drug resistant tuberculosis outbreak seen in KwaZulu-Natal region of the Republic of South Africa in 2005 led to certain doubts worldwide; this outbreak, introduced the importance and emergence of the counter measures against multi-drug resistant tuberculosis cases. Extensively drug resistant tuberculosis is defined as resistance to at least isoniazid and rifampicin from the first-line anti-tuberculosis drugs (the definition of multi-drug resistant tuberculosis) in addition to resistance to any fluoroquinolone, and to at least one of the three injectable second-line anti-tuberculosis drugs (kanamycin, capreomycin and amikacin) used in tuberculosis treatment. Mistreatment of multi-drug resistant tuberculosis cases by physicians, the use of anti-tuberculosis drugs with low quality, poor experience in management, lack of laboratories to perform second-line anti-tuberculosis drug susceptibility testing and problems in adherence of patients to treatment are factors associated to the development of extensively drug resistant tuberculosis. With the emergence of extensively drug resistant tuberculosis, World Health Organization gives importance to the mycobacteriology laboratory improvement, better multi-drug resistant tuberculosis case management, adequate drug supply, prevention of tuberculosis transmission and development of new drugs and diagnostics. Recently, a new form of tuberculosis, resistant to all first-and second-line anti-tuberculosis drugs seen in just a few number of cases, has been defined as extremely drug resistant tuberculosis and this is the end point in resistance problem in tuberculosis. In the view of this situation the stages of tuberculosis in terms of developing resistance are as follows: drugsensitive tuberculosis, mono-drug resistant tuberculosis, poly-drug resistant tuberculosis, multi-drug resistant tuberculosis, extensively drug resistant tuberculosis, and extensively drug resistant tuberculosis. In this review, the recent information about drug resistant tuberculosis forms, particularly extremely drug resistant tuberculosis that has been popular since 2005, has been discussed.

Aydemir G.,GATA Haydarpasa Training Hospital | Ozkurt F.E.,Turkish Naval High School Infirmary
Journal of International Medical Research | Year: 2011

The prevalence of otitis media with effusion (OME) and environmental risk factors were investigated in 423 children aged 7-12 years at three primary schools in Princes' Islands, Istanbul, Turkey. An ear, nose and throat examination, including tympanometry, was performed in April (end of the school year) and the families completed a questionnaire about potential risk factors. Type B or C2 tympanograms were taken as indicating OME. The overall prevalence of OME was 16%. OME was significantly associated with numbers of episodes of upper respiratory tract infections (URTI) and acute otitis media (AOM) during the previous year, class size and snoring, but not with allergic symptoms, kindergarten years, breastfeeding duration, parental smoking, domestic animals at home, numbers of siblings and family members, type of home heating, parents' educational level or monthly income. Four or more URTIs and two or more AOM episodes in a year, snoring and class size larger than 20 were risk factors for OME. © 2011 Field House Publishing LLP.

Baloglu H.,GATA Haydarpasa Training Hospital | Yigit N.,GATA Haydarpasa Training Hospital
Cancer Letters | Year: 2011

Epithelia and stroma are the main components of carcinomas that have impact on carcinogenesis. Many of the genetic changes harboring in the epithelia may possibly be seen in stromal cells during neoplastic transformation. We intended to investigate weather KRAS mutations are shared by the stromal cells in colorectal adenocarcinomas. Forty cases with KRAS mutation were studied. Glandular/epithelial and the stromal components of each primary tumor were collected and KRAS mutation analysis was performed. None of the cases revealed KRAS mutations in stromal integral. We concluded that stromal cells in colorectal carcinoma do not share KRAS mutations that the epithelial component harbors. © 2011 Elsevier Ireland Ltd.

Tanoglu A.,GATA Haydarpasa Training Hospital | Karagoz E.,GATA Haydarpasa Training Hospital
Rheumatology International | Year: 2014

We read with interest the recent article 'The relationship of neutrophil-to-lymphocyte ratio with gastrointestinal bleeding in Henoch-Schonlein purpura' by Makay et al. (Rheumatol Int. doi: 10.1007/s00296-014-2986-2 , 2014). In their study, researchers aimed to evaluate the relationship between blood neutrophil to lymphocyte ratio (NLR) and gastrointestinal bleeding in children with Henoch-Schonlein purpura (HSP). In discussion part, the authors concluded that blood NLR may be considered as a useful marker for predicting gastrointestinal bleeding in HSP. We would like to thank Makay et al. for their valuable contribution. © 2014 Springer-Verlag.

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