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Ankara, Turkey

Bozoglu E.,GATA
Turkiye Klinikleri Journal of Medical Sciences | Year: 2010

Both factitious disorders and malingering are called as simulation have a broad spectrum of presentations extending from its milder form only a slight exaggeration of physical symptoms to extreme and dramatic form called Munchausen's syndrome. Simulation may be imitated in multiple ways such as confabulation, faking symptoms, ingestion or injection of substances, tampering with specimens or instruments. Stress, personality disorders and psychodynamic factors may play role in pathogenesis. Simulation contributes to more frequent and unnecessary use of medical services by extensive and repeat testing leading to significant expense and potential morbidity. The simulations may be suspected when a patient's medical history has gaps or inconsistencies and laboratory studies are atypical, and when there is a potential external primary gain, absence of patient cooperation during diagnostic evaluation and a lack of response to treatment. The diagnosis of simulation is based on taking an appropriate history, performing a standard physical examination, and reviewing previous records. Collaboration with psychiatrists in patient management and treatment of identified underlying psychological disorders is recommended. © 2010 by Türkiye Klinikleri. Source

Kose O.,GATA | Ozdogan S.,Dermatoloji Klinigi
Turkiye Klinikleri Dermatoloji | Year: 2010

In recent years, there has been an explosion of interest in stem cells, not just within the scientific and medical communities but also among politician and religious groups. There are two different origins of stem cell systems; embriyonic stem cells and adult stem cells. Epidermal stem cells which as an adult stem cells lie within specific niches in the hair follicle and the epidermis. These stem cells have been classically characterized as slow-cycling, long-lived cells that reside in discrete niches in the skin. Gene expression studies of niche-resident cells have revealed a number of stem cell markers and regulators, including the p63, beta-integrin, keratin 15, CD44, Wnt/beta-catenin, c-Myc pathways. Epidermal stem cells in the epidermis not only ensure the maintenance of epidermal homeostasis and hair regeneration, but also contribute to repair of the epidermis after injury. Also recent studies showed that adult skin tissues contain cell populations with pluripotent characteristics. Multipotent stem cells from skin both in epidermal and dermal tissues can differentiate and generate multiple cell lineages. In this review, we aimed an overview of epidermal stem cells for better understanding their functions in the skin. Their use has also proven to be of importance on the aetiopathogenesis of genetic, neoplastic and inflammatory dermatoses, as well as in the prognosis and expansion of therapeutic options of these disorders. The potential uses of epidermal stem cells in prognosis and in expanding the therapeutic options will also be discussed. Copyright © 2010 by Türkiye Klinikleri. Source

Dental erosion is irreversible hard tissue loss resulting from any kind of chemical effect in the absence of bacterial, mechanical and traumatic causes. Diagnosis of erosion in the early period is very important since it is an irreversible process. Restorative treatment of teeth affected by erosion protects pulpal tissue, increases resistance of the tooth and sustains the continuation of oral hygiene and esthetics. However in most cases, restorative treatment is not preferred because of the difficulty of treatment, the risk of biomechanical failure and the cost of treatment. In this case, a prosthetic restoration would provide more succesful results in ensuring both esthetic and functional continuity. In this review, factors causing dental erosion and methods of treatment are presented. © Gülhane Askeri Ti{dotless}p Akademisi 2012. Source

Keskin G.,Diskapi Yildirim Beyazit Training and Research Hospital | Inal A.,GATA | Ozisik L.,DYBEA Hospital
Protein and Peptide Letters | Year: 2010

Familial mediterranean fever (FMF) is a systemic disorder characterized by recurrent attacks of fever and polyserositis. In FMF, several pro-inflammatory cytokines, such as IL-6, have been found to be elevated during the attacks. In recent years, it is shown that some proteins originated from adipose tissue play important role in inflammatory process. One of them, adiponectin decreases the expression of adhesion molecules and inhibits the attachment of active macrophages to the endothelial surface, so that it acts antiinflammatory effect. In this study, we analyzed the possible role of serum adiponectin in the pathogenesis of FMF. Thirty five patients with FMF and 13 healthy controls (5 female,8 male; mean age 22.3 ± 4.2 years) were enrolled in this study. Fifteen patients were in active stage (6 female, 9 male, mean age; 22.4 ± 4.1 years, mean disease duration 6.1±2.3 years) and 20 patients were in inactive stage (6 female,14 male, mean age;22.6 ±4.2 years, mean disease duration; 5.7 ± 1.6 years). Serum adiponectin and IL-6 levels were determined by ELISA. The mean serum adiponectin levels were 5.3 ±1.6 ng/ml in healthy controls, 55.3 ± 21.8 ng/ml in active FMF patients and 17.1 ± 4.7 ng/ml in inactive FMF patients. The mean serum IL-6 levels were 1.9 ± 0.4 ng/ml in healthy controls, 4.7 ± 1.1 ng/ml in active FMF patients and 2.9 ± 1.3 ng/ml in inactive FMF patients. Serum adiponectin levels in patients with FMF were significantly higher than in healthy controls (p<0.001). Serum adiponectin levels were significantly high both in active FMF patients and in inactive FMF patients compared with healthy control (p<0.001, p<0.001 respectively). Serum IL-6 levels were significantly higher both in patients with active and inactive disease as compared with healthy controls (p<0.01 and p<0.05 respectively). In FMF, serum adiponectin levels were correlated with high levels of serum IL-6 in the active and inactive patients. Serum adiponectin and IL-6 levels were high during both active and inactive stages in patients with FMF. © 2010 Bentham Science Publishers Ltd. Source

Kolsuz M.E.,Ankara University | Bagis N.,Ankara University | Orhan K.,Ankara University | Avsever H.,GATA | Demiralp K.O.,Public Hospitals Agency of Turkey
Dentomaxillofacial Radiology | Year: 2015

Objectives: This study assessed the influence of different voxel resolutions of two different CBCT units on the in vitro detection of periodontal defects. Methods: The study used 12 dry skulls with a maxilla and a mandible. Artificial defects (dehiscence, tunnel, fenestration) were separately created on the anterior, premolar and molar teeth using burrs. A total of 14 dehiscences, 13 fenestrations, 8 tunnels and 16 non-defect controls were used in the study. Images were obtained from two different CBCT units in six voxel sizes (voxel size: 0.080, 0.100, 0.125, 0.150, 0.160 and 0.200mm3). Kappa coefficients were calculated to assess both intra-and interobserver agreements for each image set. Results: Overall intraobserver kappa coefficients ranged between 0.978 and 0.973 for the 0.080-mm3 images and between 0.751 and 0.737 for the 0.160-mm3 images, suggesting notably high intraobserver agreement for detecting periodontal defects. CBCT performed significantly better at detecting fenestrations (p<.05) than tunnel and dehiscence defects. No statistically significant difference was found between the detection of dehiscence and tunnel defects (p>.05). Conclusions: A voxel size of 0.150mm3 was identified as the cut-off point for overall detection of periodontal defects. CBCT should be considered the most reliable imaging modality for the diagnosis of periodontal defects. © 2015 The Authors. Source

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