Gastrointestinal and Liver Diseases Research Center

Rasht, Iran

Gastrointestinal and Liver Diseases Research Center

Rasht, Iran
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Shafaghi A.,Gastrointestinal and Liver Diseases Research Center | Mansour-Ghanaei F.,Gastrointestinal and Liver Diseases Research Center | Joukar F.,Gastrointestinal and Liver Diseases Research Center | Sharafkhah M.,Tehran University of Medical Sciences | And 10 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2013

Background: Iran is a country with very high incidences of stomach cancer, especially in Northern parts. Here we assessed prognostic value of serum screening biomarkers among people >50 years old for early detection of precancerous lesions in a hot spot for gastric carcinoma in Guilan Province, North Iran. Methods: A crosssectional population-based survey was conducted on 1,390 residents of Lashtenasha city with the mean age (SD) of 61.8 (9.02) years old (50.8% females) to assess the association of gastrin and the pepsinogen (PG) I/II ratio with premalignant gastric lesions. Blood samples were taken for CBC, blood group, and serologic exams (PGI, PGII, and gastrin 17) from each subject. Expert gastroenterologists performed upper GI endoscopy and ROC curves were generated to determine appropriate cutoff points. Results: Mean values of PGI, PGII, PGI/PGII and gastrin were significantly different between patients with and without atrophy or metaplasia (P<0.05). To diagnose atrophy and intestinal metaplasia, a significantly higher AUC was observed for the PGI/PGII ratio (70 and 72%, respectively) compared to the PGI (56, 55%), PGII (63, 64%) and gastrin (59, 61%) (all p<0.001). Conclusions: Biomarker tests such as the PGI/II ratio can be used in the screening and diagnosis of subjects at high gastric cancer risk in our region.


Mansour-Ghanaei F.,Gastrointestinal and Liver Diseases Research Center | Sokhanvar H.,Gastrointestinal and Liver Diseases Research Center | Joukar F.,Gastrointestinal and Liver Diseases Research Center | Shafaghi A.,Gastrointestinal and Liver Diseases Research Center | And 9 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2012

Background & Objectives: Gastric cancer is a leading cause of cancer-related deaths in both sexes in Iran. This study was designed to assess upper GI endoscopic findings among people > 50 years targeted in a mass screening program in a hot-point region. Methods: Based on the pilot results in Guilan Cancer Registry study (GCRS), one of the high point regions for GC -Lashtenesha- was selected. The target population was called mainly using two methods: in rural regions, by house-house direct referral and in urban areas using public media. Upper GI endoscopy was performed by trained endoscopists. All participants underwent biopsies for rapid urea test (RUT) from the antrum and also further biopsies from five defined points of stomach for detection of precancerous lesions. In cases of visible gross lesions, more diagnostic biopsies were taken and submitted for histopathologic evaluation. Results: Of 1,394 initial participants, finally 1,382 persons (702 women, 680 men) with a mean age of 61.7±9.0 years (range: 50-87 years) underwent upper GI endoscopy. H. pylori infection based on the RUT was positive in 66.6%. Gastric adenocarcinoma and squamous cell carcinoma of esophagus were detected in seven (0.5%) and one (0.07%) persons, respectively. A remarkable proportion of studied participants were found to have esophageal hiatal hernia (38.4%). Asymptomatic gastric masses found in 1.1% (15) of cases which were mostly located in antrum (33.3%), cardia (20.0%) and prepyloric area (20.0%). Gastric and duodenal ulcers were found in 5.9% (82) and 6.9% (96) of the screened population. Conclusion: Upper endoscopy screening is an effective technique for early detection of GC especially in high risk populations. Further studies are required to evaluate cost effectiveness, cost benefit and mortality and morbidity of this method among high and moderate risk population before recommending this method for the GC surveillance program at the national level.


Momeni M.,Qazvin University of Medical Sciences | Ghanbari A.,Guilan University | Jokar F.,Gastrointestinal and Liver Diseases Research Center | Rahimi A.,Guilan University | Leyli E.,Guilan University
Indian Journal of Cancer | Year: 2014

Background: Colorectal cancer (CRC) is one of the most common invasive cancers and is responsible for physical and psychosocial morbidity. Quality of life (QOL) is an important outcome for these patients. The aim of this study was to determine the predictive factors of QOL in patients with CRC. Materials And Methods: A cross-sectional design was used to assess 110 patients with CRC who referred to Oncology Department of Razi Hospital, Guilan. Data were collected by structured interview with patients and review of medical records. Generic and specific QOL were evaluated by short form-36 and functional assessment of cancer therapy-colorectal, respectively. Generalized linear models identified variables significantly associated with QOL. Results: Out of 110 patients with CRC, 58.2% were men. Mean age of patients was 58.33 ± 12.39 years. Mean of Generic and specific QOL were 70.92 ± 15.56 and 95.72 ± 19.18, respectively. In regression analysis, age, sex, living condition, health insurance, hospitalization frequency, Karnofsky performance status, and co-morbidity were predictors of generic QOL and age, sex, living condition, health insurance, monthly income, family history of CRC, Karnofsky performance status, and co-morbidity were predictors of specific QOL in patients. Conclusion: There are nine socio-demographic and clinical factors that are significant predictors of QOL in patients with CRC which should be considered in treatment and care of patients. The findings of this study should be the target of future research, emphasizing the need for interventional studies that minimize the adverse impact of the disease symptoms on the QOL in patients with CRC. © 2014 Indian Journal of Cancer | Pulished by Wolters Kluwer - Medknow.


Mohseni Mehran S.M.,Guilan University | Mansour-Ghanaei F.,Gastrointestinal and Liver Diseases Research Center
Journal of Clinical and Diagnostic Research | Year: 2010

Background: Cancer of the oesophagous is one of the most malignant tumours and has a poor prognosis. The p53 and retinoblastoma (Rb) genes are involved in the regulation of the cell population by the suppression of cell proliferation. Our aim was to show whether the expression of the p53, Ck7, Ck20 and Rb genes could be used as a prognostic indicator in oesophageal squamous cell carcinoma. Methods Samples obtained from 49 patients undergoing subtotal or total oesophagectomy were mmunohistochemically stained for studying the expression of the p53, Ck7, Ck20 and Rb genes and then the clinicopathological characteristics of those patients were investigated. Results P53 was positive in 40.4% of the patients (more than 20% of the tumour cells were stained), 12.8% were partially positive and in others, it was negative. Immunohistochemical staining for the expression of the Ck7, Ck20 and Rb genes in our samples was negative. P53 seemed to have significance in the prognosis of the cancer but Ck7, Ck20 and Rb expression did not have prognostic significance in the surgical treatment of oesophageal cancer.


Shafaghi A.,Gastrointestinal and Liver Diseases Research Center | Askari K.,Guilan University | Hajizadeh H.,Guilan University | Mansour-Ghanaei F.,Gastrointestinal and Liver Diseases Research Center
American Journal of Case Reports | Year: 2012

Background: Strongyloidiasis, a common intestinal parasitic infection, is endemic in tropical and subtropical regions and occurs sporadically in temperate areas. It is endemic in Guilan province, Iran, and especially affects the rural population. Case Report: We report the case of a 43-year-old woman living in Anzali (in the north of Iran), with dyspepsia and epigastric pain for 2 years, unresponsive to H2 receptor antagonists and proton pump inhibitors. Upper gastrointestinal endoscopy was done and showed multiple small nodules at the stomach. The pathologist reported Strongyloides. Treatment with Ivermectin and antibiotic triple therapy was done. She responded well to treatment and 6 months later an upper gastrointestinal endoscopy revealed no significant lesions and all nodules had disappeared. Strongyloidiasis is usually not severe and frequently is nonspecific. For this reason, the infection is easily ignored by both the patients and physicians. Conclusions: Although gastric involvement shows nonspecific symptoms, the possibility should be carefully considered by clinicians who practice in endemic areas. © The American Journal of Case Reports, 2012.

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