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Khoshbaten M.,Tabriz University of Medical Sciences | Aliasgarzadeh A.,Tabriz University of Medical Sciences | Masnadi K.,Tabriz University of Medical Sciences | Tarzamani M.K.,Tabriz University of Medical Sciences | And 5 more authors.
Hepatitis Monthly | Year: 2010

Background and Aims: Non-alcoholic fatty liver change is a common disease of the liver in which oxidative stress plays a basic role. Studies are largely focused on protecting the liver by means of anti-oxidative material. The aim of this study is to evaluate the role of N- acetylcysteine in the process of liver injury. Methods: Thirty patients with non-alcoholic fatty liver steatosis were randomly selected to receive either N-acetylcysteine or vitamin C. Liver function tests (alanine aminotransfrase, aspartate aminotransfrase and alkaline phosphatase) were measured as well as the grade of steatosis, the pattern of its echogenicity, the span of the liver and the spleen and the portal vein diameter before the intervention. Patients were followed up using the same method of evaluation repeated in the first, second and third months. Results: The mean age (SD) was 40.1(12.4) in patients receiving NAC and 46(10.4) years in patients receiving vitamin C (P = 0.137). NAC resulted in a significant decrease of serum alanine aminotransfrase after three months, compared to vitamin C. This effect was independent of the grade of steatosis in the initial diagnosis. NAC was able to significantly decrease the span of the spleen. Conclusions: N-acetylcysteine can improve liver function in patients with non-alcoholic fatty liver disease. Better results may be achievable in a longer follow up. Source


Garjani A.,Tabriz University of Medical Sciences | Safaeiyan A.,Tabriz University of Medical Sciences | Khoshbaten M.,Liver and Gastrointestinal Diseases Research Center
Hepatitis Monthly | Year: 2015

Background: Nonalcoholic fatty liver disease has become a worldwide challenge. Liver biopsy remains the single most reliable approach to determine the severity of this disease. As patients with nonalcoholic fatty liver disease require close follow-up, performing this invasive method repeatedly seems impractical; therefore, designing a noninvasive system to follow up patients has become a common interest.Objectives: We intended to investigate the association between platelet counts of patients with nonalcoholic fatty liver disease and the severity of their disease based on serum levels of liver enzymes and grade of fatty liver on ultrasonography.Patients and Methods: One thousand, three hundred and five patients with nonalcoholic fatty liver disease were included in this descriptive study. Serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and platelet counts of patients were measured. The grade of fatty liver was determined by abdominal ultrasonography.Results: Of our study population, 54.3% (n = 708) were women. Patients with mild fatty liver on ultrasonography had lower platelet counts than those with moderate and severe fatty liver. However, no cutoff value of platelet count could reliably distinguish different grades of fatty liver. We found no significant association between platelet counts and serum levels of AST, ALT or ALP. However, we showed that male patients with abnormal levels of ALT had higher platelet counts.Conclusions: Platelet count in nonalcoholic fatty liver disease can serve as a clue to the severity of disease, but it cannot be considered as a sole test to follow up patients. © 2015, Kowsar Corp. Source


Dadashzadeh K.,Islamic Azad University | Milani M.,Liver and Gastrointestinal Diseases Research Center | Milani M.,Tabriz University of Medical Sciences | Somi M.H.,Liver and Gastrointestinal Diseases Research Center
Acta Medica Mediterranea | Year: 2015

Objective: There is continuing interest in identifying Helicobacter pylori virulence factors that might predict the risk for symptomatic clinical outcomes. It has been proposed that iceA and cagA genes are such markers and can identify patients with peptic ulcers and gastric cancer. Methods: To determine the prevalence of specific genotypes of H. pylori, clinical isolate of H.pylori obtained from 102 patients through endoscopic biopsies was cultured. The cagA alleles, iceA genotypes were determined by PCR. Results: Distribution of cagA and clinical outcome was shown that the frequency of cagA-positive isolates in PUD, NUD and GC patients was 81.25% and 65.5% and 100%, respectively. Also the iceA1 allele was identified in 2 (100%) GC patients but iceA2 allele was not detected in these patients. Overall cagA and iceA1 alleles were detected in GC patients. Conclusions: The cagA gene and iceA1 genotype was found to predominate in gastric adenocarcinoma patients, and also iceA2 genotype was also associated with PUD. Source


Khoshbaten M.,Liver and Gastrointestinal Diseases Research Center | Nejad M.R.,Shahid Beheshti University of Medical Sciences | Sharifi N.,Tabriz University of Medical Sciences | Fakhari A.,Tabriz University of Medical Sciences | And 4 more authors.
Gastroenterology and Hepatology from Bed to Bench | Year: 2012

Aim: The aim of this study was to determine the prevalence of celiac disease in Iranian patients suffering from chronic depression or schizophrenia. Background: Psychiatric disorders are common in untreated celiac disease. Patients and methods: Two hundred Iranian inpatient men with in chronic phase of depressive disorders or schizophrenia, and 200 age-matched healthy male subjects were screened for celiac disease by anti-tissue transglutaminase IgA antibodies. The mean age of the study patients was 37 years. Results: One (1 %) schizophrenic and two (2%) depressive patients were positive for anti-tissue transglutaminase IgA antibodies; duodenal biopsy was not possible in these subjects. In the control group one (0.5%) individual was positive for anti-tissue transglutaminase IgA antibodies, but had normal duodenal histology. The difference between patients and controls was not statistically significant. Conclusion: The frequency of celiac disease serology in schizophrenic and depressive inpatients was not significantly higher than that in the general population. We would therefore not advocate systematic serologic screening in these patients, but alertness to celiac disease should be kept in mind. © 2012 RIGLD, Research Institute for Gastroenterology and Liver Diseases. Source


Khoshbaten M.,Liver and Gastrointestinal Diseases Research Center | Madad L.,Liver and Gastrointestinal Diseases Research Center | Baladast M.,Liver and Gastrointestinal Diseases Research Center | Mohammadi M.,Liver and Gastrointestinal Diseases Research Center | Aliasgarzadeh A.,Liver and Gastrointestinal Diseases Research Center
Gastroenterology and Hepatology from Bed to Bench | Year: 2011

Aim: To determine the prevalence of gastrointestinal symptoms and signs among persons with diabetes mellitus in a specialist hospital. Background: Gastrointestinal symptoms and signs are common among patients with diabetes mellitus. Morbidity from Patients and methods: In this descriptive, cross-sectional study, subjects from the general population with diabetes (n=200) were recruited for this study. Subjects were randomly chosen from patients known to have diabetes, (type I&II), attending the diabetes clinic at Sina University Hospital, in Tabriz during 2003. The questionnaire recorded gastrointestinal symptoms among the subject population. Results: 91% and 9% of patients had Type II and I diabetes, respectively. Sixty seven percent of them had poor controlled diabetes and only 3% had well controlled diabetes. Gastrointestinal symptoms and signs were reported in 92% of patients. The common GI symptoms were constipation (59.5 %), followed by bloating (44 %), abdominal pain (31%), dyspepsia (30%), and mass protruding through anus (22.5%). Abdominal tenderness on deep palpation was the commonest clinical sign (54%). GI symptoms were more prevalent in subjects aged 60-69 years (97.2%). Seventy four percent of patients with GI signs and symptoms had complications such as neuropathy 61.5% and retinopathy associated with neuropathy 38.5%. Conclusion: The prevalence of GI symptoms and signs in the population studies was higher than that reported from other populations, and there is a relationship between glycaemic control and complications of diabetes in diabetic subjects. ©2011 RIGLD, Research Institute for Gastroenterology and Liver Diseases. Source

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