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Neumann H.,Friedrich - Alexander - University, Erlangen - Nuremberg | Mnkemuller K.,Gastroenterology and Infectious Diseases | Gunther C.,Friedrich - Alexander - University, Erlangen - Nuremberg | Atreya R.,Friedrich - Alexander - University, Erlangen - Nuremberg | And 2 more authors.
Gastroenterology Research and Practice

Endoscopy in IBD has tremendous importance to diagnose inflammatory activity, to evaluate therapeutic success and for the surveillance of colitis associated cancer. Thus it becomes obvious that there is a need for new and more advanced endoscopic imaging techniques for better characterization of mucosal inflammation and early neoplasia detection in IBD. This paper describes the concept of advanced endoscopic imaging for the diagnosis and characterization of Crohn's disease, including magnification endoscopy, chromoendoscopy, balloon-assisted enteroscopy, capsule endoscopy, confocal laser endomicroscopy, and endocytoscopy. Copyright © 2012 Helmut Neumann et al. Source

Neumann H.,Friedrich - Alexander - University, Erlangen - Nuremberg | Fry L.C.,Gastroenterology and Infectious Diseases | Neurath M.F.,Friedrich - Alexander - University, Erlangen - Nuremberg

Since the advent of capsule endoscopy (CE) more than one decade has passed. During this time, extensive efforts have been made to proof the relevance of CE for diagnosis of various disease entities within the esophagus, small bowel, and colon. To date, the most common indications for CE are obscure gastrointestinal bleeding, Crohn's disease, polyposis syndromes and evaluation of patients with complicated celiac disease. In this review we will focus on the current clinical applications of CE for imaging of the esophagus, small bowel and colon and will additionally give an outlook on future concepts and developments of CE. Copyright © 2013 S. Karger AG, Basel. Source

Schommers P.,University of Cologne | Hentrich M.,Oncology and Palliative Medicine | Hoffmann C.,University of Hamburg | Gillor D.,University of Cologne | And 14 more authors.
British Journal of Haematology

Overall survival (OS) of patients with acquired immunodeficiency syndrome (AIDS)-related Burkitt lymphoma (BL), diffuse large B-cell lymphoma (DLBCL) and plasmablastic lymphoma (PBL) was analysed in the German AIDS-related-Lymphoma-Cohort-Study. Of 291 patients prospectively included between January 2005 and December 2012, 154 had DLBCL, 103 BL and 34 PBL. Two-year OS rates were similar between BL (69%) and DLBCL patients (63%) but lower for PBL patients (43%). Intermediate (Hazard ratio [HR] 4·1 95% confidence interval [CI] 1·98-8·49) or high (HR 4·92 95% CI 2·1-11·61) International Prognostic Index, bone marrow involvement (HR 1·69 95% CI 1·00-2·84) and PBL histology (HR 2·24 95% CI 1·24-4·03) were independent predictors of mortality. © 2014 John Wiley & Sons Ltd. Source

Hoffmann C.,Study Center | Hoffmann C.,University of Kiel | Hentrich M.,Oncology and Palliative Care | Gillor D.,University of Cologne | And 14 more authors.
HIV Medicine

Objectives: The incidence of HIV-related non-Hodgkin lymphoma (NHL) but not that of Hodgkin lymphoma (HL) has been declining. The aim of the study was to compare HIV-infected patients with NHL and HL with respect to antiretroviral therapy (ART) exposure at the time of lymphoma diagnosis. Methods: HIV-infected patients with NHL and HL included in a prospective multicentre cohort study since January 2005 were compared with respect to ART exposure and viral load at the time of lymphoma diagnosis. Results: As of 31 December 2012, data for 329 patients with NHL and 86 patients with HL from 31 participating centres were available. Patients with HL were more likely to be on ART (73.5% vs. 39.1%, respectively; P<0.001) and more frequently had a viral load below the detection limit (57.3% vs. 27.9%, respectively; P<0.001) than patients with NHL. The proportion of patients with HL was 8.0% in ART-naïve patients, 34.8% in patients with current HIV RNA <50 HIV-1 RNA copies/mL, and 50.0% in patients with both HIV RNA <50 copies/mL for >12 months and a CD4 cell count of >200 cells/μL. Of note, 45.8% of all patients with NHL were not currently on ART and had a CD4 count of <350 cells/μL. Conclusions: This prospective cohort study shows that HL was as common as NHL in patients with sustained viral suppression and limited immune deficiency. In contrast to NHL, the majority of patients with HL were on effective ART, suggesting that ART provides insufficient protection from developing HL. The high proportion of untreated patients with NHL suggests missed opportunities for earlier initiation of ART. © 2014 British HIV Association. Source

Monkemuller K.,Gastroenterology and Infectious Diseases | Monkemuller K.,Otto Von Guericke University of Magdeburg | Neumann H.,Friedrich - Alexander - University, Erlangen - Nuremberg | Fry L.C.,Gastroenterology and Infectious Diseases | Fry L.C.,Otto Von Guericke University of Magdeburg
Best Practice and Research: Clinical Gastroenterology

Routine endoscopic imaging of the small bowel is performed with videoendoscopic white light technology. However, currently there are many new methods that improve our visual acuity when evaluating the small bowel mucosa. These methods are collectively called "advanced endoscopic imaging". These imaging methods include high-definition white light endoscopy, standard and dyeless or "virtual" chromoendoscopy, magnification endoscopy and confocal laser endomicroscopy. Regardless of the method used to image the small bowel the endosocopist needs to pay attention to detail and focus on three essential aspects: a) the shape of the lesion, b) the superficial mucosal detail (i.e. "pit pattern") and c) the submucosal vascular pattern. This review describes advances in the endoscopic imaging methods to study the small bowel. © 2012 Elsevier Ltd. All rights reserved. Source

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