Tumor Hospital of Ganzhou

Ganzhou, China

Tumor Hospital of Ganzhou

Ganzhou, China
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Zhang X.,Tumor Hospital of Ganzhou | Liu F.,Gannan Medical University | Lan X.,Tumor Hospital of Ganzhou | Huang J.,Ganzhou Institute of Cancer Research | And 2 more authors.
Oncology Letters | Year: 2015

If not promptly or properly treated, certain cervical metastatic cancers that develop from unknown primary tumors may rapidly grow into giant tumors that can invade the blood vessels, muscle and skin. The present study examined the feasibility and efficacy of radical neck dissection combined with reconstruction using the pectoralis major myocutaneous flap for the treatment of giant cervical metastatic cancers that have developed from unknown primary tumors and have invaded the skin. A total of 16 patients who met the inclusion criteria were subjected to radical neck dissection to adequately resect invaded skin, and the pectoralis major myocutaneous flap was used to repair the large skin defect created in the cervical region. Following the surgery, the patients received concurrent chemoradiotherapy. The pectoralis major myocutaneous flap survived in all 16 patients, with no cases of flap necrosis. In addition, no post-operative lymphedema, paresthesia or dysfunction of an upper extremity occurred due to the cutting of a pectoralis major muscle. In 9 cases, patients were satisfied with their post-operative shoulder movement at the donor site; in the remaining 7 cases, patients felt greater weakness in this region following surgery relative to prior to surgery. The 14 male patients were generally satisfied with the post-operative appearance of the donor region, whereas the 2 female patients were dissatisfied with the appearance of this region. Follow-up for 6-53 months after the patients were discharged following surgery and chemotherapy revealed that the recurrence of cervical tumors in 6 cases. Overall, radical neck dissection combined with the use of the pectoralis major myocutaneous flap for reconstruction is a feasible approach for the treatment of giant cervical metastatic cancers that have developed from unknown primary tumors and have invaded the skin. Post-operative concurrent chemoradiotherapy should be administered to improve the local control rate and patient quality of life, allowing a satisfactory therapeutic efficacy to be achieved. © 2015, Spandidos Publications. All rights reserved.


Zhang X.,Tumor Hospital of Ganzhou | Lan X.,Tumor Hospital of Ganzhou | Liu L.,Tumor Hospital of Ganzhou | Li R.,Tumor Hospital of Ganzhou | And 2 more authors.
Chinese-German Journal of Clinical Oncology | Year: 2012

Objective: The purpose of this study was to analyze the clinical disadvantages of non-standard surgical treatment for parotid gland cancer and probe the re-operative indication following non-standard surgical treatment. Methods: Data of 58 cases suffered parotid gland cancer who received non-standard operation at other hospital and received re-operation in tumor hospital of Ganzhou from June 1998 to October 2010 were retrospectively reviewed. Results: In all cases, parotid gland cancer were residual in 46 cases, the facial nerve remaining rate was 81.0% (47/58), facial nerve branches injury rate was 3.5% (2/58), facial nerve partial resection rate was 8.6% (5/58) and total resection rate was 6.9% (4/58). The sensitivity of residual tumor was 83.3%, scanned by contrast-enhanced CT and the CT positive predictive value was 86.9%. Conclusion: Consideration of the higher residual tumor rate in patients who received non-standard operations, the re-operations were necessary. Contrast-enhanced CT positive predictive value was high for residual tumor and it was important for re-operation. © Huazhong University of Science and Technology and Springer-Verlag Berlin Heidelberg 2012.


Zhang X.,Tumor Hospital of Ganzhou | Liu F.,Gannan Medical University | Lan X.,Tumor Hospital of Ganzhou | Yu L.,Peking Union Medical College | And 4 more authors.
Radiation Oncology | Year: 2014

Background: The aim of this study was to evaluate the clinical efficacy of submandibular gland transfer for the prevention of xerostomia after radiotherapy for nasopharyngeal carcinoma.Methods: Using the randomized controlled clinical research method, 65 patients with nasopharyngeal carcinoma were randomly divided into an experimental group consisting of 32 patients and a control group consisting of 33 patients. The submandibular glands were averted to the submental region in 32 patients with nasopharyngeal carcinoma before they received conventional radiotherapy; a lead block was used to shield the submental region during therapy. Prior to radiotherapy, the function of the submandibular glands was assessed using imaging. Submandibular gland function was measured using 99mTc radionuclide scanning at 60 months after radiotherapy. The data in the questionnaire regarding the degree of xerostomia were investigated and saliva secretion was measured at 3, 6, 12, and 60 months after radiotherapy. In addition, the 5-year survival rate was calculated.Results: After follow-up for 3, 6, and 12 months, the incidence of moderate to severe xerostomia was significantly lower in the experimental group than in the control group. The average amount of saliva produced by the experimental and control groups was 1.60 g and 0.68 g, respectively (P < 0.001). After follow-up for 60 months, the uptake and secretion functions of the submandibular glands in the experimental group were found to be significantly higher than in the control group (P < 0.001 and P < 0.001, respectively). The incidence of moderate or severe xerostomia was significantly lower than in the control group (15.4% and 76.9%, respectively; P < 0.001). The 5-year survival rates of the experimental group and the control group were 81.3% and 78.8%, respectively, and there was no significant difference between the two groups (P = 0.806).Conclusions: After a 5 year follow-up period involving 32 patients who had their submandibular glands transferred for the prevention of xerostomia after radiotherapy for nasopharyngeal carcinoma, we found that clinical efficacy was good. This approach could improve the quality of life of nasopharyngeal carcinoma patients after radiotherapy and would not affect long-term treatment efficacy. © 2014 Zhang et al.; licensee BioMed Central Ltd.


Li S.-J.,Ganzhou Institute of Cancer Research | Zhang X.-M.,Ganzhou Institute of Cancer Research | Liu L.-B.,Ganzhou Institute of Cancer Research | Zhou M.-H.,Ganzhou Institute of Cancer Research | And 4 more authors.
Chinese Journal of Cancer Prevention and Treatment | Year: 2016

OBJECTIVE: Many results of geophysical chemistry, epidemiology, nutrition, biochemistry, clinical studies and animal experiments have confirmed that the rare earth elements (REEs) were closely related to tumor occurrence, development and treatment. With the development of rare earth utilization, more and more REEs enter the human body through different approaches, and the toxic effects of REEs affected on human health has become a hot topic. In this study, our aim was to detect the REEs contents and distribution characteristics of non-small cell lung cancer (NSCLC) patients and discuss the relevance with tumor size, lymph node metastasis and clinical stage. METHODS: From April 1, 2013 to January 31, 2014, the REEs contents were measured by inductively coupled plasma-mass spectrometry (ICP-MS/MS) in 14 cases with NSCLC in Ganzhou Cancer Hospital, and the REEs contents and distribution were analyzed. RESULTS: The average standard deviation value of REEs in lung cancer was the minimum mostly. Light REEs content was higher than the medium REEs, and medium REEs content was higher than the heavy REEs content. In addition to the Y, Gd elements, the REEs contents of La, Ce, Pr, Nd, Sm, Eu, Dy, Ho, Er in T1-T3 had ascendant trends, the elements of La, Ce, Pr, Nd, Sm, Eu, Dy, Er in which T2-T3 were more higher than the T1-T2. These nine REEs concentrations in T4 were sharply decreased and the contents were more dispersed in T3. The REEs contents of La, Nd, Sm, Dy, Er, Tm, Yb, Lu had ascendant trends in N0-N3 and the distribution characteristics were more dispersed in N3. With the increase of lung cancer staging, the multiple differences in REEs contents were increased and the distribution points were more dispersed, REEs contents in lung cancer was also more disordered. The La, Pr, Nd, Sm, Dy, Er, Tm of REEs contents increased with the clinical stage progress, and these elements were positively correlated with clinical stage. CONCLUSIONS: With the staging of lung cancer increase, REEs contents have ascendant trends, and the REEs contents are more disordered. The La, Pr, Nd, Sm, Dy, Er, Tm of REEs contents is positively correlated with clinical stage. © 2016, Editorial Board of Chinese Journal of Cancer Prevention and Treatment. All right reserved.


Huang Z.,Tumor Hospital of Ganzhou | Zeng C.,Tumor Hospital of Ganzhou | Kang Z.,Tumor Hospital of Ganzhou | Lv G.,Tumor Hospital of Ganzhou | And 4 more authors.
Chinese Journal of Clinical Oncology | Year: 2012

Objective: This study aims to observe the impacts of Jinlong capsule on the clinical benefit response rate, immune function, and incidence of adverse reactions for patients with advanced non-small cell lung cancer (NSCLC) treated with chemotherapy. Methods: A total of 56 cases suffering from stage III B or IV NSCLC who were confirmed by pathology were randomly divided into 2 groups, including 28 cases of pure chemotherapy group (comparison group) and 28 cases treated with chemotherapy combined with Jinlong capsule (treatment group). After the patients completed at least three cycles of chemotherapy, the clinical benefit response rate, immune function, and incidence of adverse reactions were observed Results: The weight ≥7% of the treatment group were 15 cases (53.5%), whereas that of the comparison group were 13 cases (46.4%); no significant difference was observed between the two groups (P>0.05). A significant difference between the two groups was observed with the increase in Karnofskyp score ≥20 (P<0.05). The rate of the treatment group was 57.1% (16 cases), whereas that of the comparison group was 35.7% (10 cases). The rate of the opioids dosage reduction ≥50% in the treatment group was 46.4% (13cases), whereas that in the comparison group was 25% (7 cases); significant difference was observed between the two groups (P<0.05). Conclusions: The clinical benefit response rate of chemotherapy combined with Jinlong capsule for advanced NSCLC patients was higher than that with chemotherapy alone. In addition this combination treatment can improve chemotherapy tolerance of patients; the medicine compliance also has higher safety. Therefore, this combination treatment is worthy to popularize in clinical applications.


Li J.-W.,Tumor Hospital of Ganzhou | Xiao H.,Ganzhou Medical College | Wang R.,Ganzhou Medical College
Chinese Journal of Cancer Prevention and Treatment | Year: 2013

OBJECTIVE: To evaluate the efficacy and toxicity of the protocol of Gimeracil and oteracil porassium capsules combined with cisplatin in the treatment of elderly patients with distant metastatic nasopharyngeal carcinoma.METHODS: From January 2010 to June 2011, 30 elderly patients with distant metastatic nasopharyngeal carcinoma were collected in Ganzhou Tumor Hospital and were treated by palliative chemotherapy with the protocol of Gimeracil and oteracil porassium capsules combined with cisplatin. Gimeracil and oteracil porassium capsules 60 mg/(m2·d) was administered orally from day 1 to day 14. Cisplatin 80 mg/m2 was administered intravenously on day 1, for 5 days, 21 days as a cycle, until the stopping of the progression or severe toxicity. RESULTS: All patients were evaluable for efficacy and toxicity. Twenty-seven patients were administered with more than 3 cycles(90.0%). The objective response rate was 53.3%(16/30) and the disease control rate was 80.0%(24/30). The 1-year overall survival rates were 66.7%. The median progression-free survival and overall survival were 7.3 and 14.9 months, respectively. Major adverse events were anorexia, nausea, vomit and bone marrow suppression, mainly in grade I and II. CONCLUSION: The protocol of Gimeracil and oteracil porassium capsules combined with cisplatin for the elderly patients distant metastatic nasopharyngeal carcinoma is efficacy, low toxicity and reliable.


Zhang X.,Tumor Hospital of Ganzhou
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery | Year: 2013

To raise clinical awareness of carcinoembryonic antigen(CEA) increased as initial manifestation of medullary thyroid cancer(MTC) and explore the diagnosis and treatment. Clinical data of 2 cases CEA increased as the initial presentation of MTC were retrospectively analyzed and clinical manifestations of the disease, diagnosis, treatment were also discussed by literature reviewing. Two patients received thyroid ipsilateral lobe total resection, MTC was confirmed by intraoperative frozen pathology, re-total resection of the contralateral lobe and bilateral VI lymph node dissection were performed. Lymph nodes had no metastasis confirmed by pathological frozen examination. CEA returned to normal within 2 months after surgery. No tumor recurrence and metastasis were found after follow-up for 3 to 24 months. CEA increased as the initial presentation MTC was rare and clinical identification of CEA increased disease should be taken into account the MTC as possible. Total thyroidectomy and bilateral VI lymph node dissection was the main surgical treatment for it.

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