Gansu Provincial Maternity and Child Care Hospital
Gansu Provincial Maternity and Child Care Hospital
Wang Y.,Gansu Provincial Maternity and Child care Hospital |
Mao J.,Lanzhou University |
Wang W.,Gansu Provincial Maternity and Child care Hospital |
Qiou J.,Gansu Provincial Maternity and Child care Hospital |
And 2 more authors.
Reproductive Health | Year: 2017
Background: The relationship between maternal body compositions and birth weight was not definite. Fat Mass (FM) and Fat Free Mass (FFM) can accurately reflect the maternal body fat compositions and have been considered as better predictors of birth weight. Despite its potential role, no studies have been described the maternal compositions during pregnancy in East Asian women previously. We investigated the correlation between birth weight and Maternal body composition including fat mass (FM) and fat free mass (FFM). To determine whether birth weight is associated with maternal body fat FM and FFM during pregnancy and, if so, which trimester and parameter is more critical in determining birth weight. Methods: A longitudinal prospective observational study performed, 348, 481 and 321 non-diabetics Han Chinese women with a singleton live birth attending a routine visit in their first, second and third trimesters were recruited. Maternal body composition was measured using segmental multi-frequency bioelectrical impedance analysis. Data of the pre-pregnancy body mass index (BMI), maternal BMI, the gestational weight gain (GWG), and placental and birth weight were collected. Results: A significant correlation exists between maternal FFM in the process of pregnancy, placental weight, GWG at delivery, and birth weight (P < 0.05). On stepwise multiple linear regression analysis, material’s FFM was the most important factor associated with the birth weight. After adjustment, there was significantly associated with 2.47-fold increase in risk for birth weight more than 4 kg when FFM ≥ 40.76 kg (Upper quartile of participants). The increased maternal age became a protective factor (OR = 0.69) while the increased pre-pregnancy BMI (OR = 1.50) remained predictors to birth weight more than 4 kg. Conclusions: The change of maternal FFM during pregnancy is independently affected the birth weight. © 2017 The Author(s).
Zhang M.,Gansu Provincial Hospital |
Dong X.,The Third Hospital of Gansu Province |
Zhang D.,Gansu Provincial Maternity and Child Care Hospital |
Chen X.,Gansu Provincial Hospital |
Zhu X.,Gansu Provincial Hospital
Oncotarget | Year: 2017
In this study, we explored the roles of Snail and NF-κB in hepatocellular carcinoma (HCC). Samples of HCC tumor tissue were collected from 83 Chinese HCC patients. Snail and NF-κB expression was then examined based on immunohistochemical staining, and the relations between Snail and NF-κB expression and the clinical characteristics of the patients were assessed using Cox model analysis. Snail and NF-κB were both expressed in HCC tissue, and their levels were strongly correlated. In addition, levels of both Snail and NF-κB expression were negatively related to tumor differentiation, which was an independent factor predictive of survival in HCC patients. Snail and NF-κB may thus be useful markers of tumor differentiation and survival in HCC, and may also be useful for guiding treatment and exploring molecular mechanisms.
Zhang L.,Peking Union Medical College |
Zhu L.,Peking Union Medical College |
Xu T.,Peking Union Medical College |
Lang J.,Peking Union Medical College |
And 4 more authors.
European Urology | Year: 2015
Background: Epidemiological studies of lower urinary tract symptoms (LUTS) are few in China, and none has been conducted nationwide. Objective: To estimate the prevalence and potential risk factors of LUTS and the bother they impose on adult women in China. Design, setting, and participants: This is the second analysis of a population-based crosssectional survey on urinary incontinence conducted between February and July 2006 in six regions of China. Cluster samples were randomly selected for interviews. Interventions: No intervention was implemented. Outcome measurements and statistical analysis: A modified Chinese Bristol Female Lower Urinary Tract Symptoms questionnaire was administered. The participants were asked about the presence of individual LUTS and rated their symptom bother. Descriptive statistics, x2 tests, receiver operating characteristic curves, and multivariate logistic regressions were used for data analysis. Results and limitations: A total of 18 992 respondents (94.96%)were included. The prevalence of any LUTS, storage symptoms, or voiding symptomswas 55.5%, 53.9%, and 12.9%, respectively, and increasedwith age.Nocturiawas themostcommonsymptom(23.4%), followedbyurgency (23.3%) and stress urinary incontinence (SUI; 18.9%). Nocturia was most frequently rated as bothersome (93.0%) but was generally minor (80.5%). Urgency and urgency urinary incontinence (UUI) were most frequently reported as severe (11.5% and 10.8%) ormoderate (18.5% and 16.8%) bothers. Any LUTSweremore prevalent in urbanwomen (57.1% vs 53.9%). Multiple factors increased the odds of bother and individual LUTS, and older age and coexisting pelvic organ prolapse were strong predictors (p < 0.05). This survey was conducted 8 yr ago and did not assess all LUTS. Conclusions: Half of adult women suffered with LUTS; nocturia, urgency, and SUI were more prevalent. Urgency and UUI were most frequently reported as severe or moderate bothers. Multiple factors influenced bother and individual LUTS. Patient summary: The prevalence of lower urinary tract symptoms is high and increases with age in adult women in China. Urgency and urgency urinary incontinence were most frequently regarded as severe or moderate bothers and should be targeted for medical intervention. © 2014 European Association of Urology. Published by Elsevier B.V. All rights reserved.
PubMed | Gansu Provincial Maternity and Child care Hospital, Lanzhou University, Chinese Research Academy of Environmental Sciences and Gansu Academy of Environmental science
Type: Journal Article | Journal: Environmental monitoring and assessment | Year: 2016
The study aimed to investigate the metal compositions in indoor PM2.5 and the potential health risks they pose to residents of an urban area in China. A total of 41 and 54 households were surveyed in February and September 2013, respectively. The results showed that the indoor concentrations of metals varied depending on the types of cooking fuels used. All measured concentrations of metals were highest among households using coal for cooking. In the majority of households, non-carcinogenic risks were posed by the use of coal. The carcinogenic risks posed by chromium (VI) and arsenic were generally higher among households using coal for cooking than among those using gas or electricity. The multivariate linear regression model suggested a potential adverse effect from arsenic and cadmium on birth weight and gestational weeks. This study also found that cooking fuel was the most significant factor that contributed to the differences in concentrations of metals in indoor PM2.5 and highlighted the importance of using clean energy for cooking and heating.
PubMed | Qingdao Municipal Hospital Group, Linyi Peoples Hospital, Gansu Provincial Maternity and Child care Hospital and Qingdao University
Type: Journal Article | Journal: Hypertension in pregnancy | Year: 2016
Previous studies have been indicated that catechol-O-methyltransferase gene (COMT) might play a significant role in the development of preeclampsia (PE). Our study aims to investigate the association between polymorphism in COMT with the susceptibility to PE in Chinese Han women.A total of 1028 PE patients and 1399 normal pregnant women were enrolled. We detected the genotyping of COMT Val158Met loci by the TaqMan allelic discrimination real-time PCR .No significant difference in the genotypic and allelic distribution was found between the two groups (genotype: XThe COMT Val158Met polymorphism might not be associated with PE in Chinese women.
PubMed | Gansu Provincial Maternity and Child Care Hospital, CAS Wuhan Institute of Hydrobiology, Wuhan University of Technology and Lanzhou Jiaotong University
Type: Journal Article | Journal: Bulletin of environmental contamination and toxicology | Year: 2016
In this study, extracellular polymeric substances of Aphanizomenon flos-aquae (EPS-A) were investigated in order to explore their effect on astrocytes of zebrafish and potential risk for environment. Astrocytes were treated with varying concentrations of EPS-A, the results showed that EPS-A inhibited astrocytes growth in a dose-and time-dependent manner. With the concentrations of EPS-A increasing, the adherent ability of astrocytes decreased and the number of astrocytes floating in the culture medium increased. When treated with 2.35g/mL EPS-A, EPS-A induced cell cycle arrest and made the collapse of mitochondrial membrane potential and then led to astrocytes apoptosis. The results suggested that EPS-A could pose a threat to zebrafish and represent risk for environment, so regularly monitoring the presence of EPS-A was very important in nutrient-rich freshwaters when A. flos-aquae blooms broke out.
Li X.,Lanzhou University |
Wang Z.-X.,Gansu Provincial Maternity and Child care Hospital |
Wang Z.-S.,Lanzhou University |
Li Q.-F.,Lanzhou University
Asian Pacific Journal of Tropical Medicine | Year: 2015
Objective: To explore the effect of microRNA-101 on apoptosis of condylar cartilage cells and the specific mechanism of molecular biology. Methods: IL-1 was used to stimulate and establish the model of apoptosis of condylar cartilage cells. The expression change of miR-101 in control group was compared with that in IL-1 stimulation group by qRT-PCR. Overexpression and down-regulation models of miR-101 were established by transfecting Mimics and Inhibitor and verified by qRT-PCR. Flow cytometry was used to detect the effect of miR-101 overexpression and down-regulation on apoptosis. Target gene of miR-101 was analyzed and calculated through bioinformatics. Western blot and Luciferase report assay were used to detect whether SOX9 could become the target gene of miR-101. Results: qRT-PCR results showed that IL-1 stimulation could cause the increase of miR-101 expression. After the transfection of rabbit condylar cartilage cells by Mimics and Inhibitor, qRT-PCR results confirmed the significant effect of miR-101 overexpression and down-regulation. It was confirmed by flow cytometry that overexpression of miR-101 could promote the apoptosis of condylar cartilage cells, and down-regulation of miR-101 could reduce the apoptosis. It was confirmed by Western blot and Luciferase report assay that SOX9 was the target gene of miR-101, and miR-101 inhibited SOX9 expression through complementary pairing with 3'UTR of SOX9 mRNA. Conclusions: miR-101 can promote the apoptosis of condylar cartilage cells through inhibiting the protein level of target gene SOX9. © 2015 Hainan Medical College.
PubMed | 0 College Street and Gansu Provincial Maternity and Child Care Hospital
Type: Journal Article | Journal: European journal of nutrition | Year: 2016
Folic acid supplementation has been suggested to reduce the risk of preterm birth. However, results from previous epidemiologic studies have been inconclusive. We investigated the hypothesis that folic acid supplementation and dietary folate intake during pre- and post-conception reduces the risk of preterm birth.We analyzed data from a birth cohort study conducted between 2010 and 2012 in Lanzhou, China, including 10,179 pregnant women with live singleton births.Compared to non-users, folic acid supplement users with >12-week duration had a reduced risk of preterm birth (OR 0.67, 95% CI 0.55-0.83) with a significant dose-response relationship (P for trend=0.01). A similar pattern was observed for spontaneous preterm birth. Stronger associations were seen for ever use of folic acid supplement and very preterm birth (OR 0.50, 95% CI 0.36-0.69) and spontaneous very preterm birth (OR 0.42, 95% CI 0.29-0.63). Dietary folate intake during preconception and pregnancy were also associated with reduced risk of preterm birth (OR 0.68, 95% CI 0.56-0.83, OR 0.57, 95% CI 0.47-0.70 for the highest quartiles, respectively), particularly for spontaneous very preterm (OR 0.41, 95% CI 0.24-0.72, OR 0.26, 95% CI 0.15-0.47 for the highest quartiles, respectively). There were also decreased risks of preterm birth observed per 10-g increase in dietary folate intake, and similar associations were found after stratification by folic acid supplementation status.Our results suggest that folic acid supplementation and higher dietary folate intake during preconception and pregnancy reduces the risk of preterm birth, and the protective effect varies by preterm subtypes.
PubMed | Yale University and Gansu Provincial Maternity and Child Care Hospital
Type: | Journal: BMC public health | Year: 2016
Studies investigating the relationship between maternal tea drinking and risk of preterm birth have reached inconsistent results.The present study analyzed data from a birth cohort study including 10,179 women who delivered a singleton live birth were conducted in Lanzhou, China between 2010 and 2012.Drinking tea (OR=1.36, 95% CI: 1.09-1.69), and specifically green (OR=1.42, 95% CI: 1.08-1.85) or scented tea (OR=1.61, 95% CI: 1.04-2.50), was associated with an increased risk of preterm birth. Drinking tea was associated with both moderate preterm (OR=1.41, 95% CI: 1.12-1.79) and spontaneous preterm birth (OR=1.41, 95% CI: 1.09-1.83). Risk of preterm birth increased with decreasing age of starting tea drinking (<20years, OR=1.60, 95% CI: 1.17-2.20) and increasing duration (p for trend<0.01). The relationship between tea drinking and preterm birth is modified by both maternal age (p<0.05) and gestational weight gain (p<0.05).Despite conflicting findings in the previous literature, we saw a significant association with maternal tea drinking and risk of preterm birth in our cohort. More studies are needed both to confirm this finding and to elucidate the mechanism behind this association.
Gong R.L.,Gansu Provincial Maternity and Child Care Hospital
Zhongguo zhen jiu = Chinese acupuncture & moxibustion | Year: 2011
To compare the differences in the therapeutic effect on child amblyopia between auricular point sticking therapy and routine complex treatment. Two hundreds and thirty cases of amblyopia were randomly divided into an observation group and a control group, 120 cases (212 eyes) were in the observation group and 110 cases (194 eyes) were in the control group. The observation group was treated with auricular point sticking therapy. The main points were Yan (eye), Shenmen, Gan (liver), Pi (spleen) and Shen (kidney), etc. The control group was treated with routine complex treatment, such as wearing glasses, shade therapy and family refined performance therapy. The changes of vision were observed after treatment in the two groups. The follow-up was 3 years. The effective rate was 81.0% (64/79) in the observation group of ametropic amblyopia and 52.2% (36/69) in the control group. The effective rate was 73.1% (49/67) in the observation group of anisometropic amblyopia and 47.7% (31/65) in the control group. The effective rate was 71.2% (47/66) in the observation group of strabismic amblyopia and 45.0% (27/60) in the control group. The therapeutic effect of the observation group was superior to that of the control group (all P < 0.05). Auricular point sticking therapy can obviously improve child visual acuity with simple manipulation.