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Qi P.,Lanzhou University | Chen M.,GanSu Provincial Hospital of Traditional Chinese Medicine | Zhang L.-X.,Lanzhou University | Song R.-X.,Lanzhou University | And 4 more authors.
PLoS ONE | Year: 2015

Background Endothelin A (ET-A) receptor antagonists including zibotentan and atrasentan, have been suggested as a treatment for castration-resistant prostate cancer (CRPC). Our aim was to conduct a meta-analysis and indirect comparison to assess the efficacy and safety of ET-A receptor antagonists for treatment of CRPC. Methods We systematically searched PubMed, EMBASE, the Cochrane Library, and Web of Science from inception to November 2014 to identify randomized controlled trials (RCTs) which assessed ET-A receptor antagonists for treatment of CRPC. Meta-analysis was conducted by STATA version 12.0 software. Results Eight RCTs were identified, involving 6,065 patients. The results of direct comparison showed that compared with placebo, there was no statistically significant difference in the improvement of progression-free survival (PFS), overall survival (OS), time to disease progression (TTP), and total adverse events (AEs) with ET-A receptor antagonist treatment for CRPC. The results of ET-A receptor antagonists plus docetaxel versus docetaxel alone were similar. The indirect comparisons showed that there were no significant differences between zibotentan plus docetaxel versus atrasentan plus docetaxel when compared with docetaxel alone or zibotentan versus atrasenta compared with placebo in the improvement of PFS, OS, TTP, and total adverse events. Conclusions There were no significant benefits for ET-A receptor antagonists with or without docetaxel in the improvement of PFS, OS, TTP, and overall AEs. And there were no significant differences between zibotentan and atrasentan. Single-agent docetaxel should remain as one of the standard treatments. © 2015 Qi et al.This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


PubMed | Lanzhou University, Gansu Provincial Hospital of Traditional Chinese Medicine, Shandong University and Gansu College of Traditional Chinese Medicine
Type: Journal Article | Journal: PloS one | Year: 2014

The QUOROM and PRISMA statements were published in 1999 and 2009, respectively, to improve the consistency of reporting systematic reviews (SRs)/meta-analyses (MAs) of clinical trials. However, not all SRs/MAs adhere completely to these important standards. In particular, it is not clear how well SRs/MAs of acupuncture studies adhere to reporting standards and which reporting criteria are generally ignored in these analyses.To evaluate reporting quality in SRs/MAs of acupuncture studies.We performed a literature search for studies published prior to 2014 using the following public archives: PubMed, EMBASE, Web of Science, the Cochrane Database of Systematic Reviews (CDSR), the Chinese Biomedical Literature Database (CBM), the Traditional Chinese Medicine (TCM) database, the Chinese Journal Full-text Database (CJFD), the Chinese Scientific Journal Full-text Database (CSJD), and the Wanfang database. Data were extracted into pre-prepared Excel data-extraction forms. Reporting quality was assessed based on the PRISMA checklist (27 items).Of 476 appropriate SRs/MAs identified in our search, 203, 227, and 46 were published in Chinese journals, international journals, and the Cochrane Database, respectively. In 476 SRs/MAs, only 3 reported the information completely. By contrast, approximately 4.93% (1/203), 8.81% (2/227) and 0.00% (0/46) SRs/Mas reported less than 10 items in Chinese journals, international journals and CDSR, respectively. In general, the least frequently reported items (reported50%) in SRs/MAs were protocol and registration, risk of bias across studies, and additional analyses in both methods and results sections.SRs/MAs of acupuncture studies have not comprehensively reported information recommended in the PRISMA statement. Our study underscores that, in addition to focusing on careful study design and performance, attention should be paid to comprehensive reporting standards in SRs/MAs on acupuncture studies.


Li H.-Z.,Gansu Provincial Hospital of Traditional Chinese Medicine | Liu X.-H.,North Sichuan Medical College | Niu C.-Q.,North Sichuan Medical College | Zhang T.-X.,North Sichuan Medical College
Chinese Journal of Tissue Engineering Research | Year: 2015

BACKGROUND: Aconitum carmichaeli Debx (ACD) is the tuberous root of Aconium carmicgaekum, used as cardiotonic to restore yang for the treatment of collapse and shock, to warm the kidney and reinforce yang, and to expel cold and promote the flow of yang-qi. Studies have found that ACD has obviously cardiotonic, antihypertensive, vasodilatory, analgesic, anti-inflammatory and toxic effects. OBJESTIVE: To observe the vasodilatory effects of a water decoction of ACD on rabbit’s aorta rings and its mechanism. METHODS: Rabbits aorta arteries were isolated, pre-contracted with noradrenaline (106 mol/L) and their responses to different concentrations of ACD (0.5, 1.0, 2.0, 4.0, 8.0 g/L) were investigated. The effects of removal of vascular endothelium and different signaling pathway inhibitors (N“-nitro-L-arginine: 1X10"4 mol/L, methylene blue: 1 x10'6 mol/L, indomethacin: 1x10'6 mol/L, propranolol: 1x10'6 mol/L) on ACD-induced vasodilation were also assessed. RESULTS AND CONCLUSION: ACD could not change the resting tension of rabbit aortic rings, but ACD treatment resulted in an obvious relaxation in narodrenaline-precontracted aortic rings and the relaxant effect was dose-dependent. The vasodilatory effect of ACD was significantly reduced by removal of endothelium, 1x10-4 mol/L Nω-nitro-L-arginine and 1x10-6 mol/L methylene blue but not reduced by indomethacin and propranolol. In addition, 4 g/L water decoction of ACD did not decrease the dose-response curves of artery rings to narodrenaline or KCl in the absence of endothelial cells. ACD can relax isolated rabbit’s aorta, which may be related to endothelium-released nitric oxide, but has no significant relevance with receptor-operated and voltage-dependent calcium channels. © 2015, Journal of Clinical Rehabilitative Tissue Engineering Research. All rights reserved.


Wang Z.M.,Gansu Provincial Hospital of Traditional Chinese Medicine
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban | Year: 2013

To study whether the effects of Leflunomide were different in treating patients with rheumatoid arthritis (RA) of different Chinese medical syndrome patterns. Totally 150 RA patients were recruited and assigned to 5 Chinese medical syndrome types, i.e., the heat-dampness blocking collateral type, cold-dampness blocking collateral type, Shen-qi deficiency cold type, Gan-Shen yin deficiency type, and stagnant blood blocking collateral type according to Chinese medical syndrome typing standards. They were treated with Leflunomide, 3 months as one therapeutic course. The parameters including numbers of joint tenderness and swelling, morning stiffness time, scores estimated by Visual Analog Scale (VAS), as well as laboratory indices involving rheumatoid factor (RF), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), American College of Rheumatology 20% improvement (ACR20), and American College of Rheumatology 50% improvement (ACR50) were observed before and after treatment, and statistically analyzed. After treatment the numbers of joint tenderness, numbers of joint swelling, VAS scores, ESR, CRP, and RF all decreased, showing statistical difference when compared with those before treatment (P < 0.05). The morning stiffness time was shortened in the heat-dampness blocking collateral type, cold-dampness blocking collateral type, and stagnant blood blocking collateral type, showing statistical difference (P < 0.05). Of them, the numbers of joint tenderness, the numbers of joint swelling, the morning stiffness time, RF, VAS scores, and the improvement of the total effective rate were obviously better in the heat-dampness blocking collateral type, cold-dampness blocking collateral type, and stagnant blood blocking collateral type than in the Shen-qi deficiency cold type and Gan-Shen yin deficiency type, showing statistical difference (P < 0.05). Leflunomide showed significant effects in treating RA. Of them, its effects were obviously better in the heat-dampness blocking collateral type, cold-dampness blocking collateral type, and stagnant blood blocking collateral type than in the Shen-qi deficiency cold type and Gan-Shen yin deficiency type.


Zhao P.,Gansu Provincial Hospital of Traditional Chinese Medicine | Li S.,Gansu Provincial Hospital of Traditional Chinese Medicine
International Journal of Clinical and Experimental Medicine | Year: 2015

Inadequate venous drainage can lead to congestion and necrosis of flaps used in the repair of defects, thereby elevating the risk of flap failure. In this study, we sought to test the hypothesis that the venous drainage was better in flow-through flaps than in conventional dorsalis pedis free flaps used in the repair of dorsal foot defects. In this retrospective study, we investigated the data of 14 patients who underwent repair with flow-through flaps (n = 7) or conventional flaps (n = 7) for dorsal foot defects, between January 2007 and December 2013. The defects ranged from 6.2 × 11 cm to 9.5 × 16 cm in size. The donor sites were resurfaced using full-thickness free-skin grafts, and after transfer, the flaps were evaluated for postoperative congestion, surviving area, and sensory function. The results showed that the operative time was significantly longer for flow-through flaps than for conventional flaps (6.4 ± 1.7 h vs. 4.3 ± 1.2 h, P = 0.020), mainly due to additional dissection of the first dorsal metatarsal artery required in the case of the former. Necrosis was observed in the case of 4 conventional flaps, but not in the case of flow-through flaps. The flow-through flaps showed significantly lower incidence of congestion and higher survival area proportion than the conventional flaps (P < 0.05). The flow-through dorsalis pedis flaps have the advantages of lower incidence of necrosis and congestion and better survival over the conventional flaps in the repair of dorsal foot defects, and absence of additional morbidities, but required a longer operative time than conventional flaps. © 2015, E-Century Publishing Corporation. All rights reserved.


Zhao J.,Gansu Provincial Hospital of Traditional Chinese Medicine
Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation | Year: 2013

The design principle and application of an adjustable spine prone frame are introduced. Adjustable spine prone frame is used in posterior lumbar surgery, during operation, X-ray can shoot fast and internal fixation implants can fix accurately, the vacant abdominal ensure normal respiratory and circulatory function, and the lumbar curvature can adjust conveniently. It meets the surgical position and care requirements, can prevent the complications effectively.


PubMed | University of Leicester, Lanzhou University of Technology, Lanzhou University, Northwest University for Nationalities and Gansu Provincial Hospital of Traditional Chinese Medicine
Type: Journal Article | Journal: Pharmaceutical biology | Year: 2016

Gastric cancer remains highly prevalent, but treatment options are limited. Natural products have proved to be a rich source of anticancer drugs. Chrysosplenium nudicaule Ledeb. (Saxifragaceae) is a perennial herb that grows in the highlands of China. It has been used as a traditional Chinese medicine to treat digestive diseases for hundreds of years. Recent studies revealed that this herb had anticancer activity, and the flavonoids were speculated to be the effective components. 6,7,3-Trimethoxy-3,5,4-trihydroxy flavone (TTF) and 5,4-dihydroxy-3,6,3trimethoxy-flavone-7-O--d-glucoside (DTFG) are flavonoid compounds isolated from Chrysosplenium nudicaule.This study examined the effect of TTF and DTFG on SGC-7901 human stomach cancer cell in vitro to determine the anticancer and induction of apoptosis properties of TTF.The proliferation of cells treated with 32, 16, 8, 4, and 2g/mL of TTF or DTFG for 24, 48, and 72h was assessed by the MTT assay. After being treated with TTF, the apoptosis of SGC-7901 cells was assessed by acridine orange staining, ultrastructure, electrophoresis of DNA fragmentation, and flow cytometry.Results indicated that TTF inhibited the growth of cancer cells with an IC50 value of 8.33g/mL after 72h incubation. However, DTFG showed no inhibitory effect on the growth of the cancer cell. Further studies on TTF also confirmed that it was able to induce apoptosis of SGC-7901 cells at a concentration as low as 4g/mL.The apoptotic effect of TTF makes it a promising candidate for future chemotherapeutic application in treating stomach cancer.


Zhang W.-x.,Tianjin University of Traditional Chinese Medicine | Li S.-h.,Gansu Provincial Hospital of Traditional Chinese Medicine
Journal of Clinical Rehabilitative Tissue Engineering Research | Year: 2011

BACKGROUND: In principle, fracture treatment mainly focuses on bone remodeling from the biological and mechanical aspects to combine mechanical fixation with biological fixation as well as combine intramedullary fixation with extramedullary fixation. OBJECTIVE: To introduce the principle development of fracture treatment and bone remodeling. METHODS: A computer-based search of CNKI (2006-01/2011-05) and PubMed (2006-01/2011-05) for bone remodeling articles using the keywords of "bone structure, rebuild, principle" in Chinese and English, respectively. RESULTS AND CONCLUSION: In 30 collected articles, 14 were included in result analysis. The treatment concept of fractures has been gradually changed from mechanical fixation system to biological fixation system. Fracture treatment research focuses on the balance between stable fixation and intact soft tissues, and the design of implants and instruments is significantly improved. In recent years, there are digitized virtual human technology, bio-mechanics finite element theory, trauma-control theory, pharmacological research for osteoporosis, and tissue engineering theory and technique to repair defects. In general, the concept of bone remodeling is to choose a most reasonable patient-centered way to guide and promote bone healing and functional recovery at the macro-and micro-level.


PubMed | Gansu Provincial Hospital of Traditional Chinese Medicine
Type: Journal Article | Journal: Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation | Year: 2013

The design principle and application of an adjustable spine prone frame are introduced. Adjustable spine prone frame is used in posterior lumbar surgery, during operation, X-ray can shoot fast and internal fixation implants can fix accurately, the vacant abdominal ensure normal respiratory and circulatory function, and the lumbar curvature can adjust conveniently. It meets the surgical position and care requirements, can prevent the complications effectively.


PubMed | Gansu Provincial Hospital of Traditional Chinese Medicine
Type: Clinical Trial | Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine | Year: 2013

To study whether the effects of Leflunomide were different in treating patients with rheumatoid arthritis (RA) of different Chinese medical syndrome patterns.Totally 150 RA patients were recruited and assigned to 5 Chinese medical syndrome types, i.e., the heat-dampness blocking collateral type, cold-dampness blocking collateral type, Shen-qi deficiency cold type, Gan-Shen yin deficiency type, and stagnant blood blocking collateral type according to Chinese medical syndrome typing standards. They were treated with Leflunomide, 3 months as one therapeutic course. The parameters including numbers of joint tenderness and swelling, morning stiffness time, scores estimated by Visual Analog Scale (VAS), as well as laboratory indices involving rheumatoid factor (RF), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), American College of Rheumatology 20% improvement (ACR20), and American College of Rheumatology 50% improvement (ACR50) were observed before and after treatment, and statistically analyzed.After treatment the numbers of joint tenderness, numbers of joint swelling, VAS scores, ESR, CRP, and RF all decreased, showing statistical difference when compared with those before treatment (P < 0.05). The morning stiffness time was shortened in the heat-dampness blocking collateral type, cold-dampness blocking collateral type, and stagnant blood blocking collateral type, showing statistical difference (P < 0.05). Of them, the numbers of joint tenderness, the numbers of joint swelling, the morning stiffness time, RF, VAS scores, and the improvement of the total effective rate were obviously better in the heat-dampness blocking collateral type, cold-dampness blocking collateral type, and stagnant blood blocking collateral type than in the Shen-qi deficiency cold type and Gan-Shen yin deficiency type, showing statistical difference (P < 0.05).Leflunomide showed significant effects in treating RA. Of them, its effects were obviously better in the heat-dampness blocking collateral type, cold-dampness blocking collateral type, and stagnant blood blocking collateral type than in the Shen-qi deficiency cold type and Gan-Shen yin deficiency type.

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