Gansu Provincial Cancer Hospital

Lanzhou, China

Gansu Provincial Cancer Hospital

Lanzhou, China
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Guo Y.,Gansu Provincial Cancer Hospital | Li W.,Inner Mongolia University
Biomedical Research (India) | Year: 2017

Objective: This study aims to investigate the clinical curative effect of Video-Assisted Breast Surgery (VABS) by single incision through the anterior axillary line for removing mammary fibroma. Methods: Sixty-eight mammary fibroma cases treated in the hospital from November 2013 to June 2015 were selected and randomly divided into control and observation groups (34 cases per group). The control group was subjected to conventional ring areola incision, and the observation group was subjected to VABS by single incision through the anterior axillary line. Intraoperative blood loss, incision length, postoperative complication, and cosmetic effects after the operation were determined and compared between the two groups. Results: The observation group showed shorter incision length and hospital stay and less intraoperative blood losses than those in the control group (p<0.05). Operation duration was not significantly different between the two groups (p>0.05). The complication rates in the observation and control groups were 5.88% and 23.33%, respectively (p<0.05). The Vancouver scar scale score in the observation group was lower than that in the control group. Furthermore, breast appearance satisfaction score in the observation group was significantly higher than that in the control group (p<0.05). Conclusion: Patients with mammary fibroma who underwent VABS received improved clinical curative effects in terms of few intraoperative injuries, fast recovery after the surgery, low complication rate, non-restricted lesion depth limit, and satisfactory cosmetic effect. Overall, this technique improved the prognosis of the patients. © 2017, Scientific Publishers of India. All rights reserved.


Zhang X.,Lanzhou Jiaotong University | Li J.,Lanzhou Jiaotong University | Dang J.,Lanzhou Jiaotong University | Liu Z.,Gansu Provincial Cancer Hospital | Min Y.,Syracuse University
Journal of Engineering Science and Technology Review | Year: 2017

During the conformal radiotherapy, the multileaf collimator is usually used to block radiation to avoid the radiation in the normal tissue around the tumor for precise irradiation in target areas. However, there are several shortcomings in the ability of rapidity and anti-interference of precise leaf control in terms of the traditional controllers of leaf position for multileaf collimator. To ensure the rapidity of leaf position in place for short treatment time, a design method of controller of leaf position for multileaf collimator has been proposed, which can keep the leaves in place with short time as well as high accuracy. First, the motor that drives the leaf movement of multileaf collimator was taken as the controlled object, and the corresponding motor model was established. Second, the design method of the fractional order anti-windup controller of leaf position was proposed according to the controlled object. Finally, using quantum-behaved particle swarm optimization (QPSO) to ensure the accuracy of leaf position for multileaf collimator in place, the parameters of the controller of leaf position for multileaf collimator were optimized. The simulation results show that the rising and settling time of the output response of the leaf drive unit is 1.31s in the controller of leaf position for multileaf collimator using the proposed design method, which is better than the 6.4s in the proportional integral differential (PID) algorithm based on the particle swarm optimization (PSO) and the 12.55s in the fuzzy PID algorithm respectively. While the parameter tuning of the controller of leaf position for multileaf collimator is performed by the QPSO algorithm, the required iteration number is less. In addition, after adding the interference, the proposed controller can make the system recover to the much more stable operation state with a stronger ability of anti-interference. The proposed method provides great reference value for the research on the precise leaf position of multileaf collimator and the cooperation control strategy in the later stage. © 2017. Eastern Macedonia and Thrace Institute of Technology.


Guo Y.,Lanzhou University | Wang X.,Gansu Provincial Cancer Hospital | Yang Z.,Lanzhou University | Wang D.,Lanzhou University | Ma Y.,Lanzhou University
Proceedings - 2016 International Conference on Computational Science and Computational Intelligence, CSCI 2016 | Year: 2017

Goal: Mammography is the most effective technique for breast cancer screening, and the detection of abnormalities plays a vital role in Computer Aided Detection (CAD) system. This paper proposes a detection method for abnormal mammograms based on improved saliency detection. Methods: The proposed method comprises three main steps: firstly, enhance abnormal mammograms using dual morphological top-hat operations with a non-flat structuring element, secondly, utilize a simple and efficient saliency detector to obtain the saliency value and then employ the modified Simplified Pulse-Coupled Neural Network (SPCNN) to manipulate these saliency value for obtaining suspicious abnormal area, thirdly, the post processing is done to reduce false positives. Conclusion: The proposed method is implemented on open and common database of MIAS, the results show that this novel method outperforms the current state-of-art algorithms. In addition, this method is verified on the mammograms from Gansu Provincial Cancer Hospital, the detection results reveal that our method can accurately detect the abnormal in clinical application. Contributions: we introduce the improved saliency detection to detect abnormalities in mammograms, and the proposed method not only can detect mass, but also can detect micro-calcifications clusters. Significance: This proposed method is simple and effective, furthermore it can achieve high detection rate, we deem it could be considered to be used in CAD system to assist radiologist for breast cancer diagnosis in the future. © 2016 IEEE.


Cui M.-X.,Lanzhou University | Jiang J.-F.,Gansu Provincial Cancer Hospital | Min G.-N.,Lanzhou University | Han W.,Dingxi District of Gansu University of Chinese Medicine | Wu Y.-J.,Lanzhou University
Canadian Journal of Physiology and Pharmacology | Year: 2017

Ciliary neurotrophic factor (CNTF) and CNTF analogs were reported to have hepatoprotective effect and ameliorate hepatic steatosis in db/db or high-fat-diet-fed mice. Because hepatic steatosis and injury are also commonly induced by hepatotoxin, the aim of the present study is to clarify whether CNTF could alleviate hepatic steatosis and injury induced by carbon tetrachloride (CCl4). Unexpectedly, when combined with CCl4, CNTF aggravated hepatic steatosis and liver injury. The mechanism is associated with effects of CNTF that inhibited lipoprotein secretion and drastically impaired the ability of lipoproteins to act as transport vehicles for lipids from the liver to the circulation. While injected after CCl4 cessation, CNTF could improve liver function. These data suggest that CNTF could be a potential hepatoprotective agent against CCl4-induced hepatic injury after the cessation of CCl4 exposure. However, it is forbidden to combine recombinant mutant of human CNTF treatment with CCl4. © 2017, Canadian Science Publishing. All rights reserved.


Zhang X.-L.,Gansu Provincial Hospital | Liu R.-F.,Gansu Provincial Cancer Hospital | Liu R.-F.,Lanzhou University | Zhang D.,Lanzhou University | And 2 more authors.
International Journal of Surgery | Year: 2017

Background This meta-analysis collected studies with propensity score matching analysis (PSM) and focused on comparing the short-term and oncological outcomes of patients with colorectal liver metastases (CRLM) who underwent laparoscopic liver resection (LLR) versus open liver resection (OLR), to provide relatively high-level evidence of the additional value of LLR in treating patients with CRLM in comparison with OLR. Methods A systematic literature search was performed using the PubMed, Embase and Cochrane Library databases. Bibliographic citation management software (EndNote X7) was used for literature management. Quality assessment was performed based on a modified version of the Newcastle-Ottawa Scale. The data were analyzed using Review Manager (Version 5.1), and sensitivity analysis was performed by omitting one study in each step. Dichotomous data were calculated by odds ratio (OR) and continuous data were calculated by weighed mean difference (WMD) with 95% confidence intervals (CI). Results Overall, 10 studies enrolling 2259 patients with CRLM were included in the present meta-analysis. The pooled analysis suggested that LLR was associated with significantly less overall morbidity (OR, 0.57; 95% CI 0.40 to 0.80; I2 = 57%; P < 0.001), reduced blood loss (WMD, −124.68; 95% CI, −177.35 to −72.01; I2 = 83%; P < 0.00001), less transfusion requirement (OR, 0.46; 95% CI 0.35 to 0.62; I2 = 0%; P < 0.00001), shorter length of hospital stay (WMD, −2.13; 95% CI, −2.68 to −1.58; I2 = 0%; P < 0.00001), but longer operative time (WMD, 39.48; 95% CI, 23.68 to 55.27; I2 = 66%; P = 0.04). However, no significant differences were observed in mortality (OR, 0.50; 95% CI 0.21 to 1.2; I2 = 0%; P = 0.12). For oncological outcomes, no significant differences were observed in negative surgical margins (R0 resection), tumor recurrence, 3-year disease-free survival, 5-year disease-free survival, 5-year overall survival between the approaches. Nevertheless, LLR tended to provide higher 3-overall survival rate (OR, 1.37; 95% CI 1.11 to 1.69; I2 = 0%; P = 0.003). The pooled OR for overall morbidity in each subgroup analysis was consistent with the overall pooled OR. Additionally, the pooled OR for overall morbidity varied from (0.63; 95% CI 0.45to 0.88; I2 = 49%; P = 0.007) to (0.51; 95% CI 0.37 to 0.69; I2 = 39%; P < 0.0001) in sensitivity analysis. Conclusion LLR is a beneficial alternative to OLR in select patients, and provides more favorable short-term outcomes such as less overall morbidity, shorter length of hospital stay, less blood loss, lower blood transfusion rate. Simultaneously, LLR does not compromise oncological outcomes including surgical margins R0, tumor recurrence, disease-free survival, 5-overall survival, as well as even yielding better 3-overall survival. Considering unavoidable bias from non-randomized trials, high-quality RCTs are badly needed to determine whether LLR can become standard practice for treating patients with CRLM. © 2017


PubMed | CAS Lanzhou Institute of Modern Physics, Gansu Provincial Cancer Hospital and Peking Union Medical College
Type: Journal Article | Journal: Wounds : a compendium of clinical research and practice | Year: 2015

Radiotherapy for the management of keloids was first introduced in 1906, yet 107 years later optimal protocol has not yet been established. Most studies have been conducted using x-ray, -ray, or -ray. However, for high linear energy transfer radiation, clinical data are scarce. The aim of this study was to examine the efficacy and safety of postoperative carbon ion radiotherapy for keloids.Case records of 16 patients with 20 keloids, who were given postoperative carbon ion radiotherapy with 16GyE/8 fractions in the therapy terminal at the Heavy Ion Research Facility in Lanzhou at the Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China, were retrospectively reviewed.In a mean follow-up period of 29.7 months (range 24.3-35.3 months), overall survival and 95% success rates were achieved. No grade 3 or higher toxicity and complication occurred, and none of the 16 patients presented with local or systemic malignancy during the follow-up period.Here, the first evidence of postoperative carbon ion radiotherapy for keloids is provided. Surgical excision and immediate postoperative carbon ion radiotherapy is well tolerated and should be considered as a potential curative treatment modality of keloids in certain cases.


PubMed | No1 Hospital Of Longnan City, Northwest University for Nationalities and Gansu Provincial Cancer Hospital
Type: | Journal: Infectious agents and cancer | Year: 2017

The mortality of cervical cancer in Longnan is as high as 39/10 million, ranking first in China.Between 2012 to 2016, 329 samples with cervicitis, cervical intraepithelial neoplasia grade 1 to 3 (CINI to III), and invasive squamous cell carcinoma (SCC) were collected. HPV genotypes were examined with a validated kit for 23 different HPV subtypes.Compared to cervicitis, the HPV positivity is significantly higher in CINI, CIN II/III, and SCC (38.60%, 74.60%, 87.50% and 89.05%, These findings highlight the key role of HPV16, 58, 52 and 18 in the development of CIN and SCC in Longnan women and a fully aware of regional differences in HPV genotype distribution are tasks for cervical cancer control and prevention.


Jiang J.,Lanzhou University | Jiang J.,Gansu Provincial Cancer Hospital | Wu Y.,Lanzhou University | Wang X.,Lanzhou University | And 4 more authors.
Obesity Research and Clinical Practice | Year: 2016

Objective The close connection between high blood FFA and insulin resistance (IR) in obese individuals is well-known. The purpose of this study was to identify whether the blood FFA increased in obese-IR animals. Methods Obese-IR animal models were established using high-fat diet (HFD) or HFD and streptozocin, and treated with drugs. Results The serum FFA of obese-IR animals was not increased, even significantly lower than that of normal animals, and were not significantly decreased when insulin sensitivity and obesity-related indices were ameliorated after treatment. Conclusion The results suggest that blood FFA are unlikely the link between obesity and insulin resistance. © 2015 Asia Oceania Association for the Study of Obesity.


PubMed | Peoples Hospital of Gansu Province, Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province and Gansu Provincial Cancer Hospital
Type: Journal Article | Journal: Environmental science and pollution research international | Year: 2016

Although the relationship between asthma and exposure to fine particulate matter (PM2.5) has been frequently measured, reported conclusions have not been consistent. As emergency department (ED) visits are an effective way to estimate health outcomes for people with asthma and short-term exposure to PM2.5, this review systematically searched five databases without language or geographical restrictions from inception to January 13, 2015 to study the impact of PM2.5 on asthma ED visits. A random-effects model was used to calculate the pooled risk ratio (RR) and 95% confidence intervals (CI). With respect to short-term effects, asthma ED visits increased at higher PM2.5 concentrations (RR 1.5% per 10 g/m(3); 95% CI 1.2-1.7%), and children were more susceptible (3.6% per 10 g/m(3); 95% CI 1.8, 5.3%) than adults (1.7, 95% CI 0.7%, 2.8%) to increased PM2.5; the ED visits increased during the warm season by 3.7% (95% CI 0.5, 6.9%) per 10 g/m(3) increase in PM2.5, which was higher than the corresponding increase during the cold season (2.6, 95% CI 0.7-4.6%). This demonstrates that ambient PM2.5 has an adverse impact on asthma ED visits after short-term exposure and that children are a high-risk population when PM2.5 concentrations are high, particularly in warm seasons, during which measures should be taken to prevent PM2.5.


Liu Y.Q.,Gansu Provincial Cancer Hospital
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi | Year: 2012

To analyze the trend of incidence and mortality on thyroid cancer in China. Data from 32 cancer registry sites in China was collected and Jionpoint model was used to obtain the crude, age-specified incidence and mortality, both Chinese national and world age-standardized rates of incidence and mortality and their trends. The crude incidence of thyroid cancer was 4.44/10(5), and the Chinese national and world age-standardized rates were 2.89/10(5) and 3.31/10(5) respectively. The crude mortality of thyroid cancer was 0.44/10(5), with the Chinese national and world age-standardized rates as 0.21/10(5) and 0.29/10(5) during 2003 - 2007 in the country. Thyroid cancer accounted for 1.67% and 0.26% of the Chinese national and world age-standardized proportions, for total cancers. Both incidence and mortality of thyroid cancer were higher in females than in males, 3.38 and 1.75 times higher in urban areas than those in rural areas. The incidence of thyroid cancer showed annually increase of 14.51% while the mortality had an increase of 1.42%. The incidence and mortality of thyroid cancer increased rapidly in China, calling for more control efforts on this disease.

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