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Guo Y.,Gansu Provincial Cancer Hospital | Li W.,Inner Mongolia University
Biomedical Research (India) | Year: 2017

Objective: This study aims to investigate the clinical curative effect of Video-Assisted Breast Surgery (VABS) by single incision through the anterior axillary line for removing mammary fibroma. Methods: Sixty-eight mammary fibroma cases treated in the hospital from November 2013 to June 2015 were selected and randomly divided into control and observation groups (34 cases per group). The control group was subjected to conventional ring areola incision, and the observation group was subjected to VABS by single incision through the anterior axillary line. Intraoperative blood loss, incision length, postoperative complication, and cosmetic effects after the operation were determined and compared between the two groups. Results: The observation group showed shorter incision length and hospital stay and less intraoperative blood losses than those in the control group (p<0.05). Operation duration was not significantly different between the two groups (p>0.05). The complication rates in the observation and control groups were 5.88% and 23.33%, respectively (p<0.05). The Vancouver scar scale score in the observation group was lower than that in the control group. Furthermore, breast appearance satisfaction score in the observation group was significantly higher than that in the control group (p<0.05). Conclusion: Patients with mammary fibroma who underwent VABS received improved clinical curative effects in terms of few intraoperative injuries, fast recovery after the surgery, low complication rate, non-restricted lesion depth limit, and satisfactory cosmetic effect. Overall, this technique improved the prognosis of the patients. © 2017, Scientific Publishers of India. All rights reserved.


Chen Y.,Chinese Academy of Sciences | Chen Y.,Yale University | Zheng T.,Yale University | Lan Q.,U.S. National Institutes of Health | And 15 more authors.
American Journal of Hematology | Year: 2013

We conducted a population-based case-control study in Connecticut women to test the hypothesis that genetic variations in DNA repair pathway genes may modify the relationship between body mass index (BMI) and risk of non-Hodgkin lymphoma (NHL). Compared to those with BMI <25, women with BMI ≥25 had significantly increased risk of NHL among women who carried BRCA1 (rs799917) CT/TT, ERCC2 (rs13181) AA, XRCC1 (rs1799782) CC, and WRN (rs1801195) GG genotypes, but no increase in NHL risk among women who carried BRCA1 CC, ERCC2 AC/CC, XRCC1 CT/TT, and WRN GT/TT genotypes. A significant interaction with BMI was only observed for WRN (rs1801195; P = 0.004) for T-cell lymphoma and ERCC2 (rs13181; P = 0.002) for diffuse large B-cell lymphoma. The results suggest that common genetic variation in DNA repair pathway genes may modify the association between BMI and NHL risk. © 2013 Wiley Periodicals, Inc.


PubMed | CAS Lanzhou Institute of Modern Physics, Gansu Provincial Cancer Hospital and Peking Union Medical College
Type: Journal Article | Journal: Wounds : a compendium of clinical research and practice | Year: 2015

Radiotherapy for the management of keloids was first introduced in 1906, yet 107 years later optimal protocol has not yet been established. Most studies have been conducted using x-ray, -ray, or -ray. However, for high linear energy transfer radiation, clinical data are scarce. The aim of this study was to examine the efficacy and safety of postoperative carbon ion radiotherapy for keloids.Case records of 16 patients with 20 keloids, who were given postoperative carbon ion radiotherapy with 16GyE/8 fractions in the therapy terminal at the Heavy Ion Research Facility in Lanzhou at the Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China, were retrospectively reviewed.In a mean follow-up period of 29.7 months (range 24.3-35.3 months), overall survival and 95% success rates were achieved. No grade 3 or higher toxicity and complication occurred, and none of the 16 patients presented with local or systemic malignancy during the follow-up period.Here, the first evidence of postoperative carbon ion radiotherapy for keloids is provided. Surgical excision and immediate postoperative carbon ion radiotherapy is well tolerated and should be considered as a potential curative treatment modality of keloids in certain cases.


PubMed | No1 Hospital Of Longnan City, Northwest University for Nationalities and Gansu Provincial Cancer Hospital
Type: | Journal: Infectious agents and cancer | Year: 2017

The mortality of cervical cancer in Longnan is as high as 39/10 million, ranking first in China.Between 2012 to 2016, 329 samples with cervicitis, cervical intraepithelial neoplasia grade 1 to 3 (CINI to III), and invasive squamous cell carcinoma (SCC) were collected. HPV genotypes were examined with a validated kit for 23 different HPV subtypes.Compared to cervicitis, the HPV positivity is significantly higher in CINI, CIN II/III, and SCC (38.60%, 74.60%, 87.50% and 89.05%, These findings highlight the key role of HPV16, 58, 52 and 18 in the development of CIN and SCC in Longnan women and a fully aware of regional differences in HPV genotype distribution are tasks for cervical cancer control and prevention.


Fan J.,Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province | Fan J.,Lanzhou University | Li S.,Peoples Hospital of Gansu Province | Fan C.,Gansu Provincial Cancer Hospital | And 4 more authors.
Environmental Science and Pollution Research | Year: 2016

Although the relationship between asthma and exposure to fine particulate matter (PM2.5) has been frequently measured, reported conclusions have not been consistent. As emergency department (ED) visits are an effective way to estimate health outcomes for people with asthma and short-term exposure to PM2.5, this review systematically searched five databases without language or geographical restrictions from inception to January 13, 2015 to study the impact of PM2.5 on asthma ED visits. A random-effects model was used to calculate the pooled risk ratio (RR) and 95 % confidence intervals (CI). With respect to short-term effects, asthma ED visits increased at higher PM2.5 concentrations (RR 1.5 % per 10 μg/m3; 95 % CI 1.2–1.7 %), and children were more susceptible (3.6 % per 10 μg/m3; 95 % CI 1.8, 5.3 %) than adults (1.7, 95 % CI 0.7 %, 2.8 %) to increased PM2.5; the ED visits increased during the warm season by 3.7 % (95 % CI 0.5, 6.9 %) per 10 μg/m3 increase in PM2.5, which was higher than the corresponding increase during the cold season (2.6, 95 % CI 0.7–4.6 %). This demonstrates that ambient PM2.5 has an adverse impact on asthma ED visits after short-term exposure and that children are a high-risk population when PM2.5 concentrations are high, particularly in warm seasons, during which measures should be taken to prevent PM2.5. © 2015, Springer-Verlag Berlin Heidelberg.


Jiang J.,Lanzhou University | Jiang J.,Gansu Provincial Cancer Hospital | Wu Y.,Lanzhou University | Wang X.,Lanzhou University | And 4 more authors.
Obesity Research and Clinical Practice | Year: 2016

Objective The close connection between high blood FFA and insulin resistance (IR) in obese individuals is well-known. The purpose of this study was to identify whether the blood FFA increased in obese-IR animals. Methods Obese-IR animal models were established using high-fat diet (HFD) or HFD and streptozocin, and treated with drugs. Results The serum FFA of obese-IR animals was not increased, even significantly lower than that of normal animals, and were not significantly decreased when insulin sensitivity and obesity-related indices were ameliorated after treatment. Conclusion The results suggest that blood FFA are unlikely the link between obesity and insulin resistance. © 2015 Asia Oceania Association for the Study of Obesity.


Mi D.,Lanzhou University | Mi D.,Gansu Provincial Second Peoples Hospital | Ren W.,Lanzhou University | Ren W.,Gansu Provincial Cancer Hospital | Yang K.,Lanzhou University
Indian Journal of Medical Research, Supplement | Year: 2016

Background & objectives: The effectiveness of interleukin-2 (IL-2) and induced killer cells for non-small cell lung cancer (NSCLC) is controversial. This study evaluates the efficacy and safety of interleukin-2 and induced killer cells on NSCLC, so as to provide references for further clinical practice and research. Methods: Relevant randomized controlled trials (RCTs) were searched in Cochrane library (Issue 2, 2013), Web of Science (1980-March 2013), PubMed (1966-March 2013), China Knowledge Resource Integrated database (CNKI) (1994-March 2013), China Biology Medicine database (CBM) (1978-March 2013), VIP (1989-March 2013), and Wan Fang databases (1997-March 2013). There were no language restrictions. After independent quality assessment and data extraction by two authors, meta-analysis was conducted by RevMan 5.1 software. Results: Ten RCTs were included. Odds ratio (OR), 95% confidence intervals (CI), P value expressed as test group (interleukin-2 or induced killer cells combined chemotherapy) versus control group (chemotherapy alone), was 2.02 (1.24, 3.29; P=0.004) for disease control rate. Hazard ratios (HR) (95% CI; P value), expressed as test group (interleukin-2 or induced killer cells) versus control group, were 0.60 (0.46, 0.79; P=0.0003) for overall survival of postoperative treatment, and 0.77 (0.60, 0.99; P =0.04) for overall survival of combination with chemotherapy. Mean differences (MD) (95% CI; P value), expressed as test group (interleukin-2 or induced killer cells) versus control group (after treatment), were 11.32 (6.32, 16.33; P=0.00001) for NK cells, 11.79 (2.71, 20.86; P=0.01) for CD3+ cells, 14.63 (2.62, 26.64; P=0.02) for CD4+ cells, and -4.49 (-7.80, 1.18; P=0.008) for CD8+ cells. Interpretation & conclusions: The meta-analysis showed that IL-2 or induced killer cells combination therapy was efficacious in treating NSCLC and improved overall survival. Further analysis of trials having adequate information and data need to be done to confirm these findings. © 2016, Indian Council of Medical Research. All rights reserved.


PubMed | Peoples Hospital of Gansu Province, Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province and Gansu Provincial Cancer Hospital
Type: Journal Article | Journal: Environmental science and pollution research international | Year: 2016

Although the relationship between asthma and exposure to fine particulate matter (PM2.5) has been frequently measured, reported conclusions have not been consistent. As emergency department (ED) visits are an effective way to estimate health outcomes for people with asthma and short-term exposure to PM2.5, this review systematically searched five databases without language or geographical restrictions from inception to January 13, 2015 to study the impact of PM2.5 on asthma ED visits. A random-effects model was used to calculate the pooled risk ratio (RR) and 95% confidence intervals (CI). With respect to short-term effects, asthma ED visits increased at higher PM2.5 concentrations (RR 1.5% per 10 g/m(3); 95% CI 1.2-1.7%), and children were more susceptible (3.6% per 10 g/m(3); 95% CI 1.8, 5.3%) than adults (1.7, 95% CI 0.7%, 2.8%) to increased PM2.5; the ED visits increased during the warm season by 3.7% (95% CI 0.5, 6.9%) per 10 g/m(3) increase in PM2.5, which was higher than the corresponding increase during the cold season (2.6, 95% CI 0.7-4.6%). This demonstrates that ambient PM2.5 has an adverse impact on asthma ED visits after short-term exposure and that children are a high-risk population when PM2.5 concentrations are high, particularly in warm seasons, during which measures should be taken to prevent PM2.5.


Liu Y.Q.,Gansu Provincial Cancer Hospital
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi | Year: 2012

To analyze the trend of incidence and mortality on thyroid cancer in China. Data from 32 cancer registry sites in China was collected and Jionpoint model was used to obtain the crude, age-specified incidence and mortality, both Chinese national and world age-standardized rates of incidence and mortality and their trends. The crude incidence of thyroid cancer was 4.44/10(5), and the Chinese national and world age-standardized rates were 2.89/10(5) and 3.31/10(5) respectively. The crude mortality of thyroid cancer was 0.44/10(5), with the Chinese national and world age-standardized rates as 0.21/10(5) and 0.29/10(5) during 2003 - 2007 in the country. Thyroid cancer accounted for 1.67% and 0.26% of the Chinese national and world age-standardized proportions, for total cancers. Both incidence and mortality of thyroid cancer were higher in females than in males, 3.38 and 1.75 times higher in urban areas than those in rural areas. The incidence of thyroid cancer showed annually increase of 14.51% while the mortality had an increase of 1.42%. The incidence and mortality of thyroid cancer increased rapidly in China, calling for more control efforts on this disease.


Liu Q.-J.,Gansu Provincial Cancer Hospital | Dong F.,Gansu Provincial Cancer Hospital | Ma S.-H.,Gansu Provincial Cancer Hospital | Mei S.,Gansu Provincial Cancer Hospital
Tumor | Year: 2014

Objective: To examine the expressions of cytokeratin 19 (CK19) and polymorphic epithelial mucin (MUC1) in peripheral blood of patients with thyroid cancer, and evaluate their clinical value as the biomarkers in the detection of circulating tumor cells and blood micrometastasis. Methods: The flow cytometry (FCM) was used to detect CK19-positive and MUC1-positive cells in peripheral blood of 491 patients with thyroid cancer and 376 patients with nodular goiter. Results: The positive expression rates of CK19 in patients with thyroid cancer and nodular goiter were 35.4% (174/491) and 7.7% (29/376), respectively (P = 0.000); the positive expression rates of MUC1 in patients with thyroid cancer and nodular goiter were 32.8% (161/491) and 3.5% (13/376), respectively (P = 0.000). In univariate analysis, the tumor size, tumor capsule invasion, lymph node metastasis and distant metastasis were significantly associated with the positive expression of CK19 or MUC1 and the positive expressions of both CK19 and MUC1 (P < 0.05). In multivariate analysis, tumor capsule invasion, lymph node metastasis and distant metastasis were independent factors related to the positive expression of CK19 or MUC1 and the positive expressions of both CK19 and MUC1 (P < 0.05). There was a positive correlation between the expressions of CK19 and MUC1 (r = 0.628, P = 0.000). Conclusion: The expressions of CK19 and MUC1 were significantly related to tumor capsule invasion, lymph node metastasis and distant metastasis of thyroid cancer, and these two biomarkers may be helpful to predict the blood micrometastasis and evaluate the prognosis. Copyright© 2014 by TUMOR.

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