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Fan J.,Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province | Fan J.,Lanzhou University | Li S.,Peoples Hospital of Gansu Province | Fan C.,Gansu Provincial Cancer Hospital | And 4 more authors.
Environmental Science and Pollution Research | Year: 2016

Although the relationship between asthma and exposure to fine particulate matter (PM2.5) has been frequently measured, reported conclusions have not been consistent. As emergency department (ED) visits are an effective way to estimate health outcomes for people with asthma and short-term exposure to PM2.5, this review systematically searched five databases without language or geographical restrictions from inception to January 13, 2015 to study the impact of PM2.5 on asthma ED visits. A random-effects model was used to calculate the pooled risk ratio (RR) and 95 % confidence intervals (CI). With respect to short-term effects, asthma ED visits increased at higher PM2.5 concentrations (RR 1.5 % per 10 μg/m3; 95 % CI 1.2–1.7 %), and children were more susceptible (3.6 % per 10 μg/m3; 95 % CI 1.8, 5.3 %) than adults (1.7, 95 % CI 0.7 %, 2.8 %) to increased PM2.5; the ED visits increased during the warm season by 3.7 % (95 % CI 0.5, 6.9 %) per 10 μg/m3 increase in PM2.5, which was higher than the corresponding increase during the cold season (2.6, 95 % CI 0.7–4.6 %). This demonstrates that ambient PM2.5 has an adverse impact on asthma ED visits after short-term exposure and that children are a high-risk population when PM2.5 concentrations are high, particularly in warm seasons, during which measures should be taken to prevent PM2.5. © 2015, Springer-Verlag Berlin Heidelberg. Source

Liu Y.Q.,Gansu Provincial Cancer Hospital
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi | Year: 2012

To analyze the trend of incidence and mortality on thyroid cancer in China. Data from 32 cancer registry sites in China was collected and Jionpoint model was used to obtain the crude, age-specified incidence and mortality, both Chinese national and world age-standardized rates of incidence and mortality and their trends. The crude incidence of thyroid cancer was 4.44/10(5), and the Chinese national and world age-standardized rates were 2.89/10(5) and 3.31/10(5) respectively. The crude mortality of thyroid cancer was 0.44/10(5), with the Chinese national and world age-standardized rates as 0.21/10(5) and 0.29/10(5) during 2003 - 2007 in the country. Thyroid cancer accounted for 1.67% and 0.26% of the Chinese national and world age-standardized proportions, for total cancers. Both incidence and mortality of thyroid cancer were higher in females than in males, 3.38 and 1.75 times higher in urban areas than those in rural areas. The incidence of thyroid cancer showed annually increase of 14.51% while the mortality had an increase of 1.42%. The incidence and mortality of thyroid cancer increased rapidly in China, calling for more control efforts on this disease. Source

Lv Q.-F.,Lanzhou University | Zhang Q.-N.,Lanzhou University | Tian J.-H.,Gansu Provincial Cancer Hospital | Tian J.-H.,Lanzhou University
Journal of Practical Oncology | Year: 2015

Objective: To assess the efficacy and safety of postoperative radiotherapy of internal mammary nodes in stage I~III breast cancer with meta-analysis. Methods: CNKI, CBM, Wanfang, PubMed, EMBASE, Web of Science and The Cochrane Library were searched to retrieve clinical controlled trials on postoperative radiotherapy of internal mammary nodes for patients with stage I~III breast cancer. Quality assessment and date extraction were done according to the Cochrane Reviewer's Handbook 5.2. Meta-analysis was performed using RevMan 5.2 software. Results: Seven studies involving 6 835 patients were included in the analysis. The analysis showed that there were no differences in 5-year survival rate(OR=1.08, 95% CI: 0.93~1.27), 10-year survival rate(OR=0.86, 95% CI: 0.55~1.35) and 10-year disease-free survival rate(OR=1.20, 95% CI: 0.99~1.45) between patients with and without postoperative radiotherapy of internal mammary nodes (all P>0.05). Conclusion: Internal mammary node irradiation has no advantage in overall survival and disease-free survival for patients with stage I~III breast cancer. ©, 2015, Journal of Practical Oncology, Editorial Board. All right reserved. Source

Chen Y.,Chinese Academy of Sciences | Chen Y.,Yale University | Zheng T.,Yale University | Lan Q.,U.S. National Institutes of Health | And 15 more authors.
American Journal of Hematology | Year: 2013

We conducted a population-based case-control study in Connecticut women to test the hypothesis that genetic variations in DNA repair pathway genes may modify the relationship between body mass index (BMI) and risk of non-Hodgkin lymphoma (NHL). Compared to those with BMI <25, women with BMI ≥25 had significantly increased risk of NHL among women who carried BRCA1 (rs799917) CT/TT, ERCC2 (rs13181) AA, XRCC1 (rs1799782) CC, and WRN (rs1801195) GG genotypes, but no increase in NHL risk among women who carried BRCA1 CC, ERCC2 AC/CC, XRCC1 CT/TT, and WRN GT/TT genotypes. A significant interaction with BMI was only observed for WRN (rs1801195; P = 0.004) for T-cell lymphoma and ERCC2 (rs13181; P = 0.002) for diffuse large B-cell lymphoma. The results suggest that common genetic variation in DNA repair pathway genes may modify the association between BMI and NHL risk. © 2013 Wiley Periodicals, Inc. Source

Chen Y.,Peking Union Medical College | Dong F.,Gansu Provincial Cancer Hospital | Wang X.,Gansu Provincial Cancer Hospital | Xue J.,Gansu Provincial Cancer Hospital | And 4 more authors.
Wounds | Year: 2014

Conclusion. Here, the first evidence of postoperative carbon ion radiotherapy for keloids is provided. Surgical excision and immediate postoperative carbon ion radiotherapy is well tolerated and should be considered as a potential curative treatment modality of keloids in certain cases.Material and Methods. Case records of 16 patients with 20 keloids, who were given postoperative carbon ion radiotherapy with 16GyE/8 fractions in the therapy terminal at the Heavy Ion Research Facility in Lanzhou at the Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China, were retrospectively reviewed.Results. In a mean follow-up period of 29.7 months (range 24.3-35.3 months), overall survival and 95% success rates were achieved. No grade 3 or higher toxicity and complication occurred, and none of the 16 patients presented with local or systemic malignancy during the follow-up period.Objectives. Radiotherapy for the management of keloids was first introduced in 1906, yet 107 years later optimal protocol has not yet been established. Most studies have been conducted using x-ray, β-ray, or γ-ray. However, for high linear energy transfer radiation, clinical data are scarce. The aim of this study was to examine the efficacy and safety of postoperative carbon ion radiotherapy for keloids. Source

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