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Shi H.-P.,Lanzhou University | Hou Y.-S.,Heze City Chinese Medicine Hospital | Zhang Q.-N.,Gansu Province Tumor Hospital | Wang D.-Y.,Lanzhou University | Wang X.-H.,Lanzhou University
Journal of Practical Oncology | Year: 2014

Objective: To evaluate the efficacy and safety of zoledronic acid combined with chemotherapy versus chemotherapy alone for non-small cell lung cancer (NSCLC) patients with bone metastasis. Methods: The randomized controlled trials (RCTs) about zoledronic acid plus chemotherapy vs chemotherapy alone for advanced NSCLC with bone metastasis were searched in PubMed, the Cochrane Library, Embase, VIP, Wanfang, CNKI, CBM and other electronic databases from inception to December 2011. Two reviewers screened studies according to inclusion and exclusion criteria, extracted data and assessed quality of the included studies independently. Then meta-analyses were performed using RevMan 5.0.2. Results: A total of 14 RCTs of 1 184 cases were included. The results of meta-analyses showed that compared with the chemotherapy group, the combined group improved the rates of pain control[OR=5.78, 95%CI: (3.93, 8.51), P<0.00001] and bone metastasis control[OR=5.82, 95%CI: (3.52, 9.61), P<0.00001], there were no significant differences in primary lung lesion control [OR=1.61, 95%CI: (0.92, 2.82), P=0.09]. The adverse reaction rates of the combined group, such as fever, gastrointestinal reactions and muscle soreness, were higher(all P<0.05). Conclusion: Zoledronic acid combined with chemotherapy can improve the rates of pain control and bone metastasis control for advanced NSCLC patients with bone metastasis, and the safety is acceptable. Source


Fu H.,Shanghai JiaoTong University | Wang J.,Gansu Province Tumor Hospital | Wang L.,Shanghai JiaoTong University | Zhang Z.,Shanghai JiaoTong University | He Y.,Shanghai JiaoTong University
Journal of Pediatric Surgery | Year: 2012

Background: Pleomorphic adenomas (PAs) of the salivary glands are rare in children and adolescents. We reviewed the clinical manifestations, pathologic features, treatment, and prognosis of salivary gland PA in 90 children and adolescents. Methods: Clinical data including age, sex, location, symptoms, the period of evolution of the symptoms, pathologic type, and surgical treatment were evaluated. Results: The median age was 16.5 years old. There was a 1.43:1 female-to-male ratio. The parotid gland was the most commonly affected major gland (56.7%), and the palate, the most common site of minor salivary gland involvement. Ultrasonography and computed tomography were performed in most cases for diagnosis. Superficial parotidectomy or total parotidectomy with facial nerve dissection and preservation was the most common surgical procedure. Submandibular triangle dissection was applied to all submandibular PAs. Classic-type PA was the most common histologic subtype (43.3%). Conclusions: Salivary gland PAs in children and adolescents have different characteristics compared with their adult counterparts in regard to histologic subtype and location. Surgical removal is the best treatment option for PAs in children and adolescents. © 2012 Elsevier Inc. Source


Ma S.H.,Lanzhou University | Liu Q.J.,Gansu Province Tumor Hospital | Zhang Y.C.,Lanzhou University | Yang R.,Lanzhou University
Oncology Letters | Year: 2011

The extent of surgical resection in patients with sporadic medullary thyroid carcinoma (SMTC) remains controversial. The aim of the present study was to discuss the prognosis of sporadic medullary thyroid carcinoma with different surgical treatments. Of 73 patients with SMTC (mean age of 43.78 years at diagnosis), 70 patients were followed up for 12.0-169.0 months (median 90.0). Having given their informed consent, 12 patients underwent total thyroidectomy with bilateral central neck dissection (group A), 40 underwent subtotal thyroidectomy preserving contralateral thyroid tissue on the entrance point of the recurrent laryngeal nerve into the larynx with ipsilateral modified radical neck dissection (group B), and 18 patients underwent subtotal thyroidectomy preserving contralateral thyroid tissue on the entrance point of the recurrent laryngeal nerve into the larynx with bilateral modified radical neck dissection (group C). The diagnosis was confirmed by a pathology examination. The incidences of hypoparathyroidism and recurrent laryngeal nerve injury, the cancer recurrence rates and survival time were investigated post-operatively. Significant differences were found between groups A, B and C in the incidence of hypoparathyroidism (χ2=40.9, P<0.01), as well as that of recurrent laryngeal nerve injury (χ2=32.9, P<0.01). The cancer recurrence rates in groups A, B and C were 75.0% (9/12), 2.5% (1/40) and 44.4% (8/18) respectively, (χ2=31.1, P<0.01) and the cure rates were 25, 97.5 and 55.6% respectively (χ2=31.1, P<0.01). The mean survival times in groups A, B and C were 77.8, 106.1 and 111.0 months respectively, but significant difference was noted (χ2=3.2, P>0.05). In conclusion, compared to total thyroidectomy with bilateral central neck dissection, subtotal thyroidectomy with ipsilateral/bilateral modified radical neck dissection showed a lower incidence of hypoparathyroidism, recurrent laryngeal nerve injury and lower rates of recurrence, along with a similar cumulative survival. Source


Meng M.,Peoples Hospital of Gansu Province | Liu L.-C.,Peoples Hospital of Gansu Province | Ge B.,Peoples Hospital of Gansu Province | Tang H.,Peoples Hospital of Gansu Province | And 2 more authors.
Chinese Journal of Evidence-Based Medicine | Year: 2011

Objective: To evaluate the efficacy and safety of Celecoxib and Naproxen for treating osteoarthritis or rheumatoid arthritis. Methods: Such databases as EMbase, PubMed, The Cochrane Library, Chinese Biomedical Literature Database (CBM), China Journal Full-text Database (CJFD), and Chinese Scientific Journal Full-text Database (CSJD) were searched to collect the randomized controlled trials (RCTs) of Celecoxib and Naproxen for treating osteoarthritis or rheumatoid arthritis. Two reviewers independently assessed the quality of the included studies and extracted the data. The Review Manager (version 5.0) software was used to analyze the data. Results: Four RCTs involving 2 931 patients were included. The results of meta-analyses were as follows: a) There were significant differences in the dose of Celecoxib and Naproxen for treating rheumatoid arthritis or osteoarthritis; b) There was no significant difference in gastrointestinal reaction between the Celecoxib group and the placebo group (RR=1.29, 95%CI 0.93 to 1.79); c) The were significant differences in gastrointestinal reaction between the Celecoxib group and the Naproxen group (RR=0.78, 95%CI 0.64 to 0.95); d) There were significant differences in inducing the severity of Stomach and Duodenum Endoscopy Score between the Celecoxib group and the Naproxen group when treating rheumatoid arthritis or osteoarthritis (RR=1.29, 95%CI 0.93 to 1.79). As the Intention-To-Treat (ITT) analysis showed, there were significant differences in inducing the severity of gastrointestinal reaction between the Celecoxib group and the Naproxen group when treating rheumatoid arthritis or osteoarthritis (RR=0.84, 95%CI 0.77 to 0.92). Conclusion: Compared with Naproxen, there are significant differences in efficacy for treating rheumatoid arthritis and osteoarthritis with Celecoxib in different doses. The Celecoxib has no significant difference in gastrointestinal reaction compared with the placebo group. The Celecoxib group has fewer gastrointestinal side-effects as compared with the Naproxen group, so it can be used to treat rheumatoid arthritis and osteoarthritis in clinic. The results still need to be confirmed by high-quality RCTs. © 2011 Editorial Board of Chin J Evid-based Med. Source


Wang J.,Gansu Province Tumor Hospital | Fu H.,Shanghai JiaoTong University | Yang H.,Shanghai Tenth Peoples Hospital | Wang L.,Shanghai JiaoTong University | He Y.,Shanghai JiaoTong University
Journal of Pediatric Surgery | Year: 2011

Objective: Cervical ectopic thymus (CET) is an extremely uncommon etiology of a neck mass in an infant. The aim of this study was to study and analyze the clinical manifestations, management principles, and pathological diagnosis of CET. Methods: From 1995 to 2010, a total of 25,237 cases of head and neck lesions were treated in the Department of Oral and Maxillofacial Surgery, Shanghai Ninth People's Hospital. Among these huge numbers of lesions, there were only 3 cases of pathological-diagnosed CET presenting as neck masses. These 3 rare cases were interesting, and here, we report their clinical management and pathological diagnosis. Result: Three patients had a pathological diagnosis of CET. Their ages ranged from 4 months to 4 years. Clinically, all 3 patients presented with a painless neck mass and received surgical resection. Pathological diagnoses are based on hematoxylin and eosin and immunohistochemical staining. Conclusion: Painless swelling or neck mass is the major complaint for CET. Radiologic imaging can help determine the extent of the mass and relationship with adjacent structures. Surgery with frozen section remains the main method for pathological diagnosis and management. © 2011 Elsevier Inc. Source

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