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Li C.,CAS Northwest Institute of Plateau Biology | Li C.,University of Chinese Academy of Sciences | Zhan-Dui,Tibetan Traditional Medical College | Leng-Ben-Cai-Rang,Gansu Province Academy of Tibetan Medicine | And 13 more authors.
Guang Pu Xue Yu Guang Pu Fen Xi/Spectroscopy and Spectral Analysis | Year: 2015

In order to reveal the chemical substance basis of pharmacodynamic effects of Zuotai, energy dispersive spectrometry of X-ray (EDX), X-ray fluorescence spectroscopy (XRF), synchrotron radiation X-ray absorption fine structure (SR-XAFS), X-ray diffraction (XRD), scanning electron microscope (SEM) and atomic force microscope (AFM) were used to analyze the elements, the chemical valence and local structure of mercury, and the chemical phase composition and micro-morphology of Zuotai. EDX and XRF analysis shows that the main elements in Zuotai are Hg and S, with some other minor elements, such as O, Fe, Al, Cu, K, Ag, Ca, Mg etc. SR-XAFS analysis shows that: the oxidation state of mercury in Zuotai is divalence, its neighbor atoms are S, and its coordination number is four. XRD assay found that β-HgS (cubic, F-43m 216) and S8 (orthorhombic, Fddd 70) are the main phase compositions in Zuotai. Besides, it also has a small amount of C (hexagonal, P63/mmc 194), Fe1.05S0.95 (hexagonal, P63/mmc 194), Cu6S6 (hexagonal, P63/mmc 194), Cu1.8S (cubic, F-43m 216) and so on. And it was found that the crystallinity of Zuotai is about 59%, and the amorphous morphology substance in it is about 41%. SEM and AFM detection suggests that Zuotai is a kind of ancient micro-nano drug, and its particle size is mainly in the range of 100~600 nm, even less than 100 nm, which commonly further aggregate into several to 30 μm loose amorphous particles. In summary, the present study elucidated physicochemical characterization(elements composition, coordination information of mercury, phase composition and micro-morphology) of Zuotai, and it will play a positive role in promoting the interpretation of this mysterious drug. ©, 2015, Science Press. All right reserved.


Li C.,CAS Northwest Institute of Plateau Biology | Li C.,Chinese Academy of Sciences | Yang H.,CAS Northwest Institute of Plateau Biology | Yang H.,Chinese Academy of Sciences | And 12 more authors.
Bioinorganic Chemistry and Applications | Year: 2016

Zuotai (gTso thal) is one of the famous drugs containing mercury in Tibetan medicine. However, little is known about the chemical substance basis of its pharmacodynamics and the intrinsic link of different samples sources so far. Given this, energy dispersive spectrometry of X-ray (EDX), scanning electron microscopy (SEM), atomic force microscopy (AFM), and powder X-ray diffraction (XRD) were used to assay the elements, micromorphology, and phase composition of nine Zuotai samples from different regions, respectively; the XRD fingerprint features of Zuotai were analyzed by multivariate statistical analysis. EDX result shows that Zuotai contains Hg, S, O, Fe, Al, Cu, and other elements. SEM and AFM observations suggest that Zuotai is a kind of ancient nanodrug. Its particles are mainly in the range of 100-800 nm, which commonly further aggregate into 1-30 μm loosely amorphous particles. XRD test shows that β-HgS, S8, and α-HgS are its main phase compositions. XRD fingerprint analysis indicates that the similarity degrees of nine samples are very high, and the results of multivariate statistical analysis are broadly consistent with sample sources. The present research has revealed the physicochemical characteristics of Zuotai, and it would play a positive role in interpreting this mysterious Tibetan drug. © 2016 Cen Li et al.


Li C.,CAS Northwest Institute of Plateau Biology | Li C.,University of Chinese Academy of Sciences | Sang-Lao,Gansu Province Academy of Tibetan Medicine | Leng-Bencairang,Gansu Province Academy of Tibetan Medicine | And 4 more authors.
Guang Pu Xue Yu Guang Pu Fen Xi/Spectroscopy and Spectral Analysis | Year: 2012

Zhuxi is a mineral medicine widely used in traditional Tibetan medicine throughout history. However, the bioactive component in Zhuxi still remains unclear. In order to enunciate the material basis of its pharmacological activity, the present research has determined the chemical component and structure of Zhuxi. X-ray fluorescence spectroscopy (XRF), inductively coupled plasma optical emission spectrometer (ICP-OES) and X-ray diffraction (XRD) were utilized to assay two samples of Zhuxi. XRF and ICP-OES analysis indicated that the main elements in Zhuxi are Fe, S and O, also containing some minor elements, such as Si, Na, Mg, Al, K, Ni, Ca, Ti and so on. XRD analysis suggested that the main crystal compound in Zhuxi is FeS 2 (Cubic, Pa-3), also existing a few of Fe +3O(OH)(orthorhombic, Pbnm) and other some unknown compounds. These studies has highlighted the potential the element components and compound structures of Zhuxi, so it may be a good starting point for exploring the material basis of its pharmacological activity.


Li C.,CAS Northwest Institute of Plateau Biology | Lengbencairang,Gansu Province Academy of Tibetan Medicine | Sanglao,Gansu Province Academy of Tibetan Medicine | Gongbudongzhi,Gansu Province Academy of Tibetan Medicine | And 2 more authors.
Guang Pu Xue Yu Guang Pu Fen Xi/Spectroscopy and Spectral Analysis | Year: 2012

The element and microstructure of Tibetan medicine Fanshi were investigated, in order to explore the material basis of Fanshi. X-ray fluorescence spectroscope (XRF), inductively coupled plasma optical emission spectrometer (ICP-OES) and X-ray diffraction (XRD) were used to assay the Fanshi samples from different Tibetan regions. XRF and ICP-OES analysis show that the main elements in Fanshi are Ca, O and C, but also contain some kinds of minor elements, such as Mg, Al, Na, Si, K, Ag, Ba, Fe, Mn, S, Sr, Zn and so on. XRD analysis shows that the main material structures in Fanshi are (Mg xCa 1-x) CO 3 (rhombohedral, R-3c) and CaCO 3 (rhombohedral, R-3c), but also exists a small quantity of CaCO 3 (orthorhombic, Pmcn), SiO 2 (hexagonal, P3221), etc. The data of element and structure in Tibetan medicine Fanshi have been acquired by XRD, ICP-OES and XRD, and that is beneficial to exploring the material basis of Fanshi.

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