Lei S.-H.,Lanzhou University |
Lei S.-H.,Gansu Key Laboratory of Bone and Joint Disease |
Yue H.-Y.,Lanzhou University |
Wang J.,Gansu Key Laboratory of Bone and Joint Disease |
Wang Y.-L.,Lanzhou University
Chinese Journal of Tissue Engineering Research | Year: 2013
BACKGROUND: Bone marrow mesenchymal stem cells have the multi-potent differentiation ability, and can be induced to differentiate into the cells of various tissues including bone, cartilage, muscle, fat, liver and nerve. OBJECTIVE: To review the research progress in induced osteogenic differentiation of bone marrow mesenchymal stem cells. METHODS: We retrieved the articles in CHKD database, Pub Med database and Wanfang database published from 1995 to 2011 using the key words "bone marrow mesenchymal stem cells, osteoblast cells, osteogenic differentiation". Papers concerning bone marrow mesenchymal stem cells were initially included. After excluding papers with repeated or obsolete contents, 34 papers were included in the final analysis. RESULTS AND CONCLUSION: Bone marrow mesenchymal stem cells can rapidly differentiate into osteoblasts and proliferate under suitable induction of growth factors. It holds great promise in future application; moreover, it is easy to obtain, separate, expand, and transfect without apparent immune rejection. However, there are still some problems such as isolation and purification of bone marrow mesenchymal stem cells, optimal density for differentiation into osteoblasts, oncogenicity, and safety in vivo, which need further investigation.