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Lanzhou, China

Gansu Agricultural University is a university located in Lanzhou, Gansu province, People's Republic of China. Wikipedia.

Li H.J.,Gansu Agricultural University
Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji

The epidermal growth factor receptor (EGFR), a transmembrane protein receptor, is a member of ErbB family with signal-transducing tyrosine kinase activity. After combined with the ligand, EGFR homologous or heterologous dimers are formed to induce intracellular signal transduction, activate downstream signal transduction pathways, and then produce a series of biological effects. RAF/MEK/RAS/ERK pathway is relevant to cell proliferation, differentiation and apoptosis; while PDK1/AKT /PI3K pathway is involved in cell migration and adhesion. EGFR can promote the maturity of pulmonary type II epithelial cells and the synthesis and secretion of pulmonary surfactant. EGFR shows the effect on mammal lungs in a time-space and dose-dependent manner. The down-regulated expression of it will lead to immature lung development, while the over-expression can promote the cell proliferation, invasion and metastasis of the lung cancer cells. This paper reviewed advances in the study for EGFR and its signal pathway, as well as the relationship among EGFR, atelectasis and lung cancer. Source

She Y.,Gansu Agricultural University
Acta biochimica et biophysica Sinica

In this study, we assessed the toxic effects of formaldehyde (FA) on mouse bone marrow mesenchymal stem cells (BM-MSCs). Cytotoxicity was measured by using MTT assay. DNA strand breakage was detected by standard alkaline comet assay and comet assay modified with proteinase K (PK). DNA-protein crosslinks (DPCs) were detected by KCl-SDS precipitation assay. We found that FA at a concentration from 75 to 200 μM inhibited cell survival and induced DPCs over 125 μM. The PK-modified comet assay showed that FA-induced DNA strand breakage was increased in a dose-dependent manner from 75 to 200 μM. On the other hand, standard alkaline comet assay showed that DNA strand breakage was decreased with FA concentration over 125 μM. We confirmed by using Pearson correlation that there was a negative linear correlation between DPCs and survival rate (r = -0.987, P < 0.01) and positive linear relationships between DPCs and (i) sister chromatid exchange and (ii) micronucleus (r = 0.995, P < 0.01; r = 0.968, P < 0.01). DNA damage RT(2) profiler polymerase chain reaction array was used to investigate the changes in the expression of damage response genes. Xpa and Xpc of the nucleotide excision repair pathway and Brca2, Rad51, and Xrcc2 of the homologous recombination pathway were all up-regulated in both 75 and 125 μM FA. However, the same genes were down-regulated with 175 μM FA. The expressions of Chek1 and Hus1, which are involved in cell cycle regulation, were altered in the same manner with 75, 125, and 175 μM FA. These results indicated that Xpa, Xpc, Brca2, Rad51, Xrcc2, Chek1, and Hus1 were essential for the BM-MSCs to counteract the effects of FA. Source

Zhang F.,Stellenbosch University | Zhang F.,Gansu Agricultural University | Hui C.,Stellenbosch University
Animal Behaviour

Owing to the trade-off between time for searching for and exploiting resources, choosing a profitable food resource is key for an animal's survival and reproductive success. Although the optimal diet model (ODM) from optimal foraging theory (OFT) has demonstrated this point successfully by modelling the global maximization of energy intake rate for foraging, the behavioural mechanisms by which animals achieve optimization, especially when facing a novel environment, have yet to be understood. Here we propose a recent experience-driven (RED) decision-making rule of foraging that relies only on short-term memory of recent feeding experience and hunger aversion. This contrasts with the ODM, which assumes both global information access to the forager and its apparent ability to reach optimal choices. Despite relying only on limited past experience and hunger aversion, this behavioural rule not only accounts for nearly the same energy intake rate as predicted by the ODM but also can flexibly respond to changing environments by rapidly reaching new optimization. The RED behaviour also predicts a more realistic partial preference for diet choice, contrasting with the zero-one rule of OFT which allows for no partial preference within the forager's diet. The partial preference simply emerges from the RED strategy, as opposed to decision-making errors imposed from behavioural and physiological constraints. The RED rule further elucidates three potential traits that natural selection can act upon for optimizing foraging: (1) short-term memory of recent feeding experience, (2) ability to recognize encountered resources, and (3) basic neural set-up for alternative responses to environmental cues. This simple and flexible RED rule thus provides a behavioural mechanism for optimal foraging, and can be further applied to decision-making theory in psychology and economics. © 2013 The Association for the Study of Animal Behaviour. Source

Wei Y.J.,Gansu Agricultural University
New Zealand Entomologist

The tolerance of adult Nysius huttoni to starvation, and the effect of water and glucose on the longevity of adults, were studied. When no food or water was provided, adults lived for an average of 2-4 days. Mean longevity of first-generation adults (4.2 days) was significantly greater than that of second- and third-generation adults (2.2 and 2.5 days respectively; P < 0.05) suggesting that differences in resistance to starvation of adults between generations are influenced by the nutrient status during their nymphal development. There was no significant difference between longevity of male and female adults. When water alone was provided, mean adult longevity was 8.4 days. The effect of glucose on adult longevity was examined with the use of eight different glucose concentrations (2, 5, 10, 15, 20, 25, 30 and 40%) at 20 ± 0.5°C and 65-75% relative humidity (RH). Mean maximum longevity (49.0-51.6 days) was obtained at glucose concentrations of 10-20%, but decreased at higher (25-40%, 27.0-31.7 days) and lower (2- 5%, 32.1-41.4 days) glucose concentrations. The relationship between longevity and the absorption and metabolism of glucose by N. huttoni adults is discussed. © 2012 The Entomological Society of New Zealand. Source

Shang X.-J.,Gansu Agricultural University | Li Z.,Lanzhou University | Liu Z.-Q.,Lanzhou University
Tetrahedron Letters

An I2O5-promoted decarboxylative trifluoromethylation of a series of cinnamic acids and their derivatives by using sodium trifluoromethanesulfinate in aqueous media was demonstrated. This strategy provides a safe and convenient access to various trifluoromethylated (E)-alkenes in a very high selectivity. © 2014 Elsevier Ltd. All rights reserved. Source

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