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Zhang J.M.,Gansu Academy of Medical science
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials | Year: 2010

To study the chemical constituents from pine needles of Cedrus deodara. Chemical constituents were isolated from 95% ethanol extract by silica gel and Sephadex LH-20 column chromatography. The structures were elucidated through spectroscopic analysis. The compounds were identified as 10-nonacosanol (1), dibutyl phthalate (2), protocatechuic acid (3), phthalic acid bis-(2-ethylhexyl) ester (4), (E)-1-O-p-coumaroyl-beta-D-glucopyranoside (5), 5-p-trans-coumaroylguinic acid (6). Compounds 1- 6 are obtained from this genus for the first time. Source


Wang J.,Bioactive Products Engineering Research Center For Gansu Distinctive Plants | Wang J.,Northwest Normal University | Guo H.,Gansu Academy of Medical science | Zhang J.,Bioactive Products Engineering Research Center For Gansu Distinctive Plants | And 8 more authors.
Carbohydrate Polymers | Year: 2010

Sulfated polysaccharides exerted potent biological property which was relative to degree of sulfation (DS), Mw, substitution position and chain conformation. In the present study, sulfated derivatives of Artemisia sphaerocephala polysaccharide (ASP) with different DS were synthesized by chlorosulfuric acid/pyridine method. FT-IR and 13C NMR analysis indicated that C-6 substitution was predominant in sulfated ASP (SASP) compared with other positions at C-2. In the sulfation reaction, a sharp decrease in Mw was observed in SASP. The df values from 1.96 to 2.77 indicated that the -SO3H groups leading to the relatively expanded conformation of SASP. Antioxidant assays showed that SASP had better antioxidant activities. The data obtained in vitro models indicated that high DS and moderate Mw showed the best antioxidant capacities. Crown Copyright © 2010. Source


Zheng X.,Lanzhou University | Dong F.,Gansu Academy of Medical science | Yang J.,Lanzhou University | Duan X.,Lanzhou University | And 3 more authors.
Journal of Radioanalytical and Nuclear Chemistry | Year: 2011

This work reports the synthesis and preliminary biodistribution results of [131I]SIB-PEG4-CHC in tumor-bearing mice. The tributylstannyl precursor ATE-PEG4-CHC was synthesized by conjugation of ATE to amino pegylated colchicine NH2-PEG4-CHC. [ 131I]SIB-PEG4-CHC was radiosynthesized by electrophilic destannylation of the precursor with a yield of ~44%. The radiochemical purity (RCP) appeared to be >95% by a Sep-Pak cartridge purification. [ 131I]SIB-PEG4-CHC was lipophilic and was stable at room temperature. Biodistribution studies in tumor-bearing mice showed that [ 131I]SIB-PEG4-CHC cleared from background rapidly, and didn't deiodinate in vivo. However, the poor tumor localization excluded it from further investigations as a tumor-targeted radiopharmaceuticals. © 2010 Akadémiai Kiadó, Budapest, Hungary. Source


Shi X.F.,Gansu Academy of Medical science
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials | Year: 2012

To study the chemical constituents of the dichloromethane extracted from pine needles of Cedrus deodara. Compounds were isolated and purified from the dichloromethane extract of pine needles by chromatography on silica gel and Sephadex LH-20. Their structures were identified on the basis of spectroscopic analysis and physicochemical property. Nine compounds were isolated and purified. Their structures were identified as stigmasterol (1), oleanolic acid (2), parahydroxybenzaldehyde (3), beta-sitosterol (4), syringaresinol (5), daucosterol (6), p-hydroxybenzoic acid (7), gallicin (8) and gallic acid (9). Compounds 1-3, 5 -9 are isolated from pine needles of this genus for the first time. Source


Ma Q.H.,Gansu Academy of Medical science
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials | Year: 2012

To study the chemical constituents from Patrinia scabra Bunge. Chemical constituents were isolated and purified by silica gel and Sephadex LH-20 column chromatography. Their structures were elucidated on the basis of spectroscopic analysis and chemical evidence. Seven compounds were isolated and purified. Their structures were identified as villosol (I), patriscabrol (II), protocatechuic acid (III), beta-daucosterol (IV), oleic acid (V), beta-sitosterol (VI), erucic acid (VII). Compounds I, III, V, VII are isolated from this plant for the first time. Source

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