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Yamunānagar, India

Bansal S.,Jaypee University of Information Technology | Sharma M.,Jaypee University of Information Technology | Kumar S.S.,Jaypee University of Information Technology | Lohan S.,Jaypee University of Information Technology | And 3 more authors.
Food Research International | Year: 2013

Tea (Camellia sinensis) is one of the most popular nonalcoholic beverages, consumed by over two-thirds of the world's population because of its refreshing, mild stimulant and medicinal properties. It is processed in different ways in different parts of the world to give green, black, oolong, and pu-erh tea. Among all tea polyphenols, epigallocatechin-3-gallate has been responsible for much of the health promoting abilities of tea including anti-inflammatory, antimicrobial, antitumour, anti-oxidative, protection from cardiovascular disease, anti-obesity, and anti-aging properties. In the present review, the antibacterial, antiviral, and antifungal activities of different types of tea and their polyphenols are reported, highlighting their mechanisms of action and structure-activity relationship. Moreover, considering that the changing patterns of infectious diseases and the emergence of microbial strains resistant to current antibiotics, there is an urgent need to find out new potent antimicrobial agents as adjuvants to antibiotic therapy. The synergistic effect of tea polyphenols in combination with conventional antimicrobial agents against clinical multidrug-resistant microorganisms has also been discussed in this review. © 2013 Elsevier Ltd.


Mathur P.,Ganpati Institute of Pharmacy | Syan N.,Ganpati Institute of Pharmacy | Verma S.,Kurukshetra University
International Journal of Pharmacy and Technology | Year: 2011

Transdermal drug delivery (TDD) via skin to the systemic circulation provides a convenient route of administration for a variety of clinical situations. The skin layer stratum corneum is the main barrier for permeation of drug into the skin. So to pass the stratum corneum and to increase the flux through skin membrane, different approaches of penetration enhancement are to be used. Transdermal drug technology specialists are continuing to search for new methods that can effectively and painlessly deliver the larger molecules into the skin. Several new active rate controlled transdermal drug delivery system (TDDS) technologies (chemical based, physical based, electrically-based, structure-based, velocity-based, etc.) have been found, developed and commercialized for the TDD. This review article covers most of the new active transport enhancement technologies involved in enhancing the transdermal permeation into an effective drug delivery system. An attempt has been done in depth to cover the penetration enhancement techniques (chemical, physical and various important approaches) which are useful for a optimized and successful TDD.


Bansal S.,Ganpati Institute of Pharmacy | Syan N.,Ganpati Institute of Pharmacy | Mathur P.,Ganpati Institute of Pharmacy | Choudhary S.,Doon valley Institute of Pharmacy and Medicine
Medicinal Chemistry Research | Year: 2012

Tea (Camellia sinensis, Theaceae) is the second most consumed beverages in the world, next to water in terms of worldwide popularity. The chemical components of green tea chiefly include polyphenols, caffeine, and amino acids. Green tea is rich in catechins, of which (-)-epigallocatechin-3-gallate is the most abundant. As described in literature, green tea and its polyphenols are beneficial in curing a wide variety of diseases like cancer, diabetes, cardiovascular disease, obesity, etc. It also has antimicrobial activity, protects from solar radiations, and possesses neuroprotective properties. The current review article focuses on pharmacological profile associated with Green tea and its polyphenols. We hope that this review will expose areas for further study and encourage research on important public health issue. © Springer Science+Business Media, LLC 2011.


Syan N.,Ganpati Institute of Pharmacy | Mathur P.,Ganpati Institute of Pharmacy
Asian Journal of Pharmaceutical and Clinical Research | Year: 2011

The investigation was concerned to make a successive colon targeted delivery of compression coated aceclofenac tablets. The influence of locust bean gum and xanthan gum polymers and their various combinations was studied on drug release profile. The preformulation studies like FTIR spectroscopy and differential scanning calorimetry (DSC) showed the absence of drug-excipient interactions. The tablets were found within the permissible limits for various physicochemical parameters. Dissolution studies were performed in 0.1N HCl for 2 h, in pH 7.4 buffer for 3 h and the in pH 6.8 buffer up to 24 h. The in vitro studies were also performed in pH 6.8 phosphate buffer containing 4% w/v rat caecal content. The cumulative percentage release of aceclofenac after 24 h was found 61.40±1.02%, 54.43±1.86%, 46.27±1.96%, 39.37±2.70%, 49.63±2.88% (mean±S.D.), for formulation LX1, LX2, LX3, LX4 LX5 respectively. The effect of presence of rat ceacal content (4%w/v) on cumulative % drug release was observed significantly positive. The formulations containing locust bean alone showed rapid release of drug. Whereas combination of locust bean gum and xanthan gum was found sufficient to sustain the drug release for successful colon targeting. Present study on the polysaccharides demonstrated that the combination of locust bean gum and xanthan gum as a coating material proved capable of protecting the core tablet containing aceclofenac during the condition mimicking mouth to colon transit.

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