Korac R.R.,University of Belgrade |
Khambholja K.M.,Ganpat University
Pharmacognosy Reviews | Year: 2011
Herbs have been used in medicines and cosmetics from centuries. Their potential to treat different skin diseases, to adorn and improve the skin appearance is well-known. As ultraviolet (UV) radiation can cause sunburns, wrinkles, lower immunity against infections, premature aging, and cancer, there is permanent need for protection from UV radiation and prevention from their side effects. Herbs and herbal preparations have a high potential due to their antioxidant activity, primarily. Antioxidants such as vitamins (vitamin C, vitamin E), flavonoids, and phenolic acids play the main role in fighting against free radical species that are the main cause of numerous negative skin changes. Although isolated plant compounds have a high potential in protection of the skin, whole herbs extracts showed better potential due to their complex composition. Many studies showed that green and black tea (polyphenols) ameliorate adverse skin reactions following UV exposure. The gel from aloe is believed to stimulate skin and assist in new cell growth. Spectrophotometer testing indicates that as a concentrated extract of Krameria triandra it absorbs 25 to 30% of the amount of UV radiation typically absorbed by octyl methoxycinnamate. Sesame oil resists 30% of UV rays, while coconut, peanut, olive, and cottonseed oils block out about 20%. A "sclerojuglonic" compound which is forming from naphthoquinone and keratin is the reaction product that provides UV protection. Traditional use of plant in medication or beautification is the basis for researches and making new trends in cosmetics. This review covers all essential aspects of potential of herbs as radioprotective agents and its future prospects.
Patel R.M.,Ganpat University |
Patel S.K.,Ganpat University
Journal of Applied Pharmaceutical Science | Year: 2011
from plants which are proving to be excellent sources of new compounds. The present research article was aimed to study the cytotoxic activity of methanolic extracts of Artocarpus heterophyllus plant by various in vitro cytotoxic assays like MTT and SRB against different cell lines like HEK293, A549, HeLa and MCF-7. The IC50 values of methanolic extract of Artocarpus heterophyllus were found 35.26 μgm/ml and 35.27 μgm/ml against A549 cell line by MTT and SRB assay methods respectively whereas this extract was found to be non toxic to normal cells (HEK293), proved that the methanolic extract exhibited significant anti cancer potential with no toxicity on normal cell line. The methanolic extract had no activity against Hela and MCF-7 cell line.
Vachhani Kevin H.,Ganpat University |
Patel Satish A.,Ganpat University
Journal of Applied Pharmaceutical Science | Year: 2011
The present manuscript describes simple, sensitive, rapid, accurate, precise and economic dual wavelength spectrophotometric method for simultaneous determination of metoprolol succinate and olmesartan medoxomil in combined tablet dosage form. The utility of dual wavelength data processing program is its ability to calculate unknown concentration of components of interest in a mixture containing an interfering component. The principle for dual wavelength method is "the absorbance difference between two points on the mixture spectra is directly proportional to the concentration of the component of interest". The wavelengths selected for determination of metoprolol succinate were 225.2 nm and 258.2 nm, whereas the wavelengths selected for determination of olmesartan medoxomil were 211 nm and 229.8 nm. The two drugs follow Beer-Lambert's law over the concentration range of 5-30 μg/ml. The method was successfully applied to pharmaceutical dosage form because no interference from the tablet excipients was found. The results of analysis have been validated statistically and by recovery studies.
Soni P.,Ganpat University
Proceedings of the IEEE | Year: 2010
M-commerce is the next generation of today's PC-based wired, e-commerce technology. The evolving success of mobile communication is transforming e-commerce into m-commerce. Users as a group of mobile devices are considered as a large potential market. Mobile commerce is any transaction involving the transfer of ownership or rights to use goods and services which is initiated and/or completed by using mobile access to computer-mediated networks with the help of an electronic device. Things are more complex when one or more operators are involved. There can be the case where the consumer and the merchant have accounts in different banks. Credit card or debit card information is stored in the mobile phone, so hackers can interpret it and use it for malicious purposes. The mobile operator will ask the consumer for his mobile personal identification number (MPIN). After verification of the MPIN, the mobile operator will verify the consumer's bank information.
Jadeja Y.,Ganpat University |
Modi K.,Ganpat University
2012 International Conference on Computing, Electronics and Electrical Technologies, ICCEET 2012 | Year: 2012
With the advent internet in the 1990s to the present day facilities of ubiquitous computing, the internet has changed the computing world in a drastic way. It has traveled from the concept of parallel computing to distributed computing to grid computing and recently to cloud computing. Although the idea of cloud computing has been around for quite some time, it is an emerging field of computer science. Cloud computing can be defined as a computing environment where computing needs by one party can be outsourced to another party and when need be arise to use the computing power or resources like database or emails, they can access them via internet. Cloud computing is a recent trend in IT that moves computing and data away from desktop and portable PCs into large data centers. The main advantage of cloud computing is that customers do not have to pay for infrastructure, its installation, required man power to handle such infrastructure and maintenance. In this paper we will discuss what makes all this possible, what is the architectural design of cloud computing and its applications. © 2012 IEEE.
Sharma R.N.,Ganpat University |
Ravani R.,Ganpat University
Medicinal Chemistry Research | Year: 2013
Synthesis of novel quinazolinone derivatives was performed from the reaction of N-benzoyl substituted piperazine-1-carbothioamide with 2-chloromethyl quinazolinone derivatives and screened for their in vitro cytotoxic activity by MTT assay. The cell lines used were NCI (human lung cancer cell), MCF 7 (Breast cancer cell), and HEK 293 (Normal epidermal kidney cell). Result of screening on cell line showed moderate to good anticancer activity for all the compounds. Compound 3d (IC50 = 1.1 ± 0.03 μM) was found to be the most active compared to standard methotrexate (IC50 = 2.20 ± 0.18 μM) and 5-florouracil (IC50 = 2.30 ± 0.49 μM). Structure activity relationship of synthesized analogs suggested that the presence of NH linker with aryl moiety at the third position of quinazolinone ring was important for potent anticancer activity. Electron donating group on phenyl ring at the third position of quinazolinone ring gave better anticancer activity then unsubstituted phenyl and electron withdrawing group. Activity by substituted piperazine at 2nd position of thiazole linked with quinazolinone scaffold gave better activity in the order of H > CH 3 > CO-C6H5. Our findings may impart new direction to medicinal chemists and biochemists for further investigations of quinazolinone-thiazole containing anticancer agents. © 2012 Springer Science+Business Media New York.
Chaudhari B.G.,Ganpat University
Journal of Applied Pharmaceutical Science | Year: 2012
A simple, precise and rapid reverse-phase HPLC method has been developed and subsequently validated for the simultaneous estimation of Amlodipine besylate and Enalapril maleate from their combination drug product. The proposed RP-HPLC method utilizes a Phenomenex C18, 5 μm, 250 mm × 4.6 mm i.d. column, at ambient temperature, optimum mobile phase consisted of Methanol: Acetonitrile : Water (40:50:10, v/v/v),effluent flow rate monitored at 1.0 mL min-1, and detection using PDA detector. The described method was linear over the range of 0.5-6.0 μg/ml and 0.5-8.0 μg/ml for Enalapril maleate and Amlodipine besylate, respectively. The mean recovery was found to be 100.06± 0.49 % and 99.98± 0.63 % for Enalapril maleate and Amlodipine besylate, respectively. The intermediate precision data obtained under different experimental setup, the calculated value of coefficient of variation (CV, %) was found to be less than critical value. The proposed method can be useful in the quality control of bulk manufacturing and pharmaceutical dosage forms.
Patel S.K.,Ganpat University |
Patel N.J.,Ganpat University
Journal of AOAC International | Year: 2010
This paper describes the development of a stability-indicating RP-HPLC method for the determination of atomoxetine hydrochloride (ATX) in the presence of its degradation products generated from forced decomposition studies. The drug substance was subjected to stress conditions of acid, base, oxidation, wet heat, dry heat, and photodegradation. In stability tests, the drug was susceptible to acid, base, oxidation, and dry and wet heat degradation. It was found to be stable under the photolytic conditions tested. The drug was successfully separated from the degradation products formed under stress conditions on a Phenomenex C18 column (250 × 4.6 mm id, 5 mm particle size) by using acetonitrile-methanol-0.032 M ammonium acetate (55 + 05 + 40, v/v/v) as the mobile phase at 1.0 mL/min and 40°C. Photodiode array detection at 275 nm was used for quantitation after RP-HPLC over the concentration range of 0.5-5 μg/mL with a mean recovery of 100.8 ± 0.4% for ATX. Statistical analysis demonstrated that the method is repeatable, specific, and accurate for the estimation of ATX. Because the method effectively separates the drug from its degradation products, it can be used as a stability-indicating method.
Chaudhari B.G.,Ganpat University |
Patel A.B.,JKK Nataraja Dental College and Hospital
International Journal of ChemTech Research | Year: 2010
A simple and economical dual wavelength spectrophotometric method has been developed for the simultaneous estimation of atorvastatin calcium and amlodipine besylate in their combined dosage forms. The method was based on property of additivity of absorbances. The two wavelengths on amlodipine besylate curve were found out where it showed same absorbance, which were 257.4 and 360.0 nm. At 360.0 nm, amlodipine besylate showed some absorbance while atorvastatin calcium showed zero absorbance. Both the drugs gave absorbance at 257.4 nm. The method involved solving of an equation based on measurement of absorbances at two wavelengths 257.4 and 360.0 nm. The proposed method was found to be simple, economical, accurate and reproducible for the routine analysis of both drugs in tablet dosage forms.
Sharma R.,Ganpat University |
Pancholi S.,Ganpat University
Acta Pharmaceutica | Year: 2010
A simple, sensitive and precise RP-HPLC-DAD method was developed and validated for the determination of olmesartan medoxomil (AT-II receptor blocker) in the presence of its degradation products. Olmesartan medoxomil and all the degradation products were resolved on a C18 column with the mobile phase composed of methanol, acetonitrile and water (60:15:25, V/V/V, pH 3.5 by orthophosphoric acid) at 260 nm using a photodiode array detector. The method was linear over the concentration range of 1-18 μg mL-1 and precise with RSD < 1 % in intra- and inter-day study. Excellent recoveries of 99.3 ± 0.9 to 100.8 ± 1.2% proved the accuracy of the method. Developed method was specific, as indicated by chromatographic resolution > 2.0 for each peak and sensitive with LOD 0.03 μg mL-1 and LOQ 0.1 μg mL-1. The method was used to study the drug degradation behavior under forced conditions. Four degradation products (DP-I, II, III, IV) were formed during the degradation study in 0.1 mol L-1 HCl whereas only DP-I, II and III were formed in water, 0.01 mol L-1 NaOH and 3% H2O2. No significant thermal or photolytic degradation was observed in solid drug. The method was applied successfully for the assay of olmesartan medoxomil in the tablet dosage form.