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Park Y.H.,Gangwon Provincial Agricultural Research and Extention Services | Lim S.H.,Gangwon Provincial Agricultural Research and Extention Services | Kim H.Y.,Gangwon Provincial Agricultural Research and Extention Services | Park M.H.,Gangwon Provincial Agricultural Research and Extention Services | And 4 more authors.
Journal of the Korean Society of Food Science and Nutrition | Year: 2011

We investigated the biological activities of extracts from the flowers of Angelica gigas Nakai. The IC 50 of the DPPH radical scavenging activity was 3,535 and 105.0 μg/mL in the water and ethanol extracts, respectively, whereas it was 12.7 μg/mL for ascorbic acid. The results showed that the total polyphenol content of the ethanol extracts (48.43±0.18 mg/g) was higher than that of the water extracts (39.03±0.69 mg/g). The flavonoid content of the ethanol extracts (67.02±4.38 mg/g) was higher than that of the water extracts (50.32±1.24 mg/g). The ethanol extract showed a 34.45% lower α-glucosidase inhibition activity than that for acarbose. The ethanol extract showed a 23.62% lower α-amylase inhibition activity compared with that for acarbose. The water extract showed 16.76% lower pancreatic lipase inhibition activity. Anti-cancer and anti-inflammatory activity was also lower. These results suggest that the flower of Angelica gigas Nakai may be useful as an anti-oxidative agent.


Park Y.H.,Gangwon Provincial Agricultural Research and Extention Services | Lim S.H.,Gangwon Provincial Agricultural Research and Extention Services | Ham H.J.,Gangwon Provincial Agricultural Research and Extention Services | Jeong H.N.,Ginseng and Medicinal Plants Experiment Station | And 3 more authors.
Journal of the Korean Society of Food Science and Nutrition | Year: 2010

Biological activities of different parts (stems, leaves, roots, fruits) and solvents (water, ethanol) of seabuckthorn (Hippophae rhamnoides L.) grown in Korea were tested as follows. In the experiment of inhibiting α- glucosidase activity, ethanol extract of Hippophae rhamnoides L. stem showed the highest inhibitory activity by 93% and the next highest was the ethanol extract of its leaf by 88.7%. In the case of these two extracts, the effect of inhibiting α-glucosidase activity was extraordinarily great when comparing with control group, acarbose. In the experiment of inhibiting α-amylase activity, water extract of leaf showed the highest result by 54.7%, among all extracts. Regarding anticancer effect for HT-29 cell and DU-145 cell, water extract of root showed 47.1% and 32.3% activities, respectively. The experiment on antibacterial activity showed that the ethanol extract from the leaf inhibitory activity of Clostridium butyricum, Proteus mirabilis, and Shigella flexneri which are the several food borne pathogenic strains. In future research, materials for biological activity appear isolated and purified and research should continue.


Park Y.H.,Gangwon Provincial Agricultural Research and Extention Services | Lim S.H.,Gangwon Provincial Agricultural Research and Extention Services | Ham H.J.,Gangwon Provincial Agricultural Research and Extention Services | Kim H.Y.,Gangwon Provincial Agricultural Research and Extention Services | And 3 more authors.
Journal of the Korean Society of Food Science and Nutrition | Year: 2010

The objective of this study was to isolate and identify anti-inflammatory chemicals in Hippophae rhamnoides L. which was grown in Chuncheon, Korea. Treatment of ethanol extracts from stems, leaves, roots, and fruits to RAW 264.7 cells reduced amounts of nitrite by 56.0, 31.9, 49.1, and 18.9% respectively, compared to only lipopolysaccharide (LPS) treatment which is well-known as a inflammation-inducing agent. The stems were extracted with hexane, dichloromethane, ethyl acetate, butanol, and water and their nitrite contents in RAW 264.7 cells were measured. The dichloromethane extracts showed the highest inflammatory activity, exhibiting 80% reduction of the nitrite content at 1 mg/mL treatment. Activity-directed fractionation of dichloromethane extracts led to the identification of β-sitosterol as the anti-inflammatory chemical. 0.1 mg/mL treatment of β-sitosterol inhibited strongly the production of nitrite by 65%, compared to only LPS treatment. These results suggest that stem of H. rhamnoides L. may be useful for inflammation treatment.


Lim S.H.,Gangwon Provincial Agricultural Research and Extention Services | Park Y.H.,Gangwon Provincial Agricultural Research and Extention Services | Kwon C.J.,Gangwon Provincial Agricultural Research and Extention Services | Ham H.J.,Gangwon Provincial Agricultural Research and Extention Services | And 3 more authors.
Journal of the Korean Society of Food Science and Nutrition | Year: 2010

Hypoglycemic effect through activity inhibition of α-glucosidase and α-amylase was evaluated using leavesof Eleutherococcus senticosu, Eleutherococcus gracilistylus, Eleutherococcus sieboldianus and Eleutherococcussessiliflorus which belong to Acanthopanax sessiliflorus genus. As a result of measuring α-glucosidase activityinhibition, extract of Eleutherococcus gracilistylus showed around 43.38% of activity inhibition compared withacarbose and extract of Eleutherococcus senticosu showed 41.24% inhibitory effect. As a result of measuringα-amylase activity inhibition, acarbose showed 73.25% of activity inhibition in 10 mg/mL concentration, andthe extract of Eleutherococcus senticosu leaves showed 91.90% higher activity inhibition compared withacarbose. Also, after subjects in a model were induced diabetes with streptozotocin (STZ) intake plant extractfrom Acanthopanax sessiliflorus for 2 weeks, effect of improving blood glucose level and fat was examined.In all groups with specimen, Eleutherococcus senticosu (T1), Eleutherococcus gracilistylus (T2), Eleutherococcussieboldianus (T3) and Eleutherococcus sessiliflorus (T4), blood glucose level was significantly decreased comparedwith that in control group (C). In an experiment of examining changes in fat concentration in blood, totalcholesterol content increased in a control group compared with a normal, while in T1, T3 and T4, it decreasedsignificantly compared with the control group. As for HDL-cholesterol, it significantly increased in all diabetesinduced groups compared with the normal group, and in T3, it increased the most significantly by 55.61% comparedwith the control group. In case of LDL-cholesterol, specific difference between the normal group andthe control group was not found; however, significant increase was detected in T2 and T3, whereas in T1 andT4, it decreased significantly compared with the control group. As for triglyceride, its concentration increasedin the control group like total cholesterol. It decreased 60.16% in T3, 60.80% in T4 and 50.16% in T1 comparedwith the control group. As a result of measuring the concentration of triglyceride in extracted liver, the controlgroup showed significant increase compared with the normal group, whereas T1 and T2 showed significantdecrease compared with the normal group. The above results show that extracts from Acanthopanax sessiliflorusgenus are effective for hypoglycemic and improving fat metabolism due to diabetes.

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